Journal of global antimicrobial resistance最新文献

{"title":"Streptococcus pyogenes M1UK presence in China in 2018","authors":"Dingle Yu , Yuejie Zheng , Yunsheng Chen , Yuanhai You , Yonghong Yang","doi":"10.1016/j.jgar.2025.02.017","DOIUrl":"10.1016/j.jgar.2025.02.017","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 175-176"},"PeriodicalIF":3.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States","authors":"Hanseob Shin ,&nbsp;David M. Cwiertny ,&nbsp;Megan J. Nelson ,&nbsp;Ryan T. Jepson ,&nbsp;Michael A. Pentella ,&nbsp;Darrin A. Thompson","doi":"10.1016/j.jgar.2025.02.021","DOIUrl":"10.1016/j.jgar.2025.02.021","url":null,"abstract":"<div><h3>Background</h3><div>Carbapenemase-producing Enterobacteriaceae (CPE) are listed by the World Health Organization as one of the critical priority pathogens needing urgent attention to address global resistance to antimicrobials. Thus, the transmission and epidemiology of CPEs need to be studied via One Health perspectives.</div></div><div><h3>Methods</h3><div>An environmental CPE, referred to as BO1, was isolated from a creek in Northwest Iowa using a Colilert system (IDEXX, Westbrook, ME, USA). The presence of carbapenemase was examined using the modified carbapenem inactivation test, and then phenotypic resistance was determined using a Sensititre Complete Automated AST System (Thermo Fisher Scientific, Roskilde, Denmark). Whole-genome sequencing was performed and analysed to compare with clinical CPEs.</div></div><div><h3>Results</h3><div>BO1, carrying <em>bla</em>_NDM-5, was isolated from a creek in Northwest Iowa. BO1 exhibited resistance to 15 antimicrobials and was defined as an extensively drug-resistant organism. BO1 was also identified as ST167, which is well known as an emerging high-risk clone, and IncFIA- and IncQ1-type conjugatable plasmids were identified within the BO1 genome. The genetic environment of <em>bla</em>_NDM-5 was highly conserved as <em>bla</em>_NDM-<em>ble</em>_MBL-<em>trpF</em>-<em>dsbD</em> in all strains studied. Interestingly, single-nucleotide polymorphism analysis revealed that BO1 shared only 1, 4 and 12 single-nucleotide polymorphisms with three different clinical strains from patients at Iowa health care facilities.</div></div><div><h3>Conclusions</h3><div>The occurrence of BO1 was temporally and spatially close to that of one clinical strain, IA0018, implying the clonal spread of CPEs among humans and the environment, although the source and directionality of this spread remains unknown. This report illustrates the need for the strict control of CPEs in health care facilities and continuous surveillance within clinical and environmental settings to trace and prevent CPE transmission.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 154-160"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends of enterococcal and vancomycin-resistant Enterococcus faecium bacteraemia in the northern Dutch-German cross-border region: A 10-y multicentre analysis (2013–2022)","authors":"Cansu Cimen ,&nbsp;Andreas Voss ,&nbsp;Josef Hellkamp ,&nbsp;Axel Hamprecht ,&nbsp;Matthijs S. Berends","doi":"10.1016/j.jgar.2025.02.022","DOIUrl":"10.1016/j.jgar.2025.02.022","url":null,"abstract":"<div><h3>Objective</h3><div>To analyse the trends in occurrence of enterococcal and vancomycin-resistant <em>Enterococcus faecium</em> (VREfm) bacteraemia in the northern Dutch-German cross-border region.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted using positive blood culture results from two university hospitals, the University Medical Centre Groningen (UMCG) and the Klinikum Oldenburg (KOL) between 1 January 2013 to 31 December 2022.</div></div><div><h3>Results</h3><div>Over the 10-y period, 738 enterococcal bacteraemia episodes were observed at KOL and 1091 at UMCG, involving 685 and 999 patients, respectively. <em>E. faecium</em> was the predominant species in both institutions (60.3% at KOL and 60.8% at UMCG). The median age of patients with enterococcal, <em>E. faecium, E. faecalis</em> and VREfm bacteraemia was consistently higher at KOL than at UMCG (<em>p=</em> <em>.029</em>). In both institutions, over half of the enterococcal bacteraemia cases (53.4% at KOL, 55.8% at UMCG) were observed in intensive care units and haematology/oncology wards. From 2018 to 2022, UMCG had higher overall incidence rates of <em>E. faecium</em>, and <em>E. faecalis</em> bacteraemia, while KOL had a significantly higher incidence of VREfm (0.56 vs. 0.05 per 10,000 patient-d, <em>p&lt;</em> <em>.0001</em>). There was a significant upward trend in VREfm bacteraemia cases (<em>p=</em> <em>.01</em>) and in the proportion of VREfm among bacteraemia caused by <em>E. faecium</em> (<em>p=</em> <em>.027</em>) at KOL, but such a trend was not observed at UMCG during the study period.