Journal of global antimicrobial resistance最新文献

{"title":"ISAC News and Updates","authors":"","doi":"10.1016/j.jgar.2026.03.001","DOIUrl":"10.1016/j.jgar.2026.03.001","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages ii-iii"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147540020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk Pseudomonas aeruginosa clones ST308, ST773, and ST233 associated with carbapenem-resistant and extensively drug-resistant isolates from hospital and community settings in Casablanca, Morocco","authors":"Ihssane Benzaarate ,&nbsp;Fatima El Otmani ,&nbsp;Aboubakr Khazaz ,&nbsp;Francois Lebreton ,&nbsp;Sylvain Brisse ,&nbsp;Kaotar Nayme","doi":"10.1016/j.jgar.2025.12.012","DOIUrl":"10.1016/j.jgar.2025.12.012","url":null,"abstract":"<div><h3>Objectives</h3><div>The spread of high-risk extensively drug-resistant (XDR) <em>Pseudomonas aeruginosa</em> (Pa) clones is a global threat to public health. In Morocco, data on circulating clones and genomic features of Pa isolates are lacking. Accordingly, this study performed whole-genome sequencing (Illumina NextSeq500) of 18 Pa isolates from hospitals (n = 10) and the community (n = 8) to identify their sequence type (ST) affiliation, antimicrobial resistance determinants, virulence factors, and phylogenetic relationships.</div></div><div><h3>Methods</h3><div>Isolates were selected based on alarming resistance profiles from strains collected in Casablanca, Morocco, between January and December 2021.</div></div><div><h3>Results</h3><div>These isolates were assigned sequence type 773 (n = 11), 308 (n = 5), and 233 (n = 1), in addition to a novel ST4902 for one hospital isolate. Carbapenem resistance in hospital isolates was primarily attributed to acquired carbapenemases (NDM-1 in ST773 and ST308 clones). In contrast, resistance in one hospital (CSPa93) and one community isolate (cSPa43) was associated with mutations in the outer membrane protein. Fluoroquinolone resistance correlated with the carriage of <em>qnrVC1</em> and <em>crpP</em> genes, along with mutations in the quinolone resistance-determining regions. The isolates also carried diverse aminoglycoside modifying enzymes and 16S rRNA methyltransferase genes. Genomic analysis also identified multiple virulence genes in these isolates, notably <em>exoU</em> in ST308 and ST773 isolates. Phylogenetic analysis further revealed hospital-adapted strains being genetically related to each other and to community strains.</div></div><div><h3>Conclusion</h3><div>This first genomic investigation of circulating XDR Pa clones in both hospital and community settings in Morocco using whole-genome sequencing highlights the urgent need for enhanced surveillance and targeted strategies to contain the spread of XDR high-risk clones.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 41-48"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetic/pharmacodynamic integration of linezolid alone and in combination with fosfomycin against methicillin-resistant Staphylococcus aureus in a neutropenic murine thigh infection model","authors":"Ziyan Chen ,&nbsp;Chunhua Peng ,&nbsp;Fangrui Liang ,&nbsp;Sailan Wang ,&nbsp;Lu Lai ,&nbsp;Qin Ai ,&nbsp;Zaixing Chen ,&nbsp;Shuai Zheng ,&nbsp;Yanyan Liu ,&nbsp;Xiaohui Huang","doi":"10.1016/j.jgar.2026.01.016","DOIUrl":"10.1016/j.jgar.2026.01.016","url":null,"abstract":"<div><h3>Objectives</h3><div>This study sought to compare the pharmacokinetic-pharmacodynamic (PK/PD) targets of linezolid against methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) in monotherapy versus combination with fosfomycin.</div></div><div><h3>Methods</h3><div>We assessed the antibacterial effect of linezolid plus fosfomycin, followed by determination of the mutant prevention concentrations (MPCs) under both individual and combined regimens. Next, using a neutropenic murine thigh infection model, we determined the pharmacokinetics of linezolid and evaluated its efficacy following administration as monotherapy or in combination with fosfomycin. PK/PD analysis was subsequently conducted using an <em>E</em>_max model. Finally, we compared the %<em>f</em>T&gt;MPC (the percentage of the dosing interval during which free drug concentrations exceeded the MPC) of linezolid between its monotherapy and combination therapy with fosfomycin.