Journal of Glaucoma最新文献

{"title":"Relationship of 24-2C Central Visual Field Damage to Juxtapapillary Choriocapillaris Dropout in Glaucoma Eyes With or Without Axial Myopia.","authors":"Anuwat Jiravarnsirikul, Akram Belghith, Jasmin Rezapour, Eleonora Micheletti, Takashi Nishida, Sasan Moghimi, Min Hee Suh, Jost B Jonas, Evan Walker, Mark Christopher, Massimo A Fazio, Robert N Weinreb, Linda M Zangwill","doi":"10.1097/IJG.0000000000002606","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002606","url":null,"abstract":"<p><strong>Prcis: </strong>Larger choriocapillaris microvasculature dropout area and wider angular circumference are significantly associated with 24-2C central visual field damage in primary open-angle glaucoma eyes with and without axial myopia.</p><p><strong>Purpose: </strong>To evaluate the relationship between a juxtapapillary choriocapillaris microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with or without axial myopia.</p><p><strong>Methods: </strong>This cross-sectional study included 125 patients with POAG or glaucoma suspects stratified into no axial myopia (axial length (AL) ≤24 mm; 46 eyes), mild axial myopia (24 mm< AL ≤26 mm; 81 eyes), and high axial myopia (AL >26 mm; 59 eyes). Presence, area, and angular circumference of juxtapapillary MvD were evaluated on OCT-A en-face choroidal images and B-scans. Perimetry was conducted using the 24-2C and 10-2 Humphrey program.</p><p><strong>Results: </strong>Mean 24-2C VF mean deviation was significantly worse in eyes with MvD compared to eyes without MvD across all groups (all P<0.042). Central VF defects detected in the 24-2C and 10-2 VF tests were significantly more prevalent among eyes with MvD (68.3% and 81.7%, respectively) compared to eyes without MvD (19.0% and 38.1%, respectively) (P <0.001) in the mild axial myopia group. In multivariable analysis, larger MvD area (P=0.014) and wider MvD angular circumference (P=0.006) were significantly associated with higher likelihood of the presence of 24-2C central VF damage in overall cohort.</p><p><strong>Conclusions: </strong>MvD area and angular circumference are significantly associated with central VF damage detected by VF 24-2C in POAG eyes with and without axial myopia. Choriocapillaris MvD assessment shows promise for identifying POAG patients with a higher risk of having central VF defects and may provide clinical insights into the pathogenesis of glaucoma in myopia.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Omidenepag Isopropyl 0.002% Ophthalmic Solution in Treatment-Naïve Patients with Primary Open-Angle Glaucoma: A Prospective Multicenter Phase IV Study.","authors":"Hyoung Won Bae, Eun Ji Lee, Jong Jin Jung, Ki Ho Park","doi":"10.1097/IJG.0000000000002605","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002605","url":null,"abstract":"<p><strong>Prcis: </strong>Omidenepag isopropyl is a selective E-prostanoid subtype 2 (EP2) receptor agonist that lowers intraocular pressure. Omidenepag isopropyl 0.002% ophthalmic solution is effective and safe to use at first diagnosis of primary open-angle glaucoma.</p><p><strong>Purpose: </strong>To evaluate the effectiveness and safety of omidenepag isopropyl 0.002% ophthalmic solution in treatment-naïve patients at first diagnosis of primary open-angle glaucoma (POAG) in real-world clinical settings in Korea.</p><p><strong>Patients and methods: </strong>In a single-arm, multicenter, open-label, prospective, phase IV clinical trial, patients with newly-diagnosed POAG received omidenepag isopropyl 0.002% (one drop once daily) for 12 weeks. The primary endpoint was change from baseline in intraocular pressure (IOP) at week 12. Secondary endpoints included change from baseline in IOP at week 4; change from baseline in IOP at week 12 in a subgroup with normal tension glaucoma (NTG); occurrences, incidence rates and changes from baseline in safety-related indicators (macular edema, endothelial cell count, central corneal thickness, prostaglandin-associated peri-orbitopathy syndrome). Safety was assessed by the occurrence of adverse events (AEs).