Journal of Headache and Pain最新文献

{"title":"The dual impact of ictal and interictal burden in migraine: an analysis from the ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME) Japan second study.","authors":"Tsubasa Takizawa, Daisuke Danno, Ryotaro Ishii, Shiho Suzuki, Moemi Miura, Yoshinori Tanizawa, Satoshi Osaga, Michio Okada, Chie Hashimoto, Mika Komori","doi":"10.1186/s10194-025-02079-z","DOIUrl":"10.1186/s10194-025-02079-z","url":null,"abstract":"<p><strong>Background: </strong>Migraine adversely affects many aspects of daily life. In addition to burdens during headaches (ictal period), burdens between headaches (interictal period) are increasingly recognized. In this analysis of the ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE in Japan (OVERCOME [Japan]) 2nd study, we evaluated the contribution of interictal burden to daily activities, quality of life, work, family, costs, and medical treatment.</p><p><strong>Methods: </strong>The OVERCOME (Japan) 2nd study was a cross-sectional, web-based survey of 19,590 adults in Japan with migraine conducted between June and August 2023. Questionnaires included Headache Impact Test-6 (HIT-6), Migraine Interictal Burden Scale-4 (MIBS-4), Migraine Disability Assessment (MIDAS), Allodynia Symptom Checklist-12 (ASC-12), Migraine-Specific Quality-of-Life Questionnaire (MSQ), Impact of Migraine on Partners and Adolescent Children Scale (IMPAC), Work Productivity and Activity Impairment Questionnaire-Migraine (WPAI-M), and Migraine Treatment Optimization Questionnaire-6 (mTOQ-6). Additional questions asked about costs, frequency of migraine concerns between headaches, and experience with medical treatment. Analyses were conducted on subgroups based on HIT-6 and MIBS-4 scores: Severe (HIT-6 ≥ 60, MIBS-4 ≥ 3; n = 6854), High Interictal Burden (HIT-6 < 60, MIBS-4 ≥ 3; n = 2368), High Ictal Burden (HIT-6 ≥ 60, MIBS-4 < 3; n = 4253), and Milder (HIT-6 < 60, MIBS-4 < 3; n = 6115).</p><p><strong>Results: </strong>Number of monthly headache days, total MIDAS score, and pain severity score were higher, and MSQ scores lower, in subgroups with higher HIT-6 (HIT-High) versus subgroups with lower HIT-6 (HIT-Low). Within both HIT-High and HIT-Low subgroups, those with higher MIBS-4 had higher MIDAS and lower MSQ. IMPAC grade, ASC-12 score, and WPAI-M absenteeism were higher in the High Interictal Burden subgroup versus the High Ictal Burden subgroup. Concerns between headaches were more frequent, and costs higher, in subgroups with higher MIBS-4 (MIBS-High) versus subgroups with lower MIBS-4 (MIBS-Low). Acute treatment prescription analgesics were more commonly used in HIT-High versus HIT-Low subgroups, but triptans, lasmiditan, and preventive drugs were more common in the High Interictal Burden subgroup versus the High Ictal Burden subgroup.</p><p><strong>Conclusions: </strong>These results revealed that high interictal burden negatively affects multiple aspects of daily life in Japanese people with migraine independently of the impact of headaches.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"140"},"PeriodicalIF":7.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.","authors":"Dan Liu, Menghan Li, Heng Jiang, Yiqi Mi, Xiaolei Xu, Yali Zhou, Yaxian Hou, Yuquan Shen, Michael Maes, Xiao Xiao, Feng Zhou, Luca Giani, Keith M Kendrick, Benjamin Becker, Stefania Ferraro","doi":"10.1186/s10194-025-02051-x","DOIUrl":"10.1186/s10194-025-02051-x","url":null,"abstract":"<p><strong>Background: </strong>Accumulating evidence suggests that migraine patients present abnormal brain responses to salient sensory and emotional stimuli. However, it is still unclear whether this is a generalized or domain-specific phenomenon. Employing a well-validated fMRI paradigm, we investigated pain empathic reactivity across two domains: observation of physical pain (noxious stimulation) and affective pain (facial expressions). On the basis of a generalized hyperexcitability/hyperreactivity in migraine, we hypothesized abnormal responses to both dimensions of pain empathy.