Journal of Glaucoma最新文献

{"title":"3-Year Outcomes of iStent Implant Combined With Phacoemulsification in Asian Eyes With Glaucoma: A Multidimensional Surgical Success Analysis.","authors":"See Teng Tan, Ting Fang Tan, Yamon Thant Syn, Alice Chu, Hla Myint Htoon, Shamira A Perera, Tina T Wong, Jin Rong Low, Rahat Husain","doi":"10.1097/IJG.0000000000002685","DOIUrl":"10.1097/IJG.0000000000002685","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term performance of combined phacoemulsification and iStent implantation (iStent, iStent inject, and iStent inject W) in Asian patients with glaucoma and cataracts.</p><p><strong>Patients and methods: </strong>This retrospective study included patients who underwent combined phacoemulsification and iStent implantation at a single tertiary center from November 2016 to July 2021. Eyes with varying glaucoma subtypes and severities were included. Changes in mean intraocular pressure (IOP) and the number of glaucoma medications were assessed at baseline and postoperative months (POM) 6, 12, 24, and 36. Surgical success was evaluated using multiple definitions, including complete and qualified success (CS/QS) criteria for IOP ≤18 and ≤15 mm Hg, modified success criteria (anyIOP, anyMed, or IOPMed), and the AAO-recommended criteria.</p><p><strong>Results: </strong>A total of 284 eyes (mean age 70.8±8.9 y) had preoperative IOP of 15.8±3.9 mm Hg on 1.6±0.8 medications. At POM 36, mean IOP reduction was 1.4 mm Hg ( P <0.001), and medication use decreased by 0.8 ( P <0.001). CS and QS for IOP ≤18 mm Hg were 53.4% and 89.3%, respectively; for IOP ≤15 mm Hg were 41.2% and 63.5%, respectively. Success rates were 47.4% for anyMed, 55% for anyIOP, 42.2% for IOPMed, and 56.3% for the AAO criteria.</p><p><strong>Conclusion: </strong>Combined iStent and phacoemulsification provided sustained, long-term reductions in both IOP and medication burden over 3 years, with over half achieving success across multiple stringent criteria, supporting its role as an effective, minimally invasive surgical option in real-world clinical practice.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"289-302"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Superior Angle Access Using a Direct Goniolens for Ab Interno Needling Bleb Revisions.","authors":"Priyanga Manivel, Muralidhar Rajamani, Davinder S Grover, Vidhya Nagasubramanian, Chitra Ramamurthy","doi":"10.1097/IJG.0000000000002674","DOIUrl":"10.1097/IJG.0000000000002674","url":null,"abstract":"<p><strong>Prcis: </strong>Direct visualization of the superior angle during ab interno bleb revision can be achieved by rotating the globe with traction sutures, allowing surgeons to use a standard direct goniolens rather than an indirect gonioprism. In this series of 13 eyes with failed or failing trabeculectomy blebs, globe rotation permitted consistent identification of the trabeculectomy ostium, and facilitated effective needling with the Grover-Fellman spatula without intraoperative perforations or bleb leaks. This simple modification may broaden the adoption of ab interno bleb revision and improve access to the superior angle for a range of MIGS procedures.We describe a novel technique of globe rotation that facilitates direct gonioscopic visualization of the superior angle during ab interno bleb revision and evaluate its outcomes. A retrospective review of 13 eyes undergoing revision with the Grover-Fellman biplanar sclerostomy spatula was performed. The superior angle was visualized using a direct goniolens after globe rotation with limbal traction sutures and optimal patient and microscope positioning. All cases achieved successful access to the trabeculectomy ostium. Mean intraocular pressure decreased from 25.7 ± 13 mm Hg preoperatively to 10.5 ± 4.2 mm Hg at 6 months ( P = 0.005), and the median number of medications reduced from 4 (IQR: 2-4) to 0 (IQR: 0-2) ( P = 0.005). Three eyes required antiglaucoma medications, and 1 required an aqueous drainage implant postoperatively. No bleb leaks or conjunctival perforations occurred, and the technique was also combined with other MIGS procedures in select patients. Globe rotation provides a simple means to achieve direct visualization of the superior angle and enables ab interno bleb revision with a direct goniolens. This approach may serve as a practical alternative to indirect gonioscopy and facilitate broader adoption of ab interno techniques.