Journal of Glaucoma最新文献

{"title":"Influence of Retinopathy of Prematurity and Laser Therapy on Intraocular Pressure in Preterm Infants.","authors":"Poonam Verma, Deeksha Katoch, Simar Rajan Singh, Praveen Kumar, Ashok Kumar Singh, Faisal Thattaruthody, Surinder Singh Pandav, Sushmita Kaushik","doi":"10.1097/IJG.0000000000002600","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002600","url":null,"abstract":"<p><strong>Precis: </strong>Intraocular pressure (IOP) decreases as preterms mature and in moderate retinopathy of prematurity, IOP is initially low and transiently rises after laser treatment.</p><p><strong>Purpose: </strong>This study aimed to measure intraocular pressure (IOP) in preterm infants with and without retinopathy of prematurity (ROP) and evaluate the effect of laser treatment on IOP.</p><p><strong>Method: </strong>This prospective non-randomized comparative study included infants born before 34 weeks of gestation weighing less than 2000 grams at a tertiary care research and referral institute. Those with ocular or systemic conditions or requiring surgical intervention for ROP were excluded. Infants were divided into three groups: Group 1 (no ROP), Group 2 (ROP without treatment), and Group 3 (ROP requiring peripheral retinal ablation by laser photocoagulation). IOP was measured using a Perkins tonometer at presentation and one and three months. The primary outcome was IOP in preterm infants with and without ROP; and the secondary outcome was change in IOP post-laser treatment.</p><p><strong>Results: </strong>Of 107 infants, 40 (37.38%) had no ROP (Group 1), 25 (23.36%) had untreated ROP (Group 2), and 42 (39.25%) required laser treatment (Group 3). Average post-menstrual ages were 37.89±2.74 weeks 36.98±3.38 and 35.47±2.84 weeks respectively. A moderate negative correlation between IOP and post-menstrual age was found in Group 1 (r2=-0.382; P=0.01) and Group 2 (r2= -0.6; P=0.001). Baseline IOP was significantly lower in Group 3 compared to the other groups, with a transient increase post-laser treatment that typically normalized without needing IOP treatment.</p><p><strong>Conclusions: </strong>IOP decreases as preterm infants mature. Infants with ROP requiring laser treatment exhibit significantly low IOP at presentation, but have a post-laser spike which generally normalises without treatment.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Phacogoniotomy for Medically-Controlled and Uncontrolled Primary Open-Angle Glaucoma with Cataract: A Multicenter Study.","authors":"Yunhe Song, Xiangxiang Ye, Mingmin Yang, Zhihong Zhang, Liuzhi Zeng, Hanying Fan, Lin Xie, Xiaomin Zhu, Hongyang Zhang, Yuhan Feng, Jiangang Xu, Min Ke, Qing Bao, Xiaojing Pan, Qingshu Ge, Fengbin Lin, Zefeng Yang, Zige Fang, Zhixuan Wang, Dilimulati Xiaokaiti, Sujie Fan, Ning Fan, Yongjun Qi, Xiulan Zhang","doi":"10.1097/IJG.0000000000002598","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002598","url":null,"abstract":"<p><strong>Prcis: </strong>Phacogoniotomy, a combination of phacoemulsification and intraocular lens implantation (PEI) and 120° goniotomy (GT) was an effective and safe surgical treatment for medically-controlled or uncontrolled primary open-angle glaucoma (POAG) with cataract.</p><p><strong>Purpose: </strong>To evaluate the efficacy and safety of PEI combined with 120°GT in the treatment of medically-controlled or uncontrolled POAG with cataract.</p><p><strong>Methods: </strong>Multicenter observational study conducted in nine ophthalmic institutes/general hospitals in China. Patients with medically-controlled (baseline intraocular pressure [IOP] >21 mmHg) or uncontrolled (baseline IOP ≤21 mmHg) POAG with clinically significant cataract were included, who were followed up with at least 12 months. The IOP, topical hypotensive medication, surgery complications, visual acuity, surgery success were recorded and compared between groups at baseline and the final visit. Complete surgical success was defined as postoperative IOP of 5-18 mmHg without additional topical medications, vision-threatening complications or reoperation for glaucoma. Qualified success is same as complete success except allowing use of ocular hypotensive medications.