Journal of Headache and Pain最新文献

{"title":"Current landscape of migraine care with expert consensus from East Asia.","authors":"Shuu-Jiun Wang, Tsubasa Takizawa, Jiying Zhou, Mi Ji Lee, Daisuke Danno, Min Kyung Chu, Byung-Kun Kim","doi":"10.1186/s10194-026-02382-3","DOIUrl":"https://doi.org/10.1186/s10194-026-02382-3","url":null,"abstract":"<p><p>Migraine is a debilitating neurovascular disorder affecting over one billion people globally. While reported prevalence in Asia is lower than in Western countries, significant regional variations and unique clinical presentations necessitate a tailored approach to management. From the Advisory Board Meeting of the East Asian Network for Migraine, expert insights and current literature from China, Japan, South Korea, and Taiwan were synthesized to establish a unified perspective on the epidemiological and sociocultural contexts of the region. Patients in these East Asian countries exhibit distinct clinical features, such as a lower frequency of migraine with aura and photophobia, but a higher incidence of osmophobia compared to Western populations. Despite these clear phenotypic differences, significant gaps in care persist. Acute treatments like triptans remain underutilized, and while emerging CGRP-targeting therapies show promise, their adoption is hindered by high costs and limited accessibility. Furthermore, the region faces critical challenges, including a lack of region-specific clinical trials, culturally appropriate assessment tools, and unified clinical guidelines. Optimizing migraine care in East Asia requires a shift toward personalized, culturally sensitive strategies. Experts reached a consensus on the urgent need for collaborative research to address existing disparities and improve patient outcomes. By aligning clinical practice with the unique sociocultural landscapes of these nations, this statement provides a foundational framework for enhanced policy development and improved migraine management across East Asia.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced thalamic glutathione in migraine: a MEGA-PRESS spectroscopy study.","authors":"Hongying Huang, Jayin Miao, Yinji Piao, Zhaodong Lin, Yuqin Lin, Rui Wang, Zhongrouwen Ren, Guangsong Wang, Dafa Shi, Gen Yan, Yongmin Chang, Renhua Wu","doi":"10.1186/s10194-026-02379-y","DOIUrl":"https://doi.org/10.1186/s10194-026-02379-y","url":null,"abstract":"<p><strong>Background: </strong>Migraine and tension-type headache (TTH) are highly prevalent primary headache disorders lacking objective diagnostic biomarkers. Oxidative stress has been implicated in migraine pathophysiology, with glutathione (GSH) serving as the brain's principal antioxidant. This study investigated whether thalamic GSH levels, measured using optimized MEGA-PRESS spectroscopy, could serve as a candidate biomarker for differentiating migraine from TTH.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 76 participants: 20 healthy controls (HC), 19 TTH patients, and 37 migraine patients (27 without aura, 10 with aura). Bilateral thalamic GSH was measured using MEGA-PRESS at 3T. Group comparisons employed one-way ANOVA with Tukey HSD post-hoc tests. Sex-stratified analyses were performed. ROC analysis evaluated diagnostic performance.</p><p><strong>Results: </strong>Migraine patients showed significantly reduced thalamic GSH compared to both HC and TTH (left thalamus: F = 30.78, p < 0.001, η² = 0.457). Critically, no difference was found between HC and TTH groups. Sex-stratified analyses showed that GSH reduction was significant in both males and females. Left thalamic GSH showed good diagnostic accuracy for distinguishing migraine from both HC (AUC = 0.897) and TTH (AUC = 0.879).</p><p><strong>Conclusions: </strong>Thalamic GSH reduction appears to differentiate migraine from TTH in this sample, supporting a distinct role of oxidative stress in migraine pathophysiology. GSH may serve as a candidate biomarker for differentiating migraine from TTH.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist-led migraine consultations in community pharmacies: a pilot study of pharmacists' experiences and patient-reported outcomes.","authors":"Lene Berge Holm, Sahar Hussain, Parisa Gazerani, Tonje Krogstad","doi":"10.1186/s10194-026-02374-3","DOIUrl":"10.1186/s10194-026-02374-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential modulation of pain perception in animal models of acute sleep deprivation: implications of different stress response mechanisms.","authors":"Ya Cao, Zhe Yu, Huijian Yuan, Weinan Na, Rongfei Wang, Bozhi Li, Shengyuan Yu","doi":"10.1186/s10194-026-02371-6","DOIUrl":"https://doi.org/10.1186/s10194-026-02371-6","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, attitudes, and clinical practices related to medication-overuse headache among italian pharmacists: results from a cross-sectional survey.","authors":"Marina Romozzi, Matteo Palermo, Damiana Scuteri, Francesco Signorelli, Pietro