</p><p><strong>Results: </strong>The effectiveness analysis set comprised 37 patients and the safety analysis set 50 patients. Mean IOP decreased from 16.19 ± 2.65 mm Hg at baseline to 13.55 ± 2.46 mm Hg at week 12 (P < 0.0001), representing a 16% reduction. Mean reduction in IOP was 15% at week 4 (P < 0.0001); and 16% at week 12 (P < 0.0001) in the NTG subgroup (n=31). Aside from conjunctival injection, no notable changes were observed in safety-related evaluation indicators. The most common AEs were hyperemia (13 cases) and iridocyclitis (5 cases). No systemic AEs were reported.</p><p><strong>Conclusion: </strong>Omidenepag isopropyl 0.002% ophthalmic solution is suitable for first-line use at first diagnosis of POAG, including in patients with NTG.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wipe-out Phenomenon after Gonioscopy-Assisted Transluminal Trabeculotomy.","authors":"Enver Mirza, Gunsu Deniz Mirza, Mehmet Adam, Mehmet Okka","doi":"10.1097/IJG.0000000000002603","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002603","url":null,"abstract":"<p><strong>Purpose: </strong>To report the findings of a rare advanced pseudoexfoliation glaucoma patient with wipe-out phenomenon after gonioscopy-assisted transluminal trabeculotomy (GATT).</p><p><strong>Methods: </strong>A 360-degree uneventful GATT was performed on a 71-year-old male patient with a history of uncontrolled diabetes mellitus. Sudden vision loss occurred and cystoid macular edema (CME) were detected in the early postoperative period. The CME regressed completely over 6 months but vision loss was irreversible.</p><p><strong>Results: </strong>At the preoperative visit, the best corrected visual acuity (BCVA) was 20/70, and intraocular pressure (IOP) was 36 mmHg with maximum topical antiglaucoma medications (AGM) in his right eye. At the postoperative first month visit, BCVA was hand motion and IOP was 14.5 mmHg with topical AGM. Additionally, CME was detected. Topical non-steroidal anti-inflammatory drug and oral carbonic anhydrase inhibitor were started to reduce CME. Since CME did not regress, three doses of intravitreal anti-VEGF injections were administered at one-month intervals. At the postoperative sixth month visit, BCVA was still hand motion and IOP was 11.1 mmHg with topical AGM. The CME was regressed completely but BCVA did not improve.</p><p><strong>Conclusions: </strong>The sudden, unexplained, and irreversible vision loss attributed to wipe-out phenomenon following GATT, should be taken into consideration when offering this procedure to patients with advanced glaucoma.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Assessment of Aqueous Humor Outflow by Aqueous Angiography in Primary Open Angle Glaucoma.","authors":"Nitika Beri, Anuja Patil, Akshita Sharma, Aafreen Bari, Namrata Sharma, Tanuj Dada","doi":"10.1097/IJG.0000000000002602","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002602","url":null,"abstract":"<p><strong>Prcis: </strong>Evaluation of aqueous humor outflow (AHO) pathways shows a segmental pattern with the highest outflow in the nasal quadrant and least in the temporal quadrant in patients of primary open angle glaucoma (POAG).</p><p><strong>Aim: </strong>To quantitatively evaluate circumferential peri-limbal aqueous humor outflow (AHO) pathways in patients of primary open angle glaucoma (POAG) using aqueous angiography (AA).