Journal of global antimicrobial resistance最新文献

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Transcriptomic analysis of induced resistance to polymyxin in carbapenem-resistant Enterobacter cloacae complex isolate carrying mcr-9 携带 mcr-9 的耐碳青霉烯类肠杆菌对多粘菌素的诱导抗性转录组分析。
IF 4.6 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-06-01 DOI: 10.1016/j.jgar.2024.04.006
Jiming Wu , Longjin Liu , Jianmin Wang , Ying Wang , Xinhui Li , Xiaoyu Wang , Shan Jiang , Wengang Li , Jisheng Zhang , Xiaoli Zhang
{"title":"Transcriptomic analysis of induced resistance to polymyxin in carbapenem-resistant Enterobacter cloacae complex isolate carrying mcr-9","authors":"Jiming Wu ,&nbsp;Longjin Liu ,&nbsp;Jianmin Wang ,&nbsp;Ying Wang ,&nbsp;Xinhui Li ,&nbsp;Xiaoyu Wang ,&nbsp;Shan Jiang ,&nbsp;Wengang Li ,&nbsp;Jisheng Zhang ,&nbsp;Xiaoli Zhang","doi":"10.1016/j.jgar.2024.04.006","DOIUrl":"10.1016/j.jgar.2024.04.006","url":null,"abstract":"<div><h3>Objectives</h3><p>Polymyxins are currently the last-resort treatment against multi-drug resistant Gram-negative bacterial infections, but plasmid-mediated mobile polymyxin resistance genes (<em>mcr</em>) threaten its efficacy, especially in carbapenem-resistant <em>Enterobacter cloacae</em> complex (CRECC). The objective of this study was to provide insights into the mechanism of polymyxin-induced bacterial resistance and the effect of overexpression of <em>mcr-9</em>.</p></div><div><h3>Methods</h3><p>The clinical strain CRECC414 carrying the <em>mcr-9</em> gene was treated with a gradient concentration of polymyxin. Subsequently, the broth microdilution was used to determine the minimum inhibitory concentration (MIC) and RT-qPCR was utilized to assess <em>mcr-9</em> expression. Transcriptome sequencing and whole genome sequencing (WGS) was utilized to identify alterations in strains resulting from increased polymyxin resistance, and significant transcriptomic differences were analysed alongside a comprehensive examination of metabolic networks at the genomic level.</p></div><div><h3>Results</h3><p>Polymyxin treatment induced the upregulation of <em>mcr-9</em> expression and significantly elevated the MIC of the strain. Furthermore, the WGS and transcriptomic results revealed a remarkable up-regulation of <em>arnBCADTEF</em> gene cassette, indicating that the Arn/PhoPQ system-mediated L-Ara4N modification is the preferred mechanism for achieving high levels of resistance. Additionally, significant alterations in bacterial gene expression were observed with regards to multidrug efflux pumps, oxidative stress and repair mechanisms, cell membrane biosynthesis, as well as carbohydrate metabolic pathways.</p></div><div><h3>Conclusion</h3><p>Polymyxin greatly disrupts the transcription of vital cellular pathways. A complete PhoPQ two-component system is a prerequisite for polymyxin resistance of <em>Enterobacter cloacae</em>, even though <em>mcr-9</em> is highly expressed. These findings provide novel and important information for further investigation of polymyxin resistance of CRECC.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"37 ","pages":"Pages 225-232"},"PeriodicalIF":4.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524000791/pdfft?md5=dffa1c5a554d153cdf5659432b53eb4d&pid=1-s2.0-S2213716524000791-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Society of Antimicrobial Chemotherapy (ISAC) News and Information Page 国际抗菌化疗学会 (ISAC) 新闻和信息页面
