Journal of global antimicrobial resistance最新文献

{"title":"Epidemiological and genetic profiles of ceftazidime/avibactam-resistant Klebsiella pneumoniae conferred by KPC variants in a tertiary hospital in China.","authors":"Min Xu, Xiaofen Mo, Yuchao Zhang, Huinan Xia, Huiqiong Jia, Haishen Kong, Qixia Luo, Yiqi Fu","doi":"10.1016/j.jgar.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.013","url":null,"abstract":"<p><strong>Objective: </strong>The emergence of Klebsiella pneumoniae carbapenemase variants (KPCVs), conferring resistance to ceftazidime/avibactam (CAZ/AVI), represents a critical clinical challenge. However, investigations into KPCV-producing K. pneumoniae (KPCV-Kp) are confined to sporadic clinical cases.</p><p><strong>Methods: </strong>Clinical isolates of KPCV-Kp exhibiting resistance to CAZ/AVI were collected from a Chinese tertiary hospital from February 2015 to March 2024. The clinical characteristics, antimicrobial susceptibility, molecular epidemiology and genetic phylogeny were subjected to analysis.</p><p><strong>Results: </strong>A total of 25 KPCV-Kp strains displaying high-level resistance to CAZ/AVI were identified, with their initial isolation in 2018 and the majority obtained in 2023 (64.0%, 16/25). All patients except one had prior CAZ/AVI exposure for 3 to 38 days. Twelve KPCVs, including four novel variants (designated as KPC-219 to KPC-222), were identified. KPC-33 predominated (40.0%, 10/25), followed by KPC-71 (12.0%, 3/25), KPC-14, and KPC-90 (8.0%, 2/25 for each). Notably, 50.0% (6/12) of the KPCVs exhibited multiple mutations in the Ω-loop as well as in other regions, which were associated with a significantly longer CAZ/AVI exposure (P = 0.033). Molecular analysis highlighted the circulation of ST11-KL64 clone (72.0%, 18/25), followed by ST11-KL47 and ST11-KL25 clones (12.0%, 3/25 for each). Phylogenetic analysis revealed no epidemiological linkage between cases, and the KPCV-Kp evolved from their individual parental KPC-2-producing strains.</p><p><strong>Conclusions: </strong>Our study provided a preliminary glimpse into the epidemiology and genetic characteristics of KPCV-Kp in China, underscoring the critical need for continuous monitoring in patients treated with CAZ/AVI, even in short-term therapy, to better grasp the evolving threat posed by these variants.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization and resistance mechanisms of linezolid-resistant enterococci clinical isolates and identification of a clinical Enterococcus faecium strain co-harboring optrA, poxtA, and cfr(D) in a tertiary hospital in China.","authors":"Ni Suo, Jing Yu, Haijun Li, Nan Yi, Cailin Liu, Wanhai Wang","doi":"10.1016/j.jgar.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.008","url":null,"abstract":"<p><strong>Objectives: </strong>The emergence of linezolid-resistant enterococci has become a significant global health concern. This study aimed to investigate the molecular characterization and resistance mechanisms in clinical isolates in a tertiary hospital in China.</p><p><strong>Methods: </strong>The VITEK®2 Compact system, VITEK® MS, and whole-genome sequencing (WGS) were used to identify 59 linezolid-resistant enterococci isolates. Antimicrobial susceptibilities were assessed by broth microdilution. WGS and bioinformatics tools analyzed resistance mechanisms and molecular characteristics. Plasmid-borne linezolid resistance gene transfer was assessed via conjugation and transformation assays.</p><p><strong>Results: </strong>We collected 59 linezolid-resistant enterococci isolates, including 54 Enterococcus faecalis and 5 Enterococcus faecium strains. One strain carried the poxtA gene, one isolate carried the G2576T mutation in the 23S rRNA gene, and 56 isolates harbored the optrA gene. Notably, one isolate co-harbored the optrA, poxtA, and cfr(D) genes. Twenty-three sequence types (STs) were identified. ST16 (48.1%, 26/54) predominated in E. faecalis. Multilocus sequence typing (MLST) and evolutionary analysis indicated that E. faecalis strains of the same ST were genetically related. Among the seven strains (two E. faecium and five E. faecalis strains) selected for further investigation, IS1216E was detected on plasmids carrying linezolid resistance genes in all five strains. Additionally, transposon Tn554 was detected on the chromosome of an optrA-carrying strain.