Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-06-18DOI: 10.1097/IJG.0000000000002451
Ashley Polski, Theresa Long, Brian C Stagg, Barbara Wirostko
{"title":"Uveitis-Glaucoma-Hyphema Syndrome From Subtle Malposition of a Hydrus Microstent.","authors":"Ashley Polski, Theresa Long, Brian C Stagg, Barbara Wirostko","doi":"10.1097/IJG.0000000000002451","DOIUrl":"10.1097/IJG.0000000000002451","url":null,"abstract":"<p><p>Uveitis-glaucoma-hyphema (UGH) syndrome is a rare condition characterized by intraocular inflammation, elevated intraocular pressure, and recurrent hyphema. Although UGH syndrome is typically caused by chafing between an intraocular lens and the iris or ciliary body, microinvasive glaucoma devices are becoming increasingly recognized as potential causes of recurrent intraocular inflammation. Herein, we discuss a case of UGH syndrome due to the subtle malposition of a Hydrus microstent that ultimately required surgical removal to manage. This represents the first case of Hydrus-related UGH syndrome to include high-quality anterior segment imaging, which led us to suspect Hydrus-iris contact and supported the decision to proceed with microstent explantation.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e92-e96"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-07-15DOI: 10.1097/IJG.0000000000002462
Khaled A Elubous, Hady Saheb
{"title":"Gonioscopy-Assisted Transluminal Trabeculotomy in Angle Recession Glaucoma.","authors":"Khaled A Elubous, Hady Saheb","doi":"10.1097/IJG.0000000000002462","DOIUrl":"10.1097/IJG.0000000000002462","url":null,"abstract":"<p><p>This case report outlines the successful management of angle recession (AR) with gonioscopy-assisted transluminal trabeculotomy (GATT). A 53-year-old man with a history of blunt trauma to the left eye resulting in AR presented with an IOP of 38 mm Hg on 4 antiglaucoma agents. After GATT, a notable reduction in IOP to 10 mm Hg was observed on the first postoperative day. Subsequent 1-year follow-up visits demonstrated sustained improvement, with IOP stabilizing at 18 mm Hg without the need for antiglaucoma medication. This is the first case report that demonstrates the role of GATT in the management of AR.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e85-e88"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-08-05DOI: 10.1097/IJG.0000000000002479
Yasmine M El Sayed, Reem M Aboulhassan, Ghada I Gawdat, Amanne E Feisal, Hala M Elhilali
{"title":"Two-Year Results of Gonioscopy-Assisted Transluminal Trabeculotomy in Primary Congenital Glaucoma.","authors":"Yasmine M El Sayed, Reem M Aboulhassan, Ghada I Gawdat, Amanne E Feisal, Hala M Elhilali","doi":"10.1097/IJG.0000000000002479","DOIUrl":"10.1097/IJG.0000000000002479","url":null,"abstract":"<p><strong>Prcis: </strong>Gonioscopy-assisted transluminal trabeculotomy yielded a 45% reduction in intraocular pressure in primary congenital glaucoma, with a success rate of 86.6%. Hyphema was the most common complication. We did not encounter any vision-threatening complications.</p><p><strong>Background: </strong>To assess the outcome of gonioscopy-assisted transluminal trabeculotomy (GATT) in primary congenital glaucoma (PCG) and identify the potential prognostic factors for adverse outcomes.</p><p><strong>Methods: </strong>This prospective study included patients aged <14 years, presenting with PCG from November 2019 till November 2021. We excluded eyes with hazy cornea, secondary glaucoma, peripheral anterior synechiae ≥90 degrees, and eyes in which the extent of GATT was <270 degrees. Success was defined as a final intraocular pressure (IOP) <18 mm Hg with IOP reduction >20%. Primary outcomes were reduction in IOP and medications, secondary outcomes were complications and correlation of IOP reduction and surgical success with possible risk factors.</p><p><strong>Results: </strong>We included 60 eyes of 50 patients aged 1-156 months (mean: 25.5±36.5). A 353±21 degrees incision was created, with 85% achieving a 360-degree incision. There was a significant reduction in IOP and medications at all follow-up intervals up to 2 years, with a mean of 45% IOP reduction. The final success rate was 86.6%, with 76.7% being controlled without medications. There was a significant positive correlation between the preoperative cup-to-disc ratio (CDR) and failure rates ( P =0.03) and between the incision extent and the IOP reduction (r=0.4, P =0.001). Hyphema was the most common complication, affecting 33%, and resolved spontaneously in all cases. No vision-threatening complications occurred.