Journal of Glaucoma最新文献

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Staphylococcus Capitus Blebitis Following Preserflo MicroShunt Implantation. PRESERFLO微分流器植入后的头状葡萄球菌性水泡炎。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/IJG.0000000000002578
Bachar Kudsieh, Elena Almazan-Alonso, Jorge Ruiz-Medrano, Muhsen Samaan, Jose Maria Ruiz-Moreno
{"title":"Staphylococcus Capitus Blebitis Following Preserflo MicroShunt Implantation.","authors":"Bachar Kudsieh, Elena Almazan-Alonso, Jorge Ruiz-Medrano, Muhsen Samaan, Jose Maria Ruiz-Moreno","doi":"10.1097/IJG.0000000000002578","DOIUrl":"10.1097/IJG.0000000000002578","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of early-onset blebitis following Preserflo MicroShunt implantation.</p><p><strong>Patients and methods: </strong>Case report.</p><p><strong>Results: </strong>A 73-year-old woman with a history of open angle glaucoma secondary to pseudoexfoliative syndrome in her right eye underwent Preserflo MicroShunt implantation augmented with mitomycin C. Three months postoperatively, she experienced ocular pain and a decrease in visual acuity. Clinical examination revealed conjunctival hyperemia surrounding a whitish filtering bleb, positive conjunctival fluorescein staining, and a positive Seidel sign leading to hypotony. In addition, an inflammatory reaction was observed in the anterior chamber, along with localized vitreous haze. Management included topical antibiotic therapy, removal of necrotic tissue, and explantation of the Preserflo MicroShunt. Staphylococcus capitis was isolated from both conjunctival and implant cultures, confirming the clinical diagnosis of infectious blebitis. Intraocular pressure and visual function were successfully restored after surgery.</p><p><strong>Conclusions: </strong>Blebitis is a rare but potentially serious complication following Preserflo MicroShunt implantation with mitomycin C. Device removal may be necessary to prevent bacterial infection from extending beyond the filtering bleb into the anterior chamber.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e38-e40"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Vascular and Structural Hemiretinal Asymmetry at Different Stages of Normal Tension Glaucoma Using Optical Coherence Tomography. 光学相干断层成像评估正常张力性青光眼不同阶段血管和结构半视网膜不对称性。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-07-01 Epub Date: 2025-03-26 DOI: 10.1097/IJG.0000000000002572
Xiaonan Lu, De-Fu Chen, Chenmin Wang, Jinrui Zhang, Tao Wang, Cong Zhang, Qiangjie Huang, Yuanbo Liang
{"title":"Assessing Vascular and Structural Hemiretinal Asymmetry at Different Stages of Normal Tension Glaucoma Using Optical Coherence Tomography.","authors":"Xiaonan Lu, De-Fu Chen, Chenmin Wang, Jinrui Zhang, Tao Wang, Cong Zhang, Qiangjie Huang, Yuanbo Liang","doi":"10.1097/IJG.0000000000002572","DOIUrl":"10.1097/IJG.0000000000002572","url":null,"abstract":"<p><strong>Prcis: </strong>Hemiretinal asymmetry in different stages of normal tension glaucoma (NTG) may be helpful in diagnosis and staging.</p><p><strong>Purpose: </strong>To investigate hemiretinal asymmetry in peripapillary capillary vessel density (pcVD), macular vessel density (macVD), circumpapillary retinal nerve fibre layer (RNFL) thickness, and macular ganglion cell-inner plexiform layer (GCIPL) across various stages of normal tension glaucoma (NTG) and determine its potential as a staging tool.</p><p><strong>Subjects and methods: </strong>A total of 199 subjects were included, categorized into the preperimetric, early, moderate, and advanced stage based on mean deviation (MD). Vessel density was measured using optical coherence tomography angiography, while peripapillary RNFL and macular GCIPL thickness were assessed with spectral-domain optical coherence tomography scans. The asymmetry parameter was defined as the absolute difference between superior and inferior values in the same eye. We analysed the characteristics of these parameters across glaucoma stages and evaluated the distribution of structural damage among the groups.</p><p><strong>Results: </strong>Hemiretinal asymmetry parameters showed significant statistical differences across the 4 groups, following a trend of moderate > early > late > preperimetric stages. Furthermore, hemiretinal difference in pcVD (hd pcVD) ( P= 0.009) and hemiretinal difference in RNFL (hd RNFL) ( P= 0.003) have statistical differences between preperimetric and early stage. Besides, 50% to 80% of the participants in each stage exhibited smaller structural parameters in the inferior hemisphere.