</p><p><strong>Conclusion: </strong>This study describes the molecular characteristics and resistance mechanisms of linezolid-resistant enterococci in our hospital, including a novel E. faecium isolate with optrA, poxtA, and cfr(D), highlighting the need for enhanced surveillance to control the dissemination of resistant strains.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of bla_VIM-2-carrying Pseudomonas asiatica L2126: Identification of a ∼44 kb Untypable Plasmid with Intra-Genus Dissemination Potential.","authors":"Jinhua Zhang, Yi Liu, Lei Fang, Xinrui Wang, Hao Xu, Danfeng Lou","doi":"10.1016/j.jgar.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.012","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to elucidate the molecular characteristics of a bla_VIM-2-carrying Pseudomonas asiatica isolate (L2126) from China and to characterize a ∼44 kb untypable plasmid harboring bla_VIM-2. We investigated the genetic context of bla_VIM-2, assessed the associated antimicrobial resistance determinants, and explored the role of this plasmid in mediating gene dissemination.</p><p><strong>Methods: </strong>The isolate L2126 was recovered from an intestinal colonization sample in a patient from Hangzhou, China. Species identification was confirmed by average nucleotide identity (ANI) analysis. Hybrid whole-genome sequencing was performed using Illumina short-read and Oxford Nanopore long-read platforms. Genome assembly was conducted using Unicycler and annotated with Prokka. Antimicrobial resistance genes were identified via ResFinder and CARD. The genetic context of bla_VIM-2 was delineated using IntegronFinder. Plasmid profiles were determined by S1-nuclease pulsed-field gel electrophoresis (S1-PFGE) and in silico replicon analysis.</p><p><strong>Results: </strong>L2126 exhibited a multidrug-resistant profile with high-level resistance to carbapenems, cephalosporins, and fluoroquinolones. Genome analysis revealed 7 resistance genes, including bla_VIM-2 and sul1. Notably, bla_VIM-2 resides within a class 1 integron (intI1-attI1- bla_VIM-2-qacEΔ1-sul1) embedded in a Tn402-like platform on a ∼44 kb untypable plasmid. The adjacent tni module (tniR-tniQ-tniB-tniA) is encoded on the opposite strand, indicating that it is part of the transposition platform rather than the integron cassette array. S1-PFGE confirmed the presence of the ∼44 kb plasmid, and in silico analysis provided a schematic representation of its genetic organization. BLAST analysis demonstrated that this plasmid shares high sequence homology with a plasmid previously identified in Pseudomonas monteilii, despite the two isolates belonging to different species.</p><p><strong>Conclusions: </strong>Our findings demonstrate that the carriage of bla_VIM-2 on a novel ∼44 kb untypable plasmid in P. asiatica L2126 could facilitate horizontal gene transfer of carbapenem resistance. The plasmid's high homology to one previously identified in P. monteilii suggests that it has the potential for intra-genus dissemination, posing a significant threat to the spread of carbapenem resistance.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of eravacycline in the treatment of patients with pneumonia in respiratory departments: a real-world multicenter retrospective study.","authors":"Zhengyu Luo, Zhengyin Liu, Minya Lu, Li Zhang, Yingchun Xu, Menglan Zhou","doi":"10.1016/j.jgar.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.011","url":null,"abstract":"<p><strong>Introduction: </strong>Eravacycline (ERV), a novel fluorocycline antibiotic, demonstrates broad-spectrum activity against multidrug-resistant (MDR) pathogens. This multicenter retrospective study evaluates the real-world clinical effectiveness of ERV in treating various infections of the patients hospitalized in the respiratory departments.