Journal of Glaucoma最新文献

{"title":"Comparative Efficacy and Safety of Micropulse Versus Continuous-Wave Transscleral Cyclophotocoagulation in the Management of Refractory Glaucoma: A Prospective Cohort Study.","authors":"Shanshan Yang, Xiangyun Liu, Jiubing Xie, Chunmei Zhao","doi":"10.1097/IJG.0000000000002696","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002696","url":null,"abstract":"<p><strong>Prcis: </strong>Micropulse transscleral cyclophotocoagulation (MP-TSCPC) has gained considerable acceptance as a preferred cyclodestructive intervention for refractory glaucoma, offering significantly enhanced safety profiles through precisely controlled pulse energy delivery while maintaining equivalent therapeutic outcomes compared with traditional modalities.</p><p><strong>Objective: </strong>To compare the efficacy and safety profiles of MP-TSCPC versus continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) in patients with refractory glaucoma.</p><p><strong>Materials and methods: </strong>This prospective, randomized, single-blind study included 52 patients (52 eyes) with refractory glaucoma assigned to either MP-TSCPC or CW-TSCPC. Patients were followed for 18 months. Secondary outcomes included absolute IOP values, medication reduction, preservation of visual acuity, visual function parameters, quality of life, and complication rates. Success was defined as IOP between 6-21 mm Hg without medications (complete success), with medications (qualified success), or either (cumulative success). Patients were followed for 18 months.</p><p><strong>Results: </strong>At 18 months, 47 eyes completed follow-up (24 in MP-TSCPC and 23 in CW-TSCPC). The MP-TSCPC group (n=24) achieved a 34.43% IOP reduction from baseline, compared with 42.86% in the CW-TSCPC group (n=23), P=0.052. Complete success rates were 25.00% (6/24) for MP-TSCPC and 21.74% (5/23) for CW-TSCPC (P=0.999), while qualified success rates were 29.16% (7/24) and 39.13% (9/23), respectively (P=0.550). The cumulative success rates were 54.17% for MP-TSCPC and 60.87% for CW-TSCPC (P=0.706). The CW-TSCPC group experienced significantly higher rates of postoperative pain (56.52% vs. 20.83%, P=0.012) and prolonged inflammation (34.78% vs. 8.33%, P=0.039). Visual function parameters remained stable in both groups throughout the study period. Quality of life improved significantly in the MP-TSCPC group but not in the CW-TSCPC group, although between-group differences were not statistically significant.</p><p><strong>Conclusion: </strong>MP-TSCPC demonstrated comparable efficacy to CW-TSCPC in IOP reduction and success rates for refractory glaucoma management, while offering a significantly improved safety profile with less postoperative pain and inflammation. These findings suggest that MP-TSCPC may be considered as a preferred initial cyclodestructive option when balancing efficacy and safety, though larger studies are needed to confirm these findings.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":"35 5","pages":"317-325"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: \"Aqueous Angiography-Guided Bent Ab Interno Needle Goniectomy in High Versus Low Aqueous Humor Outflow Regions in Primary Open Angle Glaucoma\": A Pilot Randomized Controlled Trial.","authors":"Tanuj Dada, Nitika Beri","doi":"10.1097/IJG.0000000000002678","DOIUrl":"10.1097/IJG.0000000000002678","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e46"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macula Spatial Patterns and Their Association With Central Visual Field Progression in Glaucoma Using Artificial Intelligence.","authors":"Golnoush Mahmoudinezhad, Sasan Moghimi, Varun Pawar, Jiacheng Cheng, Evan Walker, Siavash Beheshtaein, Yu Xuan Yong, Soroosh Beheshtaein, Naimul A Alam, V S Raghu Parupudi, Leo Meller, Takashi Nishida, Jeffrey M Liebmann, Christopher A Girkin, Massimo A Fazio, Mark Christopher, Linda M Zangwill, Nuno Vasconcelos, Robert N Weinreb","doi":"10.1097/IJG.0000000000002706","DOIUrl":"10.1097/IJG.0000000000002706","url":null,"abstract":"<p><strong>Precis: </strong>Artificial intelligence-derived macular thinning patterns were associated with central visual field progression in glaucoma and outperformed global thickness metrics in predicting progression across disease severities.</p><p><strong>Purpose: </strong>To provide spatial patterns of ganglion cell complex thickness and assess their associations with central visual field progression in glaucoma.</p><p><strong>Methods: </strong>Macular patterns from the ganglion cell complex were determined using an artificial intelligence algorithm termed archetypal analysis (AA). The diagnostic accuracy of spatial patterns for detecting 10-2 central visual field progression in eyes with at least five 10-2 visual field tests was calculated and compared with the mean global ganglion cell complex thickness. Eyes with progression on either of 2 trend-based methods (significant MD slope less than -0.5 dB/y or clustered pointwise linear regression) were classified as \"progressors.