</div></div><div><h3>Conclusions</h3><div>The results reveal a significant difference in VREfm bacteraemia occurrences between a German and Dutch hospital in a cross-border region, reflecting national trends yet showing regional variation.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 187-194"},"PeriodicalIF":3.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone Harboring Capsular Type KL25 became the primarily prevalent capsular serotypes in a Tertiary Teaching Hospital in China.","authors":"Jing Wang, Qi Wang, Ruiqi Wang, Ruobing Wang, Jianbang Kang, Jinju Duan, Hui Wang","doi":"10.1016/j.jgar.2025.02.019","DOIUrl":"https://doi.org/10.1016/j.jgar.2025.02.019","url":null,"abstract":"<p><strong>Objective: </strong>The spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) that produces Klebsiella pneumoniae carbapenemase-2 (KPC-2) has garnered significant attention due to their increasing prevalence. In China, the dissemination of KPC-2-producing CRKP is predominantly linked to sequence type 11 (ST11), with the capsular serotypes KL47 and KL64 being the primary capsular identified.</p><p><strong>Methods: </strong>Sixty-four CRKP-ST11 strains were collected from 2020 to 2023. We performed whole-genome sequencing on all isolated ST11-CRKP strains. Antibiotic susceptibilities were tested with VITEK 2 systems. Growth curve test and in vitro competition experiments were used to assess growth adaptability of different capsular type isolates. Moreover, the biofilm assessment and phagocytosis assay were performed to evaluate the virulence of the CRKP isolates.</p><p><strong>Results: </strong>During the observed period, a no subclonal shift was perceived within the prevailing ST11-CRKP clone, wherein the previously dominant KL64 and KL47 serotypes have been largely supplanted by the KL25 serotype since 2022. The ST11-KL25-CRKP strain significantly outgrew both ST11-KL64-CRKP and ST11-KL47-CRKP. Additionally, ST11-KL25-CRKP displayed a greater enhanced capacity to form biofilms than ST11-KL64-CRKP and ST11-KL47-CRKP. Furthermore, the ST11-KL25-CRKP strain demonstrated enhanced resistance to phagocytosis than both of its counterparts.</p><p><strong>Conclusion: </strong>ST11-KL25-CRKP possesses a remarkable level of adaptability and has the potential to regionally replace ST11-KL64-CRKP as the predominant strain in the region. And the novel and high-risk ST11-KL25-CRKP strain may indicate stronger virulence.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISAC Information Page","authors":"","doi":"10.1016/S2213-7165(25)00053-0","DOIUrl":"10.1016/S2213-7165(25)00053-0","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"41 ","pages":"Page i"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISAC News and Updates","authors":"","doi":"10.1016/j.jgar.2025.02.016","DOIUrl":"10.1016/j.jgar.2025.02.016","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"41 ","pages":"Pages 290-291"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Acinetobacter towneri harbouring a novel plasmid with blaNDM-1 and tet(X7) from hospital wastewater in the Philippines","authors":"Zoe Mallonga ,&nbsp;Maho Tokuda ,&nbsp;Rin Yamazaki ,&nbsp;Shunta Tsuruga ,&nbsp;Isana Nogami ,&nbsp;Yuka Sato ,&nbsp;Ann Gelanie Tarrayo ,&nbsp;Rolly Fuentes ,&nbsp;Richard Parilla ,&nbsp;Kazuhide Kimbara ,&nbsp;Masato Suzuki ,&nbsp;Masaki Shintani","doi":"10.1016/j.jgar.2025.01.017","DOIUrl":"10.1016/j.jgar.2025.01.017","url":null,"abstract":"<div><h3>Objectives</h3><div>The clinical effectiveness of carbapenem and tigecycline, which are last-resort antimicrobials used to treat multidrug-resistant bacterial infections<em>,</em> faces challenges due to emerging plasmid-borne resistance mechanisms, including the enzymatic inactivation of antimicrobials. Here, we investigate and report the co-occurrence of <em>bla</em>_NDM-1 and <em>tet</em>(X7) genes in an <em>Acinetobacter towneri</em> isolate from hospital wastewater in the Philippines.</div></div><div><h3>Methods</h3><div>An <em>A. towneri</em> isolate PT23-B2 was obtained from a hospital wastewater treatment plant in Tacloban, Philippines in 2023. Whole-genome sequencing of PT23-B2 was performed and antimicrobial resistance genes (ARGs), plasmids, and mobile genetic elements were detected using custom sequence databases.