Journal of Headache and Pain最新文献

{"title":"Emerging treatments for chronic neuropathic pain from a cross-disease perspective: developments and applications of nanomaterials.","authors":"Rui Sun, Xiaoqin Zhang, Tao Dou, Zhiyi Xiao, Xiaoran Deng","doi":"10.1186/s10194-025-02081-5","DOIUrl":"https://doi.org/10.1186/s10194-025-02081-5","url":null,"abstract":"<p><p>Chronic neuropathic pain (CNP) results from disease or damage within the somatosensory nervous system. It represents a prevalent and challenging form of chronic pain that exerts a severe impact on patients' quality of life. This review aims to synthesize and highlight the current understanding of the mechanisms underlying CNP, as well as the evolving therapeutic landscape. With advancements in research, an increasing number of analgesic targets specific to various disease types are being developed, alongside the emergence of novel nanomaterials for treating chronic pain. In this review, we systematically summarize the applications and potential mechanisms of nanomaterials in treating CNP induced by various diseases, providing new insights for both fundamental research and clinical management of CNP.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"143"},"PeriodicalIF":7.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RAMP1-dependent hormonal regulation of CGRP and its receptor in the trigeminal ganglion.","authors":"Anja Holm, Jacob C A Edvinsson, Diana N Krause, Lars Edvinsson","doi":"10.1186/s10194-025-02071-7","DOIUrl":"https://doi.org/10.1186/s10194-025-02071-7","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"142"},"PeriodicalIF":7.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex vivo stimulation of the trigeminal nucleus caudalis induces peripheral CGRP release in the trigeminal ganglion and reveals a distinct dopamine-endocannabinoid mechanism relevant to migraine.","authors":"Isabella Mai Christiansen, Philip Victor Reducha, Lars Edvinsson, Anja Holm, Kristian Agmund Haanes","doi":"10.1186/s10194-025-02072-6","DOIUrl":"10.1186/s10194-025-02072-6","url":null,"abstract":"<p><strong>Background: </strong>Calcitonin gene-related peptide (CGRP) release from trigeminal structures is central to migraine pathophysiology. This study employed an ex vivo model preserving anatomical continuity between the trigeminal nucleus caudalis (TNC) and trigeminal ganglion (TG) to investigate (1) whether TNC stimulation induces peripheral CGRP release from the TG and (2) the potential involvement of a distinct dopamine-endocannabinoid mechanism.</p><p><strong>Methods: </strong>Tissues were dissected as a single unit and placed in custom 3D-printed chambers, allowing targeted stimulation of either the TNC or the TG while measuring CGRP in both compartments. Pharmacological tools, including capsaicin (TRPV1 agonist), KCl (depolarizing agent), dopamine, and selective enzyme inhibitors or receptor antagonists, were used to elucidate underlying signalling pathways. CGRP levels were quantified via enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Stimulation of the TNC elicited a significant rise in CGRP release locally and in the TG compartment, whereas directly stimulating the TG did not trigger CGRP release in the TNC. Subsequent experiments showed that applying dopamine to the TNC further enhanced CGRP release. TRPV1 blockade or pharmacological inhibition of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD), an enzyme important for anandamide biosynthesis, markedly attenuated dopamine-induced CGRP release, indicating that an endocannabinoid-driven mechanism is involved.</p><p><strong>Conclusion: </strong>Activating the TNC alone was sufficient to evoke CGRP release in the peripheral trigeminal compartment, underscoring a potential central-to-peripheral mechanism that may be relevant to migraine. Moreover, a dopamine-endocannabinoid-TRPV1 axis appears to modulate CGRP signalling in this system, indicating additional complexity and providing potential new strategies for migraine therapy.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"141"},"PeriodicalIF":7.