Journal of global antimicrobial resistance最新文献

{"title":"The alarming rise of antimicrobial resistance in ICUs in Bangladesh: A silent emergency and the urgent need for national action","authors":"Md Saiful Islam , Be-Nazir Ahmed , Md Tanvir Rahman","doi":"10.1016/j.jgar.2026.02.005","DOIUrl":"10.1016/j.jgar.2026.02.005","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 105-106"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic analysis of coexisting β-lactamase plasmids in Klebsiella pneumoniae from an immunocompromised patient","authors":"Thamer M. Brek ,&nbsp;Hanan A. Alshafie ,&nbsp;Musa A. Ayashi ,&nbsp;Othman I. Aljurayyad ,&nbsp;Hatim Almutairi ,&nbsp;Elaf M. Alattas ,&nbsp;Ibrahim A. Al-Zaharani","doi":"10.1016/j.jgar.2026.02.002","DOIUrl":"10.1016/j.jgar.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>Infection significantly increases morbidity and mortality in hematologic malignancies due to immunosuppression, multiple risk factors, and greater susceptibility to healthcare-associated infections. We conducted a comprehensive genomic analysis of ESBL and carbapenemase co-producing <em>K. pneumoniae</em> (KP-JZ177) isolate recovered from a vulnerable patient with acute myeloblastic leukemia (AML) in Jazan region, Saudi Arabia.</div></div><div><h3>Methods</h3><div>A clinical <em>K. pneumoniae</em> (KP-JZ177) isolate was obtained from a wound swab of a female patient with AML in the Hematology–Oncology unit of a tertiary hospital in Jazan region. Identification and AST were performed using the MicroScan WalkAway system. Whole-genome sequencing enabled comprehensive characterization of the strain’s genetic profile, resistance determinants, virulence factors, and plasmid replicons.</div></div><div><h3>Results</h3><div>KP-JZ177 isolate displayed resistance to all tested antimicrobials except amikacin, gentamicin, tigecycline, and colistin. The genomic features of KP-JZ177 indicate substantial adaptability and pathogenic potential. KP-JZ177 belongs to sequence type ST147, a globally recognized high-risk clone associated with carbapenem resistance and recurrent hospital outbreaks. Its extensive drug-resistant (XDR) profile is driven by the co-occurrence of carbapenemase genes <em>bla</em>_OXA-48 and <em>bla</em>_NDM-1, which together confer high-level β-lactam resistance. Serotyping classified the isolate as KL64 with an O1/O2v1 O-antigen. Genomic analysis also revealed eight plasmids, many carried β-lactamase determinants and several mobile genetic elements (MGEs).</div></div><div><h3>Conclusions</h3><div>Genomic profiling of KP-JZ177 reveals high-risk <em>K. pneumoniae</em> clone carrying extensive resistance and virulence determinants on multiple plasmids, including <em>bla</em>_OXA-48 and <em>bla</em>_NDM-1. Its plasmids similarity to geographically distant strains underscore global AMR circulation, emphasizing the need for enhanced surveillance of ST147 CRKP isolates in high-risk populations.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 73-78"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of carbapenem-resistant Klebsiella pneumoniae after ceftolozane–tazobactam exposure in a patient after cord blood transplantation: A case report","authors":"Shuhei Kurosawa ,&nbsp;Sohei Harada ,&nbsp;Kohji Komori ,&nbsp;Kaworu Takatsuna ,&nbsp;Hitomi Ike ,&nbsp;Yukihiro Yoshimura ,&nbsp;Yuki Iketani ,&nbsp;Yoko Tateishi ,&nbsp;Hiroyuki Hayashi ,&nbsp;Tomonori Nakazato","doi":"10.1016/j.jgar.2026.01.008","DOIUrl":"10.1016/j.jgar.2026.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>Infections caused by carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) have a poor prognosis, particularly in immunocompromised patients. While carbapenemase production is the primary resistance mechanism in carbapenem-resistant <em>K. pneumoniae</em> (CRKP), other mechanisms may contribute synergistically to carbapenem resistance. Here, we describe a case in which extended-spectrum β-lactamase (ESBL)-producing <em>K. pneumoniae</em>, initially susceptible to carbapenems, acquired carbapenem resistance without carbapenemase production following ceftolozane–tazobactam exposure.</div></div><div><h3>Methods</h3><div>Whole-genome sequencing was performed on ESBL-producing <em>K. pneumoniae</em> strains detected during the clinical course to investigate the relationship between the genetic characteristics and antimicrobial susceptibility, particularly to ceftolozane–tazobactam and carbapenems. Changes in the transcription levels of the beta-lactamase genes were also analysed using reverse transcription quantitative PCR (RT-qPCR).