</p><p><strong>Methods: </strong>We analyzed 113 adult patients treated with ERV from respiratory departments in China, examining antimicrobial susceptibility profiles and serial laboratory parameters during therapy. Microbiological and clinical outcomes were systematically evaluated at treatment completion and 30-day follow-up. Subgroup analyses focused on Acinetobacter baumannii and Klebsiella pneumoniae infections.</p><p><strong>Results: </strong>ERV exhibited 87.6% clinical efficacy and 85.8% microbiological eradication rate, accompanied by an 85.0% 30-day survival rate. The antibiotic maintained robust activity against MDR pathogens, particularly A. baumannii (n = 51) and K. pneumoniae (n = 27). Adverse events occurred in only 1.8% (2/113) of cases. Clinical outcomes showed no statistically significant differences between monotherapy (n = 70) and combination regimens (n = 43).</p><p><strong>Conclusion: </strong>This real-world evidence confirms ERV as an effective and well-tolerated therapeutic option for managing patients in the respiratory departments, particularly those caused by MDR Gram-negative pathogens. The comparable efficacy of monotherapy and combination approaches warrants further investigation.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metronidazole and Giardia: In Vitro Viability Assay under Microaerobic Conditions Indicates a Multifactorial Basis for Metronidazole Treatment Failure.","authors":"Eva Nohynkova, Aneta Perglerova, Vlasta Korenkova, Pavla Tumova","doi":"10.1016/j.jgar.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.010","url":null,"abstract":"<p><strong>Objectives: </strong>Giardiasis, a worldwide intestinal infection caused by the protozoan parasite Giardia intestinalis, is treatable with metronidazole (MTZ). However, MTZ-refractory giardiasis is common. It remains unclear, though, whether MTZ-resistant pathogens cause treatment failure because the natural resistance of Giardia to MTZ has not yet been demonstrated.</p><p><strong>Methods: </strong>We developed a simple 24-hour viability assay to assess MTZ sensitivity of Giardia parasites in vitro under two atmospheric conditions, microaerobic and anaerobic. The results of the assay were statistically evaluated.</p><p><strong>Results: </strong>We tested 18 clinical isolates. Based on the minimum lethal concentration (MLC), hierarchical cluster analysis separated the isolates into three categories, sensitive, intermediate resistant, and resistant. The resistant cluster consisted of two isolates with an MLC of 400µg/ml MTZ, which exhibited natural MTZ resistance. Interestingly, this resistance was only manifested under microaerobic conditions. The effect of oxygen on the in vitro drug response was evident in the greater variability of MLC values among the other isolates. Two in vitro-resistant isolates originated from patients with MTZ-refractory giardiasis, suggesting that parasite resistance likely contributes to treatment failure. However, two additional isolates from patients with MTZ-refractory giardiasis showed in vitro susceptibility under both test conditions. This indicates that treatment failure in giardiasis likely stems from multiple factors.</p><p><strong>Conclusions: </strong>Our study highlights the critical importance of oxygen concentration during the assessment of the Giardia parasite resistance to MTZ. However, it also indicates that MTZ refractory giardiasis may result from other reasons than parasite´s resistance.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial utilization among hospitalized patients according to WHO AWaRe Classification: results from a multicentre point prevalence survey in Saudi Arabia.","authors":"Nada A Alsaleh, Abeer AlSmari, Abrar F Alhameed, Ahmed O Alenazi, Alaa A Alsharif, Amal Ben-Akresh, Anwar M Alnakhli, Bashaier Alshehail, Eman A Alzahrani, Ghadah H Alshehri, Ghazwa B Korayem, Hanan Bakri, Khalid Eljaaly, Lina I Alnajar, Norah S Aldeghaither, Reem Almahasna, Sara Almuhisen, Yassmin Alsomali, Zikria Saleem","doi":"10.1016/j.jgar.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.009","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) threatens global health by reducing the efficacy of common infection treatments. This study examines antimicrobial use in Saudi Arabian hospitals, identifies influencing factors, and proposes interventions using the World Health Organization's (WHO) Access, Watch, Reserve (AWaRe) classification system.