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e42-e44"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Optic Nerve Head Blood Flow Correlates With an Impaired Postillumination Pupil Response in Glaucoma.","authors":"Tadanobu Yoshikawa, Hironobu Jimura, Kimie Miyata, Kenji Obayashi, Keigo Saeki, Nahoko Ogata, Satoru Kase","doi":"10.1097/IJG.0000000000002672","DOIUrl":"10.1097/IJG.0000000000002672","url":null,"abstract":"<p><strong>Prcis: </strong>In glaucomatous eyes, reduced optic nerve head blood flow was significantly associated with impaired intrinsically photosensitive retinal ganglion cell function, as assessed by the postillumination pupil response, independent of age and other confounding factors.</p><p><strong>Purpose: </strong>To investigate whether ocular nerve head (ONH) blood flow is associated with impaired intrinsically photosensitive retinal ganglion cell (ipRGC) function, assessed by the postillumination pupil response (PIPR), in eyes with glaucoma.</p><p><strong>Patients and methods: </strong>This cross-sectional study included 114 eyes from 114 patients with glaucoma (mean age, 69.5 y). PIPR was evaluated by measuring pupil diameters after red and blue light exposure. The main PIPR outcomes were the amplitudes of red and blue 6-second PIPR, which are pupil diameters 6 seconds after red and blue light exposure. ONH blood flow was assessed by the tissue-area mean blur rate (MBR) using laser speckle flowgraphy.</p><p><strong>Results: </strong>A significantly higher blue 6-second PIPR amplitude was observed in the low tissue-area MBR group than in the high tissue-area MBR group (93.5% vs. 91.1%, P =0.043). After adjusting for age, sex, body mass index, hypertension, diabetes, intraocular pressure, and axial length, a multivariable linear regression analysis showed that tissue-area MBR inversely correlated with the blue 6-second PIPR amplitude (regression coefficient=-0.40; 95% CI, -0.73 to -0.06; P =0.021), but not the red 6-second PIPR amplitude (regression coefficient=-0.01; 95% CI, -0.36 to -0.15; P =0.42).</p><p><strong>Conclusions: </strong>Lower ONH blood flow in eyes with glaucoma correlated with impairments in ipRGCs independent of potential confounders, including age.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"348-352"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beta Zone and Gamma Zone Parapapillary Atrophy in Nonmyopic Eyes.","authors":"Sung Do Cho, Young In Yun, Martha Kim, Seok Hwan Kim, Kyoung Min Lee","doi":"10.1097/IJG.0000000000002686","DOIUrl":"10.1097/IJG.0000000000002686","url":null,"abstract":"<p><strong>Prcis: </strong>Not only β​​​​-zone but also ɣ-zone atrophy is observed in nonmyopic eyes. The presence of ɣ-zone atrophy reflects optic nerve head canal offset during eyeball expansion, and its directionality is associated with the offset direction.</p><p><strong>Purpose: </strong>To evaluate the locations of β-zone and ɣ-zone parapapillary atrophy (PPA) in nonmyopic eyes.</p><p><strong>Methods: </strong>A total of 151 nonmyopic eyes with an axial length (AXL) of <24.0 mm were included in this cross-sectional study. From the Bruch membrane opening (BMO), the angular locations of the maximal width of β-zone PPA (without retinal pigment epithelium) and ɣ-zone PPA (without Bruch membrane) were compared with that of the central retinal vascular trunk (CRVT)/BMO offset, as a surrogate of lamina cribrosa/BMO offset. Based on the extent and direction of the CRVT/BMO offset, patients were classified into 3 groups: (1) minimal offset (offset index <0.2), (2) temporal offset, and (3) nasal offset.</p><p><strong>Results: </strong>Sixty-four eyes had minimal offset, 53 eyes had a temporal offset, and 34 had a nasal offset. The CRVT/BMO offset showed significant angular correlations with β-zone PPA ( r =-0.209, P =0.026) and ɣ-zone PPA ( r =-0.529, P <0.001). Presence of β-zone PPA was associated with older age [odds ratio (OR)=1.119, P <0.001], longer AXL (OR=2.260, P =0.011), and the presence of ɣ-zone PPA (OR=8.952, P <0.001). Among 56 eyes with ɣ-zone PPA, 26 eyes (46.4%) had their ɣ-zone PPAs on the nasal side, which was associated with the superotemporal direction of the CRVT/BMO offset (OR=1.008, P =0.003).