IF 4.6 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-06-01 DOI: 10.1016/j.jgar.2024.05.004
{"title":"International Society of Antimicrobial Chemotherapy (ISAC) News and Information Page","authors":"","doi":"10.1016/j.jgar.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.jgar.2024.05.004","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"37 ","pages":"Pages A1-A3"},"PeriodicalIF":4.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524000924/pdfft?md5=248229abe2db53037c88e537ca3d177f&pid=1-s2.0-S2213716524000924-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and patterns of drug-resistant Mycobacterium tuberculosis in newly diagnosed patients in China: A systematic review and meta-analysis 中国新诊断患者中耐药结核分枝杆菌的流行与模式:系统回顾与元分析》。
IF 3.7 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-31 DOI: 10.1016/j.jgar.2024.05.018
{"title":"Prevalence and patterns of drug-resistant Mycobacterium tuberculosis in newly diagnosed patients in China: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.jgar.2024.05.018","DOIUrl":"10.1016/j.jgar.2024.05.018","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB), one of the deadliest infectious diseases globally, is increasingly exacerbated in China by the emergence of resistant <em>Mycobacterium tuberculosis</em> (MTB) strains. Drug-resistant TB, including mono-drug-resistant TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB), presents significant public health challenges.</p></div><div><h3>Methods</h3><p>We conducted a systematic literature review from January 2010 to February 2024 using databases such as PubMed, Embase, Web of Science, and Google Scholar. Our focus was on empirical data related to drug resistance patterns in newly diagnosed TB cases. Non-empirical studies were excluded through meticulous filtering. For the meta-analysis, we used Review Manager (RevMan) 5.2 and assessed evidence quality using the Newcastle-Ottawa Scale (NOS).</p></div><div><h3>Results</h3><p>Our search strategy identified 40 studies that met the inclusion criteria, encompassing a total sample size of 87,667 participants. Among new TB cases, the estimated prevalence of MDR-TB in China was 6.9% (95% CI: 5.6–8.1%). Prevalence rates for mono-drug resistance to first-line anti-TB medications were as follows: isoniazid at 18.2% (95% CI: 16.4–20.6%), rifampicin at 10.5% (95% CI: 8.6–12.8%), and ethambutol at 5.7% (95% CI: 4.1–7.3%). The prevalence of streptomycin resistance, a former first-line anti-TB drug, was 17.1% (95% CI: 14.6–19.1%). The prevalence of other types of mono-drug resistance was 15.2% (95% CI: 13.9–17.3%), and for XDR-TB, it was 0.9% (95% CI: 0.6–1.4%).</p></div><div><h3>Conclusions</h3><p>The high prevalence of drug-resistant TB in China poses a significant public health challenge. There is an urgent need for targeted interventions and continued surveillance to combat the spread of drug-resistant TB.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 292-301"},"PeriodicalIF":3.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524001061/pdfft?md5=711198bd3ee71326340a73204c3ca1a4&pid=1-s2.0-S2213716524001061-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent epidemic of silicotuberculosis in India and emergence of multidrug-resistant tuberculosis? 印度矽肺病的无声流行与耐多药结核病的出现?