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The role of community pharmacists in managing common headache disorders, and their integration within structured headache services: position statement on behalf of the European Headache Federation (EHF) and Lifting The Burden (LTB: the Global Campaign against Headache), with the formal endorsement of the International Pharmaceutical federation.","authors":"Heba BaniHani, Christian Lampl, Antoinette MaassenvandenBrink, Faisal Mohammad Amin, Louise Ninett Carlsen, Gianluca Coppola, Christina Deligianni, Raquel Gil-Gouveia, Philip R Holland, Andreas K Husøy, Rigmor Jensen, Madalena Plácido, Uwe Reuter, Kristina Ryliškienė, Margarita Sanchez Del Río, Henrik Winther Schytz, Erling Tronvik, Jan Versijpt, Timothy J Steiner","doi":"10.1186/s10194-025-02073-5","DOIUrl":"10.1186/s10194-025-02073-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"139"},"PeriodicalIF":7.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dual impact of ictal and interictal burden in migraine: an analysis from the ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME) Japan second study.","authors":"Tsubasa Takizawa, Daisuke Danno, Ryotaro Ishii, Shiho Suzuki, Moemi Miura, Yoshinori Tanizawa, Satoshi Osaga, Michio Okada, Chie Hashimoto, Mika Komori","doi":"10.1186/s10194-025-02079-z","DOIUrl":"10.1186/s10194-025-02079-z","url":null,"abstract":"<p><strong>Background: </strong>Migraine adversely affects many aspects of daily life. In addition to burdens during headaches (ictal period), burdens between headaches (interictal period) are increasingly recognized. In this analysis of the ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE in Japan (OVERCOME [Japan]) 2nd study, we evaluated the contribution of interictal burden to daily activities, quality of life, work, family, costs, and medical treatment.</p><p><strong>Methods: </strong>The OVERCOME (Japan) 2nd study was a cross-sectional, web-based survey of 19,590 adults in Japan with migraine conducted between June and August 2023. Questionnaires included Headache Impact Test-6 (HIT-6), Migraine Interictal Burden Scale-4 (MIBS-4), Migraine Disability Assessment (MIDAS), Allodynia Symptom Checklist-12 (ASC-12), Migraine-Specific Quality-of-Life Questionnaire (MSQ), Impact of Migraine on Partners and Adolescent Children Scale (IMPAC), Work Productivity and Activity Impairment Questionnaire-Migraine (WPAI-M), and Migraine Treatment Optimization Questionnaire-6 (mTOQ-6). Additional questions asked about costs, frequency of migraine concerns between headaches, and experience with medical treatment. Analyses were conducted on subgroups based on HIT-6 and MIBS-4 scores: Severe (HIT-6 ≥ 60, MIBS-4 ≥ 3; n = 6854), High Interictal Burden (HIT-6 < 60, MIBS-4 ≥ 3; n = 2368), High Ictal Burden (HIT-6 ≥ 60, MIBS-4 < 3; n = 4253), and Milder (HIT-6 < 60, MIBS-4 < 3; n = 6115).</p><p><strong>Results: </strong>Number of monthly headache days, total MIDAS score, and pain severity score were higher, and MSQ scores lower, in subgroups with higher HIT-6 (HIT-High) versus subgroups with lower HIT-6 (HIT-Low). Within both HIT-High and HIT-Low subgroups, those with higher MIBS-4 had higher MIDAS and lower MSQ. IMPAC grade, ASC-12 score, and WPAI-M absenteeism were higher in the High Interictal Burden subgroup versus the High Ictal Burden subgroup. Concerns between headaches were more frequent, and costs higher, in subgroups with higher MIBS-4 (MIBS-High) versus subgroups with lower MIBS-4 (MIBS-Low). Acute treatment prescription analgesics were more commonly used in HIT-High versus HIT-Low subgroups, but triptans, lasmiditan, and preventive drugs were more common in the High Interictal Burden subgroup versus the High Ictal Burden subgroup.</p><p><strong>Conclusions: </strong>These results revealed that high interictal burden negatively affects multiple aspects of daily life in Japanese people with migraine independently of the impact of headaches.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"140"},"PeriodicalIF":7.