</div></div><div><h3>Results</h3><div>Active surveillance stool culture before cord blood transplantation (CBT) identified colonisation with an ESBL-producing <em>K. pneumoniae</em> strain. Febrile neutropenia occurred on day 7 after CBT and was treated empirically with ceftolozane–tazobactam. Fatal bacteraemia developed on day 30 after CBT due to a carbapenemase-negative isolate resistant to both ceftolozane–tazobactam and carbapenems. Whole-genome sequencing analysis revealed that <em>K. pneumoniae</em> ST307 strains harbouring <em>bla</em>_CTX−M-15, <em>bla</em>_SHV-28 and <em>bla</em>_TEM-1B acquired a nonsense mutation in <em>ompK36</em> following ceftolozane–tazobactam exposure. RT-qPCR analysis documented a significant increase in <em>bla</em>_SHV-28 transcription after ceftolozane–tazobactam exposure.</div></div><div><h3>Conclusions</h3><div>This case demonstrates that <em>K. pneumoniae</em> without carbapenemase production can acquire carbapenem resistance through a combined resistance mechanisms following exposure to non-carbapenem antibiotics. Antimicrobial stewardship must be implemented comprehensively, not focused solely on specific antibiotics.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 27-32"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist-led multidisciplinary review of carbapenem use in inpatients: A quasi-experimental study","authors":"Xiaohong Wu,&nbsp;Tingting Nan,&nbsp;Xianni Wei,&nbsp;Yonglong Su,&nbsp;Yumei Cai,&nbsp;Siheng Lian,&nbsp;Xiaoyun Ye,&nbsp;Jinbao Wei","doi":"10.1016/j.jgar.2026.02.001","DOIUrl":"10.1016/j.jgar.2026.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of a clinical pharmacist-led multidisciplinary team (MDT) review model on the appropriateness of carbapenem use amongst inpatients.</div></div><div><h3>Methods</h3><div>This study employed a quasi-experimental, pre-post design. We retrospectively analysed 1086 inpatient cases receiving carbapenem therapy between 2020 and 2024. From 2023 onward, an MDT comprising clinical pharmacists, infectious disease specialists, and microbiologists systematically reviewed medical orders against standardised criteria and provided evidence-based recommendations.</div></div><div><h3>Results</h3><div>Post-intervention, the appropriateness of initial carbapenem prescriptions increased from 77.08% to 83.79%, whereas re-evaluation appropriateness improved from 78.94% to 87.00% (<em>P</em> &lt; .05). Pharmacist intervention acceptance rates rose significantly from 56.04% to 82.35% (<em>P</em> &lt; .05). Additionally, median hospital length of stay decreased (19 vs. 15 days), with notable reductions in ICU admission (59.95% vs. 31.50%) and mortality rates (15.51% vs. 4.28%) (<em>P</em> &lt; .001). Multivariable regression identified hepatic/renal dysfunction and hypoalbuminemia as independent risk factors for ICU admission, whereas ICU admission itself strongly predicted mortality. Notably, the detection rates of carbapenem-resistant <em>Klebsiella pneumoniae</em> and <em>Pseudomonas aeruginosa</em> increased during the intervention period.</div></div><div><h3>Conclusions</h3><div>The clinical pharmacist-led MDT model enhances carbapenem-prescribing appropriateness and fosters interprofessional collaboration. Its implementation was associated with shorter hospital stays and improvements in key clinical indicators, including reduced ICU admission and mortality. However, the observed shifts in resistant pathogen epidemiology underscore that antimicrobial stewardship strategies must be integrated with rigorous infection prevention and control measures to simultaneously optimise therapeutic outcomes and mitigate resistance.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 79-86"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance in the Bacteroides fragilis group: National multicenter survey and Bayesian modelling study, France, 2022–2023","authors":"Gauthier Delvallez ,&nbsp;Pascal Campagne ,&nbsp;Corentine Alauzet ,&nbsp;Laure Diancourt ,&nbsp;Frédéric Barbut ,&nbsp;Hélène Marchandin ,&nbsp;Bruno Dupuy ,&nbsp;BFG AMR Collaborative Study group","doi":"10.1016/j.jgar.2026.01.003","DOIUrl":"10.1016/j.jgar.2026.01.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Epidemiological studies on <em>Bacteroides fragilis</em> group (BFG) species and their antimicrobial resistance (AMR) profiles remain scarce worldwide and are lacking in France. The aim of this study was to provide comprehensive national data on the distribution of BFG species, isolation sites, AMR and its potential regional disparity.