Journal of Glaucoma最新文献

{"title":"Influence of Retinopathy of Prematurity and Laser Therapy on Intraocular Pressure in Preterm Infants.","authors":"Poonam Verma, Deeksha Katoch, Simar R Singh, Praveen Kumar, Ashok K Singh, Faisal Thattaruthody, Surinder S Pandav, Sushmita Kaushik","doi":"10.1097/IJG.0000000000002600","DOIUrl":"10.1097/IJG.0000000000002600","url":null,"abstract":"<p><strong>Prcis: </strong>Intraocular pressure (IOP) decreases as preterms mature and in moderate retinopathy of prematurity, IOP is initially low and transiently rises after laser treatment.</p><p><strong>Purpose: </strong>This study aimed to measure intraocular pressure (IOP) in preterm infants with and without retinopathy of prematurity (ROP) and evaluate the effect of laser treatment on IOP.</p><p><strong>Method: </strong>This prospective nonrandomized comparative study included infants born before 34 weeks of gestation weighing <2000 g at a tertiary care research and referral institute. Those with ocular or systemic conditions or requiring surgical intervention for ROP were excluded. Infants were divided into 3 groups: Group 1 (no ROP), Group 2 (ROP without treatment), and Group 3 (ROP requiring peripheral retinal ablation by laser photocoagulation). IOP was measured using a Perkins tonometer at presentation and at 1 and 3 months. The primary outcome was IOP in preterm infants with and without ROP; and the secondary outcome was change in IOP postlaser treatment.</p><p><strong>Results: </strong>Of 107 infants, 40 (37.38%) had no ROP (Group 1), 25 (23.36%) had untreated ROP (Group 2), and 42 (39.25%) required laser treatment (Group 3). Average postmenstrual ages were 37.89±2.74 weeks 36.98±3.38, and 35.47±2.84 weeks, respectively. A moderate negative correlation between IOP and postmenstrual age was found in Group 1 ( r2 =-0.382; P =0.01) and Group 2 ( r2 = -0.6; P =0.001). Baseline IOP was significantly lower in Group 3 compared with the other groups, with a transient increase postlaser treatment that typically normalized without needing IOP treatment.</p><p><strong>Conclusions: </strong>IOP decreases as preterm infants mature. Infants with ROP requiring laser treatment exhibit significantly low IOP at presentation, but have a postlaser spike, which generally normalises without treatment.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"795-800"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision-Related Quality of Life in Glaucomatous Patients With Multifocal Intraocular Lens.","authors":"Naris Kitnarong, Theerajate Phongsuphan, Supathida Jiamsawad","doi":"10.1097/IJG.0000000000002622","DOIUrl":"10.1097/IJG.0000000000002622","url":null,"abstract":"<p><strong>Prcis: </strong>Glaucoma patients with multifocal intraocular lenses (MIOLs) reported comparable vision-related quality of life but greater spectacle independence than monofocal IOL users. MIOLs may be considered for mild to moderate glaucoma patients desiring spectacle-free vision.</p><p><strong>Purpose: </strong>To compare the vision-related quality of life (VRQoL) in glaucomatous patients receiving bilateral monofocal intraocular lens (mIOL) and multifocal intraocular lens (MIOL) implantation.</p><p><strong>Patients and methods: </strong>This was a comparative, nonrandomized, unmasked, cross-sectional study in pseudophakic patients with mild to moderate glaucoma who underwent uneventful phacoemulsification with bilateral MIOL or mIOL implantation from January 2010 to June 2022 at the Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. Data collection included distant and near best corrected visual acuity (BCVA), percent of spectacle independence and VRQoL. The 25-item National Eye Institute Visual Functional Questionnaire (NEI-VFQ-25) (translated into Thai) was used to access VRQoL (score 0 to 100). The scores were adjusted for age and glaucomatous staging using the analysis of covariance (ANCOVA).