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Journal of Global Pharma Technology最新文献

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BILIRUBIN AND URIC ACID IN TRAUMATIC BRAIN INJURY 胆红素和尿酸在外伤性脑损伤中的作用
Journal of Global Pharma Technology Pub Date : 2012-02-17 DOI: 10.1234/JGPT.V3I11.461
U. Adiga, Vickneshwaran, S. K. Sen, G. Thiagaragan
{"title":"BILIRUBIN AND URIC ACID IN TRAUMATIC BRAIN INJURY","authors":"U. Adiga, Vickneshwaran, S. K. Sen, G. Thiagaragan","doi":"10.1234/JGPT.V3I11.461","DOIUrl":"https://doi.org/10.1234/JGPT.V3I11.461","url":null,"abstract":"Background and Objectives: Oxidative stress is the imbalance between pro-oxidants and antioxidants.Uric acid and bilirubin,end products of purine ahd heme metabolism are important antioxidants in the serum, paradoxically act as pro-oxidants.Their role is controversial and to the best of our knowledge,there are few studies about uric acid and bilirubin levels in traumatic brain injury patients. \u0000Aim of our study is to estimate the levels of uric acid and bilirubin in TBI and correlate with the severity of the injury.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"9 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73248311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
ANTIBACTERIAL ACTIVITY OF TINOSPORA CORDIFOLIA cordifolia tinospora的抑菌活性
Journal of Global Pharma Technology Pub Date : 2012-02-17 DOI: 10.1234/JGPT.V3I11.459
A. Kakkar, D. Verma
{"title":"ANTIBACTERIAL ACTIVITY OF TINOSPORA CORDIFOLIA","authors":"A. Kakkar, D. Verma","doi":"10.1234/JGPT.V3I11.459","DOIUrl":"https://doi.org/10.1234/JGPT.V3I11.459","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74594235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
ANTHELMINTIC ACTIVITY OF OUGEINIA OOJEINENSIS (ROXB) HOCHR ROOT 乌吉纳乌根的驱虫活性
Journal of Global Pharma Technology Pub Date : 2012-02-17 DOI: 10.1234/JGPT.V3I11.460
R. Gunasekaran, N. Gnanasekar, M. Usha, G. Arunachalam
{"title":"ANTHELMINTIC ACTIVITY OF OUGEINIA OOJEINENSIS (ROXB) HOCHR ROOT","authors":"R. Gunasekaran, N. Gnanasekar, M. Usha, G. Arunachalam","doi":"10.1234/JGPT.V3I11.460","DOIUrl":"https://doi.org/10.1234/JGPT.V3I11.460","url":null,"abstract":"The aqueous and alcoholic extracts were evaluated for both In-vitro anthelmintic activity using earth worms, round worms and tape worms. Two different doses of 50mg/ml and 100mg/ml concentration of two different extracts on comparison with albendazole. In-vivo anthelmintic activity was done on sheep. The extract of Ougeinia oojeinensis exhibited a dose dependent inhibition of spontaneous motility (paralysis) and evoked responses to pin prick. Both the extract shows the significant anthelminitic activity.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72666677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
STRESS DEGRADATION STUDIES AND DEVELOPMENT OF VALIDATED STABILITY INDICATING METHOD FOR ASSAY OF DONEPEZIL 多奈哌齐测定的应力降解研究及稳定性指示方法的建立
Journal of Global Pharma Technology Pub Date : 2012-02-17 DOI: 10.1234/JGPT.V3I11.458
H. AhmedReema, Bhusari K.P, Tajne Mr
{"title":"STRESS DEGRADATION STUDIES AND DEVELOPMENT OF VALIDATED STABILITY INDICATING METHOD FOR ASSAY OF DONEPEZIL","authors":"H. AhmedReema, Bhusari K.P, Tajne Mr","doi":"10.1234/JGPT.V3I11.458","DOIUrl":"https://doi.org/10.1234/JGPT.V3I11.458","url":null,"abstract":"This study describes the development and validation of stability indicating RP-HPLC method for Mirtazapine, an antidepressant drug. In order to investigate the stability of drug, a stress testing of drug sample by exposing it to variety of forced degradation conditions has been recommended. Mirtazapine was subjected to stress degradation 1 under different conditions recommended by International conference on Harmonization (ICH). The ICH guideline gives parameters to be considered when validating methods, the objective of validation of an analytical procedure is to demonstrate that it is suitable for its intended purpose. Stress testing methods are screening methods to be used to understand the degradation chemistry of a drug and therefore do not need to be validate to the extent of final control methods. The sample so generated was used to develop a stability indicating