</p><p><strong>Conclusions: </strong>The hemiretinal asymmetry parameter exhibits a clear trend across different stages of NTG, aiding in the staging of NTG before reaching the moderate stage. Furthermore, it has advantages in differentiating between the preperimetric and early stages. In addition, the intraocular inferior hemisphere structure damage is more severe.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"541-548"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of Glaucoma in High-Risk Minority Populations. 少数民族青光眼高危人群的筛查
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.1097/IJG.0000000000002581
Nariman Nassiri, M Roy Wilson
{"title":"Screening of Glaucoma in High-Risk Minority Populations.","authors":"Nariman Nassiri, M Roy Wilson","doi":"10.1097/IJG.0000000000002581","DOIUrl":"10.1097/IJG.0000000000002581","url":null,"abstract":"<p><strong>Precis: </strong>This chapter reviews the current recommendations on screening for open angle glaucoma in Black and Hispanic populations. Strategies for increasing case-finding and decreasing cost, with emphasis on evolving technologies, are presented.</p><p><strong>Purpose: </strong>To address the current recommendations on primary open angle glaucoma screening in high-risk minority populations and to discuss potential strategies to improve the screening of glaucoma in these populations.</p><p><strong>Methods: </strong>A literature review was performed by searching PubMed, EMBASE, and Google Scholar. All English-language papers that resulted from the search terms from January 1980 to October 2023 were reviewed.</p><p><strong>Results: </strong>In the next few decades, the societal burden of glaucoma will increase because of the demographic shift to an older and more diverse US population, including Black and Hispanic populations, which have been shown to have a higher prevalence of the disease. The current (2022) conclusion of the US Preventive Services Task Force is that the evidence to assess the balance of benefits and harms of screening for glaucoma in adults is insufficient to recommend widespread screening. The Preferred Practice Pattern guideline similarly states that screening for glaucoma in the general population is not cost-effective. However, the guidelines state that screening is more useful and cost-effective when it is targeted at populations at high risk for glaucoma, such as older adults, those with a family history of glaucoma, and Black and Hispanic individuals. Strategies for improving the effectiveness of glaucoma screening must increase case finding and decrease cost. New screening technologies, such as telemedicine and artificial intelligence, are expanding access for underserved populations.</p><p><strong>Conclusions: </strong>There is still no clear consensus on the effectiveness of glaucoma screening for the general population. However, glaucoma screening may be useful and cost-effective when it is targeted at populations at high risk for glaucoma, particularly using emerging technologies that improve access and case-finding.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":"34 7","pages":"561-564"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemorrhagic Descemet's Membrane Detachment After Gonioscopy-Assisted Transluminal Trabeculotomy. 镜检辅助腔内小梁切开术后出血性网膜脱离。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-07-01 Epub Date: 2025-02-11 DOI: 10.1097/IJG.0000000000002551
Gunsu D Mirza, Enver Mirza
{"title":"Hemorrhagic Descemet's Membrane Detachment After Gonioscopy-Assisted Transluminal Trabeculotomy.","authors":"Gunsu D Mirza, Enver Mirza","doi":"10.1097/IJG.0000000000002551","DOIUrl":"10.1097/IJG.0000000000002551","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare case of hemorrhagic Descemet's membrane detachment (DMD) after gonioscopy-assisted transluminal trabeculotomy (GATT) and to discuss its management.</p><p><strong>Methods: </strong>A 71-year-old male patient with advanced pseudoexfoliation glaucoma and dense cataract was planned to perform combined GATT and cataract extraction. DMD was noticed after blood reflux from Schlemm canal during GATT. Circumferential ab-interno trabeculotomy was completed and DMD was reattached with air tamponade. Cataract extraction was postponed to prevent the progression of DMD.