</p><p><strong>Results: </strong>A total of 109 patients were enrolled. Fifty patients received MIOL and 59 received mIOL. There was significantly more moderate glaucoma in mIOL (39.7%) the MIOL group (17.5%) ( P =0.002). Postoperatively, there was no statistically significant difference in BCVA, but the MIOL group had significantly better uncorrected near VA ( P <0.001). Spectacle-free was significantly greater in MIOL (78%) than mIOL (25.4%) ( P <0.001). Mean adjusted NEI-VFQ-25 scores was 95.4 in MIOL and 93.5 in mIOL, which was not significantly different between groups ( P =0.114).</p><p><strong>Conclusion: </strong>Glaucomatous patients with multifocal IOL experienced comparable VRQoL, but more spectacle independence compared with monofocal IOL. Multifocal IOL could be considered in mild to moderate glaucomatous patients, who spectacle-free was warranted.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"771-775"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Intraluminal Stent Removal After PAUL Glaucoma Implant Surgery.","authors":"Constance Weber, Diana Samarghitan, Leonie Bourauel, Wolfgang Walz, Sarah Hundertmark, Michael Petrak, Frank G Holz, Karl Mercieca","doi":"10.1097/IJG.0000000000002594","DOIUrl":"10.1097/IJG.0000000000002594","url":null,"abstract":"<p><strong>Prcis: </strong>Intraluminal stent-removal post-PGI surgery significantly reduces IOP with high success rates but carries the risk of hypotony and complications, for example, suprachoroidal hemorrhage. Long-term management often requires the eventual addition of IOP-lowering therapy despite initial efficacy.</p><p><strong>Background: </strong>To report outcomes after intraluminal stent removal following PAUL Glaucoma Implant (PGI) surgery from a single-center cohort.</p><p><strong>Materials and methods: </strong>Retrospective review of patients undergoing intraluminal prolene removal following PGI surgery at the University Eye Hospital, Bonn, Germany, from April 2021 to November 2023.</p><p><strong>Results: </strong>Seventy eyes of 68 patients were included. Qualified and complete success rates (95% CI) were 92.9% and 55.7% after 1 year and 88.6% (81.4% to 95.7%) and 50% (37.1% to 62.9%) at the last follow-up time point for IOP ≤18 mm Hg and 81.4% and 54.3% and 70% and 42.9% IOP ≤15 mm Hg, respectively. Mean IOP decreased from 23.93 to 12.07 mm Hg after 12 months, 11.32 mm Hg after 24 months, and 10.41 mm Hg after 36 months. The mean number of IOP-lowering eye drops was zero before and immediately after removal and increased to 1.57 (0 to 2) at 12 months, 1.15 (0 to 4) at 24 months, and 1.12 (0 to 4) at 36 months. Postoperative complications occurred in 5 eyes (7.1%). Two eyes had suprachoroidal hemorrhage, with one needing vitrectomy and one external tube ligation; one required PGI explantation for persistent hypotony.</p><p><strong>Conclusions: </strong>Removal of the prolene stent following PGI surgery effectively lowers IOP in the short term, with a moderate increase in IOP and need for pressure-lowering therapy over time. However, it can also lead to adverse outcomes, such as hypotony and suprachoroidal hemorrhage, especially in patients with systemic risk factors or those undergoing early removal.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"789-794"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Trends in Resource Utilization Associated With Newly Diagnosed Primary Angle Closure Glaucoma in the United States.","authors":"Daniel Guth, Galo Apolo, Seth A Seabury, Khristina Lung, Brian Toy, Benjamin Y Xu","doi":"10.1097/IJG.0000000000002612","DOIUrl":"10.1097/IJG.0000000000002612","url":null,"abstract":"<p><strong>Prcis: </strong>The average cumulative 2-year cost following first primary angle closure glaucoma diagnosis was $2960. Elderly and Black patients were at higher risk of being among the costliest 5% (>$9813) of cases, accounting for 21.3% of costs.</p><p><strong>Purpose: </strong>To assess longitudinal eye care costs associated with newly diagnosed primary angle closure glaucoma (PACG) in the United States.