</p><p><strong>Conclusions: </strong>Both β-zone and ɣ-zone PPAs were found in nonmyopic eyes. Nasally located ɣ-zone PPA was associated with the temporal direction of CRVT/BMO offset, like a mirrored image of myopic PPA. ɣ-zone PPA is not restricted to myopia but represents the offset between the openings of the optic nerve head canal.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"326-334"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Patient-Reported Outcome Instruments Relevant to Glaucoma.","authors":"Michael S Kashaf, Niranjani Nagarajan, Jimmy T Le, Lori Rosman, Paul McCann, Jian-Yu E, Tianjing Li, Amanda K Bicket","doi":"10.1097/IJG.0000000000002640","DOIUrl":"10.1097/IJG.0000000000002640","url":null,"abstract":"<p><strong>Prcis: </strong>A minority (13 of 91) of patient-reported outcome measures for adult glaucoma meet rigorous quality standards for development. Others, despite limited evidence describing development, have been validated in glaucoma populations and should be used judiciously.</p><p><strong>Purpose: </strong>To identify, characterize and assess the quality of existing patient-reported outcome measures (PROMs) relevant to adult glaucoma patients, focusing on development and validation.</p><p><strong>Methods: </strong>We searched multiple databases for studies reporting development, validation, adaptation, or extension of vision-related PROMs in adults with glaucoma. Eligible reports were grouped by instrument for assessment using the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) Risk of Bias checklist's \"Standards for evaluating the quality of PROM development.\"</p><p><strong>Results: </strong>Among 91 instruments represented by 140 reports, 57 were developed for use in glaucoma patients; the remainder were validated in glaucoma patients. The instruments vary in length and complexity and evaluate domains within several constructs: vision-related QoL, health-related QoL, glaucoma knowledge, disease symptoms, vision-related activity limitation, treatment preferences, treatment side effects, patient satisfaction, and psychological status. According to COSMIN criteria, \"adequate\" development was documented for just 17 of 91 instruments, with descriptions of constructs, population(s) and context(s) for use, and published studies in the target population. Among these 17, concept elicitation was described for 13, of which 7 were developed since 2021.</p><p><strong>Conclusions: </strong>Thirteen instruments stand out in rigorous quality analysis based on the COSMIN Risk of Bias checklist. Other instruments without evidence of sound development have nevertheless been rigorously validated. PROMs we commonly use should be understood in the context of what they were designed to do, what they do well, their efficiency and limitations. It behooves us to follow and document best practices for developing and validating novel instruments.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e15-e41"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Task Gait Performance in Moderate-to-Severe Glaucoma.","authors":"Shuwen Jia, Stanley J Winser, Allen M Y Cheong","doi":"10.1097/IJG.0000000000002711","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002711","url":null,"abstract":"<p><strong>Prcis: </strong>This study found that while overall dual-task gait alterations were similar between glaucoma patients and controls, specific joint flexion differences and sex-specific patterns emerged, with most gait measures showing good reliability in glaucoma participants.</p><p><strong>Background: </strong>Progressive visual field loss in glaucoma compromises mobility, yet its effects on dual-task performance (eg, obstacle crossing or visual search) remain unclear. This study aimed to compare gait parameters between glaucoma patients and healthy controls under dual-task conditions, investigate sex-specific differences, and evaluate the test-retest reliability of these gait measures in all participants.