Journal of Hepatology最新文献

{"title":"Reply to : “Long-term outcome following liver transplantation of patients with ACLF grade 3 : Need of redefining boundaries ?”","authors":"Florent Artru, Jose Ursic-Bedoya, Sebastien L’Hermite, Faouzi Saliba, Alexandre Louvet","doi":"10.1016/j.jhep.2025.02.024","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.024","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>FA had the original idea and wrote the first draft of this correspondence. AL, SL,JUB, FS performed the critical revision of the final text for important intellectual content. All authors contributed to the writing and approved the final submitted version.</section></section><section><section><h2>Financial support</h2>The authors declare no financial support with regards to this manuscript.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no competing of interest regarding this manuscript.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"37 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Control of Hepatic Ischemia/Reperfusion Injury via HSD17B13-Mediated Autophagy in Hepatocytes","authors":"Hui Wang, Meina Guo, Baoyin Ren, Haibo Zhang, Jiayang Zhang, Rongfang Qiao, Lei Qian, Jingwen Zhu, Shuying Zhang, Xiaoyan Zhang, Guangrui Yang, Youfei Guan, Lihong Chen","doi":"10.1016/j.jhep.2025.02.029","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.029","url":null,"abstract":"<h3>Background &amp; Aims</h3>Studies have illustrated the role of circadian rhythm in hepatic ischemia/reperfusion injury (HIRI), but the mechanisms are poorly understood. <em>Bmal1</em> is the most important gene that plays significant roles in the circadian control of liver physiology and disease, however, its role in HIRI has not been investigated. Here, we aimed to explore the potential contribution of BMAL1 to HIRI.<h3>Methods</h3>The impact of ischemia/reperfusion (I/R) timing (ZT0 vs. ZT12) on liver damage were assessed in mice with <em>Bmal1</em> specifically depleted in hepatocytes or myeloid cells. RNA sequencing and other multiple molecular biology experiments were employed to explore the molecular mechanisms. Additionally, we investigated the role of HSD17B13, a lipid droplet-associated protein, in BMAL1-mediated circadian control of HIRI by utilizing global knockout, hepatocyte-specific knockdown, or hepatocyte-specific humanized <em>HSD17B13</em> overexpression mouse models.<h3>Results</h3>We found that initiating I/R operations at ZT12 resulted in significantly more severe liver injury in wild-type mice compared to ZT0. <em>Bmal1</em> in hepatocytes, but not in myeloid cells, mediated this temporal difference. Mechanistically, BMAL1 regulates the diurnal oscillation of HIRI by directly controlling <em>Hsd17b13</em> transcription via binding to E-box-like elements. Hepatocyte-specific knockdown of <em>Hsd17b13</em> blunted the diurnal variation of HIRI and exacerbated ZT0 HIRI. Furthermore, depletion of the BMAL1/HSD17B13 axis may inhibit lipid degradation by blocking autophagy flux, contributing to lipid overload and exacerbating HIRI. Finally, we demonstrated that hepatocyte-specific overexpression of humanized <em>HSD17B13</em> may confer protection during ZT0 HIRI but aggravate damage at ZT12.<h3>Conclusions</h3>Our study uncovers a pivotal role of hepatocyte BMAL1 in modulating circadian rhythms in HIRI via HSD17B13-mediated autophagy and offers a promising strategy for preventing and treating HIRI by targeting the BMAL1/HSD17B13 axis.<h3>Impact and implications</h3>This study unveils a pivotal role of the BMAL1/HSD17B13 axis in the circadian control of hepatic ischemia/reperfusion injury, providing new insights into the prevention and treatment of hepatic ischemia/reperfusion injury. The findings have scientific implications as they enhance our understanding of the circadian regulation of hepatic ischemia/reperfusion injury. Furthermore, clinically, this research offers opportunities for optimizing treatment strategies in hepatic ischemia/reperfusion injury by considering the timing of therapeutic interventions.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"34 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Metabolism in MASLD and MASH: Pathophysiology and Emerging Mechanisms","authors":"Gregory R. Steinberg, Celina M. Valvano, William De Nardo, Matthew J. Watt","doi":"10.1016/j.jhep.2025.02.033","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.033","url":null,"abstract":"The liver acts as a central metabolic hub, integrating signals from the gastrointestinal tract and adipose tissue to regulate carbohydrate, lipid, and amino acid metabolism. Gut-derived metabolites, such as acetate and ethanol and non-esterified fatty acids from white adipose tissue (WAT), influence hepatic processes, which rely on mitochondrial function to maintain systemic energy balance. Metabolic