</p><p><strong>Methods: </strong>A cross-sectional, multicentre point prevalence survey (PPS) of antimicrobial utilization was conducted in 10 hospitals across 6 regions of Saudi Arabia September 2023. All inpatients receiving antimicrobials on the PPS day were included. Data collection utilized the Global PPS tool developed by the University of Antwerp, Belgium.</p><p><strong>Results: </strong>Among 2,890 inpatients, 766 (26.5%) were prescribed at least one antimicrobial, resulting in a total of 982 prescriptions. The primary indications for these antimicrobials were community acquired infections (37.1%), Healthcare associated infections (35.9%), surgical prophylaxis (15.4%), unknown reasons (8.7%), medical prophylaxis (2.5%), and other reasons (0.3%). The most common reasons for antimicrobial use included pneumonia or lower respiratory tract infections (16.1%), skin and soft tissue infections (11%), and bacteraemia (8.9%). The most frequently prescribed antimicrobial classes were penicillins with beta-lactamase inhibitors (18.5%), carbapenems (15.7%), and third-generation cephalosporins (11.1%). Most of the antimicrobials (66.3%) were classified as Watch antimicrobials, followed by 23.8% as Access, and 8.9% as Reserve.</p><p><strong>Conclusions: </strong>The study provides valuable insights into antimicrobial utilization in Saudi Arabia, offering a baseline for assessing prescribing patterns. While findings may reflect certain antimicrobial stewardship efforts, further investigation is needed to evaluate their impact. The study also highlights key areas for improvement, emphasizing the importance of conducting future PPS to guide antimicrobial stewardship strategies and monitor progress in managing AMR.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “In vitro activity of cefiderocol against carbapenemase-producing and meropenem-non-susceptible Gram-negative bacteria collected in the Japan Antimicrobial Resistant Bacterial Surveillance” [Journal of Global Antimicrobial Resistance 38 (2024) 12–20]","authors":"Shizuo Kayama,&nbsp;Sayoko Kawakami,&nbsp;Kohei Kondo,&nbsp;Norikazu Kitamura,&nbsp;Liansheng Yu,&nbsp;Wataru Hayashi,&nbsp;Koji Yahara,&nbsp;Yo Sugawara,&nbsp;Motoyuki Sugai","doi":"10.1016/j.jgar.2025.08.001","DOIUrl":"10.1016/j.jgar.2025.08.001","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"45 ","pages":"Pages 68-69"},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Southeast‑Asian Landscape of Antimicrobial Resistance Research (2014-2024): A Bibliometric Analysis.","authors":"Alex S Borromeo, Allan M Manaloto, Ronilo Antonio","doi":"10.1016/j.jgar.2025.09.004","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.004","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to map the Southeast‑Asian research landscape on antimicrobial resistance (AMR) using bibliometric techniques.</p><p><strong>Background: </strong>Despite AMR's growing threat and Southeast Asia's high-risk profile, no comprehensive bibliometric synthesis as examined AMR research trajectories in areas such as diagnostics, genomic surveillance, and policy frameworks, along with the region's evolving contributions.</p><p><strong>Methods: </strong>A total of 1,989 Scopus-indexed articles (2014-2024; mean citations = 17.33 per document) were analyzed in VOSviewer (v 1.6.20). Bibliographic cleaning was performed in Microsoft Excel, and no additional mapping tools (e.g., CiteSpace, BibExcel) were used. Co-citation analysis identified influential publications and intellectual domains, while co-word analysis revealed thematic clusters and keyword co-occurrence patterns.