</div></div><div><h3>Results</h3><div>Combination therapy enhanced bactericidal activity against MRSA and reduced the MPCs of the agents, thereby narrowing the mutant selection window (MSW). Addition of fosfomycin significantly improved linezolid efficacy in the MRSA thigh infection model. For linezolid, the <em>f</em>AUC/MIC values required for stasis, 1-log₁₀ kill, and 2-log₁₀ kill were 18.01, 47.87, and 225.07, respectively. When administered together, fosfomycin reduced the required <em>f</em>AUC/MIC of linezolid by 1.4–6.4-fold. At equivalent linezolid doses, combination therapy increased linezolid %<em>f</em>T&gt;MPC by 1.7–4.8-fold.</div></div><div><h3>Conclusions</h3><div>Combined linezolid and fosfomycin therapy enhances in vivo anti-MRSA efficacy, reduces the risk of resistance emergence, and lowers the exposure requirements for linezolid.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 64-72"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial resistance in urinary samples from long-term care-facility and community-dwelling older people in Gauteng, South Africa","authors":"Olivia Labuschagne ,&nbsp;Stephanie Leigh ,&nbsp;Chanel Kingsburgh ,&nbsp;Christopher David Williams","doi":"10.1016/j.jgar.2026.01.012","DOIUrl":"10.1016/j.jgar.2026.01.012","url":null,"abstract":"<div><h3>Objective</h3><div>Older populations (≥ 60 years) are frequent users of health care services, often vulnerable to infections and antimicrobial resistance (AMR). Urinary tract infection is often diagnosed in this cohort based on non-specific or atypical symptoms, yet empirical therapy seldom considers the potential influence of residential setting on resistance patterns. This study therefore aimed to quantify and compare the <em>in vitro</em> AMR profiles of urinary pathogens from these two settings and assessed temporal resistance trends to inform antimicrobial stewardship priorities.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted using anonymised microbiology data from Ampath Laboratories in Gauteng. Urine cultures collected from older adults (≥60 years) between 2015 and 2023 were included. The five most common uropathogens were analysed. Resistance differences between long-term care facility (LTCF) and community samples were assessed using univariate and multivariable logistic regression models adjusting for age, sex, inpatient status, and sampling year. Temporal trends were evaluated using Kendall tau-b.</div></div><div><h3>Results</h3><div>A total of 50 704 urine cultures were analysed, of which 18.81% were from LTCFs. <em>Escherichia coli</em> and <em>P. mirabilis</em> showed consistently higher resistance in LTCF isolates. In <em>E. coli</em>, LTCF residence was associated with increased resistance to ciprofloxacin (adjusted OR 1.26; 95% CI 1.18–1.34), nitrofurantoin (1.55; 1.38–1.75), ceftriaxone (1.24; 1.14–1.34), amoxicillin/clavulanic acid (1.11; 1.05–1.19), and co-trimoxazole (1.10; 1.03–1.18). <em>P. mirabilis</em> showed similar patterns, with higher resistance to ciprofloxacin (2.16), gentamicin (1.64), fosfomycin (1.72) and co-trimoxazole (1.49). Trend analysis showed increasing fosfomycin resistance from <em>E. coli</em> isolates in both LTCFs (3.74% to 6.18%) and community settings (2.75% to 3.74%) and rising ceftriaxone resistance in community isolates (13.32% to 17.60%).</div></div><div><h3>Conclusions</h3><div>LTCF residence was independently associated with higher AMR in several common urinary pathogens. These findings suggest that empirical urinary tract infection regimens commonly used in community-dwelling older adults may be inadequate for LTCF residents. Setting-specific antibiograms, improved diagnostic stewardship, and strengthened antimicrobial stewardship interventions are needed to support appropriate prescribing. Further studies incorporating patient-level clinical factors are warranted to refine empirical treatment recommendations for older adults across care settings.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 95-104"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and facilitators to the implementation of antimicrobial stewardship in veterinary education: A scoping review","authors":"Rekhashree Raveendran ,&nbsp;Navya Vyas ,&nbsp;Yashna Bharath Salian ,&nbsp;Edlin Glane Mathias ,&nbsp;Nagappa Karabasanavar","doi":"10.1016/j.jgar.2026.01.015","DOIUrl":"10.1016/j.jgar.2026.01.015","url":null,"abstract":"<div><h3>Objective</h3><div>To identify the barriers and facilitators to implement antimicrobial stewardship (AMS) in veterinary education globally.