</p><p><strong>Results: </strong>Hemorrhagic DMD was monitored during a 3-month follow-up. Spontaneous resorption was not observed. A side port incision was made at the site of hemorrhagic DMD during cataract extraction. The space upon DM was washed out with a balanced salt solution to allow drainage of the hemorrhage and an air bubble was left in the anterior chamber. On the first postoperative day after cataract extraction, DM was observed to be attached and the hemorrhage had disappeared completely.</p><p><strong>Conclusions: </strong>Hemorrhagic DMD is an unusual complication after GATT and it may be challenging to manage. Surgeons who perform GATT should be aware of this rare corneal complication.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e34-e37"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Physical Activity Levels on Visual Field Progression in Individuals With Glaucoma. 体力活动水平对青光眼患者视野发展的影响。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-07-01 Epub Date: 2025-04-21 DOI: 10.1097/IJG.0000000000002576
Je Hyun Seo, Takashi Nishida, Sasan Moghimi, Jo-Hsuan Wu, Massimo A Fazio, Christopher A Girkin, Jeffrey M Liebmann, Linda M Zangwill, Robert N Weinreb
{"title":"Impact of Physical Activity Levels on Visual Field Progression in Individuals With Glaucoma.","authors":"Je Hyun Seo, Takashi Nishida, Sasan Moghimi, Jo-Hsuan Wu, Massimo A Fazio, Christopher A Girkin, Jeffrey M Liebmann, Linda M Zangwill, Robert N Weinreb","doi":"10.1097/IJG.0000000000002576","DOIUrl":"10.1097/IJG.0000000000002576","url":null,"abstract":"<p><strong>Prcis: </strong>Higher self-reported physical activity level was associated with a slower rate of visual field mean deviation loss in patients with primary open angle glaucoma.</p><p><strong>Purpose: </strong>To determine the impact of physical activity (PA) on visual field (VF) progression rates in patients with primary open angle glaucoma (POAG).</p><p><strong>Methods: </strong>In this longitudinal study, POAG patients were included who had ≥5 visits, ≥2 years of follow-up VFs and underwent PA questionnaire at the baseline. PA levels were assessed using the physical activity index (PAI), metabolic equivalents of task (MET)-minutes, and walking pace. Univariable and multivariable linear mixed-effects models were used to determine the impact of PA levels on the rates of VF mean deviation (MD) loss.</p><p><strong>Results: </strong>One hundred thirty-one eyes from 80 POAG patients were included over a median follow-up of 4.9 (IQR: 4.0-6.7) years. The median age of patients was 68.6 (IQR: 59.3-77.8) years and the median baseline VF MD was -3.5 (IQR: -8.3 to -1.3). In the univariable analysis, slower VF MD loss was associated with active PAI category (0.30 [95% CI: 0.01-0.58] dB/year vs. inactive PAI category; P =0.041) and higher PA amount (0.14 [95% CI: 0.01-0.27] dB/year per 1000 MET-minutes; P =0.036). Significant association with the rate of VF MD loss was not found for baseline VF MD ( P =0.263) and walking pace ( Ps >0.05). In the multivariable analysis including glaucoma severity and other covariates, slower VF MD loss was associated with higher PA amounts (0.15 [95% CI: 0.02-0.28] dB/year per 1000 MET-minutes; P =0.024).</p><p><strong>Conclusions: </strong>Higher PA amounts are an independent predictor of a slower rate of VF MD loss. Further research is needed to explore whether increased PA protects against glaucoma progression.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"499-506"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Association of Angle Closure Glaucoma in Retinitis Pigmentosa: A Meta-Analysis. 色素性视网膜炎闭角型青光眼的发病率及其相关性:一项荟萃分析。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-07-01 Epub Date: 2025-03-21 DOI: 10.1097/IJG.0000000000002570
Brendan K Tao, Madeleine Wong, Maheshver Shunmugam, Mahadev Bhalla, Jennifer Ling, Kulbir Gill, Steven Schendel, Kevin Gregory-Evans, Eduardo V Navajas
