Journal of Glaucoma最新文献

{"title":"Exposure of PreserFlo Microshunt: Risk Factors and Surgical Management.","authors":"Laura Morales-Fernández, Javier García-Bardera, José M Martínez-de-la-Casa, Julián García-Feijoo","doi":"10.1097/IJG.0000000000002618","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002618","url":null,"abstract":"<p><p>Preserflo MicroShunt (PMS) has emerged as a safe and effective subconjunctival implant for lowering intraocular pressure in glaucoma. Although most postoperative complications occur early and are transient, long-term data remain limited-particularly regarding rare but serious events such as device exposure or extrusion, which may threaten ocular integrity. This report presents three clinical cases of PMS exposure with distinct presentations, potential risk factors, and surgical management approaches. In the first case, a pseudophakic patient with primary open-angle glaucoma developed exposure of the device body eight months postoperatively, associated with conjunctival ischemia but without leakage. In the second case, exposure of a non-functioning PMS occurred two years after a second implant was placed in a different quadrant, following early failure of the original device. The exposed implant was removed without compromising IOP control. The third and most severe case involved extensive scleral melting, distal extrusion, and Seidel positivity, requiring device explantation and scleral grafting. Contributing factors included the use of 0.04% mitomycin C, previous surgeries, and intraoperative identification of thin Tenon's capsule. Based on these cases, PMS exposure may arise through different mechanisms-distal extrusion, body erosion, or conjunctival dehiscence-each necessitating tailored surgical intervention. Awareness of risk factors and prompt management are essential to prevent complications such as infection or hypotony. These findings highlight the importance of careful intraoperative assessment, personalized MMC application, and early detection to ensure long-term safety and device preservation.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelve-Month Outcomes of Ultrasound Cycloplasty After Failed Glaucoma Surgery: A Prospective Study.","authors":"Liu Li, Yingjie Li, Ling Hong, Yongbo Wang, Xuan Zhu","doi":"10.1097/IJG.0000000000002621","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002621","url":null,"abstract":"<p><strong>Prcis: </strong>UCP effectively reduced IOP by 54.10% in eyes with failed glaucoma surgeries after 12 months. Complete and qualified success rates were 21.05% and 68.42%, respectively, demonstrating UCP's potential as a safe and effective salvage treatment.</p><p><strong>Purpose: </strong>This prospective study aims to evaluate the outcomes and safety of Ultrasound Cycloplasty(UCP) in controlling intraocular pressure in patients with prior failed glaucoma surgeries.</p><p><strong>Patients and methods: </strong>A total of 19 eyes from 19 patients who underwent UCP following failed glaucoma surgery between September 2020 to September 2022, were included. All patients were followed for over 12 months. Intraocular pressure, ocular hypotensive medications, and best-corrected visual acuity were recorded and compared after surgery. Complete success was defined as intraocular pressure within the range of 6-21 mmHg after treatment and a reduction of at least 20% from baseline, without the use of ocular hypotensive medications. Qualified success was defined the same as complete success but allows the presence of ocular hypotensive medications.</p><p><strong>Results: </strong>At 12 months follow-up, intraocular pressure decreased from 44.95±10.73 mmHg to 20.63±6.19 mmHg, representing a reduction of 54.10% (P<0.01). The rates of complete successes and qualified successes were 21.05% (4 of 19 eyes) and 68.42% (13 of 19 eyes) 12 months after treatment respectively.</p><p><strong>Conclusion: </strong>UCP is an effective and safe surgical approach for eyes with prior failed glaucoma surgeries.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular and Systemic Risk Factors and Clinical Implications in Glaucoma Patients with Retinal Vein Occlusion.","authors":"Myungju Lee, Min Seon Park, Changseok Lee, Sung Uk Baek","doi":"10.1097/IJG.0000000000002619","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002619","url":null,"abstract":"<p><strong>Prcis: </strong>Ocular factors such as worse visual acuity, increased optic disc cupping, and peak IOP-commonly associated with advanced glaucoma-have been identified as risk factors for concurrent RVO in glaucoma.</p><p><strong>Purpose: </strong>This study aimed to identify ocular and systemic factors associated with concurrent retinal vein occlusion (RVO) in glaucoma and to examine their clinical significance.