</p><p><strong>Methods: </strong>Patients with a diagnosis of PACG between 2009 and 2017 were identified in Optum's deidentified Clinformatics Data Mart Database based on International Classification of Diseases (ICD) codes. Newly diagnosed PACG was defined as: (1) diagnosis by an ophthalmologist or optometrist; (2) observable for at least 12 months before and 24 months after index diagnosis; (3) no prior history of glaucoma treatment; (4) PACG-related treatment initiated after index diagnosis. Logistic regression modeling was performed to identify risk factors for being in the top 5% of cumulative 2-year costs.</p><p><strong>Results: </strong>Among 12,673 eligible patients, the average cumulative 2-year cost following first PACG diagnosis was $2960. Patient costs were highest in the 6 months immediately following diagnosis, accounting for 52.3% of all 2-year costs. 56.7% of all 2-year costs were related to treatment procedures. The costliest 5% (>$9813) of patients accounted for 21.3% of all 2-year PACG-related costs. Risk factors for being in the costliest 5% ( P <0.05) included older age, Black race, PPO or other Medicare insurance product, living in the Midwest or the South, and recent diagnosis of anatomic narrow angles (ANA).</p><p><strong>Conclusion: </strong>Costs associated with newly diagnosed PACG were found to be disproportionately driven by a small subset of cases. Elderly and Black patients were more likely to be within the top 5% of cumulative 2-year costs. Identifying and preventing the costliest PACG cases could reduce PACG-related eye care expenditures.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"776-782"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Morphologic Model of Glaucomatous Damage to the Macular Ganglion Cell Layer in Myopic Eyes.","authors":"Mi Jeung Kim, Emmanouil Tsamis, Ari Leshno, Gabriel Gomide, Carlos G De Moraes, George A Cioffi, Jeffrey M Liebmann, Ki Ho Park, Donald C Hood","doi":"10.1097/IJG.0000000000002582","DOIUrl":"10.1097/IJG.0000000000002582","url":null,"abstract":"<p><strong>Prcis: </strong>A model of glaucomatous progression based upon patterns of macular ganglion cell layer (GCL) damage can help clinicians distinguish between glaucomatous damage and other causes of GCL abnormalities in eyes with high myopia.</p><p><strong>Purpose: </strong>To evaluate a model-based approach for identifying glaucomatous macular ganglion cell layer (GCL) damage in highly myopic eyes by analyzing characteristic loss patterns.</p><p><strong>Materials and methods: </strong>This retrospective observational study involved optical coherence tomography scans of 72 myopic eyes (axial length>25 mm), including 15 normal control eyes and 57 eyes with glaucoma or glaucoma suspects. The mean axial length was 27.09±1.61 mm (range, 25.13-35.77 mm). The mean refractive error was -7.81±2.70 D in 46 eyes without prior refractive or cataract surgery. The loss pattern in the thick donut-shaped region of the macular GCL thickness map was compared with a model predicting glaucomatous damage patterns, suggesting damage originates temporally and progresses nasally.</p><p><strong>Results: </strong>As predicted, the temporal sectors of the 57 patients' GCL donuts showed the highest number of abnormalities significant at 5% (temporal superior: 28, temporal inferior: 37), followed by the middle sectors (superior: 26, inferior: 30), and then nasal sectors (nasal superior: 24, nasal inferior: 27). Among 3 eyes deviating from the model, 2 showed nasal defects without temporal involvement, while 1 showed an epiretinal membrane (ERM)-induced artifact. Of the 24 eyes with macular lesions (most commonly ERM in 19), 21 were diagnosed with glaucoma or glaucoma suspects. Of these, 20 conformed to the model, except 1.</p><p><strong>Conclusions: </strong>The proposed model of glaucomatous damage patterns in macula GCL is applicable to myopic eyes, even with coexisting macular pathology. In cases deviating from the model, clinicians are advised to seek causes besides glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"801-810"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma and Risk of Fractures: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.","authors":"Gabriele Gallo Afflitto, Francesco Aiello, Swarup S Swaminathan, Francesco Matarazzo, Kelsey V Stuart, Anthony P Khawaja, Ciro Costagliola, Carlo Nucci","doi":"10.1097/IJG.0000000000002613","DOIUrl":"10.1097/IJG.0000000000002613","url":null,"abstract":"<p><strong>Prcis: </strong>Glaucoma is associated with a significant risk of bone fracture. Comprehensive patient education and targeted interventions are crucial to mitigating this risk and improving outcomes.