Romozzi, Luca Pani, Fabio Tascedda, Sonia Di Tella, Catello Vollono, Paolo Calabresi, Federico Tosto, Luigi Francesco Iannone","doi":"10.1186/s10194-026-02376-1","DOIUrl":"https://doi.org/10.1186/s10194-026-02376-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of different microglial receptors mediating central inflammation in chronic migraine: a meta-analysis.","authors":"Xinyu Lin, Wenjing Yu, Jiafei Lou, Zhijian Cao, Wenwen Song","doi":"10.1186/s10194-026-02372-5","DOIUrl":"10.1186/s10194-026-02372-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing migraine burden and treatment response using nationwide smartphone app-based data in Korea.","authors":"Hong-Kyun Park, Yunha Noh, Min Kyung Chu, Ju-Young Shin, Yu-Jin Shin, Ha-Yeong Gil, Min-Taek Lee, Byung-Kun Kim","doi":"10.1186/s10194-026-02370-7","DOIUrl":"https://doi.org/10.1186/s10194-026-02370-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Migraine is a major source of disability in Korea, yet many patients remain underdiagnosed or undertreated. Traditional epidemiological studies are limited by recall bias and incomplete patient-reported outcomes. App-based headache diaries offer real-time, repeated measures of symptoms and treatment, enabling large-scale assessment to better understand migraine burden and treatment response. This study aimed to evaluate the large-scale implementation of a nationally distributed smartphone \"Headache Diary\" mobile application and describe migraine burden, acute treatment response, and functional impairment in real-world practice in Korea.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a retrospective, non-interventional analysis using self-reported data from the nationwide \"Headache Diary\" mobile application, developed by the Korean Headache Society. We included users who submitted at least one headache report between December 2020 and January 2025. Migraine/probable migraine were identified using an algorithm based on medication use and ICHD-3 criteria, while the remaining participants were classified into a non-migraine group (including tension-type headache or unclassifiable headache disorders). Acute-treatment failure was defined as pain relief reported after 2 hours or no effect. We also analyzed clinical characteristics, acute treatment patterns, and functional impairment associated with headache attacks.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 23,713 users, 17,913 (75.5%) had migraine or probable migraine. Migraine patients experienced more severe headache intensity (55.5% vs. 13.7%), higher rates of premonitory symptoms (67.7% vs. 29.5%), more frequent identification of triggers (89.9% vs. 61.2%), and greater use of acute medications (73.1% vs. 23.8%) compared to non-migraine users. Among 211,302 headache attacks analyzed, 155,894 attacks were migraine, and 96,742 attacks were available for acute treatment effect assessment. Of the 86,301 triptan-treated attacks, 40.3% resulted in acute treatment failure. Adolescents (10-19 years) showed the highest failure rate (62.1%). Notably, attacks with premonitory symptoms (odds ratio [OR] 0.91, 95% CI 0.89-0.94), aura (OR 0.79, 95% CI 0.75-0.83), or potential triggers (OR 0.93, 95% CI 0.91-0.96) had lower odds of treatment failure. Functional impairment was reported in 36.6% of attacks, most as decreased work or study efficiency (21.0%) and reduced household activity efficiency (17.2%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Nationwide, app-based data revealed that migraine patients in Korea frequently experience severe attacks, premonitory symptoms, and triggers, with substantial rates of acute treatment failure and functional impairment. These findings highlight the need for earlier recognition and timely intervention and suggest that real-time digital platforms can provide valuable insights for patient-centered migraine management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical trial number: &lt;/stro","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.","authors":"Geyu Liu, Cunxin Lin, Dong Qiu, Xiaoshuang Li, Zhi Guo, Yuanxiang Li, Yanliang Mei, Mantian Zhang, Jianing Wang, Xin Liu, Zhaoli Ge, Zhonghua Xiong, Binbin Sui, Yonggang Wang","doi":"10.1186/s10194-026-02375-2","DOIUrl":"https://doi.org/10.1186/s10194-026-02375-2","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice.","authors":"Xiao Ren, Xin-Tong Qiu, Yi-Yao Li, Chao-Yang Tan, Lu-Xi Zhou, Xiao-Ni Ye, Lin Li, Fen-Sheng Huang, Fu-Xing Zhang, Yun-Qing Li, Ming-Ming Zhang","doi":"10.1186/s10194-026-02373-4","DOIUrl":"10.1186/s10194-026-02373-4","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of FGF4/HIF-1α axis-mediated neuronal glycolysis on neuropathic pain.","authors":"Qiaoyun Wu, Yuewei Chen, Xintong Yao, Siqiang Ren, Han Xie, Sisi Li, Xinwang Ying, Xueqiang Wang","doi":"10.1186/s10194-026-02362-7","DOIUrl":"https://doi.org/10.1186/s10194-026-02362-7","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}