</p><p><strong>Patients and methods: </strong>This retrospective study analyzed glaucoma patients with RVO, which was compared to a matched control group of glaucoma without RVO. Various ocular and systemic factors were identified as increasing the risk of RVO. RVO subgroup analyses were performed in central retinal vein occlusion (CRVO) and branch retinal vein occlusion. The RVO group was then categorized into Correspondence and Non-correspondence groups based on the synchronicity of RVO location and glaucomatous defect.</p><p><strong>Results: </strong>A total of 86 eyes in the RVO group and 70 eyes in the control group were included. Multivariate analysis identified significant risk factors for RVO, including worse visual acuity (VA) (HR=4.887, P=0.011), higher peak intraocular pressure (IOP) (HR=4.140, P=0.005), and increased vertical cup-to-disc ratio (CDR) (HR=3.061, P=0.020). Subgroup analysis revealed that higher peak IOP (P=0.030) and lower peripapillary retinal nerve fiber layer thickness (P=0.019) were associated with CRVO. In the RVO group, 68.6% were categorized into the Correspondence group, of which the ocular and systemic profiles were similar to the Non-correspondence group.</p><p><strong>Conclusion: </strong>These findings suggest that glaucoma and RVO may share common pathophysiologic mechanisms, with elevated IOP potentially contributing to the development of RVO. The majority of RVO location in glaucoma were synchronous with existing glaucomatous defects, which highlights the need for regular fundus examinations in high-risk individuals.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Vascular Density, Macular Layer Thickness, and Foveal Avascular Zone in Pseudoexfoliation Disease.","authors":"Soha Nohasfarmaniyeh, Mohammad Mehdi Movahedi, Ali Azimi, Tahereh Mahmodi, Hamidreza Hassanipour, Pardis Bostanian, Hossein Parsaei","doi":"10.1097/IJG.0000000000002620","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002620","url":null,"abstract":"<p><strong>Prcis: </strong>Significant reductions were observed in macular vessel density and ganglion cell layer thickness in patients with XFG and XFS; suggesting these parameters may serve as early biomarkers for diagnosing and monitoring the progression of glaucoma.</p><p><strong>Objective: </strong>This study aims to enhance early glaucoma diagnosis in Pseudoexfoliation syndrome (XFS) patients by assessing changes in macular vessel density and retinal layer thickness, and by investigating the relationship between these parameters and disease progression from XFS to pseudoexfoliation glaucoma (XFG).</p><p><strong>Methods: </strong>This cross-sectional study involved 25 eyes from 17 XFS patients, 32 eyes from 21 early XFG patients, and 34 age- and gender-matched healthy controls. Vessel density in the superficial and deep vascular complexes was assessed using Optical Coherence Tomography Angiography (OCTA), while the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and outer layer thickness were analyzed via spectral-domain optical coherence tomography (SD-OCT). Foveal avascular zone (FAZ) parameters were calculated, and the correlation between vessel density and macular layer thickness was examined.</p><p><strong>Results: </strong>All groups were age- and sex-matched. Vessel density in the Superficial Vascular Complex (SVC) was significantly lower in XFG compared to controls across all sectors (P<0.05). In the Deep Vascular Complex (DVC), significant differences were seen only in the temporal sector. GCL thickness decreased significantly in all sectors, while RNFL thickness differed only in the inferior sector. Outer retinal layer thickness was significantly greater in the XFS group. FAZ area and irregularity significantly increased in the SVC across groups (P<0.05).</p><p><strong>Conclusions: </strong>The study demonstrates that early retinal microvascular and structural changes -particularly reduced superficial vessel density in the temporal macula, thinning of the GCL, thickening of the outer retina, and FAZ enlargement -are detectable in XFS before glaucoma onset. Integrating these OCTA and SD-OCT findings into routine screening may enhance early diagnosis and guide timely intervention of glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standalone Canaloplasty and Trabeculotomy Using the OMNI Surgical System in Patients with Open-Angle Glaucoma: A Systematic Review and Meta-analysis.","authors":"Daniel Zhu, Paras Shah, Charles Zhang, Benjamin Ho, Georges AbouKasm, Benjamin Musheyev, Samantha Goldburg, Edward Zhu, Amanda Wong, Elena Bitrian, Celso Tello, Alina Djougarian","doi":"10.1097/IJG.0000000000002616","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002616","url":null,"abstract":"<p><strong>Precis: </strong>This systematic review and meta-analysis found that standalone OMNI resulted in significant intraocular pressure (IOP) reduction at the 1-month, 6-month, 1-year, and 2-year time points and significantly improved topical medication burden at 1-year.