</p><p><strong>Conclusions: </strong>GATT is a safe and effective procedure in eyes with PCG and clear cornea, including eyes that had previous failed glaucoma surgery. Circumferential GATT is associated with more favorable outcomes, while eyes with a larger CDR are at a higher risk for failure.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"862-866"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-08-05DOI: 10.1097/IJG.0000000000002473
Christoph D Ennerst, Isaak R Fischinger, Manfred R Tetz
{"title":"Long-Term Outcome After Canaloplasty and Phacocanaloplasty in Primary Open Angle Glaucoma.","authors":"Christoph D Ennerst, Isaak R Fischinger, Manfred R Tetz","doi":"10.1097/IJG.0000000000002473","DOIUrl":"10.1097/IJG.0000000000002473","url":null,"abstract":"<p><strong>Prcis: </strong>Canaloplasty and phacocanaloplasty achieve a statistically significant intraocular pressure (IOP)-reduction for up to 11 years and decrease the long-term need for glaucoma medications. Both procedures have a low long-term complication rate.</p><p><strong>Purpose: </strong>To evaluate the long-term outcome of canaloplasty with and without cataract surgery in primary open angle glaucoma (POAG) patients.</p><p><strong>Patients and methods: </strong>In all, 48 eyes of 34 patients with POAG who successfully received canaloplasty alone (group A, n=28) or with phacoemulsification (group B, n=20) were retrospectively analyzed. Demographic data, IOP, and IOP-lowering medication were recorded presurgery and postsurgery with a follow-up of up to 14 years.</p><p><strong>Results: </strong>The mean follow-up time in group A was 91.4±45.0 months. Mean IOP dropped from 22.0±3.8 mm Hg at baseline to 14.0±3.3, 14.3±3.1, 14.4±3.8, and 16.5±1.2 mm Hg at 1, 4, 7, and 10 years, respectively. IOP-lowering medication count decreased from 1.5±1.0 at baseline to 0.1±0.4, 0.3±0.6, 0.6±0.9, and 0.9±1.1 at 1, 4, 7, and 10 years, respectively. The mean follow-up time in group B was 109.1±25.7 months. Mean IOP dropped from 24.5±6.0 at baseline to 13.8±2.9, 14.9±3.6, 15.3±2.9, and 14.8±2.0 mm Hg at 1, 4, 7, and 10 years, respectively. IOP-lowering medication count decreased from 2.2±1.2 before surgery to 0.0, 0.1±0.3, 0.1±0.2, and 0.5±0.9 at 1, 4, 7, and 10 years, respectively.</p><p><strong>Conclusion: </strong>Canaloplasty and phacocanaloplasty achieved a comparable decrease in IOP and glaucoma medication count with a low complication rate. Both procedures showed a high long-term success rate.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"867-873"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-08-05DOI: 10.1097/IJG.0000000000002474
Zhenbin Qian, Weihua Pan, Li Nie, Leilei Lin, Liqing Wei
{"title":"Efficacy and Safety of Phaco-Goniosynechialysis in Advanced Primary Angle Closure Glaucoma With Severe Visual Field Loss.","authors":"Zhenbin Qian, Weihua Pan, Li Nie, Leilei Lin, Liqing Wei","doi":"10.1097/IJG.0000000000002474","DOIUrl":"10.1097/IJG.0000000000002474","url":null,"abstract":"<p><strong>Prcis: </strong>Phacoemulsification with goniosynechialysis (phaco-GSL) demonstrates promise in safely and efficiently managing advanced primary angle closure glaucoma (PACG) cases with tunnel vision or limited temporal visual field. However, caution is advised for patients with only one functioning eye or high visual expectations.</p><p><strong>Objective: </strong>To assess the efficacy and safety of phaco-GSL in patients with end-stage PACG exhibiting tubular vision or temporal field island.</p><p><strong>Patients and methods: </strong>This retrospective study evaluated 68 patients (74 eyes) diagnosed with advanced PACG and exhibiting either tubular vision or temporal field island. All patients underwent phaco-GSL and were monitored for at least 1 month postoperatively. The study analyzed changes in visual acuity (VA), intraocular pressure (IOP), medication use for antiglaucoma, and postoperative complications.