</div></div><div><h3>Methods</h3><div>Following PRISMA-Scoping review guidelines and Arksey and O’Malley’s framework, this review analysed studies published between 2015 and 2025 from databases: PubMed (NCBI), Cochrane Library, Scopus (Elsevier), Embase (Elsevier), ProQuest, Web of Science (Clarivate), and CINAHL (EBSCO) to systematically identify relevant studies.</div></div><div><h3>Results</h3><div>Twenty studies were included in this review; barriers identified included inadequate AMS content integration within veterinary curricula and limited teaching hours dedicated to pharmacological training for students. Other barriers include gaps between theoretical and clinical practice, lack of electronic record systems enabling real-time monitoring of antimicrobial-use patterns in teaching hospitals, and weak policy enforcement in low- and middle-income countries (LMICs). Facilitators included student and faculty engagement, educational interventions such as workshops, symposiums, and online learnings modules. Institutional leadership and multidisciplinary collaboration have also been found effective in AMS implementation. However, the integration of One Health and AMS programs has remained limited and inconsistent in veterinary education.</div></div><div><h3>Conclusions</h3><div>The findings emphasise the need for AMS education reforms as curricula lack structured components of responsible antimicrobial usage. Future efforts must involve veterinary stakeholder collaboration to improve curricula, infrastructure, capacity, faculty development, and promote interdisciplinary and One Health education models.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 87-94"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alarming rise of antimicrobial resistance in ICUs in Bangladesh: A silent emergency and the urgent need for national action","authors":"Md Saiful Islam ,&nbsp;Be-Nazir Ahmed ,&nbsp;Md Tanvir Rahman","doi":"10.1016/j.jgar.2026.02.005","DOIUrl":"10.1016/j.jgar.2026.02.005","url":null,"abstract":"","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 105-106"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic analysis of coexisting β-lactamase plasmids in Klebsiella pneumoniae from an immunocompromised patient","authors":"Thamer M. Brek ,&nbsp;Hanan A. Alshafie ,&nbsp;Musa A. Ayashi ,&nbsp;Othman I. Aljurayyad ,&nbsp;Hatim Almutairi ,&nbsp;Elaf M. Alattas ,&nbsp;Ibrahim A. Al-Zaharani","doi":"10.1016/j.jgar.2026.02.002","DOIUrl":"10.1016/j.jgar.2026.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>Infection significantly increases morbidity and mortality in hematologic malignancies due to immunosuppression, multiple risk factors, and greater susceptibility to healthcare-associated infections. We conducted a comprehensive genomic analysis of ESBL and carbapenemase co-producing <em>K. pneumoniae</em> (KP-JZ177) isolate recovered from a vulnerable patient with acute myeloblastic leukemia (AML) in Jazan region, Saudi Arabia.</div></div><div><h3>Methods</h3><div>A clinical <em>K. pneumoniae</em> (KP-JZ177) isolate was obtained from a wound swab of a female patient with AML in the Hematology–Oncology unit of a tertiary hospital in Jazan region. Identification and AST were performed using the MicroScan WalkAway system. Whole-genome sequencing enabled comprehensive characterization of the strain’s genetic profile, resistance determinants, virulence factors, and plasmid replicons.</div></div><div><h3>Results</h3><div>KP-JZ177 isolate displayed resistance to all tested antimicrobials except amikacin, gentamicin, tigecycline, and colistin. The genomic features of KP-JZ177 indicate substantial adaptability and pathogenic potential. KP-JZ177 belongs to sequence type ST147, a globally recognized high-risk clone associated with carbapenem resistance and recurrent hospital outbreaks. Its extensive drug-resistant (XDR) profile is driven by the co-occurrence of carbapenemase genes <em>bla</em>_OXA-48 and <em>bla</em>_NDM-1, which together confer high-level β-lactam resistance. Serotyping classified the isolate as KL64 with an O1/O2v1 O-antigen. Genomic analysis also revealed eight plasmids, many carried β-lactamase determinants and several mobile genetic elements (MGEs).