Journal of Headache and Pain最新文献

{"title":"Differential fMRI neural synchrony associated with migraine during naturalistic stimuli with negative emotional valence.","authors":"Keva Klamer, Joshua Craig, Christina Haines, KiAnna Sullivan, Peter Seres, Chelsea Ekstrand","doi":"10.1186/s10194-025-01993-6","DOIUrl":"https://doi.org/10.1186/s10194-025-01993-6","url":null,"abstract":"<p><p>Migraine is a common neurological disorder that impacts approximately 12% of the general population and is characterized by moderate to severe headaches, nausea, mood changes, and fatigue. It impacts lower-level visual and auditory processing, causing hypersensitivities that lead to heightened audiovisual multisensory integration. However, the impact of migraine on the processing of complex, audiovisual stimuli is still unclear. Additionally, migraine may induce hypersensitivities to emotional arousal and valence, though the relative significance of these factors remains unknown. The current study seeks to identify how migraine impacts synchronous neural processing of complex, audiovisual stimuli, and how this differs based on the emotional arousal and valence of the stimulus. To do so, we collected functional magnetic resonance imaging data (fMRI) from 22 migraineurs and 21 healthy controls during the passive viewing of three audiovisual films of differing emotional arousal and valence. We identified that, in response to a negative valence, high arousal emotional stimulus, the migraine group showed greater neural synchrony in regions associated with multisensory integration, including the bilateral posterior superior temporal gyrus (pSTG), superior parietal lobule (SPL), and left middle temporal gyrus (MTG). There were no significant differences in neural synchrony between the migraine and control groups in response to positive valence, high arousal and neutral valence, low arousal stimuli. These findings suggest that migraine involves hypersensitivity to audiovisual movies as a function of negative emotional valence, where negative/aversive emotional states may drive greater synchrony in multisensory integration. Overall, this research highlights distinct pathways through which emotion and arousal impact neural processing in migraine.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"62"},"PeriodicalIF":7.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study.","authors":"Shuqing Wang, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Deqi Zhai, Yin Sun, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou, Zhao Dong","doi":"10.1186/s10194-025-02004-4","DOIUrl":"https://doi.org/10.1186/s10194-025-02004-4","url":null,"abstract":"<p><strong>Background: </strong>Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate the effects of acute sleep deprivation (ASD) on brain function in individuals with migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI).</p><p><strong>Methods: </strong>Twenty three MWoA individuals and 23 healthy controls (HCs) were fairly included in this study. All participants underwent two MRI scans: one at baseline (prior to sleep deprivation) and another following 24 h of ASD. Images were obtained with blood-oxygen-level-dependent and T1-weighted sequences on a Siemens 7.0 T MRI scanner. We conducted analyses of changes in the low-frequency fluctuations (ALFF) values and functional connectivity (FC) between brain networks and within network before and after ASD in both MWoA group and HC group. Additionally, we investigated the relationship between the changes in ALFF before and after ASD and the clinical features (VAS and monthly headache days).</p><p><strong>Results: </strong>In the HC group, ASD led to a significant increase in ALFF values in the left parahippocampal gyrus compared to baseline (p-FDR = 0.01). In the MWoA group, ALFF values were significantly greater in 64 brain regions after ASD than at baseline. The most significant change in ALFF before and after ASD in the MWoA group was detected in the right medial pulvinar of the thalamus (p-FDR = 0.017), which showed a significant negative correlation with monthly headache days. Moreover, seed-based connectivity (SBC) analysis using the right medial pulvinar of the thalamus as the seed point revealed significantly increased connectivity with the cerebellar vermis (p-FWE = 0.035) after ASD in individuals with MWoA, whereas connectivity with the right postcentral gyrus was significantly decreased (p-FWE = 0.048). Furthermore, we performed analyses of between-network connectivity (BNC) and within-network connectivity across 17 brain networks, utilizing the Yeo-17 atlas. Both MWoA individuals and HCs showed no significant changes in BNC after ASD compared to baseline. However, our analysis in within-network revealed that MWoA individuals exhibited a reduced within-network FC in dorsal attention network (DAN) after ASD compared to baseline (p-FDR = 0.031), whereas HCs showed no significant differences in within-network FC across all networks before and after ASD.