</p><p><strong>Results: </strong>One hundred participants with 132 eyes were included with a mean follow-up time of 17.5±5.2 months (12 to 32) postoperatively. In general, the mean IOP reduced from 21.2±7.4 mmHg at baseline to 14.7±2.9 mmHg postoperatively (P<0.05), with an average reduction of 6.4±7.9 mmHg (23.5±25.6%). The mean number of hypotensive medications declined from 1.6±1.2 to 0.3±0.6, with a mean reduction of 1.4±1.2. One hundred and eight out of 132 (81.8%) eyes achieved complete success and 118 (89.4%) achieved qualified success of surgery, respectively. The chief complications involved hyphema (15.2%), corneal edema (19.7%), IOP spike (8.3%), or hypotony (1.5%). In subgroup analysis of medically-controlled versus medically-uncontrolled pariticpants, no difference was found in IOP at final visit (14.5±0.3 mmHg vs.15.1±0.4 mmHg; P=0.28), medication (1.8±1.1 vs. 1.4±1.3; P=0.54), as well as complete (85.3% vs. 77.2%; P=0.23) or qualified success rate (95.0% vs. 86.0%; P=0.27), nor in any kind of surgery complications (all Ps>0.05), respectively.</p><p><strong>Conclusion: </strong>POAG with cataract could be effectively treated by phacogoniotomy, regardless of medically-controlled or medically-uncontrolled status at baseline.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glaucoma Patient Perspectives on Effective Coaching for Self-Management.","authors":"Noah Lee Carey, Danielle Tahira DuPuis, George Lin, Elena Flores, Jamie Mitchell, Deborah Darnley-Fisch, Nauman Imami, Michele Heisler, Kenneth Resnicow, Phalatha McHaney-Conner, Asia Priester, Chamisa MacKenzie, Paula-Anne Newman-Casey","doi":"10.1097/IJG.0000000000002593","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002593","url":null,"abstract":"<p><strong>Precis: </strong>In semi-structured exit interviews, participants in a personalized glaucoma coaching program reported improved self-efficacy in managing their disease. Coaching was frequently cited as catalyst to enhancing medication adherence, emphasizing its role in team-based care.</p><p><strong>Purpose: </strong>To assess patients' experience with coaching to motivate improved adherence to glaucoma self-management.</p><p><strong>Methods and materials: </strong>Participants in the Support, Educate, Empower (SEE) personalized glaucoma coaching program completed exit interviews after participating in a six-month coaching program. Interviews were audio-recorded and transcribed verbatim. Transcripts were analyzed using interpretivist grounded theory. Thematic saturation was reached after coding 30 interviews; 32 were included. Themes were identified, a codebook was generated, and two researchers coded the transcripts (NLC, DTD) and a third adjudicated any disagreements (EF). Main outcomes measures were defined as themes and the number of participants who expressed a theme.</p><p><strong>Results: </strong>Of the 32 participants interviewed in this study, 59% (n=19) identified as male, 41% (n=13) identified as female, 50% (n=16) identified as Black, 34% (n=11) identified as White, 6% (n=2) identified as Asian. Major themes surrounding coaching included how coaching promoted change in eye drop use, knowledge learned from the coach, feeling accountable to the coach, the coach being accessible, how coaches demonstrated empathy, how the coach collaborated to help people develop a sense of control and efficacy over glaucoma self-management, and how coaches built rapport. Additional themes were program satisfaction, fear of vision loss as a motivator to improve glaucoma self-management, and constructive feedback for the program.</p><p><strong>Conclusion: </strong>This qualitative assessment of the SEE personalized glaucoma coaching program demonstrated that high-quality coaching and rapport building may help patients with previously low medication adherence feel more motivated and in control of their glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Standard Automated Visual Field Tests in Glaucoma and the Role of Facial Contour.","authors":"Sepideh Jamali D, Armin Garmany, Tyler M Kaplan, Mostafa Sadegh Mousavi, Helia Ashourizadeh, Zin Tarakji, Cheryl L Khanna","doi":"10.1097/IJG.0000000000002599","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002599","url":null,"abstract":"<p><strong>Prcis: </strong>Using a CNN-enhanced platform, 60-4 visual fields identified peripheral glaucomatous defects missed by central testing in mild cases; facial contour correction showed these defects occurred exclusively outside the temporal visual field.