Journal of Glaucoma最新文献

{"title":"36-Month Multi-Centre Outcomes of Combined Phacoemulsification and Hydrus Microstent Implantation in Eyes with Normal Tension Glaucoma.","authors":"Bryan Chin Hou Ang, Bjorn Kaijun Betzler, Jackie Jia Lin Sim, Rajesh Ramanathan, Ashley Shuen Ying Hong, Chun Hau Chua, Thomas Khairy, Ali Salimi, Paul Harasymowycz","doi":"10.1097/IJG.0000000000002709","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002709","url":null,"abstract":"<p><strong>Precis: </strong>This retrospective multicentre study of 77 NTG eyes undergoing phacoemulsification and Hydrus implantation showed a sustained reduction in medication burden, while maintaining IOP levels. Complications were rare and non-sight-threatening.</p><p><strong>Purpose: </strong>To evaluate 36-month outcomes of combined phacoemulsification and Hydrus Microstent implantation (Phaco-Hydrus) in eyes with normal tension glaucoma (NTG).</p><p><strong>Methods: </strong>This multicentre retrospective study included 77 NTG eyes from Singapore and Canada that underwent Phaco-Hydrus between 2014 and 2023. Primary outcomes were changes in intraocular pressure (IOP) and medication burden, and cumulative success probabilities from Kaplan-Meier (KM) analyses. Longitudinal changes were analysed using generalized estimating equations.</p><p><strong>Results: </strong>Of 77 eyes, 31 completed 36 months of follow-up. Mean baseline IOP and medications was 13.5±2.5 mmHg and 1.7±0.9 respectively. No significant reductions in IOP were observed. A sustained reduction in medication use was observed at all follow-up timepoints (p≤0.001). At 36 months, medication use decreased by -0.7±0.2 (adjusted mean difference±standard error of the mean [SEM]). Proportion of medication-free eyes increased from 7.8% (n=6/77) at baseline to 45.2% (n=14/31) at 36 months. Cumulative success probabilities varied widely based on definitions. When defined as a decrease in ≥1 medication from baseline without an increase in IOP, or IOP ≤15 mmHg and reduced ≥20% from baseline while medication-free, and no additional laser or incisional glaucoma surgery, this was 40.7% at 36 months. No visual field mean deviation progression was detected. Adverse events were infrequent and non-sight-threatening.</p><p><strong>Conclusion: </strong>In eyes with NTG, Phaco-Hydrus may offer a greater role in medication reduction or achieving a medication-free status over 36 months, rather than absolute IOP reduction.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Accuracy of Four Artificial Intelligence Models in PubMed Citation Generation for Glaucoma Research.","authors":"Mustafa Civelekler, Mehmet Citirik","doi":"10.1097/IJG.0000000000002716","DOIUrl":"10.1097/IJG.0000000000002716","url":null,"abstract":"<p><strong>Précis: </strong>DeepSeek, a biomedically enriched AI model, achieved the highest accuracy in generating PubMed citations for glaucoma research, outperforming general-purpose models and highlighting the necessity of human oversight to mitigate AI-related citation errors.</p><p><strong>Purpose: </strong>This study evaluated the accuracy and reliability of four artificial intelligence (AI) models-ChatGPT (OpenAI GPT-3.5), Copilot (GitHub/Microsoft), DeepSeek (DeepSeek AI), and Gemini (Google AI)-in generating PubMed citations for glaucoma research. This study aimed to assess the potential of AI tools for academic reference generation and identify their limitations, particularly in specialized ophthalmology fields.</p><p><strong>Methods: </strong>Thirty-five standardized clinical paragraphs from The Review of Ophthalmology (4th edition) were used to test citation accuracy. Each model was instructed to generate AMA 11-style PubMed citations. Citations were evaluated for accuracy, DOI matching, and clinical relevance. An expert review validated the outputs and classified them as \"Fully Cited,\" \"Partially Cited,\" or \"Not Cited.\"</p><p><strong>Results: </strong>DeepSeek, a biomedically enriched model, outperformed the others, with an accuracy of 92.0%. Copilot and Gemini achieved moderate accuracies of 66.7% and 25.8%, respectively, while ChatGPT achieved the lowest citation accuracy at 19.4%. Frequent errors included DOI mismatches, incorrect journal names, and irrelevant references. Expert review confirmed that even the best model produced citation errors, emphasizing the need for human oversight. We interpret this apparent advantage cautiously, as model details, updates, and changes in underlying data may influence performance.