</p><p><strong>Conclusions: </strong>In comparison to HCs, MWoA individuals exhibited significant alterations in brain function after ASD, particularly within the thalamus, and MWoA individuals exhibited a reduced within-network FC in DAN after ASD compared to baseline. Brain regions and networks in MWoA individuals were more susceptible to the effects of ASD.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"60"},"PeriodicalIF":7.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of sleep patterns in migraine sufferers using the Epworth Sleepiness Scale.","authors":"Arman Hajikarim-Hamedani, Setareh Rassa, Termeh Tarjoman, Mehran Shafiei","doi":"10.1186/s10194-025-02005-3","DOIUrl":"10.1186/s10194-025-02005-3","url":null,"abstract":"<p><strong>Background: </strong>Migraine, a debilitating neurological disorder, is often co-occurring with sleep disturbances. This study used the Epworth Sleepiness Scale (ESS) to explore changes in sleep quality between individuals with migraine and healthy controls. Additionally, we examined associations between ESS scores and migraine frequency, severity, and demographic factors.</p><p><strong>Methods: </strong>This cross-sectional study included 404 participants, 204 with chronic migraine (diagnosed using ICHD-3 criteria) and 200 controls without neurological disorders. Daytime sleepiness was assessed using the Epworth Sleepiness Scale. Demographic and clinical data were analyzed using Python3 and SPSS, using t-tests and ANOVA (P < 0.05).</p><p><strong>Results: </strong>The study analyzed demographics, clinical characteristics, and daytime sleepiness in 204 migraine participants compared with 200 controls. Individuals with chronic migraine had higher Epworth Sleepiness Scale scores, with increased sleepiness associated with higher BMI, age, and female gender. Significant differences in sleepiness levels were observed with migraine severity, highlighting the impact of migraine on sleep patterns and quality, and no significant differences were found between control and migraine groups in ESS scores, sleep duration, or physical activity. Reliability testing confirmed high ESS consistency.</p><p><strong>Conclusion: </strong>This study highlights the prevalence of daytime sleepiness among individuals with chronic. Managing sleep quality emerges as an important treatment strategy. The use of standardized tools such as the Epworth Sleep Scale can guide personalized interventions, improve patient outcomes, and emphasize the role of lifestyle and overall health management.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"58"},"PeriodicalIF":7.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering drug targets for cluster headache through proteome-wide Mendelian randomization analysis.","authors":"Zhonghua Xiong, Zhi Guo, Lei Zhao, Dong Qiu, Yanliang Mei, Xiaoshuang Li, Peng Zhang, Mantian Zhang, Geyu Liu, Tianshuang Gao, Yonggang Wang, Xueying Yu","doi":"10.1186/s10194-025-01999-0","DOIUrl":"10.1186/s10194-025-01999-0","url":null,"abstract":"<p><strong>Background: </strong>Cluster headache (CH) is a highly disabling primary headache disorder with a complex underlying mechanism. However, there are currently no effective targeted therapeutic drugs available. Existing medications often have limited efficacy and numerous side effects, which frequently fail to meet clinical needs. This study aims to identify potential new therapeutic targets for CH through proteome-wide mendelian randomization (PWMR).</p><p><strong>Methods: </strong>We used PWMR to estimate the causal effects of plasma proteins on CH. This analysis integrated plasma protein quantitative trait loci (pQTL) data with genome-wide association study (GWAS) results of CH phenotypes. In addition, we conducted various sensitivity analyses, enrichment analyses, phenome-wide MR assessments, protein-protein interaction network construction, and mediation MR analyses to further validate the drug potential of the identified protein targets.</p><p><strong>Results: </strong>We identified 11 protein targets for CH (p < 2.41 × 10^-5), with high-priority candidates exhibiting minimal side effects. Phenome-wide MR revealed novel targets-PXDNL, CCN4, PKD1, LGALS9, and MRC1-that show no significant disease-related adverse effects and interact with established preventive CH drug targets. Notably, PXDNL interacts with both acute and preventive CH drug targets. Furthermore, the causal effect of plasma proteins on CH is partially mediated by cortical surface area, with mediation proportions ranging from 3.2% to 10.0%.</p><p><strong>Conclusions: </strong>We identified a set of potential protein targets for CH, characterized by rare side effects and a strong association with the biological mechanisms underlying the disorder. These findings offer valuable insights for the development of targeted drug therapies in the treatment of CH.