Nada A Alsaleh, Abeer AlSmari, Abrar F Alhameed, Ahmed O Alenazi, Alaa A Alsharif, Amal Ben-Akresh, Anwar M Alnakhli, Bashaier Alshehail, Eman A Alzahrani, Ghadah H Alshehri, Ghazwa B Korayem, Hanan Bakri, Khalid Eljaaly, Lina I Alnajar, Norah S Aldeghaither, Reem Almahasna, Sara Almuhisen, Yassmin Alsomali, Zikria Saleem
{"title":"根据世卫组织认知分类，住院患者抗菌药物使用情况：沙特阿拉伯多中心点流行病学调查结果。","authors":"Nada A Alsaleh, Abeer AlSmari, Abrar F Alhameed, Ahmed O Alenazi, Alaa A Alsharif, Amal Ben-Akresh, Anwar M Alnakhli, Bashaier Alshehail, Eman A Alzahrani, Ghadah H Alshehri, Ghazwa B Korayem, Hanan Bakri, Khalid Eljaaly, Lina I Alnajar, Norah S Aldeghaither, Reem Almahasna, Sara Almuhisen, Yassmin Alsomali, Zikria Saleem","doi":"10.1016/j.jgar.2025.09.009","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) threatens global health by reducing the efficacy of common infection treatments. This study examines antimicrobial use in Saudi Arabian hospitals, identifies influencing factors, and proposes interventions using the World Health Organization's (WHO) Access, Watch, Reserve (AWaRe) classification system.</p><p><strong>Methods: </strong>A cross-sectional, multicentre point prevalence survey (PPS) of antimicrobial utilization was conducted in 10 hospitals across 6 regions of Saudi Arabia September 2023. All inpatients receiving antimicrobials on the PPS day were included. Data collection utilized the Global PPS tool developed by the University of Antwerp, Belgium.</p><p><strong>Results: </strong>Among 2,890 inpatients, 766 (26.5%) were prescribed at least one antimicrobial, resulting in a total of 982 prescriptions. The primary indications for these antimicrobials were community acquired infections (37.1%), Healthcare associated infections (35.9%), surgical prophylaxis (15.4%), unknown reasons (8.7%), medical prophylaxis (2.5%), and other reasons (0.3%). The most common reasons for antimicrobial use included pneumonia or lower respiratory tract infections (16.1%), skin and soft tissue infections (11%), and bacteraemia (8.9%). The most frequently prescribed antimicrobial classes were penicillins with beta-lactamase inhibitors (18.5%), carbapenems (15.7%), and third-generation cephalosporins (11.1%). Most of the antimicrobials (66.3%) were classified as Watch antimicrobials, followed by 23.8% as Access, and 8.9% as Reserve.</p><p><strong>Conclusions: </strong>The study provides valuable insights into antimicrobial utilization in Saudi Arabia, offering a baseline for assessing prescribing patterns. While findings may reflect certain antimicrobial stewardship efforts, further investigation is needed to evaluate their impact. The study also highlights key areas for improvement, emphasizing the importance of conducting future PPS to guide antimicrobial stewardship strategies and monitor progress in managing AMR.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial utilization among hospitalized patients according to WHO AWaRe Classification: results from a multicentre point prevalence survey in Saudi Arabia.\",\"authors\":\"Nada A Alsaleh, Abeer AlSmari, Abrar F Alhameed, Ahmed O Alenazi, Alaa A Alsharif, Amal Ben-Akresh, Anwar M Alnakhli, Bashaier Alshehail, Eman A Alzahrani, Ghadah H Alshehri, Ghazwa B Korayem, Hanan Bakri, Khalid Eljaaly, Lina I Alnajar, Norah S Aldeghaither, Reem Almahasna, Sara Almuhisen, Yassmin Alsomali, Zikria Saleem\",\"doi\":\"10.1016/j.jgar.2025.09.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Antimicrobial resistance (AMR) threatens global health by reducing the efficacy of common infection treatments. This study examines antimicrobial use in Saudi Arabian hospitals, identifies influencing factors, and proposes interventions using the World Health Organization's (WHO) Access, Watch, Reserve (AWaRe) classification system.</p><p><strong>Methods: </strong>A cross-sectional, multicentre point prevalence survey (PPS) of antimicrobial utilization was conducted in 10 hospitals across 6 regions of Saudi Arabia September 2023. All inpatients receiving antimicrobials on the PPS day were included. Data collection utilized the Global PPS tool developed by the University of Antwerp, Belgium.</p><p><strong>Results: </strong>Among 2,890 inpatients, 766 (26.5%) were prescribed at least one antimicrobial, resulting in a total of 982 prescriptions. The primary indications for these antimicrobials were community acquired infections (37.1%), Healthcare associated infections (35.9%), surgical prophylaxis (15.4%), unknown reasons (8.7%), medical prophylaxis (2.5%), and other reasons (0.3%). The most common reasons for antimicrobial use included pneumonia or lower respiratory tract infections (16.1%), skin and soft tissue infections (11%), and bacteraemia (8.9%). The most frequently prescribed antimicrobial classes were penicillins with beta-lactamase inhibitors (18.5%), carbapenems (15.7%), and third-generation cephalosporins (11.1%). Most of the antimicrobials (66.3%) were classified as Watch antimicrobials, followed by 23.8% as Access, and 8.9% as Reserve.</p><p><strong>Conclusions: </strong>The study provides valuable insights into antimicrobial utilization in Saudi Arabia, offering a baseline for assessing prescribing patterns. While findings may reflect certain antimicrobial stewardship efforts, further investigation is needed to evaluate their impact. 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Antimicrobial utilization among hospitalized patients according to WHO AWaRe Classification: results from a multicentre point prevalence survey in Saudi Arabia.
Background: Antimicrobial resistance (AMR) threatens global health by reducing the efficacy of common infection treatments. This study examines antimicrobial use in Saudi Arabian hospitals, identifies influencing factors, and proposes interventions using the World Health Organization's (WHO) Access, Watch, Reserve (AWaRe) classification system.
Methods: A cross-sectional, multicentre point prevalence survey (PPS) of antimicrobial utilization was conducted in 10 hospitals across 6 regions of Saudi Arabia September 2023. All inpatients receiving antimicrobials on the PPS day were included. Data collection utilized the Global PPS tool developed by the University of Antwerp, Belgium.
Results: Among 2,890 inpatients, 766 (26.5%) were prescribed at least one antimicrobial, resulting in a total of 982 prescriptions. The primary indications for these antimicrobials were community acquired infections (37.1%), Healthcare associated infections (35.9%), surgical prophylaxis (15.4%), unknown reasons (8.7%), medical prophylaxis (2.5%), and other reasons (0.3%). The most common reasons for antimicrobial use included pneumonia or lower respiratory tract infections (16.1%), skin and soft tissue infections (11%), and bacteraemia (8.9%). The most frequently prescribed antimicrobial classes were penicillins with beta-lactamase inhibitors (18.5%), carbapenems (15.7%), and third-generation cephalosporins (11.1%). Most of the antimicrobials (66.3%) were classified as Watch antimicrobials, followed by 23.8% as Access, and 8.9% as Reserve.
Conclusions: The study provides valuable insights into antimicrobial utilization in Saudi Arabia, offering a baseline for assessing prescribing patterns. While findings may reflect certain antimicrobial stewardship efforts, further investigation is needed to evaluate their impact. The study also highlights key areas for improvement, emphasizing the importance of conducting future PPS to guide antimicrobial stewardship strategies and monitor progress in managing AMR.
期刊介绍：
The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes.
JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR).
Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.
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