</p><p><strong>Purpose: </strong>To determine the efficacy of standalone canaloplasty and trabeculotomy using the OMNI Surgical System in open-angle glaucoma (OAG) patients.</p><p><strong>Methods: </strong>A systematic review was performed using the PubMed, Embase, and Scopus databases for all studies using the OMNITM Surgical System for standalone canaloplasty and trabeculotomy in OAG patients with baseline intraocular pressure (IOP) >18 mmHg (PROSPERO ID: CRD420251044505). Meta-analyses were performed to calculate the IOP change following treatment at 1-month, 6-month, 1-year, and 2-year follow-ups. We also evaluated changes in topical medications and the proportion of medication-free patients at 1 year.</p><p><strong>Results: </strong>Five studies with 290 eyes at baseline were included. At the 1-month follow-up, there was a significant mean IOP reduction of 7.40 mmHg following standalone OMNI (MD=-7.40; 95% CI: -10.61 to -4.20; P<0.0001). At the 6-month follow-up, mean IOP reduction was 7.25 mmHg (MD=-7.25; 95% CI: -9.60 to -4.89; P<0.0001). At the 1-year follow-up, mean IOP reduction was 7.49 mmHg (MD=-7.49; 95% CI: -9.47 to -5.50; P<0.0001). At 2-year follow-up, mean IOP reduction was 8.77 mmHg (MD=-8.77; 95% CI: -10.35 to -7.19; P<0.0001). Additionally, at the 1-year follow-up, mean reduction of topical medications was 0.77 (MD=-0.77; 95% CI: -1.44 to -0.09; P=0.025), and 46.2% of patients were medication-free (95% CI: 35.6%-57.2%).</p><p><strong>Conclusions: </strong>The OMNI Surgical System is an effective standalone procedure for canaloplasty and trabeculotomy in OAG patients and led to a significant reduction in IOP at multiple timepoints and medication burden.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12-Month Intraocular Pressure and Hypotensive Medications Outcomes After Phaco-ELIOS Procedure-A Real World Study.","authors":"Antonio Moreno-Valladares, Anastasiya Vinokurtseva, Johanna M González-Rodríguez, Iqbal I K Ahmed, Eva Gonzalez-Aquino, Nieves Puerto-Amorós, Esther Roquet, Anna Soldevila, María I Canut","doi":"10.1097/IJG.0000000000002590","DOIUrl":"10.1097/IJG.0000000000002590","url":null,"abstract":"<p><strong>Prcis: </strong>Combined phaco-ELIOS in ocular hypertension and glaucoma showed a statistically significant reduction in the number of hypotensive medications of 1.5 compared with baseline, with 78.4% of eyes being medication-free at 12 months.</p><p><strong>Purpose: </strong>To describe the change in medication and intraocular pressure 12 months after the combined phacoemulsification-ELIOS procedure.</p><p><strong>Methods: </strong>Retrospective, multicenter interventional case series of adults with ocular hypertension or glaucoma undergoing phaco-ELIOS. Clinical data were collected and analyzed from preoperative baseline up to 12 months postoperatively. The primary outcome was the mean change in medication compared with baseline. Secondary outcomes were intraocular pressure change from baseline, incidence of acute postoperative intraocular pressure elevation, and surgical success at 1 year, defined as intraocular pressure reduction of ≥20% compared with baseline with no increase in medications, or reduction of ≥1 medications compared with baseline with intraocular pressure equal or below baseline, with no secondary glaucoma surgeries and no loss of light perception.</p><p><strong>Results: </strong>One hundred twelve eyes were included. Forty-two patients (51.2%) were female. Mean (±SD) age was 70.6 (±9.6) years. The most frequent diagnosis was primary open angle glaucoma (71.4%). The mean number of medications at baseline and 12 months was 1.8 (±0.8) and 0.4 (±0.7), respectively, representing a reduction of 1.5 (±1.0) ( P <0.0001). At the end of follow-up, 78.4% of eyes were medication-free. Mean intraocular pressure at baseline and 12 months was 19.9 (±4.0) mm Hg and 16.7 (±2.6) mm Hg, respectively, a significant decrease of 3.2 mm Hg (±4.0) or 13.7% ( P <0.0001). Surgical success was achieved in 75.9% of eyes at 12 months.</p><p><strong>Conclusions: </strong>Combined phaco-ELIOS in glaucoma significantly reduced medication use and IOP, with over 75% of eyes being medication-free at 12 months.