Journal of Hepatology最新文献

{"title":"Survival outcomes after liver transplantation in acute-on-chronic liver failure: A prospective study","authors":"Thierry Gustot, William Bernal, Javier Fernández, Eva Usón-Raposo, Juan Manuel Díaz, Alberto Queiroz Farias, Ashwin Rammohan, Sebastián Marciano, Alexander Kuo, Giovanni Perricone, Rebecca Bateman, Luis Bagulho, Sudhindran Surendran, Jordi Colmenero, Manuel Mendizabal, Nyingi Kemmer, Juan F. Gallegos-Orozco, Nazia Selzner, Laure Elkrief, Christina C. Lindenmeyer, Prasun K. Jalal, Margarita Anders, Valerio Lucidi, Carmen Vinaixa Aunés, Luca Vizioli, Krzysztof Zieniewicz, Andrea Della Penna, Angelo Z. Mattos, Michael Kriss, Pietro Lampertico, Livia Melo Carone Linhares, Carmine Gambino, Graciela Elia Castro-Narro, Caroline den Hoed, Kirti Shetty, Tasneem Pirani, Baptiste Giguet, Baptiste Michard, Helen S. Te, Sezai Yilmaz, Neeraj Saraf, Abhishek Chauhan, Takanobu Hara, Rosa Martin-Mateos, Fanny Lebossé, Takeo Toshima, Wim Laleman, Maximilian Joseph Brol, Isabel Campos-Varela, Emmanuel Weiss, Hideki Ohdan, Felix Braun, Constantine J. Karvellas, Marie Sinclair, Cornelius Engelmann, Joanna Moore, Audrey Coilly, Carmelo Loinaz, Georges-Philippe Pageaux, Hans Van Vlierberghe, Ken Liu, Michael John Williams, Chee Chien Yong, Lance L. Stein, Juan-Carlos Restrepo, Kiyoshi Hasegawa, Gabriela Berlakovich, Patricia Momoyo-Zitelli, Dinesh Jothimani, Nicholas N. Nissen, Federico D'Amico, Filipe S. Cardoso, Zubair Umer Mohamed, Pablo Ruiz, Josefina Pages, Kiran Dhanireddy, Ephrem Salamé, Bijan Eghtesad, Megha Bhongade, Julia Brutti, Antonella Putignano, Eva Montalvá-Orón, Roberto Di Donato, Joanna Raszeja-Wyszomirska, Maria Lúcia Zanotelli, Luiz Augusto Carneiro d'Albuquerque, Subathra Radhakrishnan, Jorge Martinez, Juvelyn Palomique, Hugo P. Marques, Anna Paul, Giulia Pagano, Richie Alexander Inge-Cox, Flair José Carrilho, Catherine Ann Martin, Gonzalo Gomez Perdiguero, Wellington Andraus, Adrian Gadano, Mohamed Rela, Rachel H. Westbrook, Marina Berenguer, Silvio Nadalin, Christophe Duvoux, Luca Saverio Belli, Vinay Sundaram, Yaman Tokat, Wojciech G. Polak, Constantino Fondevila, Susumu Eguchi, Geoffrey McCaughan, Elizabeth Pomfret, Anna Bosch-Comas, Joan Clària, Paolo Angeli, Jonel Trebicka, Cristina Sánchez-Garrido, Didier Samuel, Richard Moreau, Vicente Arroyo, Rajiv Jalan, Investigators of the CHANCE study group","doi":"10.1016/j.jhep.2026.09.015","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.015","url":null,"abstract":"The impact of liver transplantation (LT) on mortality among patients with advanced cirrhosis who have two organ failures (acute-on-chronic liver failure-2 [ACLF-2]) or ≥ three organ failures (ACLF-3) is unclear.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"60 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SETDB1: an epigenetic gatekeeper of antitumor immune organization in HCC","authors":"Pauline Hamon","doi":"10.1016/j.jhep.2026.09.022","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.022","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"2 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: ‘Generation of hepatobiliary organoids from human induced pluripotent stem cells’ [J Hepatol (2019) 70 (6):1145–1158]","authors":"Fenfang Wu, Di Wu, Yong Ren, Yuhua Huang, Bo Feng, Nan Zhao, Taotao Zhang, Xiaoni Chen, Shangwu Chen, Anlong Xu","doi":"10.1016/j.jhep.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.003","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"14 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Defining to Understanding Porto-Sinusoidal Vascular Disorder","authors":"Virginia Hernandez-Gea, Pierre Emmanuel Rautou","doi":"10.1016/j.jhep.2026.09.016","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.016","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"35 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Confounded time intervals and artificial variance suppression in MASLD biomarker reproducibility\".","authors":"Amanda Darekar, Vincent Wai-Sun Wong, Quentin M Anstee","doi":"10.1016/j.jhep.2026.09.013","DOIUrl":"10.1016/j.jhep.2026.09.013","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Alcohol abstinence and recompensation - time to understand the 'how?'