</p><p><strong>Conclusion: </strong>AI models-particularly biomedically enriched tools such as DeepSeek-can accelerate citation drafting, but citation hallucinations and metadata errors remain common. AI should serve as a decision support tool for reference retrieval and formatting, not a substitute for rigorous manual verification before submission.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular Pressure Measurement Variability Associated With Face Mask Use.","authors":"Ortal Fogel Tempelhof, Yael Reich, Rony Rachmiel, Ori Berliner, Michael Waisbourd, Shimon Kurtz","doi":"10.1097/IJG.0000000000002715","DOIUrl":"10.1097/IJG.0000000000002715","url":null,"abstract":"<p><strong>Précis: </strong>Masks have a multi-factorial impact on intraocular pressure measured with the Goldmann tonometer, reaching clinical significance in one-third of patients. Before making clinical decisions, repeated measurements without a mask or other tonometers should be considered.</p><p><strong>Purpose: </strong>To investigate the impact of wearing face masks on intraocular pressure (IOP), the only manageable factor today in glaucoma, a blinding disease. Given the recurrent global outbreaks of respiratory infections (e.g., COVID-19, RSV, and measles), mask use remains a crucial measure to reduce transmission.</p><p><strong>Methods: </strong>A prospective, randomized, controlled, and blinded clinical study. Adult patients without corneal pathologies or hypotony were recruited in the glaucoma clinic. Each patient underwent IOP measurements using the Goldmann applanation tonometer under three conditions: with a surgical mask, KN95 mask and without a mask as the control.</p><p><strong>Results: </strong>47 patients (94 eyes) with various types of glaucoma, were enrolled. Past ocular history included an average of IOP-lowering medications of 1.7±1.5 (range 0 to 5), 25.5% had prior laser treatment for IOP control, and 19.1% had previously undergone glaucoma surgery. The mean difference in IOP readings between the masks ranged from 0 to 7.5 mm Hg with no statistical significance, P=0.116. No significant differences were found based on gender (P=0.560), laterality (P=0.384), number of IOP-lowering medications (P=0.730), history of previous glaucoma laser treatment (P=0.456), or surgery (P=0.425). Sixteen patients (34.0%) exhibited an IOP difference of 3 mm Hg or more between the conditions, although not statistically significant (P=0.546).</p><p><strong>Conclusion: </strong>Masks exert inconsistent effects on IOP measurements. In approximately one-third of patients the differences reached clinical significance, although not statistically significant. These variations are presumably influenced by multiple factors, such as mask fit to facial structure, positioning, and alterations in breathing patterns while wearing masks.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow-Coagulation Cyclophotocoagulation versus Conventional Continuous Wave Cyclophotocoagulation and Micropulse Cyclophotocoagulation for the Treatment of Glaucoma: A Systematic Review and Meta-analysis.","authors":"Neeran Narainswami, Matheus Pedrotti Chavez, Pedro Henrique Ferrazza Sperotto, Nuno Rodrigues Alves, Guilherme Melchior Maia Lopes, Eduardo de Carvalho Mazzocato, Carolina Carvalho Soares Valentim, Nagib du Toit, Mohamed Khodeiry","doi":"10.1097/IJG.0000000000002710","DOIUrl":"10.1097/IJG.0000000000002710","url":null,"abstract":"<p><strong>Précis: </strong>SC-TSCPC significantly lowers intraocular pressure more effectively than MP-TSCPC and performs similarly to CW-TSCPC. Safety and visual outcomes are comparable, supporting its use as a non-incisional treatment option for various glaucoma patients.</p><p><strong>Introduction: </strong>Slow-coagulation transscleral cyclophotocoagulation (SC-TSCPC) is an emerging laser modality for glaucoma management designed to lower intraocular pressure (IOP) with possible fewer complications than conventional continuous-wave (CW-TSCPC) and micropulse (MP-TSCPC) approaches. We conducted a systematic review and meta-analysis to compare the efficacy and safety of SC-TSCPC to MP-TSCPC and CW-TSCPC.</p><p><strong>Methods: </strong>PubMed, Embase, and Cochrane Library were searched from inception through December 2025 for studies comparing SC-TSCPC with MP-TSCPC or \"conventional\" CW-TSCPC. Primary outcomes were IOP reduction from baseline and IOP at last follow-up. Secondary outcomes included medication burden, best-corrected visual acuity (BCVA), treatment success, and complications. We computed mean differences (MDs) for continuous endpoints and risk ratios (RRs) for binary endpoints, with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Thirteen studies comprising 992 patients were included. SC-TSCPC achieved greater IOP reduction from baseline compared to MP-TSCPC (MD 1.29 mmHg, 95% CI 0.26 to 2.32, P=0.01, I2=0%) but was comparable to conventional CW-TSCPC (MD -1.00 mmHg, 95% CI -3.14 to 1.13, P=0.36). IOP at last follow-up, number of medications, BCVA, treatment success, and total complication rates of SC-TSCPC were similar to MP-TSCPC or CW-TSCPC.