</p><p><strong>Methods: </strong>We collected fMRI and psychometric data from 21 migraine patients and matched controls. Univariate and multivariate neuroimaging analyses were utilized to examine domain-specific dysregulations in (a) neural reactivity in meta-analytically defined shared regions of pain-empathy processing, and (b) whole-brain neurofunctional signatures of physical and affective pain empathy (VPS, Zhou et al., 2020). Logistic regression models and machine learning-based classification were employed to determine differences between groups (migraine or control).</p><p><strong>Results: </strong>Migraine patients exhibit increased neural responses during empathy for physical pain in the bilateral inferior frontal gyrus (slightly more pronounced on the right side), with alterations on the right significantly associated with the pain experienced during the attack. On the whole-brain level, the predictive accuracy of the VPS for physical pain empathy was shown to be significantly higher for patients as compared to controls, reaching 100% accuracy. Across analyses, we did not find evidence of altered empathy processing for affective pain.</p><p><strong>Conclusions: </strong>Contrary to our hypothesis, our results indicate that migraine patients present a domain-specific increased brain responsivity, localized in the bilateral inferior frontal gyrus but also extending to subtle whole brain patterns, during empathy for physical pain stimuli, but not during empathy for affective pain. Based on the evidence that the neural pathways for empathy for physical pain and experimental pain robustly overlap, these results indicate a specific hyperresponsivity of the pain pathways, with the inferior frontal gyrus likely playing a regulatory role in modulating pain-related processes. Finally, the results underscore the translational application potential of neuroaffective multivariate signatures as neuromarkers for pathological dysregulations in affective and pain-related processes.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"137"},"PeriodicalIF":7.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine is a risk factor for dementia: a systematic review and meta-analysis of cohort studies.","authors":"Wenyan Zhu, Yijun Zhan, Jian Pei, Qinhui Fu, Ruiqi Wang, Qianwen Yang, Qingyang Guan, Like Zhu","doi":"10.1186/s10194-025-02078-0","DOIUrl":"10.1186/s10194-025-02078-0","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"136"},"PeriodicalIF":7.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the total cholesterol to high-density lipoprotein cholesterol ratio with all-cause mortality risk in the migraine population.","authors":"Zhao-Xuan Lu, Bing-Qing Dong, Liang Chen, Heng-Le Wei","doi":"10.1186/s10194-025-02077-1","DOIUrl":"10.1186/s10194-025-02077-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"135"},"PeriodicalIF":7.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lactylation-immune regulatory axis: a potential therapeutic target for migraine prevention and treatment.","authors":"Liu Wang, Zhixuan Lan, Ying He, Yue Cheng, Ruilin He, Zongbin Jiang","doi":"10.1186/s10194-025-02075-3","DOIUrl":"10.1186/s10194-025-02075-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"134"},"PeriodicalIF":7.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking in primary headaches - a systematic review and meta-analysis.","authors":"Bartłomiej Błaszczyk, Helena Martynowicz, Jakub Przegrałek, Piotr Niemiec, Marcin Straburzyński, Sławomir Budrewicz, Marta Waliszewska-Prosół","doi":"10.1186/s10194-025-02076-2","DOIUrl":"10.1186/s10194-025-02076-2","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"133"},"PeriodicalIF":7.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired glymphatic function contributes to high-frequency attacks in patients with episodic migraine.","authors":"Xin Cai, Wei Sun, Mengfei Cai, Dawei Li, Zhenzhen Chen, Hao Li, Bo Yuan, Yan Li, Zaiyi Liu, Yuhu Zhang","doi":"10.1186/s10194-025-02070-8","DOIUrl":"10.1186/s10194-025-02070-8","url":null,"abstract":"<p><strong>Background and objective: </strong>Previous studies have reported inconsistent results regarding glymphatic function in migraine patients. This study aimed to investigate glymphatic function in patients with episodic migraine (EM), focusing on varying attack frequencies, and to explore its potential pathophysiologic role in migraine.