</div></div><div><h3>Methods</h3><div>A retrospective multicenter study was conducted from January 2022 to December 2023 using routine data from 45 French hospitals. A total of 9458 BFG isolates identified to the species level by MALDI-ToF were included. Antimicrobial susceptibility testing (AST) was performed according to French guidelines using either disc diffusion or gradient diffusion methods. AST results were collected for ten antibiotics: amoxicillin-clavulanate (AMC), piperacillin-tazobactam (PIT), imipenem (IMI), clindamycin (CLI), metronidazole (MET), moxifloxacin, tigecycline, linezolid, rifampicin, and chloramphenicol. A Bayesian statistical model was applied to estimate regional resistance frequencies with corresponding credible intervals.</div></div><div><h3>Results</h3><div><em>Bacteroides fragilis sensu stricto</em> (<em>B. fragilis</em>) was the most prevalent species (62.4%), followed by <em>Bacteroides thetaiotaomicron</em> (14.2%). Resistance to IMI and MET remained low, while AMC, PIT, and CLI resistance varied markedly across species: 5.2%, 3.6%, and 34.4% for <em>B. fragilis</em>; 18.0%, 50.1%, and 72.9% for <em>B. thetaiotaomicron</em>; and 32.1%, 19.5%, and 75.2% for <em>Parabacteroides distasonis</em>, respectively. Bayesian modelling produced robust regional estimates for <em>B. fragilis</em>, revealing noticeable regional disparities, particularly for AMC, PIT, and MET.</div></div><div><h3>Conclusion</h3><div>Bayesian modeling revealed substantial interspecies and interregional differences in BFG resistance, highlighting the importance of species-level identification and localized surveillance to inform empirical antibiotic therapy.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 9-19"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terrestrial plastisphere as a reservoir of high-risk mcr-1-positive Escherichia coli ST744 in a farmhouse","authors":"João Pedro Rueda Furlan ,&nbsp;Rafael da Silva Rosa ,&nbsp;Micaela Santana Ramos ,&nbsp;Lucas David Rodrigues dos Santos ,&nbsp;Eliana Guedes Stehling","doi":"10.1016/j.jgar.2025.11.015","DOIUrl":"10.1016/j.jgar.2025.11.015","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"46 ","pages":"Pages 146-147"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance in India: Integrating the response into health systems for universal health coverage","authors":"Sudha Chandrashekar ,&nbsp;Shambhavi Nimisha Prasad ,&nbsp;Ramesh Masthi N R ,&nbsp;Sheilja Walia ,&nbsp;Anushree Trikha ,&nbsp;Rajeev Sadanandan","doi":"10.1016/j.jgar.2025.12.001","DOIUrl":"10.1016/j.jgar.2025.12.001","url":null,"abstract":"<div><h3>Background</h3><div>Antimicrobial resistance (AMR) poses a formidable threat to public health in India, requiring a multidimensional response that bridges policy, innovation and intersectoral collaborations. The rapid emergence and spread of multidrug-resistant pathogens driven by the misuse of antimicrobials in human health, animal health, agriculture and environmental settings has rendered many existing therapies obsolete, leaving the population vulnerable to untreatable infections.</div></div><div><h3>Objectives</h3><div>To examine the multifactorial drivers of AMR in India, review current national and state-level policies and explore the potential role of artificial intelligence (AI) in AMR surveillance, prevention and control.</div></div><div><h3>Methods</h3><div>This review synthesises evidence from published literature, reports and policy documents. It analyses AMR determinants across human, animal and environmental sectors, evaluates policy frameworks such as India’s National Action Plan and State Action Plans to combat AMR.</div></div><div><h3>Results</h3><div>Key AMR drivers include antibiotic misuse, inadequate regulation, over-the-counter availability, pharmaceutical and hospital wastewater contamination and gaps in infection prevention. India has come up with national and six state level action plans for AMR containment. The measures include stewardship programs, laboratory network strengthening, spreading awareness and intersectoral coordination. The role of AI in strengthening AMR surveillance and clinical decision-making by integrating complex, high-dimensional data for predictive modelling has been explored.</div></div><div><h3>Conclusion</h3><div>While India has made significant policy and surveillance advances, enforcement gaps, limited awareness and fragmented data hinder progress. Strengthening governance, expanding One Health surveillance, integrating AI and embedding AMR strategies into universal health coverage are critical to mitigating AMR’s health and economic burden.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"46 ","pages":"Pages 195-202"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcome comparison between adjunctive clindamycin vs. linezolid for invasive group A streptococcal infection","authors":"Eriko Hashimoto ,&nbsp;Sayaka Yoshida ,&nbsp;Taito Kitano","doi":"10.1016/j.jgar.2025.12.013","DOIUrl":"10.1016/j.jgar.2025.12.013","url":null,"abstract":"<div><h3>Purpose</h3><div>Although the non-inferiority of adjunctive linezolid (LZD) was indicated for the treatment of invasive group A streptococcal (iGAS) infection, compared with adjunctive clindamycin (CLDM), additional evaluation of comparative effectiveness by subpopulation may further strengthen the evidence. We compared the efficacy of CLDM and LZD combination therapy for iGAS infection.