</p><p><strong>Purpose: </strong>To develop a methodology to separate facial contour-induced visual field defects from defects related to glaucoma in patients with peripheral field defects.</p><p><strong>Methods: </strong>Ninety-seven eyes from fifty patients previously diagnosed with glaucoma were enrolled in the study. Thirty-one (62%) participants were male, and 86% were white. The study involved patients with glaucoma who underwent visual field testing using standard automated perimetry, including 10-2, 24-2, 30-2, and 60-4 visual fields. A convolutional neural network (CNN)-enhanced platform, previously developed to identify facial contour-dependent defects in healthy subjects, was used to analyze the visual field data.</p><p><strong>Patients: </strong>The study included ninety-seven eyes from fifty patients with glaucoma, with the majority having primary open angle glaucoma.</p><p><strong>Results: </strong>In ninety out of ninety-seven eyes, there were 60-4 visual field defects. However, 20 (22%) of these eyes did not have glaucomatous defects on the 10-2 or 30-2 visual fields. All patients with 60-4 defects in the absence of more central defects had mild glaucoma, and these eyes comprised 38% of the mild glaucoma group. 60-4 visual field increased the sensitivity of identifying glaucoma in mild disease. Without facial contour, the 60-4 visual field mean threshold summation was 1099.6±346.6 dB, and decreased to 1057±331 dB when accounting for facial contour, which affected 8.03±4.02% of test points. Facial contour-dependent visual field defects were exclusively found outside the temporal visual field.</p><p><strong>Conclusion: </strong>The study demonstrated the potential utility of 60-4 visual fields for identifying early functional glaucomatous changes that may not be detected by more central visual field tests (10-2 or 30-2). It may be important to consider peripheral visual field defects, which can be affected by facial contour, in the diagnosis and monitoring of glaucoma, particularly in mild cases.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Long-Term Metformin Use and Risk of Open-Angle Glaucoma in Patients With Diabetes Mellitus.","authors":"Shiang-Wen Huang, Yung-Rung Lai, Yih Yang, Shuo-Yan Gau, Ning-Jen Chung, Tung-Han Tsai, Kuang-Hua Huang, Chien-Ying Lee","doi":"10.1097/IJG.0000000000002597","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002597","url":null,"abstract":"<p><strong>Prcis: </strong>Metformin use wasn't dose-dependently linked to open-angle glaucoma. Lower doses showed a protective effect, while higher doses had no significant impact.</p><p><strong>Purpose: </strong>The present study examined the enigmatic relationship between long-term metformin use and the risk of developing open-angle glaucoma (OAG) in patients with diabetes mellitus (DM). Additionally, we questioned whether metformin use affects the risk of OAG in a dose-dependent manner.</p><p><strong>Methods: </strong>This research was a retrospective cohort study using a nationally representative database established by the Health and Welfare Data Science Center of the Ministry of Health and Welfare, Taiwan, ROC. Patients diagnosed with new-onset DM between 2002 and 2013 were divided into two groups: a metformin-treated group and a sulfonylureas-treated group. The aim of our investigation is to evaluate the risk of OAG after a 5-year follow-up period. Using the Cox proportional hazard model, researchers estimated the risk of OAG in correlation with metformin treatment by the cumulative defined daily dose (cDDD), after adjusting for several key risk factors such as sex, age, income, urbanization level, diabetes severity, and various comorbidities.