</div></div><div><h3>Conclusions</h3><div>Genomic profiling of KP-JZ177 reveals high-risk <em>K. pneumoniae</em> clone carrying extensive resistance and virulence determinants on multiple plasmids, including <em>bla</em>_OXA-48 and <em>bla</em>_NDM-1. Its plasmids similarity to geographically distant strains underscore global AMR circulation, emphasizing the need for enhanced surveillance of ST147 CRKP isolates in high-risk populations.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 73-78"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of carbapenem-resistant Klebsiella pneumoniae after ceftolozane–tazobactam exposure in a patient after cord blood transplantation: A case report","authors":"Shuhei Kurosawa ,&nbsp;Sohei Harada ,&nbsp;Kohji Komori ,&nbsp;Kaworu Takatsuna ,&nbsp;Hitomi Ike ,&nbsp;Yukihiro Yoshimura ,&nbsp;Yuki Iketani ,&nbsp;Yoko Tateishi ,&nbsp;Hiroyuki Hayashi ,&nbsp;Tomonori Nakazato","doi":"10.1016/j.jgar.2026.01.008","DOIUrl":"10.1016/j.jgar.2026.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>Infections caused by carbapenem-resistant <em>Klebsiella pneumoniae</em> (CRKP) have a poor prognosis, particularly in immunocompromised patients. While carbapenemase production is the primary resistance mechanism in carbapenem-resistant <em>K. pneumoniae</em> (CRKP), other mechanisms may contribute synergistically to carbapenem resistance. Here, we describe a case in which extended-spectrum β-lactamase (ESBL)-producing <em>K. pneumoniae</em>, initially susceptible to carbapenems, acquired carbapenem resistance without carbapenemase production following ceftolozane–tazobactam exposure.</div></div><div><h3>Methods</h3><div>Whole-genome sequencing was performed on ESBL-producing <em>K. pneumoniae</em> strains detected during the clinical course to investigate the relationship between the genetic characteristics and antimicrobial susceptibility, particularly to ceftolozane–tazobactam and carbapenems. Changes in the transcription levels of the beta-lactamase genes were also analysed using reverse transcription quantitative PCR (RT-qPCR).</div></div><div><h3>Results</h3><div>Active surveillance stool culture before cord blood transplantation (CBT) identified colonisation with an ESBL-producing <em>K. pneumoniae</em> strain. Febrile neutropenia occurred on day 7 after CBT and was treated empirically with ceftolozane–tazobactam. Fatal bacteraemia developed on day 30 after CBT due to a carbapenemase-negative isolate resistant to both ceftolozane–tazobactam and carbapenems. Whole-genome sequencing analysis revealed that <em>K. pneumoniae</em> ST307 strains harbouring <em>bla</em>_CTX−M-15, <em>bla</em>_SHV-28 and <em>bla</em>_TEM-1B acquired a nonsense mutation in <em>ompK36</em> following ceftolozane–tazobactam exposure. RT-qPCR analysis documented a significant increase in <em>bla</em>_SHV-28 transcription after ceftolozane–tazobactam exposure.</div></div><div><h3>Conclusions</h3><div>This case demonstrates that <em>K. pneumoniae</em> without carbapenemase production can acquire carbapenem resistance through a combined resistance mechanisms following exposure to non-carbapenem antibiotics. Antimicrobial stewardship must be implemented comprehensively, not focused solely on specific antibiotics.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 27-32"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacist-led multidisciplinary review of carbapenem use in inpatients: A quasi-experimental study","authors":"Xiaohong Wu,&nbsp;Tingting Nan,&nbsp;Xianni Wei,&nbsp;Yonglong Su,&nbsp;Yumei Cai,&nbsp;Siheng Lian,&nbsp;Xiaoyun Ye,&nbsp;Jinbao Wei","doi":"10.1016/j.jgar.2026.02.001","DOIUrl":"10.1016/j.jgar.2026.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of a clinical pharmacist-led multidisciplinary team (MDT) review model on the appropriateness of carbapenem use amongst inpatients.</div></div><div><h3>Methods</h3><div>This study employed a quasi-experimental, pre-post design. We retrospectively analysed 1086 inpatient cases receiving carbapenem therapy between 2020 and 2024. From 2023 onward, an MDT comprising clinical pharmacists, infectious disease specialists, and microbiologists systematically reviewed medical orders against standardised criteria and provided evidence-based recommendations.