High Performance liquid Chromatographic method for Mirtazapine. The chromatographic separation of Mirtazapine and its degradation products was done on C18 column. The mobile phase containing mixture of Water and Acetonitrile in ratio 80:20 was found to be most satisfactory at a flow rate of 1mllmin. Detection was carried out using single wavelength detector at 225nm. The retention time under optimized chromatographic condition was found to be 8.43 minutes, with asymmetry of 1.50. A good linear response was observed in the range of 5-25ug/ml. The method showed good recoveries (average 101.37).","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81760526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN VITRO ANTIOXIDANT ACTIVITY OF EMBELIA RIBES FRUIT EXTRACTS 枸杞果实提取物体外抗氧化活性的研究
Journal of Global Pharma Technology Pub Date : 2012-01-23 DOI: 10.1234/JGPT.V3I10.454
Vaghela Js
{"title":"IN VITRO ANTIOXIDANT ACTIVITY OF EMBELIA RIBES FRUIT EXTRACTS","authors":"Vaghela Js","doi":"10.1234/JGPT.V3I10.454","DOIUrl":"https://doi.org/10.1234/JGPT.V3I10.454","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75105383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
CHARACTERIZATION AND SOLUBILITY ENHANCEMENT OF GLICLAZIDE SOLID DISPERSION USING PVP-K30 & K -90 用pvp-k30和k -90表征格列齐特固体分散体及其溶解度
Journal of Global Pharma Technology Pub Date : 2012-01-23 DOI: 10.1234/JGPT.V3I10.453
R. Guleria
{"title":"CHARACTERIZATION AND SOLUBILITY ENHANCEMENT OF GLICLAZIDE SOLID DISPERSION USING PVP-K30 & K -90","authors":"R. Guleria","doi":"10.1234/JGPT.V3I10.453","DOIUrl":"https://doi.org/10.1234/JGPT.V3I10.453","url":null,"abstract":"The purpose of this study was to design Polyvinylpyrrolidone (PVP) based solid dispersions bearing gliclazide. Polyvinylpyrrolidone (PVP K-30 and K-90) based solid dispersions containing the drug in different mass ratio i.e. 1:1, 1:3, 1:5 and 1:7 were prepared using fusion method. The prepared solid dispersions were characterized for their drug content, phase solubility studies, fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry, x-ray diffraction, and in-vitro dissolution studies. All the formulations showed marked improvement in the solubility and dissolution rate of drug from solid dispersion is due to decrease in crystallinity of drug and additives. It was concluded that prepared solid dispersion of the gliclazide with Polyvinylpyrrolidone may improved the solubility and dissolution rate of the drug.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81789162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROLE MATRIX METALLOPROTEINASES 2 IN GLIOMA PATIENT SPECIFIC IN AGE, GENDER & MENOPAUSAL STATUS 基质金属蛋白酶2在胶质瘤患者中的作用与年龄、性别和绝经状态有关
Journal of Global Pharma Technology Pub Date : 2011-11-04 DOI: 10.1234/JGPT.V3I3.358
M. Patani, J. Jain, B. Marya, M. Patel
{"title":"ROLE MATRIX METALLOPROTEINASES 2 IN GLIOMA PATIENT SPECIFIC IN AGE, GENDER & MENOPAUSAL STATUS","authors":"M. Patani, J. Jain, B. Marya, M. Patel","doi":"10.1234/JGPT.V3I3.358","DOIUrl":"https://doi.org/10.1234/JGPT.V3I3.358","url":null,"abstract":"Matrix metalloproteinases (MMP) are proteolytic enzymes that play an important role in various aspects of cancer progression. In the present work, I have studied the prognostic significance of serum levels of gelatinase A (MMP-2). The Circulatory level of MMP-2 was estimated by enzyme link immunosorbant assay. Pretherapeutic Circulating levels of MMP-2 were estimated in Total 48 Glioma patients and in same number of controls. Level of MMP-2 in significantly elevated in controls than Glioma patients (p<0.001). Male of both categories it indicates level of MMP-2 is significant in Age ?40 and age 40-60. Tumor cells usually express low constitutive levels of MMP-2. Stromal cells have strong but short induction of MMP-2. This very high and complex regulation of the expression of MMPs represents a host response to the tumor and neoplastic cell interaction with the tumor stromal component is fundamental for cancer invasion and metastasis.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"38 1","pages":"38-44"},"PeriodicalIF":0.0,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88300157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