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"57"},"PeriodicalIF":7.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of headache disorders in Benin: national estimates from a population-based door-to-door survey.","authors":"Thierry Adoukonou, Mendinatou Agbetou, Eric Dettin, Oyéné Kossi, Andreas Husøy, Dismand Houinato, Timothy J Steiner","doi":"10.1186/s10194-025-01992-7","DOIUrl":"10.1186/s10194-025-01992-7","url":null,"abstract":"<p><strong>Background: </strong>Continuing the series of population-based studies conducted within the Global Campaign against Headache, here we report estimates of headache-attributed burden among adults in Benin, West sub-Saharan Africa, adding to those already published of prevalence.</p><p><strong>Methods: </strong>In a cross-sectional survey using cluster-randomized sampling, we visited households unannounced in three geographical regions of Benin: Borgou, Atlantique and Littoral. We randomly selected and interviewed one adult member (18-65 years) of each household, using the HARDSHIP structured questionnaire. Screening and diagnostic questions based on ICHD-3 were followed by burden enquiry in multiple domains including symptom burden and impaired participation. Enquiry timeframes were 1 year, 3 months, 1 month and 1 day (headache yesterday). Data collection took place from May to July 2020.</p><p><strong>Results: </strong>There were 2,400 participants. Those reporting any headache spent, on average, 8.0% of their total time with headache of moderate-to-severe intensity. Females had more frequent headache than males. Participants with migraine spent twice as much time with headache as those with TTH (5.2% vs. 2.6%). Those with probable medication-overuse headache or other headache on ≥ 15 days/month spent over 50% of their time with headache. Factoring in prevalence and adjusting for age and gender, we estimated that 6.4-6.5% of all time among the adult population of Benin was spent with headache. An estimated 26.7% of the population were assessed as in need of (likely to benefit from) health care for headache.</p><p><strong>Conclusion: </strong>The burden of headache in Benin is substantial in terms of lost health. These findings are important to national health and economic policies.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"56"},"PeriodicalIF":7.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation.","authors":"Tzu-Ting Liu, Pin-Yu Chen, Chyun-Yea Tseng, Yun-Ning Chen, Jian-Bang Chen, Tz-Han Ni, Shuu-Jiun Wang, Shih-Pin Chen, Jiin-Cherng Yen","doi":"10.1186/s10194-025-01997-2","DOIUrl":"10.1186/s10194-025-01997-2","url":null,"abstract":"<p><strong>Background: </strong>Transient receptor potential melastatin 8 (TRPM8), a gene encoding a nonselective cation channel responsive to cold stimuli, has been implicated in migraine susceptibility. Despite this association, the role of TRPM8 to migraine pathogenesis remains elusive. This study aims to elucidate the potential role of TRPM8 in migraine pathophysiology.</p><p><strong>Methods: </strong>TRPM8 expression in the cortex and primary trigeminal ganglion (TG) cells was analyzed via immunostaining. The central role of TRPM8 was assessed using a spreading depolarization (SD) model, where intracerebroventricular injections or topical applications of TRPM8 agonists and antagonists were administered to rats to investigate their effects on KCl-evoked SD and SD-induced cortical inflammation. The peripheral role of TRPM8 in migraine was evaluated using primary cultures of rat TG cells by analyzing the effects of TRPM8 activation on calcitonin gene-related peptide (CGRP) expression, release, and trigeminal neuroinflammation.</p><p><strong>Results: </strong>TRPM8 was homogeneously distributed in the cerebral cortex, predominantly co-localizing with cortical neurons. Activation of cortical TRPM8 increased the frequency of KCl-evoked SD and exacerbated SD-induced cortical inflammation. Interestingly. Interestingly, inhibition of cerebral TRPM8 had negligible effects. In TG primary cultures, TRPM8 activation upregulated CGRP expression and release and induced cyclooxygenase-2 (Cox2) upregulation via a calmodulin kinase II (CaMKII)-dependent mechanism.</p><p><strong>Conclusions: </strong>TRPM8 activation increased susceptibility to SD and facilitated the effects of CGRP and trigeminal neuroinflammation, implicating that TRPM8 may contribute to migraine pathophysiology through central and peripheral mechanisms.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"55"},"PeriodicalIF":7.