</div></div><div><h3>Results</h3><div>Whole-genome sequencing analysis of <em>A. towneri</em> PT23-B2 resulted in the complete genome sequence consisting of one chromosome and five putative plasmids. One of the five plasmids identified, the 134-kb plasmid named pPT23-B2_1 (of which replicon was classified as R3-T45 or GR31), contained multiple ARGs, including <em>bla</em>_NDM-1 and <em>tet</em>(X7). The <em>bla</em>_NDM-1 was flanked by IS<em>Aba125</em>, and <em>tet</em>(X7) was associated with one IS<em>26</em> family insertion sequence (IS), indicating probable transpositions into the plasmid via these mobile genetic elements. Antimicrobial susceptibility tests showed that PT23-B2 is resistant to tigecycline, in addition to meropenem.</div></div><div><h3>Conclusions</h3><div>This is the first report on an environmental bacterial isolate from the Philippines harbouring both carbapenem-resistance gene (<em>bla</em>_NDM-1) and tigecycline-resistance gene [<em>tet</em>(X7)]. This study highlights the potential dissemination of clinically important ARGs, such as <em>bla</em>_NDM and <em>tet</em>(X), in environmental reservoirs, necessitating continuous monitoring and urgent intervention strategies.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"41 ","pages":"Pages 287-289"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes and key factors contributing to unfavourable outcomes among isoniazid-resistant pulmonary tuberculosis patients in Shanghai, China","authors":"Wenjing Xiao ,&nbsp;Jing Chen ,&nbsp;Lixin Rao ,&nbsp;Xiao Xiao ,&nbsp;Xubin Zheng ,&nbsp;Zheyuan Wu ,&nbsp;Xin Shen","doi":"10.1016/j.jgar.2025.02.003","DOIUrl":"10.1016/j.jgar.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>Given that more than 1 million people annually develop isoniazid-resistant tuberculosis (Hr-TB), the issue of Hr-TB may go unnoticed. However, limited studies have focused on the clinical treatment of Hr-TB in China, particularly regarding treatment outcomes and influencing factors. This study aimed to evaluate the treatment outcomes of Hr-TB patients in Shanghai from 2018 to 2021 and analyse the influencing factors, including demographic characteristics, clinical features, and treatment-related factors.</div></div><div><h3>Methods</h3><div>This study retrospectively reviewed the medical records of Hr-TB patients registered in the TB management information system from 2018 to 2021. Differences in demographic characteristics, clinical information, and treatment outcomes were evaluated. Multivariable logistic regression was used to identify risk factors associated with unfavourable outcomes.</div></div><div><h3>Results</h3><div>A total of 664 patients with Hr-TB were included in the analysis. A total of 84 cases (12.7%) had unfavourable outcomes. Only 318 (47.9%) Hr-TB patients used regimens containing fluoroquinolones. Adverse events occurred in 127 cases (19.1%), of which 12 cases (1.81%) discontinued treatment due to adverse events. There was statistically significant difference in the occurrence of adverse events between the different treatment regimens (<em>P</em> &lt; 0.001). Multivariable logistic regression showed that older age (adjusted odds ratio = 6.13, 95% confidence intervals [CI] = 1.24–30.24, <em>P</em> = 0.026), use of injectable agents (adjusted odds ratio = 3.75, 95% CI = 1.29–10.94, <em>P</em> = 0.016), and treatment duration (95% CI = 21.85–1487.61, <em>P</em> &lt; 0.001) were risk factors for unfavourable treatment outcomes.</div></div><div><h3>Conclusions</h3><div>Unfavourable outcomes were more frequent among older patients and those receiving injectable agents among Hr-TB patients in Shanghai, a low-endemic region for TB. This emphasizes the need for timely diagnosis and optimized treatment strategies for isoniazid-resistant tuberculosis.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 177-186"},"PeriodicalIF":3.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined dual β-lactams and diazabicyclooctane β-lactamase inhibitor is highly effective against Mycobacterium abscessus species in vitro","authors":"Kana Misawa ,&nbsp;Tomoyasu Nishimura ,&nbsp;Maiko Yoshikawa ,&nbsp;Rina Shimamura ,&nbsp;Shoko Kashimura ,&nbsp;Yuki Enoki ,&nbsp;Kazuaki Taguchi ,&nbsp;Kazuaki Matsumoto ,&nbsp;Naoki Hasegawa","doi":"10.1016/j.jgar.2025.02.015","DOIUrl":"10.1016/j.jgar.2025.02.015","url":null,"abstract":"<div><h3>Objective</h3><div><em>Mycobacterium abscessus</em> pulmonary disease is a refractory infectious disease. Developing an effective treatment is urgent as the number of patients infected with <em>M. abscessus</em> species (MABS) is increasing worldwide. We previously reported that nacubactam, a diazabicyclooctane (DBO) β-lactamase inhibitor, could inhibit MABS β-lactamase. Few reports have indicated that dual β-lactams are effective with a DBO β-lactamase inhibitor against MABS. The objective of this study was to determine which dual β-lactams have high antibacterial activity against MABS in the presence and absence of nacubactam.