Journal of Hepatology最新文献

{"title":"Thyroid hormone receptor-β analogs for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH)","authors":"Vlad Ratziu, Thomas S. Scanlan, Eveline Bruinstroop","doi":"10.1016/j.jhep.2024.10.018","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.018","url":null,"abstract":"The association between suboptimal thyroid function ((sub)clinical hypothyroidism or low normal thyroid function) and the metabolic syndrome and metabolic dysfunction-associated steatotic liver disease (MASLD) is clearly established. Furthermore, in MASLD, thyroid hormones have low intracellular concentrations and the activation of the thyroid hormone receptor (THR) is reduced. Administration of thyroid hormone has been shown to reduce liver triglycerides by stimulating fatty acid disposal through lipophagy and beta-oxidation, and to lower LDL-cholesterol. As thyroid hormone exerts it’s effects in many different organs, including heart and bone, several drug candidates have been developed acting as selective thyromimetics for the THR-β nuclear receptor with potent and targeted liver actions. Importantly, these compounds have reduced affinity for the THR-α nuclear receptor and tissue distribution profiles that differ from endogenous thyroid hormones thereby reducing unwanted cardiovascular side effects. The most advanced compound, resmetirom, is an oral drug that demonstrated, in a large phase 3 trial in MASH patients, the ability to remove liver fat, reduce aminotransferase levels and improve atherogenic dyslipidemia with a good tolerability profile. This translated into histological improvement that led to accelerated approval of this drug for active fibrotic steatohepatitis, a milestone achievement as a first MASH drug.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"4 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142450256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of hepatitis flare and hepatic decompensation after nucleos(t)ide analogue cessation in chronic hepatitis B patients","authors":"Yen-Chun Liu, Yun-Fan Liaw","doi":"10.1016/j.jhep.2024.10.017","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.017","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors contribution:</h2>Yen-Chun Liu: manuscript draftingYun-Fan Liaw: Study concept, manuscript revision</section></section><section><section><h2>Grant support</h2>This study was supported by grants from Chang Gung Medical Research Fund (CMRPG1N0111) and the Prosperous Foundation, Taipei, Taiwan</section></section><section><section><h2>Conflict of interest</h2>The authors have no financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"33 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective trials support plasma exchange improving survival in acute liver failure. Retrospective data analysis should not change clinical practice","authors":"Brian John Hogan, Mark John William McPhail, Julia Alexis Wendon","doi":"10.1016/j.jhep.2024.10.016","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.016","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Author contributions</h2>All authors contributed equally to the manuscript in terms of concept, writing, editing.</section></section><section><section><h2>Financial disclosure</h2>none</section></section><section><section><h2>Declaration of Competing Interest</h2>none</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"46 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Fracture Risk with Tenofovir and Entecavir: Evidence from Pharmacovigilance Data","authors":"Wukun Ge, Zhen Wei, Haiyan Xie","doi":"10.1016/j.jhep.2024.10.014","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.014","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Funding information</h2>The study was supported by Quzhou City Science and Technology Research Project in 2023 (Grant No. 2023k193)</section></section><section><section><h2>Authors' contributions:</h2>Wukun Ge: Formal analysis, Investigation, Writing - original draft, Writing - review &amp; editing; Zhen Wei: Investigation, Writing - review &amp; editing; Haiyan Xie: Conceptualization, Methodology, Project administration, Resources, Supervision, Writing - review &amp; editing.</section></section><section><section><h2>Data Availability Statement</h2>This data can be accessed through the FDA's FAERS Public Dashboard at <span><span>https://fis.fda.gov/extensions/FPD-QDE-FAERS/FPD-QDE-FAERS.html</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors disclose no conflicts.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"32 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALT to qHBsAg ratio predicts HBsAg seroclearance in HBeAg-negative hepatitis B patients with Peg-IFN-α-based therapy","authors":"Jian Wang, Qun Zhang, Shaoqiu Zhang, Chao Wu, Rui Huang","doi":"10.1016/j.jhep.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.008","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Contributors</h2>Jian Wang: Conceptualization; writing – original draft. Qun Zhang: writing – original draft. Shaoqiu Zhang: writing – original draft. Chao Wu: Conceptualization; writing – review and editing. Rui Huang: Conceptualization; writing – original draft; writing – review and editing; supervision.</section></section><section><section><h2>Financial support</h2>This work was supported by grants of Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University (No. 2022-LCYJ-MS-07 and 2021-LCYJ-PY-43).</section></section><section><section><h2>Declaration of Competing Interest</h2>None.</section></section><section><section><h2>Acknowledgements</h2>We thank Chuanwu Zhu and Weimao Ding for data support.