</p><p><strong>Conclusion: </strong>SC-TSCPC may provide comparable IOP control to CW-TSCPC and appears more effective than MP-TSCPC in lowering IOP, with a similar safety profile. It may represent a viable non-incisional treatment option for glaucoma, including patients who retain visual potential. These results require cautious interpretation due to the overall low-to-very low quality of evidence and significant heterogeneity among studies. Larger randomized studies are needed to validate these findings.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Major Retinal Vessel Position on Sectoral Peripapillary Retinal Nerve Fiber Layer Thickness in Healthy Eyes.","authors":"Ari Leshno, Emmanouil Tsamis, Donald C Hood, Charu Vyas, Mijeung Kim, Carlos Gustavo De Moraes, Aakriti Shukla Garg, George A Cioffi, Jeffrey M Liebmann, Noga Harizman","doi":"10.1097/IJG.0000000000002681","DOIUrl":"10.1097/IJG.0000000000002681","url":null,"abstract":"<p><strong>Précis: </strong>The position of the major retinal vessels varies across healthy individuals. This measurement significantly correlates with sectoral retinal nerve fiber layer thickness and can potentially improve the use of normative databases.</p><p><strong>Objective: </strong>Evaluate the variability of major vessel position (MVP) among healthy individuals and its effect on optical coherence tomography (OCT) sectoral retinal nerve fiber layer (RNFL) thickness measurements.</p><p><strong>Methods: </strong>Circumpapillary RNFL (cpRNFL) circle scans were collected from 88 healthy individuals (88 eyes). The MVP was determined using the commercial Heidelberg Eye Explorer software. For each of the 4 main temporal vessels, the MVP was defined as the angular distance (degrees) on the 3.5 mm diameter circumpapillary B-scan between the point where the circle scan intersects the vessel and the point where the circle intersects with the disc-to-fovea line.</p><p><strong>Results: </strong>There was considerable variability in MVP among the healthy individuals. The positions of the superior and inferior veins were distributed normally, whereas the distributions of the arteries were skewed temporally. Sectoral cpRNFL thickness significantly correlated with superior and inferior MVP. As the MVP angle increased, the cpRNFL thickness in the superior-nasal and inferior-nasal sectors increased (Spearman correlations coefficient between 0.2 and 0.42, P <0.05). In contrast, cpRNFL thickness of the superior-temporal and inferior-temporal sectors decreased (correlation between -0.41 and -0.26, P <0.05). The thickness of the temporal sector also decreased as MVP increased (correlation between -0.43 and -0.22, P <0.05). No significant correlation was found between MVP and nasal sector thickness.</p><p><strong>Conclusions: </strong>The MVP is a reliable proxy for the distribution of the major RNFL bundles. Adjusting cpRNFL measurements based on MVP might improve the reliability of normative databases and reduce artifacts, particularly false positives, related to RNFL bundle position.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e1-e6"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes of Ahmed Glaucoma Valve in Neovascular Glaucoma Secondary to Diabetic Retinopathy Versus Central Retinal Vein Occlusion.","authors":"Ayşe Yağmur Kanra, Tuğçe Dursun Yilmazşamli, Meltem Güzin Altinel, Serhat İmamoğlu","doi":"10.1097/IJG.0000000000002680","DOIUrl":"10.1097/IJG.0000000000002680","url":null,"abstract":"<p><strong>Précis: </strong>Ahmed glaucoma valve implantation is an effective and reliable intervention for neovascular glaucoma, demonstrating higher success and longer survival in proliferative diabetic retinopathy compared with central retinal vein occlusion. Age significantly impacts surgical outcomes.</p><p><strong>Purpose: </strong>To evaluate and compare the surgical outcomes and prognostic factors of Ahmed glaucoma valve (AGV) implantation in neovascular glaucoma (NVG) secondary to proliferative diabetic retinopathy (PDR) and central retinal vein occlusion (CRVO).