</p><p><strong>Methods: </strong>A cross-sectional, observational, single centre study recruited patients between 45-80 years with POAG, controlled on antiglaucoma medications along with visually significant age-related cataract planned for phacoemulsification surgery. AA was performed using 0.1% indocyanine green (ICG) dye injected into the anterior chamber, just prior to the capsulorrhexis step. Images of 30 eyes of 30 patients were analyzed at 60 seconds from the injection of ICG dye for angiographic signal intensity (ASI) in four quadrants (90° each), with each quadrant further divided into two sectors of 45° each (total eight sectors), circumferentially along the limbus. ASI was assessed by estimating the mean gray value using Image J software and compared between quadrants, sectors, severity of POAG, males versus females, and right versus left eyes. Further, calculating the normalized flow for each of the quadrants and sectors for every image, a division into high-flow(HF), intermediate-flow(IF) and low-flow(LF) regions was done. The correlation and relation of ASI with age and severity of POAG were also assessed using appropriate statistical tests.</p><p><strong>Results: </strong>The mean age of the patients was 60.5±6.32 years (range 48 - 71 yrs), with 20 males and 10 females. Out of the 30 eyes recruited, mild/moderate POAG was seen in 13 patients, and severe POAG was present in 17 patients. Non-uniform, segmental AHO pathways with the highest ASI were seen in the nasal quadrant [52.41(42.78-57.67)] followed by superior [43.34(34.75-53.48)], inferior [28.73(21.42-35.85)] and temporal quadrant [27.71(21.23-34.87)] (P=<0.0001). The highest percentage of HF, IF and LF regions were documented in nasal (83.33%), superior (36.67%) and temporal (73.33%) quadrants, respectively. A negative correlation of ASI with age (using Spearman rank correlation coefficient) was seen (r=-0.470, P=0.009) with linear regression of β=-1.354, P=0.008. Additionally, ASI between mild/moderate versus severe POAG, males versus females and right versus left eyes were not statistically significant (P>0.05).</p><p><strong>Conclusion: </strong>Segmental AHO pathways were noted along the limbus with maximum ASI in the nasal quadrant (HF region) followed by superior (IF region), inferior and temporal (LF region) quadrants in patients of POAG. Patterns were similar in mild/moderate versus severe POAG, males versus females and right versus left eyes. With increasing age, a decrease in ASI was documented.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes of 180-degree Gonioscopy-Assisted Transluminal Trabeculotomy: Comparison of Nasal Versus Temporal Incisions.","authors":"Yo Okada, Hiroki Mieno, Morio Ueno, Kengo Yoshi, Kazuhiko Mori, Chie Sotozono","doi":"10.1097/IJG.0000000000002604","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002604","url":null,"abstract":"<p><strong>Prcis: </strong>Performing 180-degree gonioscopy-assisted transluminal trabeculotomy for primary open-angle glaucoma and pseudoexfoliation glaucoma patients can be expected to be equally effective with either a nasal or temporal incision at 12-months postoperative.</p><p><strong>Purpose: </strong>Anatomically, there are more collector channels on the nasal-side (NS) than on the temporal-side (TS) of the eye. This study aimed to clarify the differences in efficacy between NS and TS incisions for lowering intraocular pressure (IOP) in glaucoma patients who underwent 180-degree gonioscopy-assisted transluminal trabeculotomy (hemi-GATT).</p><p><strong>Patients and methods: </strong>This multicenter retrospective cohort study was conducted on 423 consecutive eyes with primary open-angle glaucoma and pseudoexfoliation glaucoma that underwent hemi-GATT between April 2016 and March 2022 at Kyoto Prefectural University of Medicine Hospital, Kyoto, Japan and three affiliated medical facilities. Only the patients who had the same type of glaucoma in both eyes and underwent the same surgical procedure were included. Hemi-GATT was performed with an NS incision in the right eye (NS group) and a TS incision in the left eye (TS group). IOP and medication scores were retrospectively investigated.