IF 3.7 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-31 DOI: 10.1016/j.jgar.2024.05.012
Dharmendra Singh , Bidisa Sarkar , Saurabh Yadav , Kamalesh Sarkar
{"title":"Silent epidemic of silicotuberculosis in India and emergence of multidrug-resistant tuberculosis?","authors":"Dharmendra Singh ,&nbsp;Bidisa Sarkar ,&nbsp;Saurabh Yadav ,&nbsp;Kamalesh Sarkar","doi":"10.1016/j.jgar.2024.05.012","DOIUrl":"10.1016/j.jgar.2024.05.012","url":null,"abstract":"<div><h3>Objectives</h3><p>India's projected silica-dust-exposed workers will be 52 million at the end of 2025. The elimination of tuberculosis (TB) is also targeted in India by 2025. Scientists in India have already pointed out that unless silicosis is controlled, the said elimination will be difficult to achieve.</p></div><div><h3>Methods and Results</h3><p>This study provides evidence of an increasing incidence of tuberculosis (TB) including multidrug-resistant TB (MDR-TB) with mortality owing to treatment failure among the silica dust-exposed workers compared to their unexposed counterpart. It was also observed that TB as well as MDR-TB were directly proportional to the dose and/or duration of silica dust exposure (progression of silica-dust induced lung damage). This means the occurrence of both TB and MDR-TB is lowest in the unexposed group, moderate in the radiologically negative but silica dust-exposed group (subradiological silicosis owing to moderate exposure), and highest in the radiologically confirmed silicotic workers (maximally exposed group). Because India has a huge burden of silicosis cases, the said cases are vulnerable to pulmonary TB, including MDR-TB. The study indicates there will be an emergence of MDR-TB among the silica dust-exposed workers unless appropriate intervention measures are initiated with immediate effect. Failure to do so, it will probably lead to a silent epidemic of silicotuberculosis in India shortly.</p></div><div><h3>Conclusions</h3><p>It is important to have tools to detect silicosis cases quickly and at an early stage to identify a vulnerable population and adopt an effective intervention measure.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 163-166"},"PeriodicalIF":3.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524001000/pdfft?md5=887cc15f147b058bda5c747b515e62fa&pid=1-s2.0-S2213716524001000-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trimethoprim-sulfamethoxazole versus levofloxacin for the treatment of Stenotrophomonas maltophilia infections: A multicentre cohort study 治疗嗜麦芽单胞菌感染的三甲双胍-磺胺甲恶唑与左氧氟沙星:一项多中心队列研究。
IF 4.6 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-30 DOI: 10.1016/j.jgar.2024.05.016
Thamer A. Almangour , Zakiyah Alkherb , Shatha Alruwaite , Renad Alsahli , Hussain Alali , Abdullah Almohaizeie , Sara Almuhisen , Shuroug A. Alowais , Khalid Bin Saleh , Lolwa Fetyani , Fai Alnashmi , Alnajla Alghofaily , Noran Ibrahim Abouobaid , Khalifa M. Binkhamis , Essam A. Tawfik , Yazed Saleh Alsowaida
{"title":"Trimethoprim-sulfamethoxazole versus levofloxacin for the treatment of Stenotrophomonas maltophilia infections: A multicentre cohort study","authors":"Thamer A. Almangour ,&nbsp;Zakiyah Alkherb ,&nbsp;Shatha Alruwaite ,&nbsp;Renad Alsahli ,&nbsp;Hussain Alali ,&nbsp;Abdullah Almohaizeie ,&nbsp;Sara Almuhisen ,&nbsp;Shuroug A. Alowais ,&nbsp;Khalid Bin Saleh ,&nbsp;Lolwa Fetyani ,&nbsp;Fai Alnashmi ,&nbsp;Alnajla Alghofaily ,&nbsp;Noran Ibrahim Abouobaid ,&nbsp;Khalifa M. Binkhamis ,&nbsp;Essam A. Tawfik ,&nbsp;Yazed Saleh Alsowaida","doi":"10.1016/j.jgar.2024.05.016","DOIUrl":"10.1016/j.jgar.2024.05.016","url":null,"abstract":"<div><h3>Background</h3><p>Trimethoprim-sulfamethoxazole (TMP-SMX) has long been considered the treatment of choice for infections caused by <em>Stenotrophomonas maltophilia</em>. Levofloxacin has emerged as a potential option for treating these infections. This study aimed to evaluate the clinical outcomes in patients who received TMP-SMX versus levofloxacin for treating <em>S. maltophilia</em> infections.