\"</p><p><strong>Results: </strong>A total of 4031 macular scans of 1093 eyes (611 patients) were included, with a mean (SD) age of 67.8 (12.7) years. Eleven distinct spatial patterns were identified. While the macular vulnerable zone was preferentially affected in 4 patterns, most of the less vulnerable zones were preserved. The AA models at baseline achieved AUROC [0.73 (95% CI, 0.62-0.84)] and outperformed global ganglion cell complex thickness [0.55 (95% CI, 0.46-0.61), P =0.01] for predicting central VF progression in eyes with early disease at baseline. The AA models AUROC [0.70 (95% CI, 0.59-0.80)] also outperformed ganglion cell complex thickness [0.55 (95% CI, 0.48-0.60), P =0.02] for predicting central VF progression across all severities.</p><p><strong>Conclusions: </strong>Using unsupervised artificial intelligence, characteristic patterns of macular thinning were identified and associated with progression in the central visual field. Spatial macular pattern analysis may enhance individualized care and improve risk stratification for those at risk of central VF damage.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"273-282"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: \"Aqueous Angiography-Guided Bent Ab Interno Needle Goniectomy in High Versus Low Aqueous Humor Outflow Regions in Primary Open Angle Glaucoma\": A Pilot Randomized Controlled Trial.","authors":"Neelambika Kulkarni, Julie Pegu, Mazhar Khan, Suneeta Dubey","doi":"10.1097/IJG.0000000000002657","DOIUrl":"10.1097/IJG.0000000000002657","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e45-e46"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Efficacy After Viscogonioplasty in Primary Angle Closure Disease With Different Mechanisms.","authors":"Jin Wang, Yue Wang, Ye Zhang, Xin Tang, Dabo Wang, Ningli Wang, Dapeng Mou","doi":"10.1097/IJG.0000000000002631","DOIUrl":"10.1097/IJG.0000000000002631","url":null,"abstract":"<p><strong>Prcis: </strong>Nonpupillary block mechanisms are associated with larger postoperative peripheral anterior synechiae (PAS) extent at 1-year follow-up compared with pupillary block mechanisms in primary angle-closure disease (PACD).</p><p><strong>Purpose: </strong>To evaluate the impact of preoperative angle closure mechanisms on the surgical outcomes of phacoemulsification and intraocular lens implantation (PEI) combined with VGP in PACD patients with cataracts.</p><p><strong>Patients and methods: </strong>This prospective cohort study enrolled 56 patients (68 eyes) with PACD and cataracts. Participants were classified into pupillary block (PB) and nonpupillary block (Non-PB) groups based on the anatomic characteristics of angle closure shown in preoperative ultrasound biomicroscopy imaging. Primary outcomes included peripheral anterior synechiae (PAS) extent, intraocular pressure (IOP), and number of IOP-lowering medications over a 12-month follow-up period.</p><p><strong>Results: </strong>Both groups showed significant reductions in PAS extent at the end of surgery compared with the baseline. At 6 and 12 months postoperatively, the Non-PB group exhibited significantly larger PAS extent compared with the PB group ( P =0.025 and 0.017, respectively). Both groups demonstrated significant IOP reduction and decreased use of IOP-lowering medications postoperatively, with no significant differences between groups. The overall complete and qualified success rates at 12 months were 71.6% and 98.5%, respectively, with no significant difference between groups.</p><p><strong>Conclusions: </strong>Non-PB mechanisms are associated with larger postoperative PAS extent at 1-year follow-up compared with PB mechanisms, emphasizing the importance of comprehensive preoperative angle closure mechanisms assessment in predicting and potentially minimizing PAS progression for enhanced long-term surgical efficacy in PACD treatment.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"303-308"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Wipe-Out Phenomenon After Gonioscopy-Assisted Transluminal Trabeculotomy.","authors":"Bin Lin, Dong-Kan Li, Meng Xu, Peng Shi, Wei Liang","doi":"10.1097/IJG.0000000000002655","DOIUrl":"10.1097/IJG.0000000000002655","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e46-e48"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Year Efficacy of OMNI Canaloplasty With and Without Additional Hydrus Microstent During Cataract Surgery.","authors":"Madeline C Rocks, Jason Dossantos, Hoang-Viet Tran, Brandon Bonilla, Anna Dickinson, Luke Leidy, Jella An","doi":"10.1097/IJG.0000000000002722","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002722","url":null,"abstract":"<p><strong>Precis: </strong>After one year, OMNI canaloplasty with or without Hydrus Microstent achieved comparable surgical outcomes, reductions in IOP, and medication reduction.