</p><p><strong>Results: </strong>This study involved 100 eyes of 50 patients. Median IOP (NS group/TS group) (mmHg) at before surgery and at 1-day and 1-, 3-, 6-, and 12-months postoperative was 17.0 (interquartile range, 15.0-19.8)/16.0 (15.0-19.8), 11.0 (9.0-12.8)/11.0 (10.0-13.0), 14.0 (11.8-16.0)/13.0 (11.8-15.3), 13.0 (11.0-14.0)/11.0 (11.0-13.0), 13.5 (11.3-15.0)/12.5 (11.3-14.0), and 13.0 (11.0-15.0)/12.0 (11.0-14.0), respectively, thus showing a significant postoperative decrease of IOP. The median medication scores (NS group/TS group) were 3.0 (interquartile range, 2.0-4.0)/3.0 (2.0-4.0) at preoperative and 0.0 (0.0-2.0)/0.0 (0.0-1.0) at 12-months postoperative, thus showing a significant postoperative reduction. No significant differences were observed between the NS and TS groups at any point.</p><p><strong>Conclusions: </strong>Our findings revealed no significant difference in efficacy between NS and TS incisions for lowering IOP in glaucoma patients who underwent hemi-GATT.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Central Corneal Thickness and Inter-Eye Disease Severity in Primary Angle Closure Glaucoma.","authors":"Shimna C Prasad, Ruthra M Umapathi, Tin Nwe Hlaing, Eray Atalay, Michael J Girard, Tin Aung, Monisha E Nongpiur","doi":"10.1097/IJG.0000000000002553","DOIUrl":"10.1097/IJG.0000000000002553","url":null,"abstract":"<p><strong>Prcis: </strong>Interocular comparison of primary angle closure glaucoma subjects with asymmetrical and symmetrical visual field loss, revealed significantly thinner central corneal thickness and higher presenting intraocular pressure in the worse eye of the asymmetrical group.</p><p><strong>Purpose: </strong>To compare the interocular clinical and biometric parameters of primary angle closure glaucoma (PACG) with asymmetrical and symmetrical visual-field loss at presentation.</p><p><strong>Patient and methods: </strong>A retrospective study in which the following clinical data were extracted: presenting intraocular pressure (IOP), gonioscopy, visual-field mean deviation (MD), central corneal thickness (CCT), anterior chamber depth (ACD), and axial length (AL). Asymmetrical PACG was defined as the inter-eye visual-field MD difference >6 dB, symmetrical PACG <3 dB, and those with inter-eye differences between 3 and 6 dB were excluded. Linear mixed effects model was used to adjust for the interdependence of the right and left eyes.</p><p><strong>Results: </strong>Of 243 PACG subjects, 122 (50.3%) presented with asymmetrical, and 69 (28.4%) with symmetrical disease. The worse eyes in subjects with asymmetrical PACG had significantly higher presenting IOP ( P <0.001), narrower angles ( P <0.001), more myopic refraction ( P <0.001), and thinner CCT (529.2±36.1 vs. 535.8±38.5 μm; P <0.001) compared with the fellow eyes; but no inter-eye differences were observed for AL ( P =0.93) and ACD ( P =0.53). In symmetric PACG, no significant inter-eye differences were observed for CCT (532.3±33.1 vs. 533.1±34.6 μm, P =0.67), AL ( P =0.85) and ACD ( P =0.18), but the relatively worse eye had higher presenting IOP ( P =0.003). In the stepwise multiple linear regression analysis in the asymmetrical group, CCT was the only significant variable ( P =0.006), explaining 12% of the variability of the visual-field MD of the worse eye.</p><p><strong>Conclusions: </strong>In asymmetrical PACG, worse eyes have thinner CCT and higher presenting IOP. Difference in CCT could either be inherent or acquired, and more tests would be needed to tease that out.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"462-467"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of Self-Monitoring of Intraocular Pressure With iCare Home2 Rebound Tonometry.","authors":"Dario Romano, Giovanni Montesano, Amir A Aminoleslami, Benedetta Colizzi, Luca M Rossetti","doi":"10.1097/IJG.0000000000002560","DOIUrl":"10.1097/IJG.0000000000002560","url":null,"abstract":"<p><strong>Prcis: </strong>Using iCare Home2 (iCare, Finland) rebound tonometry, self-measurement of intraocular pressure has demonstrated good reliability and ease of use.</p><p><strong>Purpose: </strong>To investigate the reliability and repeatability of self-measured intraocular pressure (IOP) with rebound tonometry using iCare Home2.