</p><p><strong>Results: </strong>The mean follow-up time was 9.11 ± 10.49 months. The mean preoperative visual field deviation and VA were -28.01 ± 3.30 dB and 0.36 ± 0.37 log minimum angle of resolution unit, respectively. Postoperatively, the VA for over half (54.1%) of the eyes increased, 29.7% remained unchanged, and 16.2% worsened. The final IOP decreased significantly from 24.65 ± 8.61 to 14.81 ± 3.54 mm Hg. Glaucoma medication use also reduced from 1.46 ± 1.43 to 0.88 ± 1.18. The success rate was 48.6% for complete and 89.2% for qualified. IOP spikes (27.0%) and wipe-out (8.1%) were the most common postoperative complications. Vision recovered gradually in 5 of 6 wipe-out patients. One eye (1.4%) developed permanent vision loss with VA decreasing to hand motion.</p><p><strong>Conclusion: </strong>Phaco-GSL appears safe and effective in treating advanced PACG cases with tubular vision or temporal field island. However, caution is warranted when considering this treatment option for patients at high wipe-out risk or those with high expectations for visual outcomes.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"900-907"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-08-02DOI: 10.1097/IJG.0000000000002471
Ali Azimi, Pardis Bostanian, Mohammad Hassan Jalalpour, Hamid Reza Hassanipour, Jay Chhablani, Elham Sadeghi
{"title":"Evaluation of the Inner Macula Layers, Circumpapillary Retinal Nerve Fiber Layer, and Minimum Rim Width Thickness in Patients With Pseudoexfoliation Syndrome Without Glaucoma Compared With Controls.","authors":"Ali Azimi, Pardis Bostanian, Mohammad Hassan Jalalpour, Hamid Reza Hassanipour, Jay Chhablani, Elham Sadeghi","doi":"10.1097/IJG.0000000000002471","DOIUrl":"10.1097/IJG.0000000000002471","url":null,"abstract":"<p><strong>Prcis: </strong>Minimum rim width (MRW) is thinner in patients with non-glaucomatous pseudoexfoliation syndrome (XFS) and may be the first parameter affected in these patients due to the vascular nature of this disease.</p><p><strong>Objective: </strong>To evaluate the macular inner layers, circumpapillary retinal nerve fiber layer (cp-RNFL), and MRW in non-glaucomatous XFS compared with healthy patients.</p><p><strong>Patients and methods: </strong>In this prospective study, using Heidelberg Spectralis optical coherence tomography with Glaucoma Module Premium Edition, 8×8 grids of macular inner layers were exported, and the global, superior, and inferior thicknesses were used. Also, on the deviation map, the elliptical annulus around the fovea, which was 4.8×4 mm in size, was analyzed. Moreover, both groups calculated cp-RNFL and MRW values in 3 superior and 3 inferior sectors.</p><p><strong>Results: </strong>Thirty-two eyes of 32 patients with clinically detected non-glaucomatous XFS and 30 right eyes of age-sex-matched healthy controls were included. No significant difference was found between the case and control groups concerning the intraocular pressure (14.94 ± 2.09 vs 15.27 ± 2.27 mm Hg, respectively, P = 0.556). The MRW of the superotemporal segment (MRW-temporal superior) was significantly thinner in the XFS group compared with the control ones (303.69 ± 60.49 vs 341.43 ± 56.19 µm, P = 0.014). No significant differences were found in the other sectors of MRW, macular inner layers, and cp-RNFL thickness between the groups.</p><p><strong>Conclusion: </strong>These findings indicate that the MRW, especially in the superotemporal sector, may show early eye damage in patients with non-glaucomatous XFS, and it may be used to detect the early stage of glaucoma in XFS.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"894-899"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-07-15DOI: 10.1097/IJG.0000000000002467
Anne Strong Caldwell, Zafar S Gill, Deidre M St Peter