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"585-590"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micropulse Transscleral Laser Treatment Versus Continuous Wave Transscleral Cyclophotocoagulation for the Treatment of Glaucoma or Ocular Hypertension: A Meta-Analysis.","authors":"Matheus P Chavez, Guilherme B Guedes, Eric Pasqualotto, Izabela N F de Almeida, Lucca M Lopes, Tiago S Prata, Tiago T de Souza","doi":"10.1097/IJG.0000000000002583","DOIUrl":"10.1097/IJG.0000000000002583","url":null,"abstract":"<p><strong>Prcis: </strong>Micropulse transscleral laser treatment (MP-TLT) and continuous wave transscleral cyclophotocoagulation demonstrated comparable intraocular pressure across all follow-ups. MP-TLT was associated with significantly lower risks of ocular complications, such as hypotony, prolonged inflammation, and phthisis bulbi.</p><p><strong>Purpose: </strong>To compare the efficacy and safety of micropulse transscleral laser treatment (MP-TLT) and continuous wave transscleral cyclophotocoagulation (CW-TSCPC) for the treatment of glaucoma or ocular hypertension.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Cochrane Library, Embase, and ClinicalTrials.gov. Randomized controlled trials (RCTs) or cohort studies comparing MP-TLT and CW-TSCPC were included. Weighted mean differences (MDs) were computed for continuous endpoints and risk ratios (RRs) for binary endpoints, with 95% CIs. Heterogeneity was assessed with I2 statistics. Software R, version 4.4.0, was used for statistical analyses. Subgroup analyses were conducted on glaucoma types.</p><p><strong>Results: </strong>Eleven studies encompassing 1054 eyes from 986 patients were included, with 47.4% receiving MP-TLT. There were no significant differences in IOP between CW-TSCPC and MP-TLT at 1 week, 1 month, 3 months, 6 months, 12 months, and 18 months of follow-up. The MP-TLT group required a significantly higher number of hypotensive medications but displayed significantly reduced risks of overall complications, ocular hypotony, prolonged inflammation, and phthisis bulbi compared with CW-TSCPC.</p><p><strong>Conclusion: </strong>MP-TLT and CW-TSCPC showed similar efficacy in IOP control. However, MP-TLT demonstrated a greater safety profile, suggesting its potential suitability for patients requiring repeat interventions or those with lower tolerance for ocular complications.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"575-584"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractal Dimension Analysis of Peripapillary Microvasculature in Primary Congenital Glaucoma.","authors":"Emily K Tam, Marco H Ji, Alaa E Fayed, Sherin H Sadek, Nagwa Ahmed, Qais Dihan, Ahmad Alzein, Mohsen Adelpour, Yasmine M El Sayed, Abdelrahman M Elhusseiny","doi":"10.1097/IJG.0000000000002566","DOIUrl":"10.1097/IJG.0000000000002566","url":null,"abstract":"<p><strong>Prcis: </strong>In this prospective multicenter study, eyes with primary congenital glaucoma exhibited lower retinal vascular parameters compared to healthy controls, as assessed by optical coherence tomography angiography fractal dimension analysis.</p><p><strong>Purpose: </strong>To study the retino-choroidal peripapillary microvascular pattern in primary congenital glaucoma (PCG) using fractal dimension (FD) analysis and compare it to healthy controls.</p><p><strong>Methods: </strong>This was a prospective multicenter comparative study. We obtained peripapillary optical coherence tomography angiography (OCTA) scans (Optovue Inc) and computed FD at the vitreous/retina (large retinal vessels), inner limiting membrane/nerve fiber layer (ILM-NFL) (radial peripapillary capillary plexus, RPC), and the choroid. Other peripapillary OCTA parameters, including the whole image inside the disk and peripapillary superior and inferior vascular density (VD) parameters, were also collected. 1 eye per patient was included in the analysis.</p><p><strong>Results: </strong>We included a total of 17 PCG eyes and 24 control eyes. The mean age at the time of enrollment was 8.24±0.75 years in the PCG group compared to 8.33±1.09 in controls ( P =0.74). Eight patients (47%) in the PCG group and 14 (58.3%) in the control group were male. Among the PCG group, the mean vitreo-retina (large retinal vessels) FD (1.79) and ILM-NFL (RPC) FD (1.75) were significantly reduced compared to controls [vitreo-retina FD (1.85), ILM-NFL FD (1.82), P -value 0.011 and 0.014, respectively]. There was no statistically significant difference in the averaged choroidal FD between both groups (1.89 vs. 1.88, P =0.29). All optic nerve VD parameters (whole image, inside disc, superior, and inferior-hemi) were also significantly reduced in the PCG group.</p><p><strong>Conclusions: </strong>PCG was associated with lower vascular parameters in the vitreo-retina (large retinal vessels) and ILM-NFL (RPC) layers as detected by OCTA FD.