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study.","authors":"Yin Sun, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Shuqing Wang, Deqi Zhai, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou, Zhao Dong","doi":"10.1186/s10194-025-01988-3","DOIUrl":"10.1186/s10194-025-01988-3","url":null,"abstract":"<p><strong>Background: </strong>Chronic migraine (CM) patients with medication overuse headache (MOH) exhibit distinct neurobiological alterations compared to those without MOH. However, prior studies, often limited to single imaging modalities, have yielded inconsistent findings. This study employs multimodal MRI-combining structural, diffusion tensor, and functional imaging-to characterize brain abnormalities in CM patients with and without MOH, while investigating the relationship between acute analgesic use frequency and these changes.</p><p><strong>Methods: </strong>The study employed comparative analyses to examine differences in gray matter volume, white matter integrity, and spontaneous brain activity between CM patients with (CM + MOH) and without (CM - MOH) medication overuse headache, as well as healthy controls. Additionally, brain regions associated with the frequency of acute medication use were identified and further investigated.</p><p><strong>Results: </strong>Nineteen CM - MOH patients, twenty-five CM + MOH patients, and nineteen healthy controls were enrolled. Compared to CM - MOH patients, CM + MOH patients exhibited significantly reduced gray matter volume in the parahippocampal gyrus and middle occipital gyrus, alongside markedly lower fractional anisotropy (FA) in the left cingulum bundle. Moreover, fractional amplitude of low-frequency fluctuations (fALFF) values in the right putamen were significantly decreased and demonstrated a negative correlation with the frequency of acute pain medication use. Functional connectivity analysis further revealed significantly enhanced connectivity between the right putamen and regions such as the frontal lobe, middle cingulate gyrus, lingual gyrus, and precuneus, which positively correlated with the frequency of acute analgesic use.</p><p><strong>Conclusion: </strong>Compared to CM - MOH patients, those with MOH exhibit distinct patterns of gray matter volume reduction in regions associated with memory and visual processing, accompanied by significant white matter disruption. Additionally, decreased spontaneous activity in the right putamen and heightened functional connectivity between the putamen and multiple brain regions are strongly correlated with the frequency of acute medication use. These results highlight the significant impact of medication overuse on brain structure and function, shedding light on the mechanisms of migraine chronification.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"54"},"PeriodicalIF":7.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Headache types and characteristics in patients with Amyotrophic Lateral Sclerosis.","authors":"Radwa Soliman, Nagia Fahmy, Mahmoud S Swelam","doi":"10.1186/s10194-025-01987-4","DOIUrl":"10.1186/s10194-025-01987-4","url":null,"abstract":"<p><strong>Background: </strong>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neurons, this result in muscle denervation, atrophy and consequently death takes place due to respiratory failure within 3-5 years of onset of symptoms.</p><p><strong>Our aim: </strong>Was to investigate types and frequency of headache in ALS patients.</p><p><strong>Methods: </strong>This is cross sectional hospital based study. Clinically definite 100 ALS Patients (diagnosed according to El Escorial revised criteria) were recruited out of 137 ALS patients presented to the Neuromuscular Clinic in Ain Shams university Hospital from February 2022 to June 2024. Patients were screened for headache types and symptoms diagnosed according to International Headache Society criteria (IHS). Headache severity and impact were assessed using Arabic versions of Headache Impact Test (HIT) and Migraine Disability Assessment (MIDAS). Depression was also assessed via Arabic version of Beck's Depression Inventory (BDI). ALS symptoms severity was assessed via Arabic version of Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R). Cognitive functions were assessed via the Egyptian version of the Edinburgh Cognitive and Behavioral Amyotrophic Lateral Sclerosis Screen (ECAS‑EG). Demographic data and ALS related parameters were collected.</p><p><strong>Results: </strong>Among 100 patients with clinically definite ALS, 79 patients reported headaches, 62 of them had primary headaches; with tension-type headache being the most commonly reported in 46 patients, Migraine in 16 patients. Fifteen ALS patients had secondary headaches; among them 12 had headache secondary to respiratory insufficiency and 3 patients developed headache after the initiation of Riluzole therapy. Two patients had non specific headache. Mean age for the patients at ALS presentation was 43.9 ± 13.8, Mean ALSFRS-R score 33.3 ± 9.04. The relationships between headache and clinical features of ALS were also investigated.</p><p><strong>In conclusion: </strong>ALS patients should be evaluated for Headache; Not only headache secondary to respiratory compromise and hypercapnea, but also primary headaches which can be overlooked in patients with ALS.