</p><p><strong>Patients and methods: </strong>This retrospective study included 48 eyes of 46 patients with NVG due to PDR (n = 28) or CRVO (n = 18) who underwent AGV implantation. Patients with prior glaucoma surgery were excluded. All procedures were performed by a single glaucoma surgeon using a standardized long tunnel technique. Surgical success was defined as ≥20% intraocular pressure (IOP) reduction from baseline and IOP ≤ 21 mm Hg without additional glaucoma surgery or vision loss to no light perception. Kaplan-Meier survival analysis assessed surgical success, and Cox regression identified failure risk factors.</p><p><strong>Results: </strong>The mean surgical success duration was longer in PDR (45.87 mo) than in CRVO (38.68 mo). One-year, 2-year, and 3-year success rates were 95.5%, 90.4%, and 90.4% in PDR, compared with 92.3%, 64.6%, and 55.4% in CRVO. Early complications, such as hyphema, were more frequent in PDR but not statistically significant. Tube exposure was observed in only one case (2.1% of total cases), which was in the CRVO group. Including the tube exposure case, tube explantation was performed in 2 patients (4.2% of total cases). Older age was a significant risk factor for failure (HR = 1.066, P = 0.049).</p><p><strong>Conclusion: </strong>AGV implantation provides favorable long-term outcomes for NVG secondary to PDR and CRVO, with higher success rates in PDR. Careful patient selection and standardized surgical techniques remain critical for optimizing AGV outcomes in NVG.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"190-197"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancy Between Real-World Objective Functioning and Subjective Quality of Life in Visually Impaired Adults.","authors":"Mariah Diaz, Aleksandra Mihailovic, Louay Almidani, Chhavi Saini, Pradeep Y Ramulu","doi":"10.1097/IJG.0000000000002668","DOIUrl":"10.1097/IJG.0000000000002668","url":null,"abstract":"<p><strong>Précis: </strong>Discrepancy between objective measures of functioning and self-reported quality of life is predicted by depressive symptoms, females, and advanced field loss, while significant variability between these measures remains unexplained.</p><p><strong>Purpose: </strong>To determine the degree to which functional metrics and self-reported quality of life agree in glaucoma, and identify factors associated with discrepancies between the two.</p><p><strong>Patients and methods: </strong>Individuals with glaucoma or suspected glaucoma (n=227) were evaluated. Subjective functioning was assessed with the Glaucoma Quality-of-Life-15 (GQL-15) questionnaire. Objective metrics of functioning included balance (total sway), gait (cadence), and reading speed, which were compiled into a z- scored composite measure of function. Discrepancy scores were defined as the difference between composite functioning and GQL-15 z -scores. Linear regression models were computed to identify patient-level and neighborhood-level factors associated with discrepancies between objective functioning and self-reported quality of life.</p><p><strong>Results: </strong>Composite functioning and GQL-15 z -scores were poorly correlated (the Pearson coefficient r =0.15, P =0.024). In multivariable analyses, positive discrepancy (greater function than self-report) was associated with female gender (β=0.53, P <0.001), depressive symptoms (β=0.19, P <0.001), and greater visual field damage (β=0.28, P =0.001). The multivariable model, including gender, depressive symptoms, and visual field sensitivity, accounted for 20% of the variance in discrepancy scores.</p><p><strong>Conclusions: </strong>Female gender, depressive symptoms, and greater visual field damage are associated with greater subjective vision-related disability than predicted by objective functional impairment. The overall ability of the studied measures to predict agreement between function and self-report was poor, highlighting the complexity of both self-reported impairment and functional evaluation.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"135-142"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PyOPV: An Open-Source Python Package for Ophthalmic Visual Field Data Management.","authors":"Shahin Hallaj, Michael V Boland, William Halfpenny, Jonathan S Myers, Robert N Weinreb, Linda M Zangwill, Sally L Baxter","doi":"10.1097/IJG.0000000000002654","DOIUrl":"10.1097/IJG.0000000000002654","url":null,"abstract":"<p><strong>Précis: </strong>PyOPV is a software designed and validated for handling standard visual field DICOM files, enabling multiple functionalities for glaucoma researchers.</p><p><strong>Purpose: </strong>To introduce PyOPV, a novel vendor-agnostic Python-based software package we designed for the management and analysis of OPhthalmic Visual field (OPV) DICOM data. PyOPV addresses limitations in interoperability and data accessibility encountered by vision researchers by providing tools that check DICOM compliance, parse, and convert OPV DICOM files into formats easily usable for research and integration with research data systems (eg, Pandas Dataframes, JSON).