</p><p><strong>Purpose: </strong>To evaluate the risk ratio (RR) and hazard ratio (HR) of fractures in subjects with glaucoma compared with healthy controls.</p><p><strong>Materials and methods: </strong>The study protocol (CRD42024527785) was registered prospectively. PubMed, EMBASE, and Web of Science were searched from their inception to April 2024. Glaucoma was identified by the presence of a visual field defect (GVFD) consistent with glaucomatous optic neuropathy, ICD codes (or similar disease-classifying codes), and self-report. Visual field damage severity was classified using the Hodapp-Anderson-Parrish criteria, with study-specific criteria for severity deemed suitable on a case-by-case basis. Both frequentist inference meta-analysis and Bayesian network meta-analysis (NMA) were conducted.</p><p><strong>Results: </strong>Seven articles were deemed eligible for synthesis, covering a combined population of 570,694 subjects and reporting a total of 45,957 fractures. Bayesian NMA indicated that both mild and severe glaucomatous visual field defects were associated with an 80% increased RR of fractures compared with healthy counterparts [RR mild: 1.8, 95% Credible Interval (95%CrI): 1.5 to 2.3; RR severe: 1.8, 95% CrI: 1.3-2.4]. A higher HR of fractures was observed in individuals with mild (HR: 1.2; 95% CrI: 1.1-1.3) and moderate (HR: 1.4; 95% CrI: 1.1-1.8) glaucoma compared with healthy subjects.</p><p><strong>Conclusions: </strong>Low- to moderate-quality evidence indicates a significant association between glaucoma and increased fracture risk, with individuals with mild to moderate GVFD showing the highest HR and RR of fractures. These results emphasize the role of patient education and the necessity for targeted interventions and preventive strategies to mitigate the risk of fracture among affected individuals.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"744-753"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ahmed Glaucoma Valve Implantation Versus Trabeculotomy as Initial Intervention for Primary Congenital Glaucoma-Long-Term Follow-Up.","authors":"Elizabeth Tal-Mushinski, Ahed Imtirat, Tomer Kerman, Itamar Yariv, Omer Dor, Nir Amitai, Razan Saadi, Baker Elsana, Erez Tsumi","doi":"10.1097/IJG.0000000000002580","DOIUrl":"10.1097/IJG.0000000000002580","url":null,"abstract":"<p><strong>Prcis: </strong>Ahmed glaucoma valve (AGV) emerges as a more effective primary procedure compared with trabeculotomy for pediatric glaucoma patients, especially within the first 2 years.</p><p><strong>Purpose: </strong>To compare the outcomes between initial AGV implantation and trabeculotomy in children with primary congenital glaucoma (PCG).</p><p><strong>Patients and methods: </strong>This retrospective cohort study was conducted on patients with PCG who underwent either trabeculotomy or AGV implantation between 1998 and 2022 at Soroka University Medical Center. Outcome measures included intraocular pressure (IOP) change, cup-to-disc ratio, corneal clarity, additional surgeries, ocular hypotensive medication use, and the occurrence of adverse events over 36 months of follow-up. Primary success was defined as a postoperative IOP of 5-21 mmHg without additional surgeries or serious sight-threatening complications.</p><p><strong>Results: </strong>A total of 83 eyes from 55 patients were included: 34 in the AGV group and 49 in the trabeculotomy group. The primary success rate was significantly higher at all time points of the follow-up period in the AGV group compared with the trabeculotomy group ( P =0.014). Trabeculotomy was associated with a significantly higher risk of surgical failure compared with AGV implantation (HR: 3.23; 95% CI: 1.35-7.71; P =0.008). Notably, only 2 eyes in the AGV group underwent additional surgeries, compared with 25 in the trabeculotomy group ( P <0.001).