</p><p><strong>Results: </strong>Between 2014 and 2024, AMR publications in Southeast Asia grew steadily, peaking in 2024 with over 320 articles. The four co-citation clusters encompassed (1) global AMR governance and risk framing, (2) genomic tools for resistance detection, (3) foodborne AMR and standardized lab protocols, and (4) phylogenomic tracking of resistance evolution. The four co-word clusters revealed focus areas in diagnostic surveillance, sociodemographic patterns, One Health perspectives, and molecular epidemiology. Despite this growth (1,989 total articles), Southeast Asian research played a prominent role in zoonotic AMR surveillance and genomic studies but remained underrepresented in highly cited publications and globally influential policy discussions.</p><p><strong>Conclusions: </strong>The findings underscore the need for equitable integration of Southeast Asia into the global AMR agenda. Strengthening regional genomic surveillance, adapting global frameworks to local systems, and embedding AMR competencies in public health and nursing education are critical for advancing policy and capacity-building.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Pharmacokinetics of Imipenem in Solid Tumor Patients with Infections: A Real-World Study.","authors":"Tingting Xu, Tingting Zou, Junyan Zhang, Zhuoran Li, Fangyu Li, Juan Du, Zhiying Hao","doi":"10.1016/j.jgar.2025.09.005","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.005","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize the population pharmacokinetics (PPK) of imipenem in critically ill solid tumor patients and to optimize dosing regimens through pharmacodynamic analysis.</p><p><strong>Methods: </strong>A PPK model was developed using nonlinear mixed-effects modeling (Monolix 2023R1) based on 25 critically ill solid tumor patients with infections. Model selection used objective function value (OFV), Akaike/Bayesian information criteria(AIC/BIC), and goodness-of-fit diagnostics. Covariate screening involved a dual-algorithm approach (SAMBA and COSSAC) for validation. Monte Carlo simulations (n=10,000) evaluated the probability of target attainment (PTA) for 100% fT>MIC across different renal function groups.</p><p><strong>Results: </strong>A linear one-compartment model best described imipenem pharmacokinetics. Typical population estimates were clearance (CL) = 2.7 L/h and volume of distribution (Vd) = 10.6L-significantly lower than values reported in general critical care populations. Creatinine clearance (CLCR) and septic shock were identified as significant covariates affecting CL. Severe malnutrition contributed to reduced Vd. Simulations revealed: For MIC ≤2 mg·L⁻¹, 500 mg q6h achieved PTA >90% when CLCR >30 mL/min; for MIC=4 mg·L⁻¹, 1000 mg q6h was required for patients with CLCR >60 mL/min (PTA=94.9-100%); no regimen achieved PTA >20% for MIC ≥16 mg·L⁻¹.</p><p><strong>Conclusion: </strong>This study highlights the significant effect of specific pathophysiological changes in solid tumor patients (such as cachexia-induced reduction in volume of distribution) on drug disposition, providing essential evidence for informing personalized imipenem dosing in this vulnerable group to improve efficacy and reduce resistance risks.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Pulmonary Mycobacterium wolinskyi Infection in a Hemodialysis Patient.","authors":"Lin Zheng, Yanwan Shangguan, Wanru Guo, Zhongkang Ji, Kaijin Xu","doi":"10.1016/j.jgar.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.09.006","url":null,"abstract":"<p><p>In recent years, the detection rate of nontuberculous mycobacteria has increased, drawing attention in clinical settings. Here, we present a case of pulmonary Pseudomonas aeruginosa and Mycobacterium wolinskyi coinfection in a 60-year-old hemodialysis recipient. To the best of our knowledge, this is the first instance of isolating the M. wolinskyi strain from human respiratory samples, including a comprehensive exploration of its susceptibility to clinically available antimicrobials. This discovery deepened our understanding of the infection spectrum of M. wolinskyi, highlighting the need to consider the potential for coinfections with common pathogens and less common atypical pathogens when managing immunocompromised patients. Furthermore, this study also assessed the in vitro antibacterial activity of newly available antibacterial drugs in clinical practice against the M. wolinskyi strain.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}