</p><p><strong>Methods: </strong>In this cross-sectional study, migraine clinical parameters and psychiatric comorbidities, including depression, anxiety, and sleep disorders, were collected. Three MRI measures were quantified, i.e., the diffusion tensor imaging (DTI) along the perivascular space (DTI-ALPS) index, perivascular space (PVS) volume in the basal ganglia (BG) and white matter (WM), and white matter hyperintensity (WMH) volume in the periventricular WM and deep WM. Patients with 4 or more monthly migraine days (MMDs) were categorized into the high-frequency episodic migraine (HFEM) group, whereas patients with fewer than 4 MMDs were placed in the low-frequency episodic migraine (LFEM) group. The differences in the DTI-ALPS index, PVS volume, and WMH volume were compared between the controls and patients with EM, as well as among the EM subgroups. Correlations between the DTI-ALPS index and migraine clinical parameters, WMH, and PVS were determined.</p><p><strong>Results: </strong>A total of 74 patients with EM without cardiovascular risk factors and 42 age- and sex-matched controls were enrolled. The HFEM group (1.37 ± 0.12) exhibited a significantly lower DTI-ALPS index compared to controls (1.45 ± 0.10; p = 0.011; CI:-0.15 to -0.014) and those with LFEM (1.44 ± 0.12; p = 0.022; CI: -0.14 to -0.008). The reduced DTI-ALPS index was correlated with several clinical parameters, including MMDs, photophobia, phonophobia, and severe headache-related disability. Compared with controls, EM patients presented larger WMH volumes, but no significant differences in PVS volumes were observed. Increased MMDs, long disease duration, the presence of phonophobia, and increased deep WMH volumes were independently associated with the reduced DTI-ALPS index in EM.</p><p><strong>Conclusion: </strong>A reduced DTI-ALPS index, rather than larger PVS volume, may serve as a potential noninvasive measure of compromised glymphatic activity in migraine patients with high-frequency attacks, suggesting potential pathogenic mechanisms for central sensitization. Further longitudinal studies are warranted to investigate the causal relationship between glymphatic function and migraine attacks.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"132"},"PeriodicalIF":7.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on gepants for acute and preventive treatment of migraine in Thailand.","authors":"Prakit Anukoolwittaya, Wanakorn Rattanawong, Kiratikorn Vongvaivanich, Thanakit Pongpitakmetha, Sekh Thanprasertsuk, Thaninjitra Poonpedpun, Pannathat Soontrapa, Kanokrat Suwanlaong, Kannikar Kongbunkiat, Surasak Komonchan, Petcharat Dusitanond, Chutithep Teekaput, Nopdanai Sirimaharaj, Nadolporn Yuvasilp, Surat Tanprawate","doi":"10.1186/s10194-025-02074-4","DOIUrl":"10.1186/s10194-025-02074-4","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"131"},"PeriodicalIF":7.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast reprogramming in the dura mater of NTG-induced migraine-related chronic hypersensitivity model drives monocyte infiltration via Angptl1-dependent stromal signaling.","authors":"Guangyu Guo, Lei Zhang, Xuyang Liu, Yiping Deng, Peiyu Wu, Ruofan Zhao, Wei Wang","doi":"10.1186/s10194-025-02058-4","DOIUrl":"10.1186/s10194-025-02058-4","url":null,"abstract":"<p><strong>Background: </strong>Migraine, characterized by recurrent episodes of severe headache, remains mechanistically enigmatic. While traditional theories emphasize trigeminovascular activation, the role of meningeal stromal-immune crosstalk in disease chronicity is poorly understood.</p><p><strong>Methods: </strong>A migraine-related chronic hypersensitivity model was utilized via intermittent intraperitoneal nitroglycerin (NTG, 10 mg/kg, every other day for 9 days) and peripheral mechanical hypersensitivity was assessed using von Frey filaments. Single-cell RNA sequencing (scRNA-seq) was performed on dura tissues to construct a cellular atlas of NTG-induced remodeling. These data were then integrated with migraine genome-wide association study (GWAS) risk genes, cell-cell interaction networks, and transcriptional regulation analysis to dissect NTG-driven meningeal remodeling.