</div></div><div><h3>Methods</h3><div>Antimicrobial susceptibility tests were conducted through a checkerboard assay of 27 β-lactams using the broth microdilution method for three subspecies-type strains and 20 clinical isolates of MABS. The number of intracellular and extracellular bacteria was measured using human macrophages infected with <em>M. abscessus</em> treated with effective combinations confirmed in susceptibility tests.</div></div><div><h3>Results</h3><div>In antimicrobial susceptibility tests, 91 combinations of dual β-lactams with nacubactam exhibited synergistic effects on <em>M. abscessus</em> JCM13569. Among them, the combination of cefazolin, cefotiam, cefoxitin, or cefuroxime with imipenem and nacubactam exhibited highly synergistic effects, resulting in low MICs against MABS clinical isolates. Without nacubactam, the combination of imipenem and cefoxitin showed the lowest MIC. In experiments using human macrophages infected with <em>M. abscessus</em>, these dual β-lactam combinations reduced the number of intracellular and extracellular bacteria compared with those of single β-lactams.</div></div><div><h3>Conclusions</h3><div>The combination of cefazolin, cefotiam, cefoxitin, or cefuroxime with imipenem and nacubactam was highly effective against MABS. Without nacubactam, the combination of cefoxitin and imipenem was effective.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 142-150"},"PeriodicalIF":3.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spread of the Fosfomycin resistance fosA3 gene via the IS26 mobile element between plasmids and the chromosome of carbapenem-resistant Escherichia coli in China","authors":"Ying Zhang ,&nbsp;Chuanxin Yang ,&nbsp;Jiayao Yao ,&nbsp;Longjie Zhou ,&nbsp;Xiaofan Zhang ,&nbsp;Huan Wang ,&nbsp;Lijuan Liu ,&nbsp;Yuexing Tu ,&nbsp;Xi Li","doi":"10.1016/j.jgar.2025.02.011","DOIUrl":"10.1016/j.jgar.2025.02.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated <em>fosA3</em>-positive strains selected from carbapenem-resistant <em>Escherichia coli</em> (CREC) and further characterized them through genomic and phenotypic analyses.</div></div><div><h3>Methods</h3><div><em>fosA3-</em>positive CREC strains were subjected to agar dilution. Whole-genome sequencing (WGS) was used to identify molecular mechanisms of fosfomycin resistance and to investigate plasmid structure characteristics through comparative analysis. Conjugative transfer experiments were used to evaluate plasmid transfer ability, followed by plasmid stability assessment. Growth rate analysis evaluated the fitness costs of transconjugants. Phylogenetic analysis was performed on <em>fosA3</em>-positive CREC strains. Furthermore, analysis of <em>fos</em> genes carrying <em>E. coli</em> sequence types (STs) from the NCBI database explored the evolution and spread of fosfomycin resistance.</div></div><div><h3>Results</h3><div>Between 2016 and 2023, a total of 11.23% CREC strains (10/89) carrying <em>fosA3</em> were collected from a hospital for further analysis. These ten <em>fosA3</em>-positive strains were also resistant to fluoroquinolones and ceftazidime-avibactam. The <em>fosA3</em> gene was located within a similar genetic background (IS<em>26</em>-<em>fosA3</em>–1811bp-IS<em>26</em>) on plasmids or chromosomes. The <em>fosA3</em>-carrying IncFII(pHN7A8)-IncX3 cointegrate plasmid pEC00–2–145k was transferable, with fitness cost of 20% to host. Furthermore, three of ten <em>fosA3</em>-positive CREC strains belonged to ST156. Analysis of <em>fos</em> genes carrying <em>E. coli</em> strains from China in the NCBI database identified ST156 (5.39%, 147/2,725) and ST167 (5.21%, 142/2,725) as predominant STs.</div></div><div><h3>Conclusions</h3><div>This study revealed <em>fosA3</em> in CREC strains was associated with IS<em>26</em> and spreads fosfomycin resistance through horizontal transfer, occurring both on chromosomes and plasmids. The first <em>fosA3</em>-carrying cointegrate plasmid pHN7A8-IncX3-type in <em>E. coli</em> isolates was reported, highlighting a new route of fosfomycin resistance spread. Additionally, notable diversity of ST among <em>fosA3</em>-carrying <em>E. coli</em> strains highlights complexity of fosfomycin resistance dissemination and the importance of surveillance and control measures.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"42 ","pages":"Pages 80-87"},"PeriodicalIF":3.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}