</p></div><div><h3>Methods</h3><p>A retrospective, cohort study was conducted in 4 tertiary centres and included patients who were treated with either TMP-SMX or levofloxacin for infections caused by <em>S. maltophilia</em>. The main study outcomes were overall in-hospital mortality, 30-d mortality, and clinical cure. Safety outcomes were also evaluated. Multivariate analysis using logistic regression was used to control for the effect of the covariables.</p></div><div><h3>Results</h3><p>We included 371 patients in this study, 316 received TMP-SMX and 55 patients received levofloxacin. A total of 70% were in the intensive care unit and 21% presented with bacteraemia. No statistically significant differences were observed in overall in-hospital mortality (52% vs. 40%; <em>P</em> = 0.113; odd ratio [OR], 1.59; 95% confidence interval [CI], 0.89–2.86), 30-d mortality (28% vs. 25%; <em>P</em> = 0.712; OR, 1.13; 95% CI, 0.59–2.18), or clinical cure (55% vs. 64%; <em>P</em> = 0.237; OR, 0.70; 95% CI, 0.37–1.31). Rates of acute kidney injury were comparable between the two groups (11% vs. 7%; <em>P</em> = 0.413).</p></div><div><h3>Conclusion</h3><p>Patients receiving levofloxacin for the treatment of infections caused by S<em>. maltophilia</em> demonstrated clinical outcomes similar to those receiving TMP-SMX. Our study suggests that levofloxacin can be a reasonable alternative to TMP-SMX to treat these infections.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 42-48"},"PeriodicalIF":4.6,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221371652400105X/pdfft?md5=c024158b95a131ad8cd5f9712a1feb36&pid=1-s2.0-S221371652400105X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial resistance and genetic relatedness among Campylobacter coli and Campylobacter jejuni from humans and retail chicken meat in Taiwan 台湾地区人类和零售鸡肉中大肠弯曲杆菌和空肠弯曲杆菌的抗菌药耐药性和遗传亲缘关系。
IF 4.6 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-29 DOI: 10.1016/j.jgar.2024.05.013
Hsiao-Lun Wei, Ying-Shu Liao, Bo-Han Chen, Ru-Hsiou Teng, You-Wun Wang, Jui-Hsien Chang, Chien-Shun Chiou
{"title":"Antimicrobial resistance and genetic relatedness among Campylobacter coli and Campylobacter jejuni from humans and retail chicken meat in Taiwan","authors":"Hsiao-Lun Wei,&nbsp;Ying-Shu Liao,&nbsp;Bo-Han Chen,&nbsp;Ru-Hsiou Teng,&nbsp;You-Wun Wang,&nbsp;Jui-Hsien Chang,&nbsp;Chien-Shun Chiou","doi":"10.1016/j.jgar.2024.05.013","DOIUrl":"10.1016/j.jgar.2024.05.013","url":null,"abstract":"<div><h3>Objectives</h3><p><em>Campylobacter</em> is a significant zoonotic pathogen primarily transmitted through poultry. Our study aimed to assess antimicrobial resistance and genetic relationships among <em>Campylobacter</em> isolates from retail chicken meat and humans in Taiwan.</p></div><div><h3>Methods</h3><p><em>Campylobacter</em> isolates were analysed using whole-genome sequencing to investigate their antimicrobial resistance, genetic determinants of resistance, and genotypes.</p></div><div><h3>Results</h3><p><em>Campylobacter coli</em> and <em>Campylobacter jejuni</em> accounted for 44.9% and 55.1% of chicken meat isolates, and 11.4% and 88.6% of human isolates, respectively. <em>C. coli</em> displayed significantly higher resistance levels. Furthermore, isolates from chicken meat exhibited higher levels of resistance to most tested antimicrobials compared to isolates from humans. Multidrug resistance was observed in 96.3% of <em>C. coli</em> and 43.3% of <em>C. jejuni</em> isolates from chicken meat and 80.6% of <em>C. coli</em> and 15.8% of <em>C. jejuni</em> isolates from humans. Macrolide resistance was observed in 85.5% of <em>C. coli</em> isolates, primarily attributed to the <em>erm(B)</em> rather than the A2075G mutation in 23S rRNA. Among the 511 genomes, we identified 133 conventional MLST sequence types, indicating significant diversity among <em>Campylobacter</em> strains. Notably, hierarchical Core-genome multilocus sequence typing clustering, including HC0, HC5, and HC10, revealed a significant proportion of closely related isolates from chicken meat and humans.