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"625-629"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Event-based Analysis Versus Trend-based Analysis in the Detection of Glaucoma Progression by Optical Coherence Tomography 3-Dimensional Rim Measurements.","authors":"Tamara D Scott, Maria A Guzman Aparicio, Kitiya Ratanawongphaibul, Hang Lee, Michele Zemplenyi, Edem Tsikata, Milica A Margeta, Courtney L Ondeck, Anne L Coleman, Fei Yu, Johannes F de Boer, Teresa C Chen","doi":"10.1097/IJG.0000000000002573","DOIUrl":"10.1097/IJG.0000000000002573","url":null,"abstract":"<p><strong>Prcis: </strong>Compared with trend-based analysis, event-based analysis detects OCT structural progression in more patients and at an earlier time point. Using event-based analysis, MDB rim thickness detects progression more often than RNFL thickness.</p><p><strong>Purpose: </strong>To determine whether event-based or trend-based analysis best detects glaucoma progression using spectral domain optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim measurements.</p><p><strong>Methods: </strong>Over 5 years, 124 open angle glaucoma patients had yearly dilated eye examinations, disc photography, Humphrey visual field (HVF 24-2) testing, 2-dimensional (2D) OCT RNFL thickness measurements, and 3-dimensional (3D) OCT MDB rim measurements, all on the same day. One eye of each patient was analyzed, which was randomly selected if both eyes from a patient were eligible. Using global RNFL thickness and global MDB rim thickness, event-based progression was defined as change greater than normal aging change and expected inter-test variability. Trend-based analysis used linear regression with progression defined as rate of decline greater than age-related decline.</p><p><strong>Results: </strong>The average follow-up for the 124 open angle glaucoma patients was 66.9±16.4 months. Event-based analysis was better than trend-based analysis because it detected progression in more patients (15.3% by RNFL event-based analysis versus 8.1% by RNFL trend-based analysis, P =0.025; 52.4% by MDB event-based analysis versus 9.7% by MDB trend-based analysis, P <0.001) and earlier (RNFL: mean 28.8 vs. 63.2 mo; P <0.001; MDB: mean 30.7 vs. 56.2 mo; P <0.003) whether using MDB rim thickness or RNFL thickness. Using event-based analysis, MDB rim thickness detected progression more often than RNFL thickness (52.4% vs. 15.3%; P <0.001).</p><p><strong>Conclusions: </strong>Compared with trend-based analysis, event-based analysis detected OCT structural progression in more glaucoma patients and at an earlier time point.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"616-624"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Periodontitis and Open Angle Glaucoma: The Korea National Health and Nutrition Examination Survey.","authors":"Jeong Hwan Noh, Mi Yeon Lee, Chungkwon Yoo, Kyung Rim Sung, Joon Mo Kim","doi":"10.1097/IJG.0000000000002584","DOIUrl":"10.1097/IJG.0000000000002584","url":null,"abstract":"<p><strong>Prcis: </strong>Using Korean National Health and Nutrition Examination Survey (KNHANES) data, this study reveals a significant association between periodontitis and open angle glaucoma.</p><p><strong>Purpose: </strong>To investigate the relationship between periodontitis and open angle glaucoma.</p><p><strong>Methods: </strong>Data from 17,478 subjects in the KNHANES 2010-2011 were analyzed. We included 6215 subjects aged 19 years or older who underwent both dental and ophthalmological examinations that met International Society of Geographical and Epidemiological Ophthalmology criteria. Exclusions included ocular surgery (eg, refractive, cataract, retina), age-related macular degeneration, those who were pregnant or who were undergoing orthodontic treatment, and those with missing data. The final analysis included 3681 subjects. Periodontal disease was assessed using the Community Periodontal Index (CPI) developed by the WHO.</p><p><strong>Results: </strong>Of 3681 subjects, 197 (4.59%) had glaucoma and 3484 (95.41%) did not. Among the 197 glaucoma patients, 80 (39.48%) had periodontitis; among those without glaucoma, 892 (22.20%) had periodontitis ( P <0.001). The periodontitis group was more likely to have glaucoma than the nonperiodontitis group [odds ratio (OR), 1.53; 95% CI, 1.06-2.22; adjusted for age, sex, DM, HTN, smoking rate, and drinking rate]. For those older than 40 years, the OR was 1.75 (95% CI, 1.18-2.61), and that for men was 1.65 (95% CI, 1.01-2.70). When comparing the group with and without periodontitis in DM patients, the OR was 2.70 (95% CI, 1.46-5.02).</p><p><strong>Conclusion: </strong>This study shows a significant association between periodontitis and glaucoma, especially in patients aged 40 and older, men, and those with diabetes. Future follow-up studies are needed to elucidate the mechanism behind this association.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"565-574"},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}