dysregulation from obesity, insulin resistance, and type 2 diabetes disrupt these pathways, leading to metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). This review explores the metabolic fluxes within the gut-adipose tissue-liver axis, focusing on the pivotal role of de novo lipogenesis (DNL), dietary substrates like glucose and fructose, and changes in mitochondrial function during MASLD progression. It highlights the contributions of white adipose tissue insulin resistance and impaired mitochondrial dynamics to hepatic lipid accumulation. Further understanding how the interplay between substrate flux from the gastro-intestinal tract integrates with adipose tissue and intersects with structural and functional alterations to liver mitochondria will be important to identify novel therapeutic targets and advance the treatment of MASLD and MASH.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"35 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Post-TIPS Hemodynamic Targets to Clinical Indications: Variceal Bleeding vs. Refractory Ascites","authors":"Yong Lv, Zhengyu Wang, Bohan Luo, Guohong Han","doi":"10.1016/j.jhep.2025.02.036","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.036","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Adjustments to PPG During the Second Measurement</h2>Zipprich et al. note that adjustments to the portal pressure gradient (PPG) in our cohort were limited to cases of suboptimal stent positioning or stenosis/occlusion, rather than PPG exceeding the target range. This approach aligns with the primary objective of our study: to identify optimal timing and hemodynamic targets for PPG measurement post-TIPS, not to evaluate intervention efficacy^[1]. To preserve the natural trajectory of PPG evolution and avoid confounding effects, we deliberately</section></section><section><section><h2>Discrepancy in Outcomes with the 7–14 mmHg Target Range</h2>Zipprich et al. report no survival or decompensation differences using a 7–14 mmHg target in their cohort (n=84), contrasting with our findings. Two factors likely explain this divergence: a) Population Heterogeneity: Our cohort exclusively included patients with variceal bleeding, whereas Zipprich et al. enrolled a mixed population (71% refractory ascites). These groups exhibit distinct hemodynamic profiles. For bleeding, excessive PPG reduction (&lt;10 mmHg) risks hepatic encephalopathy (OHE)</section></section><section><section><h2>Authors' contributions</h2>Yong Lv, Zhengyu Wang, Bohan Luo and Guohong Han designed the letter; Yong Lv drafted the letter; Guohong Han revised the letter.</section></section><section><section><h2>Financial support</h2>None.</section></section><section><section><h2>Declaration of Competing Interest</h2>All authors have nothing to declare.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Acknowledgements</h2>None.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"27 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent Roles of MASLD Components in Chronic Hepatitis B: A Double-Edged Sword","authors":"Shang-Chin Huang, Tung-Hung Su","doi":"10.1016/j.jhep.2025.02.035","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.035","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>SC Huang: study concept and design; drafting of the manuscript; obtaining fundingTH Su: study concept and design; critical revision for important intellectual content; obtaining funding</section></section><section><section><h2>Declaration of AI-assisted technologies in the writing process</h2>During the preparation of this work, the authors used Grammarly for English proofreading and editing. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.</section></section><section><section><h2>Financial support</h2>This work was supported by grants from the National Science and Technology Council, Taiwan (grant number NSTC 112-2628-B-002-004, 112-2314-B-002-121-MY3), Ministry of Health and Welfare (MOHW113-TDU-B-221-134003), National Taiwan University Hospital (grant numbers VN-113-04, 113-TMU09, 113-S0156, 113-L3004, 113-L3005), and National Taiwan University Hospital Bei-Hu Branch, Taiwan (grant number 11308).</section></section><section><section><h2>Declaration of Competing Interest</h2>S.-C. H. was on speaker’s bureau for Gilead Sciences.T.-H. S. received a research grant from Gilead Sciences, served as a consultant for Gilead Sciences, and was on speaker’s bureaus for Abbvie, Bayer, Bristol-Myers Squibb, Gilead Sciences, Lilly, Merck Sharp and Dohme, Roche, Sysmex and Takeda.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"32 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Inclusion of patients with active urinary sediment in treatment of hepatorenal syndrome” by Hamadah A. and Gharaibeh K.","authors":"Mitra K. Nadim, John A. Kellum, François Durand","doi":"10.1016/j.jhep.2025.02.038","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.038","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Mitra K. Nadim, John A. Kellum and François Durand contributed to write and revise this letter.