Journal of Hepatology最新文献

{"title":"Interpreting HCC risk and HBsAg clearance in the long-term PAGE-B cohort.","authors":"George V Papatheodoridis, Vana Sypsa","doi":"10.1016/j.jhep.2026.10.007","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.10.007","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling the navigation of homing pigeons - a new function for liver macrophages.","authors":"Prakash Ramachandran","doi":"10.1016/j.jhep.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.009","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance of patients at risk of liver cancer: Expert Opinions - authors' reply.","authors":"Hamish Innes, Peter Jepsen, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip","doi":"10.1016/j.jhep.2026.10.004","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.10.004","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal left ventricular mass as a prognostic marker for outcomes in infants and children with cirrhosis.","authors":"Dalia A Bashir, Sameer Thadani, Taylor Nack, Nour Gebara, Noelle Gorgis, Manpreet Virk, Anna M Banc Husu, Tam T Doan, Nhu Thao Nguyen Galvan, Muhammad Umair M Mian, Kathleen Hosek, Kelby Fuller, Kalyani R Patel, Divya Sabapathy, Sammie T James, Thomas Fogarty, Daniel J Penny, Duy Dinh, Curtis E Kennedy, Moreshwar S Desai","doi":"10.1016/j.jhep.2026.09.024","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.024","url":null,"abstract":"<p><strong>Background/aims: </strong>Cirrhotic cardiomyopathy (CCM), a clinically consequential comorbidity of cirrhosis, remains undefined and underappreciated in children. This study aimed to characterize myocardial structural, functional, morphometric, and histopathologic features in pediatric cirrhosis and objectively derive a reliable echocardiographic (2DE) metric to predict perioperative adverse events, including mortality.</p><p><strong>Methods: </strong>2DE, morphometry, histopathology, and vasoactive-inotropic score (VIS) were compared between children with (n=226) and without (n=160) cirrhosis listed for liver transplantation (LT) over 2011-2021. Discriminatory performance of left ventricular mass index (height)^2.7(LVMI g/m^2.7) for predicting waitlist decompensation, composite serious adverse events post liver transplant and mortality was assessed using ROC analysis, with AUCs and optimal thresholds compared against PELD-Cr/MELD scores.</p><p><strong>Results: </strong>LV mass was significantly higher in children with cirrhosis on 2DE and necropsy specimens compared to non-cirrhotic controls, with ∼25% demonstrating LV hypertrophy, with OR of 6.9 [CI 3,16], p< 0.0001. In the cirrhotic cohort, LVMI correlated with vasoactive needs under stress of LT (p <0.001) and was significantly higher in patients with WLD, CSAE, and non-survivors. In cirrhosis, LVMI values ≥ 88 g/m^2.7, ≥ 91 g/m^2.7, and ≥ 95 g/m^2.7 were independently associated with WLD, CSAE, and mortality, when adjusting for PELD-Cr/MELD, bilirubin, and INR (p <0.01). Combining LVMI + PELD-Cr/MELD significantly outperformed PELD-Cr/MELD in discriminating both WLD and CSAE, whereas LVMI alone significantly outperformed PELD-Cr/MELD for CSAE and was comparable for WLD. All three models performed comparably in discriminating death.</p><p><strong>Conclusion: </strong>LVMI is a strong predictor of morbidity and mortality, serving as a prognostic marker in children with cirrhosis. Incorporating LVMI into PELD-Cr/MELD may enhance risk stratification and organ allocation.</p>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-line durvalumab and tremelimumab in poor-prognosis unresectable hepatocellular carcinoma: Phase IIIb single-arm SIERRA study","authors":"Stephen L. Chan,Masatoshi Kudo,Bruno Sangro,Robin Kate Kelley,Jee Hyun Kim,Binh Pham,Jung Yong Hong,Dirk-Thomas Waldschmidt,Donatella Marino,René Gerolami,Adam M. Burgoyne,Gianluca Masi,Robert John Walsh,Jens U. Marquardt,Ugochinyere Emeribe,Kavitha Balaji,Peng Sun,Boris Baur,Lorenza Rimassa","doi":"10.1016/j.jhep.2026.10.002","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.10.002","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"26 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal assessment of spatial and single-cell transcriptomes identifies CD226-NECTIN2 T cell-cholangiocyte interaction in bile duct inflammation","authors":"Markus S. Jördens,Kathrine S. Nordhus,Jonas Øgaard,Enya Amundsen-Isaksen,Oda H. Ramberg,Jeremy Yeoh,Kristian Holm,Xiaojun Jiang,Tom Luedde,Tom H. Karlsen,Brian K. Chung,Espen Melum","doi":"10.1016/j.jhep.2026.09.021","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.021","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"42 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors’ Reply to: \"Beyond portal pressure: what does CIRI really predict?\" and \"Can the CIRI model reliably predict cACLD decompensation for clinical adoption?\"","authors":"Georg Kramer,Philip Ambery,Thomas Reiberger","doi":"10.1016/j.jhep.2026.09.014","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.014","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"13 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification of the ELM score performance tables","authors":"Mauro Giuffrè,Antonio Colecchia,Elton Dajti","doi":"10.1016/j.jhep.2026.10.011","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.10.011","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"31 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of MASH risk genotypes on resmetirom efficacy in patients with MASH and fibrosis","authors":"Naga P. Chalasani,Rebecca Taub,Robin Mogg,Dominic Labriola,Raul C. Camacho,Hang Zhang,Quentin M. Anstee","doi":"10.1016/j.jhep.2026.08.037","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.037","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"218 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Hepatitis D Remain Hidden? Revisiting HDV Persistence and Mechanisms of Reactivation","authors":"Heiner Wedemeyer","doi":"10.1016/j.jhep.2026.10.003","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.10.003","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"64 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}