{"title":"Occlusion of Xen Gel Stent With Descemet's Membrane Relieved by Nd:YAG Laser.","authors":"Anne Strong Caldwell, Zafar S Gill, Deidre M St Peter","doi":"10.1097/IJG.0000000000002467","DOIUrl":"10.1097/IJG.0000000000002467","url":null,"abstract":"<p><strong>Abstract: </strong>The Xen gel stent is a minimally invasive glaucoma surgical implant designed to decrease intraocular pressure (IOP) by creating an aqueous outflow path into the subconjunctival space. Since FDA approval, it has demonstrated good safety and efficacy data; however, there are multiple reports of Xen stent occlusions with debris from the anterior chamber. Herein, we report a case of a Descemet's membrane Xen stent occlusion in a 67-year-old woman with a past medical history of primary open angle glaucoma who underwent Xen stent placement through the ab externo approach. Her Descemet's membrane occlusion was successfully managed by Nd:YAG laser lysis. Although uncommon, small Descemet's tears or flaps can occlude the ostia of Xen stents causing elevated IOP or bleb failure. Few reports have described the use of Nd:YAG laser to successfully treat ostium occlusion of any kind with the Xen stent. We discuss the importance of early Nd:YAG laser to relieve Descemet's membrane occlusions, lower IOP, and rescue the bleb from failure.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e89-e91"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2024-11-01Epub Date: 2024-07-15DOI: 10.1097/IJG.0000000000002460
Ji Young Lee, Jin A Choi
{"title":"Risk Factors for Disease Progression in Glaucoma Patients With Disk Hemorrhage.","authors":"Ji Young Lee, Jin A Choi","doi":"10.1097/IJG.0000000000002460","DOIUrl":"10.1097/IJG.0000000000002460","url":null,"abstract":"<p><strong>Prcis: </strong>Glaucoma eyes with recurrent disk hemorrhage were associated with increased systolic blood pressure and diastolic blood pressure, and increased visit-to-visit diastolic blood pressure variability was associated with glaucoma progression.</p><p><strong>Purpose: </strong>In this study, we investigated the effects of the clinical characteristics of disk hemorrhage (DH) and hemodynamic factors on glaucoma progression.</p><p><strong>Methods: </strong>This retrospective cohort study included 81 eyes with open angle glaucoma and nonrecurrent or recurrent DH. Recurrent DH was further classified according to the DH location. Visual field (VF) progression was determined using event-based analysis and Guided Progression Analysis software. The coefficient of variation (CV) of systolic blood pressure (SBP) and diastolic blood pressure (DBP) was used to measure visit-to-visit variability. Kaplan-Meier survival analysis was used to compare the cumulative risk ratio of progression between groups.</p><p><strong>Results: </strong>The recurrent DH group had significantly higher SBP and DBP ( P =0.014 and=0.021, respectively) and a higher proportion of VF progression ( P =0.019) than the nonrecurrent DH group. In particular, females with recurrent DH had the highest cumulative probability of VF progression ( P =0.047, log-rank test). Recurrent DH in a different quadrant was associated with the highest cumulative probability of VF progression than nonrecurrent DH ( P =0.038, log-rank test). In Cox regression analysis, higher visit-to-visit DBP variability, female gender, and recurrent DH in a different quadrant were significantly associated with glaucoma progression.</p><p><strong>Conclusion: </strong>In glaucomatous eyes with DH, increased visit-to-visit DBP variability was associated with glaucoma progression. Our results suggest that hemodynamic factors are involved in the recurrence of DH and progression of glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"828-834"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between Risk of Obstructive Sleep Apnea and Intraocular Pressure based on the Korea National Health and Nutrition Examination Survey VIII.","authors":"Jung Lim Kim, Kayoung Lee","doi":"10.1097/IJG.0000000000002512","DOIUrl":"10.1097/IJG.0000000000002512","url":null,"abstract":"<p><strong>Prcis: </strong>A higher STOP-BANG score and loud snoring, observed breathing interruptions during sleep, hypertension, and wide neck circumference were individually and in combination associated with high intraocular pressure in Koreans aged 40 years and older.</p><p><strong>Purpose: </strong>To evaluate the relationship between intraocular pressure (IOP) and the risk of obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>In this population-based, cross-sectional study, we included Korean adults aged 40 years or above recruited between 2019 and 2021. 