</p><p><strong>Patients and methods: </strong>One hundred four patients out of 110 consecutive patients were recruited for this observational cross-sectional study. One randomly selected eye from each patient underwent 6 consecutive IOP measurements with Goldmann applanation tonometry (GAT), iCare IC200, and iCare Home2. Every eye was tested twice with each device, in random order, by an ophthalmologist for GAT and IC200, and by the patient itself for Home2. In addition, central corneal thickness (CCT) has been collected. The reliability of Home2 has been tested by calculating limits of agreement (LoA) between self-measured and physician-measured IOP, using the Bland-Altman analysis. The repeatability of each device has been tested by calculating the limits of repeatability (LoR) with the same method. Pearson correlation coefficient was used to determine the correlation between differences in IOP measurements and CCT.</p><p><strong>Results: </strong>The mean difference between GAT and iCare Home2 was -0.28±1.57 mmHg ( P =0.070), 95%-LoA: (-3.36 to 2.79 mmHg). The mean difference between IC200 and iCare Home2 was 0.92±1.48 mmHg ( P <0.0001), 95%-LoA (-1.98 to 3.82 mmHg). The mean difference between the first and second measurements with GAT, iCare IC200, and iCare Home2 measurements was 0.21±0.98 mmHg ( P =0.03), -0.02±1.11 mmHg ( P =0.88) and -0.23±1.04 mmHg ( P =0.05).</p><p><strong>Conclusions: </strong>Self-measured IOP with rebound tonometry showed good reliability and repeatability when compared with physician-measured IOP with both standard GAT and rebound tonometry.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"447-454"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Year Outcomes of Gonio Scratch as a Minimally Invasive Glaucoma Surgery With Cataract Removal.","authors":"Kana Tokumo, Mitsunobu Yokoyama, Taro Baba, Naoki Okada, Ayaka Edo, Kaori Komatsu, Hideaki Okumichi, Hideki Mochizuki, Teruyuki Miyoshi, Yoshiaki Kiuchi, Kazuyuki Hirooka","doi":"10.1097/IJG.0000000000002563","DOIUrl":"10.1097/IJG.0000000000002563","url":null,"abstract":"<p><strong>Prcis: </strong>This study evaluated the 1-year efficacy and safety of a novel minimally invasive glaucoma surgery, gonio scratch, in reducing intraocular pressure of eyes with open angle glaucoma and cataracts.</p><p><strong>Purpose: </strong>To evaluate the 1-year efficacy and safety of phacoemulsification cataract extraction combined with gonio scratch (GS-Phaco), a novel minimally invasive glaucoma surgery, in patients with open angle glaucoma and cataracts.</p><p><strong>Patients and methods: </strong>This prospective multicenter clinical trial was conducted at Hiroshima University, Yokoyama Retina Clinic, Kusatsu Eye Clinic, and Miyoshi Eye Clinic in Japan. The primary outcome measure was the rate of intraocular pressure (IOP) control. Failure was defined as an IOP of >18 mm Hg or >14 mm Hg, a <20% reduction from baseline IOP on 2 consecutive follow-up visits after 3 months, the need for additional glaucoma surgery, or loss of light perception. Kaplan-Meier analysis was used to assess surgical success rates.</p><p><strong>Results: </strong>Forty-seven eyes of 47 patients who underwent GS-Phaco surgery were included in the analysis. None of the patients had undergone prior ocular surgery. The median baseline IOP was 17 mm Hg. At 12 months postoperatively, there was a significant reduction in IOP to a median of 12 mm Hg ( P <0.01). The number of glaucoma medications also decreased significantly, from a median of 2 to 1 ( P <0.01). The surgical success rate at 12 months was 80.9%. The only complication observed was transient elevation of IOP in 2 (4.3%) eyes. No patients developed anterior chamber hemorrhage or hyphema with niveau formation.</p><p><strong>Conclusion: </strong>GS-Phaco achieved sustained IOP reduction and a decrease in medication use at 12 months postoperatively in patients with open angle glaucoma and cataracts.