</p></div><div><h3>Conclusions</h3><p>Our research highlights significant associations in antimicrobial resistance and genetic relatedness between <em>Campylobacter</em> isolates from chicken meat and humans in Taiwan. The genetic analysis data suggest that campylobacteriosis outbreaks may occur more frequently in Taiwan than previously assumed. Our study emphasizes the need for strategies to control multidrug-resistant strains and enhance outbreak prevention.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 27-34"},"PeriodicalIF":4.6,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524001012/pdfft?md5=f0d91a150d8d902cd0231aa5417101be&pid=1-s2.0-S2213716524001012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of plasmid-mediated mcr-1 and chromosomal blaCTX−M-2 in Escherichia coli from fresh vegetables 鉴定新鲜蔬菜中大肠埃希菌质粒介导的 mcr-1 和染色体 blaCTX-M-2。
IF 4.6 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-29 DOI: 10.1016/j.jgar.2024.05.019
João Pedro Rueda Furlan, Ralf Lopes, Micaela Santana Ramos, Rafael da Silva Rosa, Lucas David Rodrigues dos Santos, Eliana Guedes Stehling
{"title":"Identification of plasmid-mediated mcr-1 and chromosomal blaCTX−M-2 in Escherichia coli from fresh vegetables","authors":"João Pedro Rueda Furlan,&nbsp;Ralf Lopes,&nbsp;Micaela Santana Ramos,&nbsp;Rafael da Silva Rosa,&nbsp;Lucas David Rodrigues dos Santos,&nbsp;Eliana Guedes Stehling","doi":"10.1016/j.jgar.2024.05.019","DOIUrl":"10.1016/j.jgar.2024.05.019","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 66-68"},"PeriodicalIF":4.6,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524001048/pdfft?md5=85e2a30faf54fc9e5f2e25565d6026ac&pid=1-s2.0-S2213716524001048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of first-line dalbavancin for cellulitis on hospital admissions and costs: A case series 达巴万星一线治疗蜂窝织炎对入院人数和费用的影响:病例系列。
IF 3.7 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-29 DOI: 10.1016/j.jgar.2024.05.020
{"title":"Impact of first-line dalbavancin for cellulitis on hospital admissions and costs: A case series","authors":"","doi":"10.1016/j.jgar.2024.05.020","DOIUrl":"10.1016/j.jgar.2024.05.020","url":null,"abstract":"<div><h3>Background</h3><p>Many patients with cellulitis are treated with oral antibiotics as outpatients, but some require hospital admission for intravenous antibiotics. During the coronavirus disease 2019 pandemic, Betsi Cadwaladr University Health Board in Wales approved use of dalbavancin as first-line intravenous antibiotic from April to December 2020 to facilitate early discharge and prevent hospital admission.</p></div><div><h3>Objectives</h3><p>To report cost savings and admission avoidance through first-line intravenous use of dalbavancin for cellulitis in one health board in Wales.</p></div><div><h3>Patients and methods</h3><p>Patients with cellulitis who presented to the emergency department or medical assessment unit at Betsi Cadwaladr University Health Board's two hospitals between April and December 2020 were identified for treatment with dalbavancin, because they had not responded to oral antibiotics or their initial presentation warranted intravenous antibiotics. Patients received 1500 mg dalbavancin by intravenous infusion according to prescribing information and were sent home without being admitted. Outcomes were admission within 30 d of dalbavancin and cost savings from avoiding admission.