</div></div><div><h3>Results</h3><div>Post-intervention, the appropriateness of initial carbapenem prescriptions increased from 77.08% to 83.79%, whereas re-evaluation appropriateness improved from 78.94% to 87.00% (<em>P</em> &lt; .05). Pharmacist intervention acceptance rates rose significantly from 56.04% to 82.35% (<em>P</em> &lt; .05). Additionally, median hospital length of stay decreased (19 vs. 15 days), with notable reductions in ICU admission (59.95% vs. 31.50%) and mortality rates (15.51% vs. 4.28%) (<em>P</em> &lt; .001). Multivariable regression identified hepatic/renal dysfunction and hypoalbuminemia as independent risk factors for ICU admission, whereas ICU admission itself strongly predicted mortality. Notably, the detection rates of carbapenem-resistant <em>Klebsiella pneumoniae</em> and <em>Pseudomonas aeruginosa</em> increased during the intervention period.</div></div><div><h3>Conclusions</h3><div>The clinical pharmacist-led MDT model enhances carbapenem-prescribing appropriateness and fosters interprofessional collaboration. Its implementation was associated with shorter hospital stays and improvements in key clinical indicators, including reduced ICU admission and mortality. However, the observed shifts in resistant pathogen epidemiology underscore that antimicrobial stewardship strategies must be integrated with rigorous infection prevention and control measures to simultaneously optimise therapeutic outcomes and mitigate resistance.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 79-86"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance in the Bacteroides fragilis group: National multicenter survey and Bayesian modelling study, France, 2022–2023","authors":"Gauthier Delvallez ,&nbsp;Pascal Campagne ,&nbsp;Corentine Alauzet ,&nbsp;Laure Diancourt ,&nbsp;Frédéric Barbut ,&nbsp;Hélène Marchandin ,&nbsp;Bruno Dupuy ,&nbsp;BFG AMR Collaborative Study group","doi":"10.1016/j.jgar.2026.01.003","DOIUrl":"10.1016/j.jgar.2026.01.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Epidemiological studies on <em>Bacteroides fragilis</em> group (BFG) species and their antimicrobial resistance (AMR) profiles remain scarce worldwide and are lacking in France. The aim of this study was to provide comprehensive national data on the distribution of BFG species, isolation sites, AMR and its potential regional disparity.</div></div><div><h3>Methods</h3><div>A retrospective multicenter study was conducted from January 2022 to December 2023 using routine data from 45 French hospitals. A total of 9458 BFG isolates identified to the species level by MALDI-ToF were included. Antimicrobial susceptibility testing (AST) was performed according to French guidelines using either disc diffusion or gradient diffusion methods. AST results were collected for ten antibiotics: amoxicillin-clavulanate (AMC), piperacillin-tazobactam (PIT), imipenem (IMI), clindamycin (CLI), metronidazole (MET), moxifloxacin, tigecycline, linezolid, rifampicin, and chloramphenicol. A Bayesian statistical model was applied to estimate regional resistance frequencies with corresponding credible intervals.</div></div><div><h3>Results</h3><div><em>Bacteroides fragilis sensu stricto</em> (<em>B. fragilis</em>) was the most prevalent species (62.4%), followed by <em>Bacteroides thetaiotaomicron</em> (14.2%). Resistance to IMI and MET remained low, while AMC, PIT, and CLI resistance varied markedly across species: 5.2%, 3.6%, and 34.4% for <em>B. fragilis</em>; 18.0%, 50.1%, and 72.9% for <em>B. thetaiotaomicron</em>; and 32.1%, 19.5%, and 75.2% for <em>Parabacteroides distasonis</em>, respectively. Bayesian modelling produced robust regional estimates for <em>B. fragilis</em>, revealing noticeable regional disparities, particularly for AMC, PIT, and MET.</div></div><div><h3>Conclusion</h3><div>Bayesian modeling revealed substantial interspecies and interregional differences in BFG resistance, highlighting the importance of species-level identification and localized surveillance to inform empirical antibiotic therapy.</div></div>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":"47 ","pages":"Pages 9-19"},"PeriodicalIF":3.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}