</p><p><strong>Methods: </strong>Twenty-eight individuals with moderate-to-severe bilateral glaucoma and 25 age-matched controls participated in the study. Gait analysis was conducted using a 10-camera Vicon system on a 7 m walkpath with obstacles of varying heights (0, 5, 15 cm) during visual tasks (fixation, visual search). Group and condition effects were analyzed with Generalized Estimating Equations. Ten glaucoma participants repeated testing after 2 weeks; reliability was quantified using intraclass correlation coefficients (ICCs).</p><p><strong>Results: </strong>Gait parameters did not differ significantly between the glaucoma and healthy control groups under dual-task conditions. Sex-specific differences revealed that males with glaucoma showed reduced knee and hip flexion during visual search compared with healthy counterparts (P<0.05). Most gait measures demonstrated moderate-to-excellent test-retest reliability for glaucoma (ICCs: 0.63-0.97).</p><p><strong>Conclusion: </strong>Glaucoma did not greatly alter dual-task gait alterations, although specific differences in knee and hip flexion were observed, with distinct sex-specific patterns. Most gait measures were reliable. These findings highlight the importance of considering sex-specific strategies when addressing dual-task challenges in individuals with glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":"35 5","pages":"309-316"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Wipe-Out Phenomenon After Gonioscopy-Assisted Transluminal Trabeculotomy.","authors":"Enver Mirza, Gunsu Deniz Mirza, Mehmet Adam, Mehmet Okka","doi":"10.1097/IJG.0000000000002676","DOIUrl":"10.1097/IJG.0000000000002676","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e48"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Original vs Shoji Edition of Tanito Microhook Trabeculotomy Combined with Cataract Surgery: Comparative Clinical Outcomes.","authors":"Takuhei Shoji, Takashi Nishida, Masaki Tanito","doi":"10.1097/IJG.0000000000002667","DOIUrl":"10.1097/IJG.0000000000002667","url":null,"abstract":"<p><strong>Prcis: </strong>This matched-cohort study compares the original and Shoji editions of the Tanito microhook trabeculotomy (TMH), a reusable, FDA-cleared MIGS device, when combined with cataract surgery. Both designs demonstrated similar 2-year surgical success and safety profiles. While the Shoji edition incorporates ergonomic refinements, no significant differences in clinical outcomes were observed, supporting the continued use of either version in routine glaucoma care.</p><p><strong>Purpose: </strong>To compare the clinical efficacy and safety of the Shoji edition of the Tanito microhook trabeculotomy (TMH Shoji edition) with the original version, both performed in combination with phacoemulsification and intraocular lens implantation, in patients with open angle glaucoma.</p><p><strong>Methods: </strong>A retrospective matched-cohort study including 518 eyes (original: 259, Shoji: 259) was conducted. Groups were matched on age, sex, glaucoma type, baseline IOP, visual field mean deviation, and number of medications. The primary outcome was surgical success over 2 years, followed by the American Academy of Ophthalmology's recommended criteria for MIGS combined with cataract surgery: ≥1 medication reduction without IOP increase, or ≥20% IOP reduction to ≤21 mm Hg without additional surgery, loss of light perception vision, or hypotony. IOP, number of medications, and postoperative complications were also recorded. Statistical analyses included Fisher exact tests and Kaplan-Meier survival with log-rank testing.</p><p><strong>Results: </strong>At 12 months, surgical success was achieved in 46.4% of the original group and 50.1% of the Shoji group; at 24 months, the rates were 32.0% and 44.2%, respectively. Kaplan-Meier estimates showed no significant difference between groups (log-rank P = 1.000). Both groups achieved reductions from baseline in mean IOP and number of glaucoma medications at all time points. Postoperative complications were infrequent and comparable between groups.</p><p><strong>Conclusions: </strong>Both versions of TMH trabeculotomy combined with cataract surgery demonstrated acceptable mid-term surgical success and safety profiles. The Shoji edition, designed to improve access and usability, may offer advantages in certain surgical settings.