</p><p><strong>Results: </strong>The NTG-induced migraine-related chronic hypersensitivity model demonstrated sustained mechanical allodynia, as evidenced by significantly decreased paw withdrawal thresholds (p < 0.0001). Single-cell profiling of the dura mater revealed a 2.4-fold expansion of a pro-inflammatory fibroblast subpopulation (Fibro_c5: 1.9% in Vehicle vs. 4.6% in NTG group), which exhibited marked activation of TNF-α/NF-κB signaling pathways (normalized enrichment score [NES] = 1.83). Concomitantly, we observed an 82% increase in meningeal monocytes (5.7-10.4%) that showed preferential interaction with Fibro_c5 fibroblasts through Angptl1-mediated stromal-immune crosstalk (log2 fold change = 1.41). Regulatory network analysis identified Mafk as the upstream transcriptional regulator orchestrating Angptl1 expression in this pathological communication axis.</p><p><strong>Conclusion: </strong>Our study reveals that NTG reprograms meningeal fibroblasts to expand a pro-inflammatory fibroblast subtype, which drives migraine-related chronic hypersensitivity through TNF-α/NF-κB signaling and Angptl1-mediated monocyte crosstalk. The identified Mafk-Angptl1 axis presents a potential therapeutic target, though human validation remains essential.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"130"},"PeriodicalIF":7.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8).","authors":"François Gabrielli, Melissa Zuel, Camille Magaud, Sophia Sickout-Arondo, Bruno Pereira, Jérémie Dassa, Solène De Gaalon, Geneviève Demarquay, Anne Donnet, Anne Ducros, Pierric Giraud, Evelyne Guégan-Massardier, Christian Lucas, Jérôme Mawet, Mitra Najjar, Caroline Roos, Elise K Van Obberghen, Christian Dualé, Radhouane Dallel, Xavier Moisset","doi":"10.1186/s10194-025-02067-3","DOIUrl":"10.1186/s10194-025-02067-3","url":null,"abstract":"<p><strong>Background: </strong>In addition to headache, migraine patients often experience sensory hypersensitivity to external stimuli. While photophobia and phonophobia are part of the diagnostic criteria of migraine, many patients also exhibit cutaneous allodynia and osmophobia. However, the presence and intensity of these four hypersensitivities are rarely assessed systematically and simultaneously due to the lack of a simple and rapid self-report questionnaire.</p><p><strong>Methods: </strong>We have identified existing questionnaires for allodynia, photophobia and phonophobia and selected one of each, that were translated in French and validated (according to COSMIN's recommendations). We also proposed a 2-item questionnaire (presence and intensity) for each of these 3 hypersensitivities plus osmophobia, resulting in the 8-item Migraine Hypersensitivity Questionnaire (MHQ-8) exploring these four hypersensitivities. In addition, the headache impact test (HIT-6), the migraine disability assessment (MIDAS) and the hospital anxiety and depression scale (HADS) were also answered. The survey was conducted in Pain and Neurology departments during specialised consultations for headaches. Content validity, structural validity, internal consistency, transcultural validity, reliability, criterion validity, construct validity and responsiveness were tested. Confirmatory factor analysis (CFA) was used to test the dimensionality of the questionnaires.</p><p><strong>Results: </strong>The study sample consisted in N = 329 patients with a mean age of 43.7 ± 13.2 and a mean number of 10.2 ± 7.0 migraine days per month; 84% of them were women and 27% had chronic migraine. Overall, 312 to 327 questionnaires were usable for the hypersensitivity questionnaires. The reliability of the MHQ-8 was good to excellent with a Cronbach's alpha of α = 0.88 (photophobia), α = 0.89 (phonophobia), α = 0.91 (allodynia), α = 0.95 (osmophobia), and α = 0.85 for the whole questionnaire. The intraclass correlation coefficient assessing test-retest reliability was 0.83, 0.77, 0.87, and 0.90, respectively; it was 0.88 for the whole questionnaire. The factor analysis on the MHQ-8 items showed excellent exploratory results, and the indicators of the CFA showed good performances with CFI and TLI at 0.999, RMSEA at 0.054 and SRMR at 0.021.</p><p><strong>Conclusions: </strong>The MHQ-8 developed in this study is valid and reliable. It serves as a new diagnostic tool for the four sensory hypersensitivities that can occur during migraine attacks and may be useful in both clinical research and daily practice.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"128"},"PeriodicalIF":7.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}