PHYTO PHARMACOGNOSTIC AND PHARMACOLOGICAL REVIEW OF PONGAMIA PINNATA FAMILY FABACEAE 荸荠科植物生药学及药理研究进展
Journal of Global Pharma Technology Pub Date : 2011-11-04 DOI: 10.1234/JGPT.V3I3.361
Anupriya Pandey, Pankaj Khatri, P. Patel, Vaibhavi Jakhetia, S. Sharma
{"title":"PHYTO PHARMACOGNOSTIC AND PHARMACOLOGICAL REVIEW OF PONGAMIA PINNATA FAMILY FABACEAE","authors":"Anupriya Pandey, Pankaj Khatri, P. Patel, Vaibhavi Jakhetia, S. Sharma","doi":"10.1234/JGPT.V3I3.361","DOIUrl":"https://doi.org/10.1234/JGPT.V3I3.361","url":null,"abstract":"Pongamia pinnata belonging to the family Fabaceae (Papilionaceae) commonly known as Karanj. It is a small evergreen tree, which is widely distributed in India, Bangladesh, China, and Australia. The plants have been described as a useful remedy for foul ulcer, fistulous sores, gonorrhea and urethritis. The current review aims to describe the pharmacognostic descriptions and phytochemical potential of plant. Important phytoconstituents which had been reported consists of various flavonoid derivatives such as pongamones A-E in stem. Whereas flavonoids ponaganones had been isolated from root bark of Pongamia pinnata. Karangin, pongamol, pongagalabrone, pongapin, pinnatin and Kanjone have been isolated and characterized from seeds of Pongamia pinnata. The review also collaborates the pharmacological activities such as hypoglycemic, anti-dyslipidemic, antibacterial, anti-inflammatory, anti-diarrhoeal activity etc which had been recently elaborated by various research scientist around the globe.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"4 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76098863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
SYNTHESIS, CHARACTERIZATION AND ANTICONVULSANT ACTIVITY OF SOME PYRAZOLE DERIVATIVES 吡唑衍生物的合成、表征及抗惊厥活性
Journal of Global Pharma Technology Pub Date : 2011-11-04 DOI: 10.1234/JGPT.V3I3.357
Anandarajagopal Kalusalingam, Illavarasu Arumugamb, Rajamanickam Velayutham, U. Natarajan, Anbu Jeba Sunilson Johnsamuela, Proom Promwichita
{"title":"SYNTHESIS, CHARACTERIZATION AND ANTICONVULSANT ACTIVITY OF SOME PYRAZOLE DERIVATIVES","authors":"Anandarajagopal Kalusalingam, Illavarasu Arumugamb, Rajamanickam Velayutham, U. Natarajan, Anbu Jeba Sunilson Johnsamuela, Proom Promwichita","doi":"10.1234/JGPT.V3I3.357","DOIUrl":"https://doi.org/10.1234/JGPT.V3I3.357","url":null,"abstract":"A several number of novel 4-(aryl/substituted aryl)-1-(unsubstituted/aryl/substituted aryl)-3-phenyl-1H-pyrazoles have been synthesized by the reaction of 1-substituted phenyl-3-phenyl-2,3-dibromo prop-1-ones and appropriate unsubstituted and substituted hydrazine in ethanol. 1-substituted phenyl-3-phenyl-2,3-dibromo prop-1-ones were synthesized by the bromination of 1-substituted phenyl-3-phenyl-prop-2-en-1-ones which were synthesized by the reaction of acetophenone with appropriate unsubstituted and substituted aromatic aldehyde. The synthesized compounds were confirmed by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. The anticonvulsant activity of the synthesized compounds has indicated that all the compounds significantly reduce the electro shock induced convulsions, compared to phenytoin. The pharmacological evaluation may be concluded that the replacement of 1H position of pyrazole with phenyl and substituted phenyl increases the anticonvulsant activity.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"49 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75362466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
EVALUATION OF ANTI-RHEUMATIC ACTIVITY OF EXTRACT OF STEM BARK OF FICUS BENGALENSIS 榕树茎皮提取物抗风湿活性评价
Journal of Global Pharma Technology Pub Date : 2011-11-04 DOI: 10.1234/JGPT.V3I3.356
N. Manocha
{"title":"EVALUATION OF ANTI-RHEUMATIC ACTIVITY OF EXTRACT OF STEM BARK OF FICUS BENGALENSIS","authors":"N. Manocha","doi":"10.1234/JGPT.V3I3.356","DOIUrl":"https://doi.org/10.1234/JGPT.V3I3.356","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"14 1","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2011-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88923705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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