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"53"},"PeriodicalIF":7.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular disorders and mental health: shared etiologies and treatment approaches.","authors":"Jiamin Wan, Jiu Lin, Tingfeng Zha, Francisco Ciruela, Shaokang Jiang, Zuping Wu, Xinyi Fang, Qianming Chen, Xiaoyan Chen","doi":"10.1186/s10194-025-01985-6","DOIUrl":"10.1186/s10194-025-01985-6","url":null,"abstract":"<p><p>The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, particularly depression and anxiety, affecting a significant portion of the global population. The interplay between TMDs and mental health disorders contributes to a complex comorbidity, perpetuating a cycle of mutual influence and reinforcement. This review investigates the neurobiological mechanisms and epidemiological evidence supporting the shared etiology of TMDs and mental health disorders, exploring potential shared vulnerabilities and bidirectional causal relationships. Shared vulnerabilities between TMDs and mental health disorders may stem from genetic and epigenetic predispositions, psychosocial factors, and behavioral aspects. Inflammatory cytokines, neurotransmitters, neurotrophins, and neuropeptides play pivotal roles in both peripheral and central sensitization as well as neuroinflammation. Brain imaging studies suggest that TMDs and mental health disorders exhibit overlapping brain regions indicative of reward processing deficits and anomalies within the triple network model. Future research efforts are crucial for developing a comprehensive understanding of the underlying mechanisms and confirming the reciprocal causal effects between TMDs and mental health disorders. This review provides valuable insights for oral healthcare professionals, stressing the importance of optimizing treatment strategies for individuals dealing with concurrent TMDs and mental health issues through a personalized, holistic, and multidisciplinary approach.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"52"},"PeriodicalIF":7.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and continuability of 675 mg fremanezumab administration over 2 years.","authors":"Shohei Yoshida, Noboru Imai, Masato Keicho, Jun Kamimura, Asami Moriya, Nobuyasu Yagi, Rieko Suzuki, Takashi Konishi, Masahiro Serizawa","doi":"10.1186/s10194-025-01994-5","DOIUrl":"10.1186/s10194-025-01994-5","url":null,"abstract":"<p><strong>Background: </strong>Real-world data on the long-term adherence to- and efficacy of fremanezumab 675 mg quarterly dosing remain scarce. Our study evaluated the efficacy of- and patient adherence to 675 mg fremanezumab for episodic migraine (EM) and chronic migraine (CM) over 2 years and analyzed the reasons for discontinuation.</p><p><strong>Methods: </strong>Among patients attending our headache outpatient clinic, those aged ≥ 15 years who commenced fremanezumab 675 mg quarterly dose schedule from November 2021 to June 2022 were enrolled in this single-center observational study. The frequency and severity of headaches were recorded using a headache diary. The observation period ended for each patient at 24 months after treatment initiation. The reasons for discontinuation were documented based on follow-up medical records.</p><p><strong>Results: </strong>Twenty-eight patients were enrolled, of whom 15 had CM and 13 had EM. One patient with CM was excluded due to withdrawal after the first injection. Of the 27 remaining patients, the treatment was effective in 70.4% (n = 19). 44.4% (n = 12) continued fremanezumab 675 mg until study termination. Among those patients who remained on fremanezumab for two years, seven updated the monthly headache calendars consistently: 2 had CM, and 5 had EM. Mean changes in MMD from the baseline were - 2.2 at 3 months,, -1.8 at 12 months, and - 1.6 (SD = 3.0) at 2 years. Treatment was discontinued because of sustained improvement in 25.9% (n = 7). 22.2% of cases (n = 6) experienced insufficient effectiveness, resulting in discontinuation. One patient (3.7%) discontinued because of injection-site erythema. One patient (3.7%) was discontinued because of pregnancy. Among the non-responders, three switched from fremanezumab to erenumab, with one returning to fremanezumab at a monthly injection of 225 mg after efficacy with erenumab waned. Two patients switched to galcanezumab. All patients who switched medication continued the new medication owing to its effectiveness. One patient was lost to follow-up.</p><p><strong>Conclusions: </strong>Fremanezumab 675 mg quarterly dose effectively reduces headache frequency over an extended period and may facilitate medication cessation in patients who experience substantial recovery.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"51"},"PeriodicalIF":7.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}