</p></div><div><h3>Results</h3><p>31 patients were treated with dalbavancin for cellulitis in the emergency department or medical assessment unit. No patient was admitted within 30 d of receiving dalbavancin. Use of dalbavancin is estimated to have saved 248 bed-days over the study period, with an estimated saving of $120,444.23 based on avoidance of admission. The cost of dalbavancin for these 31 patients was $69,959.08, giving an overall cost saving of $50,485.15 ($1529.95 per patient).</p></div><div><h3>Conclusions</h3><p>Prescribing dalbavancin as first-line intravenous antibiotic for cellulitis prevents admission, saving bed-days and admission-related costs.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 306-308"},"PeriodicalIF":3.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524001085/pdfft?md5=ff92a633f2c7cae31b370d140c2325ae&pid=1-s2.0-S2213716524001085-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A scoping review of bacterial resistance among inpatients amidst the COVID-19 pandemic 对 COVID-19 大流行期间住院病人细菌耐药性的范围审查。
IF 4.6 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-23 DOI: 10.1016/j.jgar.2024.05.010
Noora Reffat , Rebecca J. Schwei , Meggie Griffin , Aurora Pop-Vicas , Lucas T. Schulz , Michael S. Pulia
{"title":"A scoping review of bacterial resistance among inpatients amidst the COVID-19 pandemic","authors":"Noora Reffat ,&nbsp;Rebecca J. Schwei ,&nbsp;Meggie Griffin ,&nbsp;Aurora Pop-Vicas ,&nbsp;Lucas T. Schulz ,&nbsp;Michael S. Pulia","doi":"10.1016/j.jgar.2024.05.010","DOIUrl":"10.1016/j.jgar.2024.05.010","url":null,"abstract":"<div><h3>Objectives</h3><p>The COVID-19 pandemic disrupted antimicrobial stewardship and infection prevention operations worldwide, raising concerns for an acceleration of antimicrobial resistance (AMR). Therefore, we aimed to define the scope of peer reviewed research comparing AMR in inpatient bacterial clinical cultures before and after the start of the COVID-19 pandemic.</p></div><div><h3>Methods</h3><p>We conducted a scoping review and searched PubMed, Scopus, and Web of Science through 15 June 2023. Our inclusion criteria were: (1) English language, (2) primary evidence, (3) peer-reviewed, (4) clinical culture data from humans, (5) AMR data for at least one bacterial order/species, (6) inpatient setting, (7) use of statistical testing to evaluate AMR data before and during the COVID-19 pandemic. Reviewers extracted country, study design, type of analysis, study period, setting and population, number of positive cultures or isolates, culture type(s), method of AMR analysis, organisms, and AMR results. Study results were organised by organism and antibiotic class or resistance mechanism. AMR results are also summarised by individual study and across all studies.</p></div><div><h3>Results</h3><p>In total, 4805 articles were identified with 55 papers meeting inclusion criteria. <em>Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa</em>, and <em>Staphylococcus aureus</em> were the most commonly studied organisms. There were 464 bacterial AMR results across all studies with 82 (18%) increase, 71 (15%) decrease, and 311 (67%) no change results.</p></div><div><h3>Conclusions</h3><p>The literature examining the impact of COVID-19 on AMR among inpatients is diverse with most results reflecting no change pre/post pandemic. Ongoing inquiry is needed into evolving patterns in AMR post COVID-19.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 49-65"},"PeriodicalIF":4.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524000973/pdfft?md5=b0fd0622e84aa7cd34b0dd482c89fd77&pid=1-s2.0-S2213716524000973-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Draft genome sequences of clinical mastitis-associated Enterococcus faecalis and Enterococcus faecium carrying multiple antimicrobial resistance genes isolated from dairy cows 从奶牛中分离出的携带多种抗菌药耐药性基因的临床乳腺炎相关粪肠球菌和粪肠球菌的基因组序列草案