\".","authors":"Benedikt Silvester Hofer, Georg Semmler, Thomas Reiberger","doi":"10.1016/j.jhep.2026.09.008","DOIUrl":"10.1016/j.jhep.2026.09.008","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBV-reactive KIR+ CX3CR1+ CD8+ T cells mediate liver transplantation tolerance.","authors":"Yongbo Liu, Bingran Wang, Di Sun, Aiwei Zhou, Zimeng Cai, Tao Zhou, Sen Yang, Qi Pan, Yunmu Gao, Jiaqi Song, Zhipeng Zong, Wanglong Xiao, Hongyuan Liu, Taihua Yang, Zhicong Zhao, Yi Luo, Jianjun Zhang, Jianchen Fang, Zhenzhen Zhan, Linrong Lu, Yuan Liu, Qiang Xia","doi":"10.1016/j.jhep.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.004","url":null,"abstract":"<p><strong>Background & aims: </strong>Immune tolerance after transplantation reduces immunosuppression-related complications and improves the overall survival rates. The unique tolerogenic microenvironment of the liver enables a proportion of liver transplantation (LT) recipients to develop tolerance with intact liver function. However, the underlying immunological mechanisms remain unclear.</p><p><strong>Method: </strong>s: We integrated single-cell transcriptome/TCR profiling, flow cytometry, in vitro killing assays, HLA-E peptidome from a retrospective cohort including 347 LT recipients, murine LT models, and a 20-participant prospective immunosuppressant withdrawal trial in pediatric LT recipients with median 26 months follow-up.</p><p><strong>Results: </strong>We demonstrated that Epstein-Barr virus (EBV)-derived peptides can be presented by HLA-E on alloreactive CD4⁺ T cells to prime KIR⁺ CX3CR1⁺ CD8⁺ T cells, thereby promoting immune tolerance after LT. As a subset of CD8⁺ T_EMRA cells, KIR⁺ CX3CR1⁺ CD8⁺ T cells utilize perforin and granzyme B to suppress alloreactive CD4⁺ T cells after LT. In vitro analysis unveiled that the EBV-derived peptide SQAPLPCVL could stabilize HLA-E expression on alloreactive CD4⁺ T cells and mediate recognition and elimination by KIR⁺ CX3CR1⁺ CD8⁺ T cells through a TCR-dependent mechanism. Furthermore, BATF was indispensable for induction of KIR⁺ CX3CR1⁺ CD8⁺ T cells. In the prospective immunosuppressant withdrawal clinical trial, the peripheral ratio of CD8⁺ T_EMRA and KIR⁺ CX3CR1⁺ CD8⁺ T cells were suggested to be potentially useful in identifying tolerant recipients.</p><p><strong>Conclusions: </strong>Our study demonstrated a new immune tolerance mechanism mediated by KIR⁺ CX3CR1⁺ CD8⁺ T cells and established the connection between viral infection and tolerance formation, providing new insights into tolerance-inductive strategies after transplantation.</p>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation instead of depletion: Rethinking B cell-targeted therapies in IgG4-related cholangitis.","authors":"David C Trampert","doi":"10.1016/j.jhep.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.012","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curative conversion and confounding in a bevacizumab dose comparison.","authors":"Jiaju Zhao, Bin Qiao","doi":"10.1016/j.jhep.2026.08.030","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.030","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Surveillance of patients at risk of liver cancer: Expert Opinions.","authors":"Maria Qurashi, Jessica Howell, Rohini Sharma","doi":"10.1016/j.jhep.2026.08.031","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.031","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}