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, data were extracted and analysed using TriNetX, a multicentre database. Data were extracted from 1 January 2015 to 30 April 2025, creating two cohorts (adjunctive CLDM and LZD groups). The primary endpoint was mortality within 90 d from diagnosis, which was compared between groups using propensity score matching. Subgroup analyses were conducted according to age, concomitant intravenous immunoglobulin treatment, and study period.</div></div><div><h3>Results</h3><div>For analysis, 5841 cases were identified in the CLDM combination group and 1426 in the LZD group. The primary endpoint was observed in 170 (12.0%) cases in the CLDM group and 195 (13.8%) in the LZD group. Odds ratio was 0.854 (95% confidence interval 0.685–1.065, <em>P</em> = 0.161), with odds ratio &lt;1 indicating a CLDM-favourable result.</div></div><div><h3>Conclusions</h3><div>Clinical efficacy of adjunctive CLDM and LZD was compared in patients with iGAS infection. No significant difference in mortality was observed in the overall population. LZD may be a potential alternative in cases where CLDM use is limited by resistance, intolerance, or contraindications.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"46 ","pages":"Pages 241-245"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New NDM-producing and blaKPC-2 harbouring Klebsiella pneumoniae ST6668 (CC147) clone in Milan, Northern Italy","authors":"Sara Giordana Rimoldi ,&nbsp;Francesco Comandatore ,&nbsp;Chiara Cogliati ,&nbsp;Stefano Odelli ,&nbsp;Loriana Morelli ,&nbsp;Pierachille Santus ,&nbsp;Spinello Antinori ,&nbsp;Alberto Dolci","doi":"10.1016/j.jgar.2025.11.016","DOIUrl":"10.1016/j.jgar.2025.11.016","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"46 ","pages":"Pages 126-127"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiological and molecular characteristics and sulbactam-durlobactam susceptibility of carbapenem-resistant Acinetobacter baumannii in a Chinese teaching hospital","authors":"Hanlian Huang ,&nbsp;Qiaomin Zhang ,&nbsp;Shaobo Li ,&nbsp;Xiaoyan Dai,&nbsp;Zhongbiao Chen,&nbsp;Guili Zhang,&nbsp;Wen Ma,&nbsp;Hongwei Shen","doi":"10.1016/j.jgar.2025.12.003","DOIUrl":"10.1016/j.jgar.2025.12.003","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate sulbactam-durlobactam (SUL-DUR) susceptibility and molecular features of carbapenem-resistant <em>Acinetobacter baumannii</em> (CRAB) isolates from a Shenzhen teaching hospital.</div></div><div><h3>Methods</h3><div>A retrospective study on CRAB was conducted from January 2018 to June 2025. Isolates were screened for <em>gyrB</em> and β-lactamase genes (<em>bla</em>OXA-23, −24, −51, and −58). Multi-locus sequence typing (MLST) was used for genotyping, and SUL-DUR susceptibility was tested by disk diffusion. The SUL-DUR-resistant isolate underwent whole-genome sequencing to identify resistance mechanisms.</div></div><div><h3>Results</h3><div>Of 741 non-duplicate <em>A. baumannii</em> isolates, 147 were CRAB, with its annual percentage rising from 11.4% (2018) to 47.2% (2025). Most isolates came from the ICU (53.7%), and affected patients were predominantly aged ≥60 years (62.6%). Sputum was the primary source (49.7%). Resistance rates exceeded 90% for multiple antibiotics, but only one isolate (0.7%) was resistant to SUL-DUR. This strain harbored nine resistance genes (including <em>bla</em>OXA-23 and <em>bla</em>OXA-66) and had substitutions in penicillin-binding protein 2 (PBP2) and a putative D-Ala-D-Ala carboxypeptidase.</div><div>Five sequence types (STs) were identified, including ST2, ST877, ST133, ST195, and a novel sequence type (ST3267), with ST2 being predominant (96.6%). The <em>bla</em>OXA-23 gene was present in 72.8% of isolates, while <em>bla</em>OXA-24 was rare (2.7%). All isolates carried intrinsic <em>bla</em>OXA-51 and <em>gyrB</em>, but <em>bla</em>OXA-58 was absent.</div></div><div><h3>Conclusions</h3><div>The increasing percentage of carbapenem-resistance among <em>A. baumannii</em>, dominated by ST2 and <em>bla</em>OXA-23-positive strains, highlights an urgent need for stricter infection control. Meanwhile, the notable <em>in vitro</em> susceptibility of CRAB to SUL-DUR offers a promising therapeutic alternative for patients infected with CRAB.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"46 ","pages":"Pages 137-145"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}