{"title":"Incidence and Association of Angle Closure Glaucoma in Retinitis Pigmentosa: A Meta-Analysis.","authors":"Brendan K Tao, Madeleine Wong, Maheshver Shunmugam, Mahadev Bhalla, Jennifer Ling, Kulbir Gill, Steven Schendel, Kevin Gregory-Evans, Eduardo V Navajas","doi":"10.1097/IJG.0000000000002570","DOIUrl":"10.1097/IJG.0000000000002570","url":null,"abstract":"<p><strong>Prcis: </strong>Low certainty evidence suggests elevated angle closure glaucoma incidence [1.30% 95% CI (0.71-2.36)] with retinitis pigmentosa than without [risk ratio: 2.01, 95% CI (1.59-2.53)]. RP patients may benefit from enhanced monitoring for glaucomatous complications.</p><p><strong>Purpose: </strong>To determine the literature-pooled rate and association of angle closure glaucoma (ACG) with retinitis pigmentosa (RP). ACG is a potentially sight-threatening cause of optic neuropathy. To date, several reports have documented the potential association between ACG and RP.</p><p><strong>Materials and methods: </strong>Cochrane Library, Embase, and Medline were searched to August 2024. We included all studies that reported the incidence of ACG among patients with RP, or the comparative risk of ACG among patients with or without RP. Two independent reviewers completed study screening, data extraction, and risk of bias assessment using the Cochrane risk of bias (ROB) in nonrandomized studies (exposure) tool. Non-pairwise and pairwise meta-analyses, using random effects and the Mantel-Haenszel method, were conducted to calculate the pooled rate of ACG in RP patients and to determine whether this risk differed significantly from patients without RP. Subgroup analysis excluded \"high\" ROB studies.</p><p><strong>Results: </strong>Eight observational studies (n=31,501 patients; 456 events) were identified, 3 of which were of comparative design. Of this pooled population, there were 29,363 patients with RP (238 events). Across all studies, the pooled incidence of ACG with RP was 1.30% [95% CI (0.71-2.36), I2 : 97%], although this heterogeneity resolved when subgrouped by studies with low ROB [1.59%, 95% CI (1.31-0.192), I2 : 0%]. In the comparative analysis, patients with RP had a significantly higher risk of developing ACG [RR: 2.02, 95% CI (1.61-2.55), I2 : 0%] compared with patients without RP. For either outcome, there was no significant evidence of publication bias, and the results remained consistent across subgroup and sensitivity analyses. Six of 8 studies were rated as having \"high\" ROB due to a lack of adjusted analyses.</p><p><strong>Conclusion: </strong>Low certainty evidence suggests that RP may confer an increased risk of ACG compared with patients without RP. The results of this study seem to support the view that more extensive clinical monitoring for ACG may be of benefit for patients with RP. Further studies controlling for individual patient-level confounding are needed.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"549-554"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Costs Associated with the Use of Disposable Gonioscopy Lenses and Tonometry Tips. 使用一次性角膜镜和眼压测量提示的相关费用。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-06-26 DOI: 10.1097/IJG.0000000000002601
Alexis Kassotis, Sean T Berkowitz, Shriji Patel, Emily Schehlein, Jeffrey M Liebmann, George A Cioffi, Alan L Robin, Aakriti Garg Shukla
{"title":"Costs Associated with the Use of Disposable Gonioscopy Lenses and Tonometry Tips.","authors":"Alexis Kassotis, Sean T Berkowitz, Shriji Patel, Emily Schehlein, Jeffrey M Liebmann, George A Cioffi, Alan L Robin, Aakriti Garg Shukla","doi":"10.1097/IJG.0000000000002601","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002601","url":null,"abstract":"<p><strong>Purpose: </strong>The authors performed a cost analysis comparing the use of disposable and reusable tonometry equipment and gonioscopy lenses.</p><p><strong>Methods: </strong>All adult patient (16 years old) visits in a one-year period were included. Scenario analysis was employed to calculate the cost of disposable (Goldmann applanation tonometry (GAT) tips, rebound tonometry tips, gonioscopy lenses) and reusable equipment (GAT tips and gonioscopy lenses) as well as sanitization over 2, 5, and 10 years at a single institution. To account for variability in scenario modeling, a sensitivity analysis was additionally performed. The main outcome measure was cost differences for disposable equipment compared to reusable equipment with sanitization.</p><p><strong>Results: </strong>The total volume included was 80,356 patient visits. Accounting for variable costs, the additional cost associated with disposable tonometry (GAT or rebound tonometry tips) instead of reusable GAT was $118,723 over 2 years and $603,924 over 10 years. Assuming a gonioscopy frequency of 3.2%, the additional cost associated with disposable gonioscopy lenses was $171,100 at 5 years and $361,237 at 10 years. At a gonioscopy frequency of 10%, the additional cost associated with disposable lenses was $1,208,096 without inflation at 10 years. Overall, the total additional cost associated with disposable tonometry tips and gonioscopy lenses over reusable versions of this equipment was $965,161 over 10 years at a single institution.