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.","authors":"Dan Liu, Menghan Li, Heng Jiang, Yiqi Mi, Xiaolei Xu, Yali Zhou, Yaxian Hou, Yuquan Shen, Michael Maes, Xiao Xiao, Feng Zhou, Luca Giani, Keith M Kendrick, Benjamin Becker, Stefania Ferraro","doi":"10.1186/s10194-025-02051-x","DOIUrl":"10.1186/s10194-025-02051-x","url":null,"abstract":"<p><strong>Background: </strong>Accumulating evidence suggests that migraine patients present abnormal brain responses to salient sensory and emotional stimuli. However, it is still unclear whether this is a generalized or domain-specific phenomenon. Employing a well-validated fMRI paradigm, we investigated pain empathic reactivity across two domains: observation of physical pain (noxious stimulation) and affective pain (facial expressions). On the basis of a generalized hyperexcitability/hyperreactivity in migraine, we hypothesized abnormal responses to both dimensions of pain empathy.</p><p><strong>Methods: </strong>We collected fMRI and psychometric data from 21 migraine patients and matched controls. Univariate and multivariate neuroimaging analyses were utilized to examine domain-specific dysregulations in (a) neural reactivity in meta-analytically defined shared regions of pain-empathy processing, and (b) whole-brain neurofunctional signatures of physical and affective pain empathy (VPS, Zhou et al., 2020). Logistic regression models and machine learning-based classification were employed to determine differences between groups (migraine or control).</p><p><strong>Results: </strong>Migraine patients exhibit increased neural responses during empathy for physical pain in the bilateral inferior frontal gyrus (slightly more pronounced on the right side), with alterations on the right significantly associated with the pain experienced during the attack. On the whole-brain level, the predictive accuracy of the VPS for physical pain empathy was shown to be significantly higher for patients as compared to controls, reaching 100% accuracy. Across analyses, we did not find evidence of altered empathy processing for affective pain.</p><p><strong>Conclusions: </strong>Contrary to our hypothesis, our results indicate that migraine patients present a domain-specific increased brain responsivity, localized in the bilateral inferior frontal gyrus but also extending to subtle whole brain patterns, during empathy for physical pain stimuli, but not during empathy for affective pain. Based on the evidence that the neural pathways for empathy for physical pain and experimental pain robustly overlap, these results indicate a specific hyperresponsivity of the pain pathways, with the inferior frontal gyrus likely playing a regulatory role in modulating pain-related processes. Finally, the results underscore the translational application potential of neuroaffective multivariate signatures as neuromarkers for pathological dysregulations in affective and pain-related processes.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"137"},"PeriodicalIF":7.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine is a risk factor for dementia: a systematic review and meta-analysis of cohort studies.","authors":"Wenyan Zhu, Yijun Zhan, Jian Pei, Qinhui Fu, Ruiqi Wang, Qianwen Yang, Qingyang Guan, Like Zhu","doi":"10.1186/s10194-025-02078-0","DOIUrl":"10.1186/s10194-025-02078-0","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"136"},"PeriodicalIF":7.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the total cholesterol to high-density lipoprotein cholesterol ratio with all-cause mortality risk in the migraine population.","authors":"Zhao-Xuan Lu, Bing-Qing Dong, Liang Chen, Heng-Le Wei","doi":"10.1186/s10194-025-02077-1","DOIUrl":"10.1186/s10194-025-02077-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"135"},"PeriodicalIF":7.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lactylation-immune regulatory axis: a potential therapeutic target for migraine prevention and treatment.","authors":"Liu Wang, Zhixuan Lan, Ying He, Yue Cheng, Ruilin He, Zongbin Jiang","doi":"10.1186/s10194-025-02075-3","DOIUrl":"10.1186/s10194-025-02075-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"134"},"PeriodicalIF":7.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking in primary headaches - a systematic review and meta-analysis.","authors":"Bartłomiej Błaszczyk, Helena Martynowicz, Jakub Przegrałek, Piotr Niemiec, Marcin Straburzyński, Sławomir Budrewicz, Marta Waliszewska-Prosół","doi":"10.1186/s10194-025-02076-2","DOIUrl":"10.1186/s10194-025-02076-2","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"26 1","pages":"133"},"PeriodicalIF":7.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}