</p><p><strong>Result: </strong>A total of 2,102 patients (0.29%) developed OAG after 5 years of being diagnosed with DM. Among patients treated with metformin, the incidence rates of OAG were 0.27%, 0.27%, 0.29%, and 0.33% with cDDDs of<30, 30-120, 120-240, and >240, respectively. Following adjustments for relevant variables, patients who received metformin treatment at cDDDs of <30, 30-120, 120-240, and >240 exhibited HRs of 0.81 (95% CI=0.71-0.92), 0.83 (95% CI=0.74-0.93), 0.90 (95% CI=0.79-1.03), and 1.03 (95% CI=0.82-1.29), respectively, compared with those treated with sulfonylureas.</p><p><strong>Conclusion: </strong>Our findings suggest a moderate protective effect on the risk of open-angle glaucoma at lower cumulative metformin dosages. A dose-dependent effect was not observed.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Intraluminal Stent Removal After PAUL® Glaucoma Implant Surgery.","authors":"Constance Weber, Diana Samarghitan, Leonie Bourauel, Wolfgang Walz, Sarah Hundertmark, Michael Petrak, Frank G Holz, Karl Mercieca","doi":"10.1097/IJG.0000000000002594","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002594","url":null,"abstract":"<p><strong>Precis: </strong>Intraluminal stent-removal post-PGI surgery significantly reduces IOP with high success rates but carries the risk of hypotony and complications, e.g. suprachoroidal hemorrhage. Long-term management often requires the eventual addition of IOP-lowering therapy despite initial efficacy.</p><p><strong>Background: </strong>To report outcomes after intraluminal stent removal following PAUL® Glaucoma Implant (PGI) surgery from a single-center cohort.</p><p><strong>Methods: </strong>Retrospective review of patients undergoing intraluminal prolene removal following PGI surgery at the University Eye Hospital Bonn, Germany, from 04/2021 to 10/2023.</p><p><strong>Results: </strong>70 eyes of 68 patients were included. Qualified and complete success rates (95% CI) were 92.9% and 55.7% after one year and 88.6% (81.4-95.7%) and 50% (37.1-62.9%) at the last follow-up time point for IOP≤18 mmHg and 81.4% and 54.3 and 70% and 42.9% IOP≤15 mmHg, respectively. Mean IOP decreased from 23.93 mmHg to 12.07 mmHg after 12 months, 11.32 mmHg after 24 months and 10.41 mmHg after 36 months. The mean number of IOP-lowering eye drops was zero before and immediately after removal and increased to 1.57 (0-2) at 12 months, 1.15 (0-4) at 24 months and 1.12 (0-4) at 36 months. Postoperative complications occurred in 5 eyes (7.1%). Two eyes had suprachoroidal hemorrhage with one needing vitrectomy and one external tube ligation; one required PGI explantation for persistent hypotony.</p><p><strong>Conclusions: </strong>Removal of the prolene stent following PGI surgery effectively lowers IOP in the short term, with a moderate increase in IOP and need for pressure-lowering therapy over time. However, it can also lead to adverse outcomes, such as hypotony and suprachoroidal hemorrhage, especially in patients with systemic risk factors or those undergoing early removal.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trabeculectomy Bleb Characteristics in Relation to Bleb Success using Anterior Segment Optical Coherence Tomography - A Systematic Review and Meta-Analysis.","authors":"Jackie Jia Lin Sim, Bjorn Kaijun Betzler, Syril Dorairaj, Tanuj Dada, Bryan Chin Hou Ang","doi":"10.1097/IJG.0000000000002595","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002595","url":null,"abstract":"<p><strong>Prcis: </strong>ASOCT features of greater bleb height, thicker bleb walls and lower reflectivity are associated with trabeculectomy success, supporting the ASOCT's utility in monitoring and predicting outcomes post-surgery through standardized imaging protocols.</p><p><strong>Purpose: </strong>To evaluate and quantify the relationship between bleb characteristics on ASOCT with surgical outcomes.</p><p><strong>Methods: </strong>Literature search was conducted across Medline, Embase, Cochrane, and Scopus for studies from the past 20 years, until 16 September 2024 on \"glaucoma\", \"trabeculectomy\", and \"ASOCT\". Data collected included patient characteristics, each study's definition of bleb success, clinical outcomes, as well as bleb characteristics. A literature review was conducted on studies which could not be used for meta-analysis.