</p><p><strong>Conclusion: </strong>A widespread transition from reusable to disposable tonometry and gonioscopy equipment was associated with an additional cost of $965,161 over a 10- year period at a single institution.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Lens Anterior and Posterior Capsular Bag Laxity with Clinical Characteristics in Primary Angle-Closure Disease. 原发性闭角症患者晶状体前后囊袋松弛与临床特征的关系。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-06-23 DOI: 10.1097/IJG.0000000000002607
Xue-Ting Pei, Shuo Zhang, Lin Deng, Xiao-Wei Yu, Feng Mei, Guo-Ping Qing, Zhi-Gang Fan
{"title":"Association of Lens Anterior and Posterior Capsular Bag Laxity with Clinical Characteristics in Primary Angle-Closure Disease.","authors":"Xue-Ting Pei, Shuo Zhang, Lin Deng, Xiao-Wei Yu, Feng Mei, Guo-Ping Qing, Zhi-Gang Fan","doi":"10.1097/IJG.0000000000002607","DOIUrl":"10.1097/IJG.0000000000002607","url":null,"abstract":"<p><strong>Prcis: </strong>The presence of anterior capsular laxity caused acute angle-closure glaucoma, and posterior capsular laxity alone was associated with a chronic progressive course, revealing new insight into the pathogenesis of primary angle closure disease.</p><p><strong>Purpose: </strong>This study investigates the association between anterior or posterior capsular bag laxity during cataract surgery and clinical characteristics in patients with primary angle-closure disease (PACD).</p><p><strong>Methods: </strong>This retrospective study included 137 patients (200 eyes) diagnosed with PACD and undergoing phacoemulsification cataract surgery. Patients were categorized into four groups based on the condition of the capsular bag: loose anterior capsular bag (LACB), loose posterior capsular bag (LPCB), loose anterior and posterior capsular bag (LAPCB), and stable capsular bag (SCB). We analyzed the association of capsular bag laxity with clinical characteristics using ANOVA and χ2.</p><p><strong>Results: </strong>Significant differences were observed among the groups in terms of gender, disease duration, anterior chamber depth (ACD), lens vault (LV), and lens Front R, while age, PACD classification, mean corneal power, axial length, and lens thickness showed no significant variation. The ACD was notably deeper in the LPCB and SCB groups. The LV was higher, and the lens Front R was smaller in the LACB and LAPCB groups. Lens Back R varied more in the LPCB group. Anterior capsular laxity, alone or combined with posterior capsular laxity, was more prevalent in cases of acute angle-closure glaucoma (ACG) (56.0%) compared to chronic ACG (19.4%). Posterior capsule laxity alone was more common in chronic ACG (45.2%) than in acute ACG (10.7%).</p><p><strong>Conclusion: </strong>The presence of anterior capsular laxity, with or without posterior capsular laxity, is associated with the development of acute ACG, whereas posterior capsular laxity alone is typically linked to the development of chronic ACG.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia. 伴有或不伴有轴性近视的青光眼24-2C中心视野损害与绒毛毛细血管下滴的关系。
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-06-20 DOI: 10.1097/IJG.0000000000002606
Anuwat Jiravarnsirikul, Akram Belghith, Jasmin Rezapour, Eleonora Micheletti, Takashi Nishida, Sasan Moghimi, Min Hee Suh, Jost B Jonas, Evan Walker, Mark Christopher, Massimo A Fazio, Robert N Weinreb, Linda M Zangwill
{"title":"Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia.","authors":"Anuwat Jiravarnsirikul, Akram Belghith, Jasmin Rezapour, Eleonora Micheletti, Takashi Nishida, Sasan Moghimi, Min Hee Suh, Jost B Jonas, Evan Walker, Mark Christopher, Massimo A Fazio, Robert N Weinreb, Linda M Zangwill","doi":"10.1097/IJG.0000000000002606","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002606","url":null,"abstract":"<p><strong>Prcis: </strong>Larger choriocapillaris microvasculature dropout area and wider angular circumference are significantly associated with 24-2C central visual field damage in primary open-angle glaucoma eyes with and without axial myopia.