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"1 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperfunctional T cell responses unchecked by regulatory T cells are unable to resolve hepaciviral infection without humoral contribution","authors":"Fengzhi Jin, John Gridley, Anuradha Kumari, Alireza Saeidi, Brantley Holland, Elizabeth Elrod, Piyush Dravid, Sheetal Trivedi, Amit Kapoor, Manoj Thapa, Arash Grakoui","doi":"10.1016/j.jhep.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.012","url":null,"abstract":"<h3>Background &amp; Aims</h3>The most recent T cell-based vaccine against hepatitis C virus (HCV) in human subjects failed to swing the pendulum from chronicity to resolution despite eliciting cellular responses in the majority of individuals. These results naturally evoke the question of whether hyperactivated responses of a single adaptive immune arm are capable of inducing HCV clearance or if coordinated efforts between antibodies and T cells are indeed necessary. Here, we sought to address this point in determining whether the suppression of antiviral T cell and IgG responses by regulatory T cells (Tregs) is a critical prerequisite of delayed viral clearance or overt chronicity.<h3>Methods</h3>Using a surrogate model of HCV infection, rodent hepacivirus (RHV) infection in mice, we utilized Foxp3-DTR mice to assess how Tregs modulate the generation of acute antiviral adaptive immune responses and indirectly dictate infection fate via intracellular flow cytometry staining, ELISA, RNA sequencing, and qPCR.<h3>Results</h3>Transient depletion of Tregs prior to infection decreased viral-specific CD4⁺ T cell function, IgG production, and delayed viral clearance. In contrast, transient Treg depletion after infection increased both T cell functionality and IgG production, thereby facilitating accelerated viral clearance. Hyperactivated T cells, achieved via transient Treg depletion, were unable to clear the virus as an isolated effector arm without the help of viral-specific IgG production.<h3>Conclusions</h3>Tregs control the outcome of RHV infection via direct modulation of CD4⁺ T cells and IgG production. Hyperactivated T cell responses are incapable of compensating for experimentally induced lack of antibodies, further reinforcing the notion of cooperative interplay between adaptive immune arms in facilitating hepaciviral clearance.<h3>Impact and implications</h3>We demonstrate herein how timing of Treg depletion determines the fate of effector T cells, humoral responses, and the kinetics of viral clearance. Our observations provide direct evidence that functional T cell responses are incapable of compensating for suboptimal humoral responses in facilitating viral resolution. Our results imply that future HCV vaccine regimens should not solely rely on eliciting focused responses of a single effector arm, but rather incorporate immunogens capable of inducing durable features of both humoral and cellular memory.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"209 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular Carcinoma Patients as an Ideal Study Population for Immune Checkpoint Inhibitors in Hepatitis B","authors":"Guanglin Xiao, Hong Ren","doi":"10.1016/j.jhep.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.010","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial support</h2>This work was supported by a Remarkable Innovation-Clinical Research Project and the DengFeng Program of the Second Affiliated Hospital of Chongqing Medical University</section></section><section><section><h2>Authors’ contributions</h2>G.X.: Manuscript writing &amp; Study design. H.R.: Manuscript revision &amp; Study design.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors do not have any disclosures to report.Please refer to the accompanying ICMJE disclosure form for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"73 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential therapy with antisense oligonucleotide and immune modulator as a strategy for HBV cure","authors":"Henry Lik Yuen Chan","doi":"10.1016/j.jhep.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.011","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial support</h2>none</section></section><section><section><h2>Declaration of Competing Interest:</h2>HLY Chan is an advisor for Aligos, Glaxo-Smith-Kline, Roche, Vaccitech, Virion Therapeutics; a speaker for Echossens, Gilead, Roche; and a data management board member for Aligos, Arbutus, Precision BioSciences, Roche, Vaccitech, Zhimeng Therapeutics.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"30 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel biomarkers predicting successful regeneration would likely improve patient selection for plasma exchange in acute liver failure","authors":"Oliver D. Tavabie, Varuna R. Aluvihare","doi":"10.1016/j.jhep.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.009","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Contributions</h2>Both authors conceptualised the manuscript. ODT composed the first draft. VRA made critical revisions</section></section><section><section><h2>Financial support</h2>Nil</section></section><section><section><h2>Conflicts of interest</h2>ODT have received consultancy fees from Chiesi. VRA has nil to declare</section></section><section><section><h2>Acknowledgements</h2>Nil</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"1 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two episodes of jaundice within 1 year in a teenager","authors":"Hanyi Song ,&nbsp;Lin Xiao ,&nbsp;Xiangzhen Meng ,&nbsp;Yang Li ,&nbsp;Junmin Song","doi":"10.1016/j.jhep.2024.06.041","DOIUrl":"10.1016/j.jhep.2024.06.041","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"81 5","pages":"Pages e218-e220"},"PeriodicalIF":26.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}