</p><p><strong>Purpose: </strong>This study compares the one-year effectiveness of performing a canaloplasty during concurrent cataract surgery (CS) with or without a microstent in patients with glaucoma.</p><p><strong>Methods: </strong>A retrospective analysis was performed on 66 eyes: 33 received OMNI canaloplasty and 33 received OMNI canaloplasty with additional Hydrus Microstent during CS. The mean number of ocular hypotensive medications and intraocular pressure (IOP) were assessed after one year. The primary outcome was surgical success, defined as attaining the target IOP without additional medications or procedures. Eyes were matched (1:1) based on demographics and disease characteristics. Statistical analysis included paired t-tests and regression modeling.</p><p><strong>Results: </strong>Mean IOP at one year was reduced by 18.0% in the canaloplasty alone group and by 12.8% in the canaloplasty with microstent group (P=0.445). Mean medications at one year were reduced by 47.8% in the canaloplasty alone group and by 60.0% in the canaloplasty with microstent group (P=0.554). Surgical success at one year was 75.8% for canaloplasty alone and 87.9% for canaloplasty with microstent (P=0.339). The total adverse event rate was 9.09% (n=6).</p><p><strong>Conclusion: </strong>Combining canaloplasty with a microstent did not yield statistically significant improvements in surgical success, IOP reduction, medication use, or safety outcomes at one year compared to standalone canaloplasty. This suggests that for patients undergoing CS with concurrent canaloplasty, the addition of a microstent may not confer substantial long-term clinical benefit. Small cohort size and differences in population between groups may also affect this outcome.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Retinopathy as a Risk Factor for Ocular Hypertension or Primary Open Angle Glaucoma in a United States-Based Cohort Study.","authors":"Kaersti L Rickels, Muhammad Z Chauhan, Osamah J Saeedi, Krishna S Kishor, Sami H Uwaydat, Sanjoy K Bhattacharya, Richard K Lee, Ahmed B Sallam, Abdelrahman M Elhusseiny","doi":"10.1097/IJG.0000000000002687","DOIUrl":"10.1097/IJG.0000000000002687","url":null,"abstract":"<p><strong>Purpose: </strong>Assess the association between diabetic retinopathy (DR) and the risk of ocular hypertension (OHT) or primary open-angle glaucoma (POAG) in patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM).</p><p><strong>Patients and methods: </strong>This retrospective cohort study utilized the TriNetX US Collaborative Network, including 166,471 patients with T1DM and 5,745,652 patients with T2DM, categorized by DR status, ages ≥ 18 years. International Classification of Diseases 10 th Revision (ICD-10) codes identified T1DM, T2DM, and DR. Propensity score matching (PSM) adjusted for age, sex, race/ethnicity, body mass index (BMI), relevant medical history, blood markers, glycemic-controlling medications, intravitreal injections, and ophthalmic service visits. The primary outcome was the development of coded OHT or POAG over 10 years and lifetime, expressed as adjusted hazard ratios (aHR).</p><p><strong>Results: </strong>DM patients with DR exhibited a significantly heightened risk of developing coded OHT or POAG. T1DM patients showed a 4.966-fold increased lifetime risk of developing OHT (95% CI: 2.178-11.325) and 4.262-fold increased lifetime risk of developing POAG (95% CI: 1.435-13.255), while T2DM patients had a 2.651-fold increased lifetime risk of developing OHT (95% CI: 2.412-2.915) and 2.62-fold POAG (95% CI: 2.37-2.89). This risk remained high in our subanalysis, and patients with PDR were at a higher risk compared with those with any stage of NPDR. Sensitivity analyses confirmed these findings across various demographic and clinical variables.</p><p><strong>Conclusions: </strong>DR is significantly associated with OHT and POAG, particularly in T1DM. These findings emphasize the need for vigilant screening and comprehensive management of diabetic patients with coexisting DR.</p><p><strong>Precis: </strong>Diabetic retinopathy in diabetic patients significantly increases the risk of ocular hypertension and primary open-angle glaucoma, with the highest risk in type 1 diabetics, as high as 5-fold compared with those without diabetic retinopathy.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"240-248"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Disagreement Between Gonioscopy and Ultrasound Biomicroscopy in Eyes With Occludable Angle.","authors":"Naomi Mataki, Koichi Mishima, Makoto Araie, Aiko Iwase, Hiroshi Murata, Shinichiro Otani, Hiroshi Sakai, Atsuo Tomidokoro, Makoto Aihara, Kazunori Miyata","doi":"10.1097/IJG.0000000000002661","DOIUrl":"10.1097/IJG.0000000000002661","url":null,"abstract":"<p><strong>Précis: </strong>Disagreement in the angle closure assessment was seen between gonioscopy and ultrasound biomicroscopy (UBM), to which not only anterior, but also posterior chamber configuration UBM parameters were significantly related.