</p><p><strong>Methods: </strong>PyOPV was developed using Python 3.8.2. It uses Supplement 146 of the DICOM standard to check compliance, which defines the \"ophthalmic-visual-field-static-perimetry-measurements\" Composite Information Object Definition. Sample OPV DICOM files from 3 vendors that provide perimetry devices were used to design the package and analyzed for DICOM. The functionalities were then validated at 2 different institutions.</p><p><strong>Results: </strong>PyOPV successfully extracted and converted OPV DICOM data into Pandas DataFrames and JSON formats, facilitating data access, analysis, and visualization. The validation on longitudinal files from different protocols demonstrated excellent agreement between PyOPV outputs and ground truth data extracted using in-place workflows of each institution. Further, it highlighted significant interoperability challenges by demonstrating missing attributes across vendors, with a considerable proportion (range: 17%-51%) of the required tags missing from the files.</p><p><strong>Conclusions: </strong>PyOPV provides an efficient solution for handling ophthalmic visual field data, bridging a critical gap in data interoperability and research scalability. It can incorporate OPV files from different vendors and distinct protocols in bulk, thereby enhancing the ability to analyze and integrate visual field data into large-scale health data warehouses, supporting ophthalmic informatics and advancing clinical research. PyOPV is limited by the vendors' failure to provide all data elements.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":"35 3","pages":"150-156"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Glaucomatous Progression in Eyes With Prior Refractive Corneal Surgery.","authors":"Sujin Yeo, Kyung Rim Sung","doi":"10.1097/IJG.0000000000002682","DOIUrl":"10.1097/IJG.0000000000002682","url":null,"abstract":"<p><strong>Précis: </strong>Glaucomatous patients with longer axial length and thinner central cornea have a higher risk of progression after refractive surgery, emphasizing the need for close monitoring for early detection and timely intervention.</p><p><strong>Purpose: </strong>To identify risk factors associated with glaucomatous progression in eyes with a history of refractive corneal surgery (RCS).</p><p><strong>Methods: </strong>This retrospective observational cohort study included 65 eyes of 65 patients with primary open angle glaucoma (POAG) who underwent RCS. Glaucoma progression was determined based on structural changes in optic disc/retinal nerve fiber layer (RNFL) photographs and/or visual field (VF) deterioration. Cox proportional hazards analysis was used to identify risk factors for disease progression. VF mean deviation (MD) and RNFL thickness progression rates obtained using a linear mixed-effects model were compared across tertile groups based on axial length (AXL) and central corneal thickness (CCT), respectively.</p><p><strong>Results: </strong>Over the follow-up period (mean: 9.1±2.9 y), 23 eyes (35%) exhibited glaucomatous progression. The progression group had significantly longer AXL ( P <0.001), thinner CCT ( P =0.009) compared with those in the stable group. Multivariate analysis identified longer AXL [hazard ratio (HR): 1.507, P =0.037] and thinner CCT (HR: 0.988, P =0.037) as significant predictors of glaucoma progression. VF MD declined faster in the middle and highest AXL tertile groups, whereas RNFL thinning was the most pronounced in the highest AXL tertile group. The lowest CCT tertile group exhibited the fastest VF MD decline and RNFL thinning.</p><p><strong>Conclusions: </strong>Patients with POAG and a history of RCS who present with longer axial length and thinner central corneal thickness, are at significantly higher risk of glaucomatous progression, highlighting the importance of vigilant long-term monitoring in these eyes.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"157-165"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor: Diagnostic Capacity and Correlation of Optic Nerve Colorimetry With Structural Parameters in Primary Open Angle Glaucoma.","authors":"Liseth Salazar-Quiñones, Yadhira Pérez-Quiñones, Haizea Etxabe-Ávila, Rafael Sánchez-Del-Hoyo, José Ignacio Fernández-Vigo, Julián García-Feijóo","doi":"10.1097/IJG.0000000000002664","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002664","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":"35 3","pages":"e13-e14"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}