</p><p><strong>Conclusions: </strong>AGV as an initial procedure seems to be safe and more effective than trabeculotomy for the treatment of PCG in this select population, with fewer additional surgeries.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"783-788"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Endoscopic Cyclophotocoagulation on the Outcomes of Excisional Goniotomy With and Without Phacoemulsification.","authors":"Maxwell Mayeda, Anthony T Scott, Cara Capitena Young, Jeffrey R SooHoo, Mina B Pantcheva, Jennifer L Patnaik, Malik Y Kahook, Leonard K Seibold","doi":"10.1097/IJG.0000000000002610","DOIUrl":"10.1097/IJG.0000000000002610","url":null,"abstract":"<p><strong>Prcis: </strong>Combination MIGS procedures are a potentially more efficacious method to decrease mean IOP and glaucoma medication burden; however, our findings question whether the addition of ECP to excisional goniotomy provides significant additional benefit.</p><p><strong>Purpose: </strong>Combined microinvasive glaucoma surgery (MIGS) procedures are gaining popularity. Although the individual efficacy of excisional goniotomy and endoscopic cyclophotocoagulation (ECP) is well established, data supporting their use in combination is lacking. Our study aims to evaluate the additive benefit of ECP to excisional goniotomy with the Kahook Dual Blade (KDB) in the largest patient cohort evaluated to date.</p><p><strong>Materials and methods: </strong>A retrospective chart review was performed of adults seen at a tertiary eye center between May 2015 and August 2019. Patients who received goniotomy alone were compared with those who received standalone goniotomy and ECP (KDB/ECP), whereas those who received goniotomy and phacoemulsification (KDB/phaco) were compared with those undergoing phacoemulsification, goniotomy, and ECP (PEcK).</p><p><strong>Results: </strong>A total of 723 eyes were included. All 4 study groups had a decrease in mean IOP at 6, 12, and 24 months (all P <0.05) and a significant decrease in glaucoma medications at 12 months (all P <0.05). When comparing the KDB group to the KDB/ECP group, there were no statistical differences in mean IOP or number of glaucoma medications at any timepoint ( P >0.05 for all). When comparing the KDB/phaco group to the PEcK group there were no statistical differences in mean IOP ( P >0.05 for all) or glaucoma medications at 12 and 24 months. However, only the KDB/ECP and PEcK groups maintained a significant reduction in medications at 24 months.</p><p><strong>Conclusions: </strong>Both standalone KDB goniotomy with ECP and the PEcK procedure are efficacious at lowering IOP and glaucoma medication burden. Although success rates were not improved, the addition of ECP to KDB goniotomy seems to achieve a more sustained reduction in medication burden compared with goniotomy alone.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"819-826"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between MRI-Measured Structure of the Visual Cortex and Visual Function in Patients With Glaucoma.","authors":"Akio Yamada, Yasuko Tatewaki, Kazuko Omodaka, Izumi Matsudaira, Yasuyuki Taki, Toru Nakazawa","doi":"10.1097/IJG.0000000000002614","DOIUrl":"10.1097/IJG.0000000000002614","url":null,"abstract":"<p><strong>Prcis: </strong>The area corresponding to the peripheral visual field in the primary visual cortex of the brain is associated with ophthalmologic parameters.</p><p><strong>Purpose: </strong>Reproducing the relationship of the visual field with the primary visual cortex is known as retinotopic mapping. The primary visual cortex is known to be atrophic in glaucoma patients. However, there are few reports on which areas most reflect glaucomatous changes. In this study, we used magnetic resonance imaging to evaluate the relationship between various ophthalmic parameters and overall and regional structural changes in the primary visual cortex to better understand changes in the brain associated with glaucoma.