</p><p><strong>Purpose: </strong>To study diagnostic disagreement and its relating factors in assessing the angle classified as \"occludable\" by gonioscopy and by ultrasound biomicroscopy in eyes with van Herick grade 2 or less (eyes ≤VH2).</p><p><strong>Methods: </strong>In 93 eyes ≤VH2 (93 subjects) with no peripheral anterior synechia, gonioscopy, UBM, and anterior segment-optical coherence tomography (AS-OCT) were performed in dark, the number of eyes with ≥2 ITC-positive quadrants (contact ≥180 degrees) based on UBM (eyes ≥2-ITC UBM Quad) and that with the angle classified as occludable by gonioscopy (eyes≥2-ITC GONIO Quad) were determined, and the number of eyes not meeting these criteria, that is, eyes <2-ITC UBM Quad (contact <180 degrees) and eyes <2-ITC GONIO Quad, was also determined. Multivariable logistic regression analysis was performed with systemic, ocular, UBM, and AS-OCT parameters as explanatory variables.</p><p><strong>Results: </strong>Out of the 93 eyes, 49 were diagnosed as eyes ≥2-ITC GONIO Quad based on gonioscopy, 63 as eyes ≥2-ITC UBM Quad on UBM, 37 as both eyes ≥2-ITC GONIO Quad and eyes ≥2-ITC UBM Quad (agreement between gonioscopy and UBM), 12 as eyes ≥2-ITC GONIO Quad base on gonioscopy, but as eyes <2-ITC UBM Quad on UBM (UBM under-diagnosing), and 26 as eyes <2-ITC GONIO Quad based on gonioscopy, but as eyes ≥2-ITC UBM Quad on UBM (UBM over-diagnosing), respectively (McNemar test, P =0.0388). Longer axial length ( P =0.0002), deeper anterior chamber depth ( P =0.0121), greater angle-opening distance at 500 μm ( P =0.0159), and smaller iris convexity ( P =0.0031) were related to UBM over-diagnosing, while a greater angle-opening distance at 500 μm ( P =0.0046) and smaller trabecular ciliary angle ( P =0.0158) to UBM under-diagnosing.</p><p><strong>Conclusion: </strong>Both anterior and posterior chamber configuration parameters determined based on UBM were significantly related to disagreement between gonioscopy and UBM in assessing the appositional angle closure.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"218-225"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective One-Year Outcomes of Preserflo MicroShunt Implantation in Glaucoma Following Keratoplasty.","authors":"Bartłomiej Bolek, Adam Wylęgała, Edward Wylęgała","doi":"10.1097/IJG.0000000000002691","DOIUrl":"10.1097/IJG.0000000000002691","url":null,"abstract":"<p><strong>Précis: </strong>This study evaluates the efficacy and safety of Preserflo MicroShunt implantation in secondary glaucoma following corneal transplantation over a consecutive 1-year follow-up period, demonstrating high success, significant IOP reduction, and no observed graft decompensation.</p><p><strong>Purpose: </strong>This study aims to assess the efficacy and safety of Preserflo MicroShunt (PMS) implantation in patients with secondary glaucoma following keratoplasty over a 1-year follow-up.</p><p><strong>Methods: </strong>In this prospective, single-center study, 19 patients (19 eyes) diagnosed with secondary glaucoma following corneal graft surgery were included for PMS implantation. The study cohort comprised 17 eyes after penetrating keratoplasty and 2 after deep anterior lamellar keratoplasty. The primary outcome measures were intraocular pressure (IOP) reduction, success rates, glaucoma medication use, endothelial cell density (ECD), and visual acuity after the procedure. An IOP reduction of 20% compared with the baseline value without reintervention was considered a successful treatment. Complete success was defined as discontinuation of antiglaucoma medications. Secondary outcome measures included intraoperative and postoperative complications. Measurements were performed preoperatively and at 1 day, 1 week, 1, 3, 6, and 12 months postoperatively.</p><p><strong>Results: </strong>The reduction in IOP was statistically significant at follow-up visits compared with baseline, with a mean decrease of 57.8% at the final follow-up. Similarly, the number of antiglaucoma medications was significantly reduced at follow-up visits relative to baseline. The qualified success rate was 84.2% and the complete success rate was 63.2%. There were no statistically significant differences in visual acuity or endothelial cell density (ECD) compared with preoperative values.</p><p><strong>Conclusion: </strong>Preserflo MicroShunt implantation appears to be an effective and well-tolerated method of reducing intraocular pressure in patients with secondary glaucoma following keratoplasty. Long-term follow-up in a larger patient cohort is needed to confirm these results.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"199-206"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}