</p><p><strong>Purpose: </strong>To evaluate the relationship between a juxtapapillary choriocapillaris microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with or without axial myopia.</p><p><strong>Methods: </strong>This cross-sectional study included 125 patients with POAG or glaucoma suspects stratified into no axial myopia (axial length (AL) ≤24 mm; 46 eyes), mild axial myopia (24 mm< AL ≤26 mm; 81 eyes), and high axial myopia (AL >26 mm; 59 eyes). Presence, area, and angular circumference of juxtapapillary MvD were evaluated on OCT-A en-face choroidal images and B-scans. Perimetry was conducted using the 24-2C and 10-2 Humphrey program.</p><p><strong>Results: </strong>Mean 24-2C VF mean deviation was significantly worse in eyes with MvD compared to eyes without MvD across all groups (all P<0.042). Central VF defects detected in the 24-2C and 10-2 VF tests were significantly more prevalent among eyes with MvD (68.3% and 81.7%, respectively) compared to eyes without MvD (19.0% and 38.1%, respectively) (P <0.001) in the mild axial myopia group. In multivariable analysis, larger MvD area (P=0.014) and wider MvD angular circumference (P=0.006) were significantly associated with higher likelihood of the presence of 24-2C central VF damage in overall cohort.</p><p><strong>Conclusions: </strong>MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia. Choriocapillaris MvD assessment shows promise for identifying POAG patients with a higher risk of having central VF defects and may provide clinical insights into the pathogenesis of glaucoma in myopia.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Treatment-Naïve Patients with Primary Open-Angle Glaucoma: A Prospective Multicenter Phase IV Study. 0.002%异丙基奥米尼帕格眼液治疗Treatment-Naïve原发性开角型青光眼的有效性和安全性:一项前瞻性多中心IV期研究
IF 2 4区 医学
Journal of Glaucoma Pub Date : 2025-06-17 DOI: 10.1097/IJG.0000000000002605
Hyoung Won Bae, Eun Ji Lee, Jong Jin Jung, Ki Ho Park
{"title":"Effectiveness and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Treatment-Naïve Patients with Primary Open-Angle Glaucoma: A Prospective Multicenter Phase IV Study.","authors":"Hyoung Won Bae, Eun Ji Lee, Jong Jin Jung, Ki Ho Park","doi":"10.1097/IJG.0000000000002605","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002605","url":null,"abstract":"<p><strong>Prcis: </strong>Omidenepag isopropyl is a selective E-prostanoid subtype 2 (EP2) receptor agonist that lowers intraocular pressure. Omidenepag isopropyl 0.002% ophthalmic solution is effective and safe to use at first diagnosis of primary open-angle glaucoma.</p><p><strong>Purpose: </strong>To evaluate the effectiveness and safety of omidenepag isopropyl 0.002% ophthalmic solution in treatment-naïve patients at first diagnosis of primary open-angle glaucoma (POAG) in real-world clinical settings in Korea.</p><p><strong>Patients and methods: </strong>In a single-arm, multicenter, open-label, prospective, phase IV clinical trial, patients with newly-diagnosed POAG received omidenepag isopropyl 0.002% (one drop once daily) for 12 weeks. The primary endpoint was change from baseline in intraocular pressure (IOP) at week 12. Secondary endpoints included change from baseline in IOP at week 4; change from baseline in IOP at week 12 in a subgroup with normal tension glaucoma (NTG); occurrences, incidence rates and changes from baseline in safety-related indicators (macular edema, endothelial cell count, central corneal thickness, prostaglandin-associated peri-orbitopathy syndrome). Safety was assessed by the occurrence of adverse events (AEs).</p><p><strong>Results: </strong>The effectiveness analysis set comprised 37 patients and the safety analysis set 50 patients. Mean IOP decreased from 16.19 ± 2.65 mm Hg at baseline to 13.55 ± 2.46 mm Hg at week 12 (P < 0.0001), representing a 16% reduction. Mean reduction in IOP was 15% at week 4 (P < 0.0001); and 16% at week 12 (P < 0.0001) in the NTG subgroup (n=31). Aside from conjunctival injection, no notable changes were observed in safety-related evaluation indicators. The most common AEs were hyperemia (13 cases) and iridocyclitis (5 cases). No systemic AEs were reported.</p><p><strong>Conclusion: </strong>Omidenepag isopropyl 0.002% ophthalmic solution is suitable for first-line use at first diagnosis of POAG, including in patients with NTG.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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