</p><p><strong>Materials and methods: </strong>Twelve healthy subjects [56.1±9.3 y old, male to female ratio 6:6, mean deviation (MD) 0.6±0.7 dB] and 23 patients with glaucoma (57.8±8.0 y old, male to female ratio 8:15, MD: -10.2±6.4 dB) were enrolled. We acquired 3D-T1-weighed images to measure the overall and regional gray matter density of the visual cortex based on a priori retinotopic projection. Optical coherence tomography and visual field testing were performed, and a weighted count of retinal ganglion cells (wRGC) was calculated from the ophthalmological tests. The Spearman rank correlation coefficient was used for evaluating the correlations between these structural parameters of the visual cortex and the ophthalmological parameters.</p><p><strong>Results: </strong>The overall primary visual cortex was positively correlated with MD ( r =0.40, P =0.02) and wRGC ( r =0.41, P =0.02). Regarding retinotopic projection, the inner area in the visual cortex, which corresponds to the peripheral visual field, was positively correlated with MD and wRGC.</p><p><strong>Conclusion: </strong>The inner part of the primary visual cortex, which corresponds to the peripheral visual field, is closely correlated with ophthalmologic parameters commonly used for diagnosing and detecting the progression of glaucoma clinically. This suggests that evaluation of this area with MRI may be of clinical use in glaucoma assessment and monitoring.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"735-743"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Associated Factors in Chinese Glaucoma Patients.","authors":"Yunsheng Qiao, Chen Tan, Junyi Lai, Jiangnan He, Jianfeng Zhu, Haidong Zou, Xinghuai Sun, Junyi Chen","doi":"10.1097/IJG.0000000000002609","DOIUrl":"10.1097/IJG.0000000000002609","url":null,"abstract":"<p><strong>Prcis: </strong>Quality of life scores in Chinese glaucoma patients were mainly associated with disease severity, measured by patients' visual acuity, stages of visual field defects, and intraocular pressure.</p><p><strong>Purpose: </strong>To examine the effect of demographic, clinical, and socioeconomic factors on glaucoma patient-reported quality of life (QoL) scores.</p><p><strong>Patients and methods: </strong>In this cross-sectional study, 1057 consecutive glaucoma patients aged 18 and above were recruited from 34 hospitals across China between November 1, 2022 and December 18, 2022. A smartphone-based survey collected demographic/socioeconomic data and incorporated the Chinese version of the Glaucoma Quality of Life-17 (Glau-QoL-17) questionnaire for patient-reported QoL evaluation. Visual functions (best-corrected visual acuity [BCVA], the higher intraocular pressure [IOP] of both eyes, and the stages of visual field impairment) were assessed by ophthalmic professionals. Multiple linear regression models were constructed to identify predictors for both overall and subscale QoL scores. Least Absolute Shrinkage and Selection Operator (LASSO) analysis was used to screen the most influential factors for the overall QoL score.</p><p><strong>Results: </strong>The median (interquartile range) QoL score was 57 (49-65). BCVA and the stage of visual field defects of the better eye, the higher IOP reading between both eyes, the employment status, and the city tier of residence were independent predictors for QoL after adjusting for age, sex, education level, and comorbidities. LASSO analysis additionally identified primary open angle glaucoma and combined surgical and pharmacological treatment as one of the most influential factors affecting QoL. Clinical factors explained the largest variation in the multiple linear regression model.</p><p><strong>Conclusions: </strong>QoL of glaucoma patients is primarily determined by clinical indices. Unemployment is also an important correlate of low QoL among glaucoma patients.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"754-761"},"PeriodicalIF":1.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}