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"468-475"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydipsia-Induced Acute Angle Closure Crisis.","authors":"Akash Maheshwari, Noor Laylani, Pamela Davila Siliezar, Andrew G Lee","doi":"10.1097/IJG.0000000000002546","DOIUrl":"10.1097/IJG.0000000000002546","url":null,"abstract":"<p><p>We present a case of acute angle closure crisis (AACC) precipitated by primary transient psychogenic polydipsia; we believe that our case is the first of its kind to be reported. A 74-year-old male presented to the emergency department with altered mental status due to acute-onset hyponatremia. Six days after admission, the patient noticed a painful loss of vision in his right eye and an ipsilateral headache lasting 10-15 minutes. Upon follow-up with his primary care physician several days later, a fixed, dilated right pupil was noted. On ophthalmologic evaluation in the ER the next day, the patient was found to have markedly elevated intraocular pressure (IOP) at 47 mm Hg in the right eye. He started topical brimonidine, dorzolamide 2%/timolol 0.5%, and latanoprost, and underwent phacoemulsification with placement of a posterior chamber intraocular lens (PCIOL) in the right eye. Several mechanisms of polydipsia-induced AACC are proposed, including choroidal expansion, increased sympathetic α-adrenergic tone, or differences in osmotic potential forces.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e26-e27"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Capacity and Correlation of Optic Nerve Colorimetry With Structural Parameters in Primary Open Angle Glaucoma.","authors":"Liseth Salazar-Quiñones, Yadhira Pérez-Quiñones, Haizea Etxabe-Ávila, José Ignacio Fernández-Vigo, Carmen Méndez-Hernández, Julián García-Feijóo","doi":"10.1097/IJG.0000000000002542","DOIUrl":"10.1097/IJG.0000000000002542","url":null,"abstract":"<p><strong>Prcis: </strong>The discriminant function of glaucoma, obtained by the Laguna ONhE colorimetric program, significantly correlates with the BMO-MRW. Furthermore, the diagnostic capacity was inferior to other structural tests in open angle glaucoma (POAG) patients.</p><p><strong>Purpose: </strong>To evaluate the diagnostic capability for glaucoma and the correlation between peripapillary and macular parameters using spectral domain optical coherence tomography (SD-OCT) and optic nerve head hemoglobin (OHN Hb) levels assessed by the Laguna ONhE software using colorimetric analysis.</p><p><strong>Methods: </strong>This cross-sectional study included 112 eyes from 112 primary POAG patients and 112 eyes from 112 healthy controls. The peripapillary analysis included standard peripapillary retinal nerve fiber layer (pRNFL), Bruch's membrane opening-minimum ring width (BMO-MRW), and peripapillary RNFL thickness measured with the Glaucoma Module Premium Edition program (RNFLT). The macular analysis assessed the ganglion cell layer (GCL), inner plexiform layer (IPL), macular RNFL (mRNFL), total retina, ganglion cell complex (GCC), and the GCL-IPL complex. The Laguna ONhE program evaluated ONH Hb levels and the glaucoma discriminant function (GDF). Pearson correlation was used to analyze the relationships between variables, and the area under the curve (AUC) was calculated.</p><p><strong>Results: </strong>Significant differences in AUC were found between GDF (0.80) and RNFLT global (G) (0.91), BMO-MRW G (0.89), and outer-temporal GCL (0.88). BMO-MRW showed the strongest correlation with the Laguna ONhE parameters ( r from 0.271 to 0.682). In addition, a significant correlation was observed between the temporal-inferior sector of ONH Hb and the inferior macular sector ( r =0.40-0.56 for GCL-IPL) ( P <0.05 for all).</p><p><strong>Conclusions: </strong>GDF demonstrated lower diagnostic capacity compared with other structural tests. BMO-MRW showed the strongest correlation with the Laguna ONhE parameters, and a significant relationship was identified between the temporal-inferior sector ONH Hb and the inferior macular region.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"484-493"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}