IF 3.7 3区 医学
Journal of global antimicrobial resistance Pub Date : 2024-05-23 DOI: 10.1016/j.jgar.2024.05.011
Mohammad H. Rahman , Mohamed E. El Zowalaty , Linda Falgenhauer , Mohammad Ferdousur Rahman Khan , Jahangir Alam , Najmun Nahar Popy , Md. Bahanur Rahman
{"title":"Draft genome sequences of clinical mastitis-associated Enterococcus faecalis and Enterococcus faecium carrying multiple antimicrobial resistance genes isolated from dairy cows","authors":"Mohammad H. Rahman ,&nbsp;Mohamed E. El Zowalaty ,&nbsp;Linda Falgenhauer ,&nbsp;Mohammad Ferdousur Rahman Khan ,&nbsp;Jahangir Alam ,&nbsp;Najmun Nahar Popy ,&nbsp;Md. Bahanur Rahman","doi":"10.1016/j.jgar.2024.05.011","DOIUrl":"10.1016/j.jgar.2024.05.011","url":null,"abstract":"<div><h3>Objectives</h3><p>The emergence of antimicrobial-resistant and mastitis-associated <em>Enterococcus faecalis</em> and <em>Enterococcus faecium</em> is of great concern due to the huge economic losses associated with enterococcal infections. Here we report the draft genome sequences of <em>E. faecalis</em> and <em>E. faecium</em> strains that were isolated from raw milk samples obtained from mastitis-infected cows in Bangladesh.</p></div><div><h3>Methods</h3><p>The two strains were isolated, identified, and genomic DNA was sequenced using the Illumina NextSeq 550 platform. The assembled contigs were analysed for virulence, antimicrobial resistance genes, and multilocus sequence type. The genomes were compared to previously reported <em>E. faecalis</em> and <em>E. faecium</em> genomes to generate core genome phylogenetic trees.</p></div><div><h3>Results</h3><p><em>E. faecalis</em> strain BR-MHR218Efa and <em>E. faecium</em> strain BR-MHR268Efe belonged to multilocus sequence types ST-190 and ST-22, respectively, both of which appear to represent relatively rare sequence types. BR-MHR268Efe harboured only one antibiotic resistance gene encoding resistance towards macrolides (<em>lsa</em>(<em>A</em>)), while BR-MHR218Efa harboured ten different antibiotic resistance genes encoding resistance to aminoglycosides (<em>ant</em>[6]-Ia, <em>aph</em>(3′)-III), sulphonamides (<em>aac</em>(6′)-II), lincosamides (<em>lnu</em>(<em>B</em>)), macrolides (<em>erm</em>(<em>B</em>)), MLSB antibiotics (<em>msr</em>(<em>C</em>)), tetracyclines (<em>tet</em>(<em>M</em>), <em>tet</em>(<em>L</em>)), trimethoprim (<em>dfrG</em>), and pleuromutilin-lincosamide-streptogramin A (<em>lsa</em>(<em>E</em>)). Virulence gene composition was different between the two isolates. BR-MHR218Efa harboured only two virulence genes involved in adherence (<em>acm</em> and <em>scm</em>). BR-MHR268Efe harboured eight complete virulence operons including three operons involved in adherence (Ace, Ebp pili, and EfaA), two operons involved in biofilm formation (BopD and Fsr), and three exoenzymes (gelatinase, hyaluronidase, SprE).</p></div><div><h3>Conclusions</h3><p>The genome sequences of the strains BR-MHR268Efe and BR-MHR218Efa will serve as a reference point for molecular epidemiological studies of mastitis-associated <em>E. faecalis</em> and <em>E. faecium</em>. Additionally, the findings will help understand the complex antimicrobial-resistance in livestock-assoiated <em>Enterococci</em>.</p></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"38 ","pages":"Pages 111-115"},"PeriodicalIF":3.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213716524000997/pdfft?md5=ac31ae0cedc25d3fa4b087317072e767&pid=1-s2.0-S2213716524000997-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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