</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>NonePlease refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"23 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: STRIDE's Efficacy and Safety in Asian Hepatocellular Carcinoma","authors":"George Lau, Ghassan K. Abou-Alfa, Stephen L. Chan","doi":"10.1016/j.jhep.2025.02.037","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.037","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Aetiology</h2>Drs. Liu, Shan and Han comment that the aetiology of hepatocellular carcinoma (HCC) varies regionally, with hepatitis B virus (HBV)-related HCC as the predominant aetiologic subtype in Asia. We agree that variation in HCC aetiology is an important consideration, as we commented on this extensively in the Introduction and Discussion sections of our publication. In particular, the better relative outcomes observed with immune checkpoint inhibitors (ICI) in HBV-related HCC was a motivation for our</section></section><section><section><h2>Safety</h2>We respectfully disagree with the concerns raised by Drs. Liu, Shan and Han regarding the safety outcomes in our publication. We specifically and extensively report on the incidence and nature of immune-mediated adverse events (imAEs) observed in the Asian subgroup of HIMALAYA, which were similar to those observed in the global HIMALAYA population, and specifically noted that the overall safety profile of STRIDE was tolerable and manageable in both the Asian subgroup and global population.[1],</section></section><section><section><h2>Context</h2>We believe that our results have been appropriately contextualised, as the consistent cross-trial regional vs. global trends are noted in the Discussion. Specific reference is made to the global IMbrave150 analysis and the IMbrave150 Chinese subpopulation.¹ We consider the suggestion to discuss the findings of the phase III, randomised controlled HIMALAYA trial in the context of CheckMate 040 to be inappropriate, as CheckMate 040 was an uncontrolled phase I/II study with a smaller study</section></section><section><section><h2>Authors' contributions</h2>George Lau: Manuscript writing and revisionGhassan K. Abou-Alfa: Manuscript writing and revisionStephen L. Chan: Manuscript writing and revision</section></section><section><section><h2>Financial support</h2>The HIMALAYA study was sponsored by AstraZeneca. Medical writing support, under the direction of the authors, was provided by Brian Woolums, PhD, CMC Connect, a division of IPG Health Medical Communications, and was funded by AstraZeneca, in accordance with Good Publication Practice (GPP 2022) guidelines (Ann Intern Med 2022;175:1298-1304).</section></section><section><section><h2>Declaration of Competing Interest</h2>George Lau reports lecture fees from AstraZeneca and BeiGene.Ghassan K. Abou-Alfa reports research support from AbbVie, Agenus, Arcus, AstraZeneca, Atara, BeiGene, BioNtech, BMS, Digestive Care, Elicio, Genentech/Roche, Helsinn, Parker Institute, Pertyze, Yiviva, and consulting fees from AbbVie, Ability Pharma, Agenus, Alligator Biosciences, Arcus, Astellas, AstraZeneca, Autem, Berry Genomics, BioNtech, BMS, Boehringer Ingelheim, Fibrogen, Genentech/Roche, Ipsen, J-Pharma, Merck, Merus, Moma</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"75 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral fat mobilization and mitochondrial fat metabolism: Fueling the energy demands of liver regeneration","authors":"Cornelius Engelmann","doi":"10.1016/j.jhep.2025.01.034","DOIUrl":"10.1016/j.jhep.2025.01.034","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Pages 942-944"},"PeriodicalIF":26.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histone Serotonylation in HCC: Decoding the Impact of \"Happy\" Histones on Liver Cancer Progression","authors":"Amaia Navarro-Corcuera, María L. Martínez-Chantar","doi":"10.1016/j.jhep.2025.02.020","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.020","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors’ contributions</h2>Both authors contributed equally.</section></section><section><section><h2>Financial support</h2>No funding was received for this article.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"51 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B cell-depleting anti-CD19 monoclonal antibody holds promise for treating IgG4-related cholangitis","authors":"David C. Trampert","doi":"10.1016/j.jhep.2025.01.033","DOIUrl":"10.1016/j.jhep.2025.01.033","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Pages 940-941"},"PeriodicalIF":26.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}