</p><p><strong>Results: </strong>11 studies, with a pooled total of 528 eyes in 517 patients, were included in the final meta-analysis. Successful blebs had significantly higher mean bleb height (mean difference [MD] 0.38 mm, 95%-CI: 0.20-0.56 mm, P=0.002), greater maximum bleb wall thickness (MD 0.21 mm, 95%-CI: 0.07-0.35 mm, P=0.009), and decreased reflectivity (MD -48.9%, 95%-CI: -78.3 to -19.4%, P=0.010), compared to failed blebs. No significant differences were found in bleb fluid cavity height and bleb area. Narrative synthesis revealed that wider blebs, increased fluid-filled cavity height, increased number of microcysts, larger filtration opening widths, and multiform bleb walls were also associated with higher rates of bleb success. Early bleb parameters were statistically significant predictors of bleb success up to 12 months post-operatively.</p><p><strong>Conclusions: </strong>Greater bleb height, thicker bleb walls, and lower reflectivity on ASOCT are consistently associated with successful trabeculectomy outcomes. The ASOCT may be useful in predicting bleb success and in supplementing post-operative monitoring, hence guiding timely medical or procedural interventions, to ensure long-term bleb success.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Discrepancies in Intraocular Pressure Measurements Between iCare IC200 and Goldmann Tonometer.","authors":"Haowei Zhang, Jeong Woo Nam, Mi Sun Sung, Sang Woo Park","doi":"10.1097/IJG.0000000000002591","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002591","url":null,"abstract":"<p><strong>Prcis: </strong>Intraocular pressure measured by Goldmann applanation tonometry, central corneal thickness, and history of cataract surgery are factors in the discrepancies in intraocular pressure measurements between the iCare IC200 rebound tonometer and the Goldmann applanation tonometer.</p><p><strong>Purpose: </strong>To investigate the factors affecting the discrepancies in intraocular pressure (IOP) measurements between the iCare IC200 rebound tonometer (RBT) and Goldmann applanation tonometer (GAT).</p><p><strong>Materials and methods: </strong>The IOP was measured sequentially using RBT followed by GAT. Bland-Altman analysis was used to determine the agreement between the RBT and GAT. Eyes were classified into three groups based on the difference calculated as RBT minus GAT: Group A (-1-1 mmHg), Group B (≥3 mmHg), and Group C (≤-3 mmHg). Logistic regression analysis was performed to identify the factors associated with the measurement discrepancies.</p><p><strong>Results: </strong>A total of 402 right eyes were included in the study. The RBT and GAT measurements were significantly correlated (Spearman's r=0.885, P<0.001). The mean IOP differences between the RBT and GAT were 0.114±2.13 mmHg (range: -7-8, 95% limit of agreement: -4.06-4.29 mmHg). Multivariate logistic analyses revealed that greater central corneal thickness (CCT) (P=0.002) was significantly associated with overestimation of IOP by RBT relative to GAT. We found that underestimated IOP by RBT relative to GAT in patients with higher GAT-measured IOP (P=0.002) and those with a history of cataract surgery (P=0.006).</p><p><strong>Conclusions: </strong>RBT tends to overestimate IOP relative to GAT in patients with thicker CCTs, while it underestimates IOP in those with higher GAT-measured IOP or a history of cataract surgery.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Smart Supra Perimetry in Comparison with Standard Automated Perimetry in the Detection of Early Glaucoma.","authors":"Subash Sukumar, Robert A Harper, Emmanouil Tsamis, Donald Hood, David B Henson","doi":"10.1097/IJG.0000000000002596","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002596","url":null,"abstract":"<p><strong>Prcis: </strong>The diagnostic performance for detecting early glaucoma of a supra-threshold and a threshold visual field tests are compared. Their performance was found to be equivalent with the supra-threshold test being faster.