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"342-347"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Hybrid Telemedicine Model for Glaucoma Management.","authors":"Leena Surapaneni, Sofia Miguez, Mark Dibbs, Paola Rivera Morales, Amisha Dave, Vicente Diaz","doi":"10.1097/IJG.0000000000002702","DOIUrl":"10.1097/IJG.0000000000002702","url":null,"abstract":"<p><strong>Prcis: </strong>In a hybrid telemedicine model consisting of alternating in-person and telemedicine visits, ∼95% of telemedicine visits for glaucoma had findings and assessments consistent with in-person visits, suggesting this model's effectiveness in monitoring glaucoma.</p><p><strong>Purpose: </strong>A hybrid model of teleophthalmology involves an in-person visit for imaging with a technician, followed by a telemedicine visit with an ophthalmologist. At our institution, we alternate in-person visits with hybrid telemedicine visits. The purpose of this study is to evaluate the sensitivity and specificity of this novel telemedicine platform for identifying findings that can lead to management changes for glaucoma.</p><p><strong>Patients and methods: </strong>The medical records of patients seen by a telemedicine-using ophthalmologist at a tertiary eye center for a glaucoma-related condition from September 2023 to October 2024 were reviewed. The main outcome measures were cup-disc ratio, retinal nerve fiber layer thinning, visual field defects, and changes in findings or management between in-person and telemedicine visits. Sensitivity and specificity were calculated, and paired t tests and χ 2 testing were also used.</p><p><strong>Results: </strong>A total of 102 patients (mean age 65 y; 63% female) underwent 162 hybrid telemedicine visits for glaucoma-related concerns. The most common diagnoses were glaucoma suspect (36%) and moderate stage glaucoma (26%). Using a χ 2 test, telemedicine visits demonstrated significantly greater consistency in findings and assessments with in-person visits than would be expected by chance ( P <0.001). The sensitivity of telemedicine in detecting worsening clinical findings was 75%, and the specificity was 100%.</p><p><strong>Conclusion: </strong>Approximately 95% of telemedicine visits had findings and assessments consistent with both preceding and subsequent in-person visits, indicating the effectiveness of a hybrid telemedicine model for monitoring and managing glaucoma progression.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"335-341"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Corneal Biomechanics and 24-Hour Intraocular Pressure Variation in Untreated Glaucoma.","authors":"Na Wu, Xianmuseye Aihemaiti, Xinghuai Sun, Yuhong Chen","doi":"10.1097/IJG.0000000000002656","DOIUrl":"10.1097/IJG.0000000000002656","url":null,"abstract":"<p><strong>Prcis: </strong>In patients with untreated primary open angle glaucoma, the higher the corneal deformability, the lower the changes in 24-hour intraocular pressure variation.</p><p><strong>Purpose: </strong>To investigate the relationship between corneal biomechanics and 24-hour intraocular pressure (IOP) variation in patients with untreated primary open angle glaucoma (POAG).</p><p><strong>Methods: </strong>Two hundred forty-five (245) eyes of 124 patients with POAG were included in this cross-sectional study. Each patient underwent measurement of corneal biomechanics with Corvis ST. IOP measurements were taken every 2 hours during a 24-hour period by a noncontact tonometer.</p><p><strong>Results: </strong>The study included 70 men and 54 women. The mean age was 51.41 ± 14.42 years. In the multivariate regression analyses, lower SP-A1 was associated with smaller values of 24-hour IOP fluctuation (difference between peak and trough IOP of 24-hour recordings), mean amplitude of intraocular pressure excursion (MAPE) and average, peak and trough IOPs of the 24-hour, diurnal and nocturnal time periods. Integrated radius was negatively correlated with average, peak, and trough IOPs of both the 24-hour and diurnal time course, as well as with the trough nocturnal IOP.</p><p><strong>Conclusions: </strong>Corneal deformability reflected by biomechanical properties measured by Corvis ST is associated with 24-hour IOP variation in untreated POAG patients. Increased corneal deformability is associated with lower 24-hour IOP changes.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"283-288"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}