Journal of Headache and Pain最新文献

{"title":"Sex differences in behaviors, neuronal activation, and gut-microbiota-metabolic axis in a repeated nitroglycerin-induced chronic migraine model.","authors":"Cancan Chen, Jiao He, Zhenjie Ma, Weinan Na, Ya Cao, Bozhi Li, Zizi He, Huijuan Yuan, Han Xiao, Shuqing Wang, Ruozhuo Liu, Shengyuan Yu, Li Kang","doi":"10.1186/s10194-026-02360-9","DOIUrl":"https://doi.org/10.1186/s10194-026-02360-9","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking the noise: aberrant cortical oscillations in visual snow syndrome.","authors":"Fu-Jung Hsiao, Francesca Puledda, Wei-Ta Chen, Shih-Pin Chen, Li-Ling Hope Pan, Yen-Feng Wang, Kuan-Lin Lai, Gianluca Coppola, Shuu-Jiun Wang","doi":"10.1186/s10194-026-02355-6","DOIUrl":"https://doi.org/10.1186/s10194-026-02355-6","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache.","authors":"Gurueswar Nagarajan, Yumin Zhang","doi":"10.1186/s10194-026-02356-5","DOIUrl":"10.1186/s10194-026-02356-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic investigation of HMGB1 in an in vitro model of the trigeminovascular system under migraine-like conditions.","authors":"Maomei Song, Angelica Barone, Suiyi Xu, Changxin Li, Giuseppe Gigli, Giacomo Frati, Cherubino Di Lorenzo, Gianluca Coppola, Barbara Cortese","doi":"10.1186/s10194-026-02357-4","DOIUrl":"https://doi.org/10.1186/s10194-026-02357-4","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a complex neurovascular disorder driven by abnormal activation of the trigeminovascular system (TVS), neurogenic inflammation and excessive release of calcitonin gene-related peptide (CGRP). While CGRP-targeted therapies have demonstrated clinical efficacy, the upstream molecular mechanisms sustaining CGRP dysregulation remain incompletely understood. High-mobility group box 1 (HMGB1), a pro-inflammatory damage-associated molecule implicated in neuroinflammation, has emerged as a potential contributor to migraine pathophysiology. However, its role in neuron-endothelial interactions within the TVS under migraine -relevant conditions remains unclear.</p><p><strong>Methods: </strong>To model inflammatory and hypoxic stress associated with migraine, SH-SY5Y neuron-like cells were stimulated with lipopolysaccharide (LPS) and cobalt chloride (CoCl₂). HMGB1 expression was silenced using siRNA to evaluate its role in regulating CGRP and NF-κB signaling. Conditioned medium from stimulated neuronal cells was applied to human umbilical vein endothelial cells (HUVECs) to investigate neuron-endothelial interactions, and CGRP signaling was inhibited using a receptor antagonist. Protein expression of HMGB1, CGRP, and NF-κB pathway components was assessed by Western Blot. In addition, neuronal migration and intracellular reactive oxygen species (ROS) were assessed to evaluate cellular activation under inflammatory stress conditions.</p><p><strong>Results: </strong>Inflammatory and hypoxic stimulation increased HMGB1 expression and activated NF-κB signaling in SH-SY5Y cells, accompanied by elevated CGRP production. HMGB1 knockdown reduced NF-κB activation and attenuated CGRP upregulation, suggesting that HMGB1 contributes to CGRP regulation under these conditions. Conditioned medium enriched in CGRP promoted NF-κB activation and HMGB1 expression in endothelial cells, effects that were attenuated by CGRP receptor blockade. In addition, HMGB1 enhanced neuronal migration and oxidative stress responses in stimulated SH-SY5Y cells.</p><p><strong>Conclusion: </strong>These findings support a model in which HMGB1 and CGRP participate in a positive neuron-endothelial feedback loop under inflammatory and hypoxic stress, potentially amplifying neurovascular signaling relevant to migraine. Although derived from an in vitro system, this study identifies HMGB1 as a potential upstream modulator of CGRP-associated pathways and highlights its possible contribution to peripheral mechanisms involved in trigeminovascular activation.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine, headache disorders, and brain health: aligning advocacy with the UN Sustainable Development Goals.","authors":"Paolo Martelletti, Arão Belitardo de Oliveira, Rajinder K Dhamija, Patty Francis, Riadh Gouider, Alla Guekht, Amr Hassan Al-Hasany, Mendinatou Agbetou Houessou, Michel Lanteri-Minet, Matilde Leonardi, Martha Lu-Bolanos, Manoji Pathirage, Abdul Malik, Reza Mosaddeghi-Heris, M Netravathi, Rajeev Ojha, Mayowa O Owolabi, Raju Paudel, Jason Ray, Alberto Raggi, Anna Ranta, Nadie Rathnayake, Uwe Reuter, Devi Ariani Sudibyo, Surat Tanprawate, Jin Tao, Yiheng Tu, Lawrence Tucker, Nina Vashchenko, Janaka Waidyasekara, Yonggang Wang, Yohannes W Woldeamanuel, Tissa Wijeratne","doi":"10.1186/s10194-026-02348-5","DOIUrl":"10.1186/s10194-026-02348-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine in pediatric population: the role of biochemical markers.","authors":"Gabriele Monte, Carmen Granata, Fabiana Ursitti, Giorgia Sforza, Massimiliano Valeriani, Laura Papetti","doi":"10.1186/s10194-026-02344-9","DOIUrl":"10.1186/s10194-026-02344-9","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteomics identifies proteins and pathways associated with incident migraine in 50,668 adults.","authors":"Yanggang Hong, Feng Chen, Yuze Mi, Wanyi Shu, Yi Wang, Zhendi Shu","doi":"10.1186/s10194-026-02345-8","DOIUrl":"10.1186/s10194-026-02345-8","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA methylation signatures of treatment response in medication-overuse headache.","authors":"Katarzyna Malgorzata Kwiatkowska, Valentina Favoni, Francesca Ferraresi, Chiara Pirazzini, Francesco Ravaioli, Maria Giulia Bacalini, Daniele Dall'Olio, Claudia Sala, Gastone Castellani, Luciano Calzari, Davide Gentilini, Rossana Terlizzi, Giulia Pierangeli, Pietro Cortelli, Davide Mascarella, Paolo Garagnani, Sabina Cevoli","doi":"10.1186/s10194-026-02354-7","DOIUrl":"10.1186/s10194-026-02354-7","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.","authors":"Geyu Liu, Cunxin Lin, Dong Qiu, Xiaoshuang Li, Zhi Guo, Yuanxiang Li, Yanliang Mei, Mantian Zhang, Jianing Wang, Xin Liu, Zhaoli Ge, Zhonghua Xiong, Binbin Sui, Yonggang Wang","doi":"10.1186/s10194-026-02351-w","DOIUrl":"10.1186/s10194-026-02351-w","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shift work migraine disorder: evidence, mechanisms, and implications for diagnosis, prevention, and management.","authors":"Zarmeen Azhar, Zehra Sadia, Muhammad Yousaf, Joshua Ekouo, Nouraiz Abbas, Laiba Akram","doi":"10.1186/s10194-026-02349-4","DOIUrl":"https://doi.org/10.1186/s10194-026-02349-4","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}