</p><p><strong>Purpose: </strong>To compare the diagnostic accuracy of a supra-threshold and a threshold visual field test in detecting early glaucoma using optical coherence tomography (OCT) as the reference standard.</p><p><strong>Methods: </strong>Data from 54 early/suspect glaucoma patients and 37 controls underwent a Humphrey Visual field Analyzer (HFA) SITA standard 24-2 threshold test, a Henson 9000 Smart Supra test (SS) supra-threshold test and Topcon Triton OCT scan: Smart Track 3D Wide (H) (12 ×9). OCT data were classified by 3 experts as either No Glaucoma (n=42), Suspect (n=6) or Glaucoma (n=43). Overall and Selective global indices and Receiver Operating Characteristics (ROC) curve analysis were used to compare visual field outcomes with OCT classifications.</p><p><strong>Results: </strong>SS was significantly faster than SITA standard (3.9 vs. 6 min). Sixty-one percent of the glaucoma sample and 81% of controls showed substantial agreement between OCT and visual field testing using the most sensitive criteria (Henson-N-miss SS, stage 2 and 3, >0 misses; HFA VFI <99%). The area under the ROC curve showed good discrimination for all global indices. The 24-2 global indices MD, PSD and VFI ranged from 86-89% while those for the SS test ranged from 84-88%. Partial area under the ROC curve (80-100% specificity) showed a fall for all global indices. HFA MD, PSD and VFI range (61-73%), SS test range (71-78%).</p><p><strong>Conclusions: </strong>The SS supra-threshold test was faster and had equivalent diagnostic accuracy to the SITA standard 24-2 threshold test in early/suspect glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12-month Intraocular Pressure and Hypotensive Medications Outcomes after Phaco-ELIOS Procedure - A Real World Study.","authors":"Antonio Moreno-Valladares, Anastasiya Vinokurtseva, Johanna Matilde González-Rodríguez, Iqbal Ike K Ahmed, Eva Gonzalez-Aquino, Nieves Puerto-Amorós, Esther Roquet, Anna Soldevila, María Isabel Canut","doi":"10.1097/IJG.0000000000002590","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002590","url":null,"abstract":"<p><strong>Prcis: </strong>Combined phaco-ELIOS in ocular hypertension and glaucoma showed a statistically significant reduction in the number of hypotensive medications of 1.5 compared to baseline, with 78.4% of eyes being medication-free at 12 months.</p><p><strong>Purpose: </strong>To describe change in medication and intraocular pressure 12 months after combined phacoemulsification-ELIOS procedure.</p><p><strong>Methods: </strong>Retrospective, multicenter interventional case series of adults with ocular hypertension or glaucoma undergoing phaco-ELIOS. Clinical data was collected and analyzed from pre-operative baseline up to 12 months postoperatively. Primary outcome was mean change in medication compared to baseline. Secondary outcomes were intraocular pressure change from baseline, incidence of acute postoperative intraocular pressure elevation, and surgical success at 1 year, defined as intraocular pressure reduction of ≥20% compared to baseline with no increase in medications, or reduction of ≥1 medications compared to baseline with intraocular pressure equal or below baseline, with no secondary glaucoma surgeries and no loss of light perception.</p><p><strong>Results: </strong>112 eyes were included. Forty-two patients (51.2%) were female. Mean (±SD) age was 70.6 (±9.6) years. Most frequent diagnosis was primary open angle glaucoma (71.4%). Mean number of medications at baseline and 12 months was 1.8 (±0.8) and 0.4 (±0.7), respectively, representing a reduction of 1.5 (±1.0) (P<0.0001). At the end of follow-up, 78.4% of eyes were medication-free. Mean intraocular pressure at baseline and 12 months was 19.9 (±4.0) mmHg and 16.7 (±2.6) mmHg, respectively, a significant decrease of 3.2 mmHg (±4.0) or 13.7% (P<0.0001). Surgical success was achieved in 75.9% of eyes at 12 months.</p><p><strong>Conclusions: </strong>Combined phaco-ELIOS in glaucoma significantly reduced medication use and IOP, with over 75% of eyes being medication-free at 12 months.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}