6315 subjects were included from the Korea National Health and Nutrition Examination Survey Ⅷ database. The risk of OSA was measured by STOP-BANG questionnaire. The IOPs were measured using rebound tonometer. Logistic regression was used to analyze the association between IOP quartiles (highest quartile vs. lower 1-3rd quartiles) with OSA risk after adjusting for sociodemographic characteristics, lifestyle, and diabetes.</p><p><strong>Results: </strong>The adjusted odds ratio for high IOP, was 1.27 (95% CI 1.12 to 1.43) for participants with a STOP-BANG score of 3 to 8 compared with those with a score of 0 to 2. Participants with loud snoring, observed breathing interruptions during sleep, hypertension, or wide neck circumference had 24%-40% higher odds of high IOP than those without these components. The odds ratio for high IOP in the group with all four factors was 2.09 times higher (95% CI 1.26 to 3.46) than in the group without these factors.</p><p><strong>Conclusions: </strong>A higher STOP-BANG score was associated with an increased risk of high IOP in Koreans aged 40 years and older. Furthermore, among the STOP-BANG components, loud snoring, observed breathing interruptions during sleep, hypertension, and wide neck circumference were individually and in combination associated with high IOP.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Hong Kim, Jooyoung Yoon, Kyeong Ik Na, Rim Kyung Hong, Won June Lee
{"title":"Association of Peripapillary Arterial Circle of Zinn-Haller with Glaucoma in Highly Myopic Eyes.","authors":"Ji Hong Kim, Jooyoung Yoon, Kyeong Ik Na, Rim Kyung Hong, Won June Lee","doi":"10.1097/IJG.0000000000002514","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002514","url":null,"abstract":"<p><strong>Prcis: </strong>The visualization of circle of Zinn-Haller (CZH) on optical coherence tomography angiography (OCTA) or its pattern does not have a clear effect on glaucoma, while the location of CZH is associated with axial length in highly myopic eyes.</p><p><strong>Purpose: </strong>To investigate the association between the CZH and the presence of glaucoma using swept-source optical coherence tomography angiography (SS-OCTA) images of the optic nerve of patients with high myopia (HM).</p><p><strong>Methods: </strong>This retrospective case series included 227 eyes with HM, comprising 134 and 93 eyes with and without glaucoma, respectively. The characteristics of CZH, including visualization, pattern, and location, were assessed using SS-OCTA. Vascular parameters, such as vessel density and microvascular dropout (MvD), were quantified. The factors affecting the presence of glaucoma and the correlations between the CZH distance and axial length (AXL) were identified using logistic regression analysis and Pearson correlation analysis, respectively.</p><p><strong>Results: </strong>CZH was detected more frequently in HM patients with glaucoma (71.6%) than in patients without glaucoma (51.6%) (P<0.002). However, the visualization of CZH was not related to the presence of glaucoma in multivariate regression analysis (odds ratio [OR], 0.688; 95% confidence interval [CI], 0.328-1.444; P=0.322). Moreover, compared to the annular pattern used as a reference, triangular and irregular patterns were not associated with the presence of glaucoma (OR: 1.043, 95% CI: 0.101-10.763, P=0.971; OR: 0.527, 95% CI: 0.255-1.092, P=0.085, respectively). MvD was significantly higher in patients with glaucoma (61.2%) than that in patients without glaucoma (2.2%) (P<0.001) and was identified as a significant factor affecting the presence of glaucoma (OR, 42.120; 95% CI, 9.416-188.413; P<0.001). AXL showed a significant correlation with CZH distance in all patients (R=0.399; P<0.001).</p><p><strong>Conclusions: </strong>CZH was more commonly detected in HM patients with glaucoma. However, no clear associations of glaucoma with the visualization, pattern, or location of CZH were observed in the present study. The correlation between AXL and CZH distance in eyes with HM warrants further investigation. These results may offer insights into the pathogenesis of glaucoma in eyes with HM as OCTA technology advances.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}