Journal of Hepatology最新文献

{"title":"Albumin infusion in Hepatorenal Syndrome-Acute Kidney Injury: new evidence challenges recent consensus.","authors":"Paolo Angeli, Christian Labenz, Salvatore Piano, Adrià Juanola, Aleksander Krag, Paolo Caraceni, Jonel Trebicka, Rakhi Maiwall, Virendra Singh, Elisa Pose, Carmine Gambino, Sebastian Marciano, Peter R. Galle, Shiv K. Sarin, Pere Ginès, Patrick S. Kamath","doi":"10.1016/j.jhep.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.04.011","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>The new evidence in the management of HRS-AKI in patients with cirrhosis</h2>The conclusions of the ADQI and ICA Joint Multidisciplinary Consensus Meeting were published in the Journal of Hepatology in July 2024 (2).Subsequently, a prospective observational study was published in the same Journal in September 2024 analyzing the effectiveness of the algorithm proposed by the EASL CPGs in the management of AKI in patients with cirrhosis and a letter as explanatory corollary by the Barcelona research team led by Pere Ginès 3, 4. The main content of these papers can be</section></section><section><section><h2>Discussion</h2>To rectify any misunderstanding, it is accepted that at the time of developing the position paper of the ADQI and ICA the results of this research group have not yet been published. This being said, the issue of volume expansion in the management of AKI should be discussed. Without any doubt, the need for assessing the patient volume status and thus the real need for volume replacement, and the need to standardize methods to assess volume status and monitor the response to volume replacement is</section></section><section><section><h2>Conclusions</h2>The application of the EASL AKI algorithm, derived from the previous statements proposed by the ICA, is associated with very good response rates and does not significantly delay initiation of therapy with terlipressin. The use of 48-hour albumin infusion and the use of the old diagnostic criteria to differentiate HRS-AKI and ATN-AKI are both essential components of the algorithm. There is need for studies addressing the important questions on the dose and duration of albumin treatment to</section></section><section><section><h2>Authors’ contribution</h2>Conceptualization (PA, SP, PC, PG, PK), drafting of the manuscript (PA), revision for important intellectual content and approval of the final manuscript (all authors).</section></section><section><section><h2>Funding</h2>No specific funding supported this paper.</section></section><section><section><h2>Declaration of Competing Interest</h2><strong>PA</strong> received grant/research support from Grifols and CSL Behring; held a patent with Biovie; served as consulting for Sequana Medical and BioMarin. <strong>CL</strong> received speaker fees from CSL Behring. <strong>SP</strong> received grant/research support from Italian Minstry of Health, European Union; speaker fees from Ferring, Grifols, MEDSCAPE; served as consulting for Boehringer Ingelheim. <strong>AK</strong> received grant/research support from European Union, Novo Nordisk Foundation, AstraZeneca; speaker fees from Norgine, Siemens,</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"28 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rat hepacivirus model to aid hepatitis C viral vaccine development ?","authors":"Michael Houghton","doi":"10.1016/j.jhep.2025.04.016","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.04.016","url":null,"abstract":"No Abstract","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"34 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing our understanding of recompensated cirrhosis - the new “holy grail” of decompensated cirrhosis","authors":"Thomas REIBERGER, Benjamin MAASOUMY","doi":"10.1016/j.jhep.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.04.014","url":null,"abstract":"No Abstract","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"37 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Register now for the EASL Congress 2025, 7-10 May in Amsterdam!","authors":"","doi":"10.1016/S0168-8278(25)00178-3","DOIUrl":"10.1016/S0168-8278(25)00178-3","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Page ii"},"PeriodicalIF":26.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Sleeve or Not to Sleeve: Validation of Liver Transplantation with Sleeve Gastrectomy","authors":"Linda W. Moore, Elizabeth W. Brombosz, R Mark Ghobrial","doi":"10.1016/j.jhep.2025.04.015","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.04.015","url":null,"abstract":"No Abstract","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"6 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JHEP at a glance (May 2025)","authors":"","doi":"10.1016/S0168-8278(25)00189-8","DOIUrl":"10.1016/S0168-8278(25)00189-8","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Pages e211-e221"},"PeriodicalIF":26.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The A-TANGO consortium performs Phase II clinical studies of an innovative therapeutic strategy, called \"G-TAK\", to fight end-stage cirrhosis and ACLF. Discover the project!","authors":"","doi":"10.1016/S0168-8278(25)00181-3","DOIUrl":"10.1016/S0168-8278(25)00181-3","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Page v"},"PeriodicalIF":26.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diving deep: finding pathogenic intronic variants and making them actionable","authors":"Benedikt Schaefer, Heinz Zoller","doi":"10.1016/j.jhep.2025.04.013","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.04.013","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Conflict of interest:</h2>The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Authors’ contributions:</h2>BS and HZ wrote the manuscript and prepared the figure.Diagnostic pathways for liver diseases are guided by clinical and biochemical presentation, as well as by findings from imaging studies¹. The most common imaging finding suggestive of liver disease is hepatic steatosis, which is present in 25% to 30% of the general population on abdominal ultrasound examinations2, 3. Hepatic steatosis is frequently caused by increased alcohol intake and cardiometabolic risk factors, and is classified as</section></section><section><section><h2>Financial support:</h2>The financial support by the Austrian Federal Ministry of Labour and Economy, the National Foundation for Research, Technology and Development and the Christian Doppler Research Association is gratefully acknowledged.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"243 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Editor’s Desk...","authors":"Philip Newsome,&nbsp;Frank Tacke,&nbsp;Heiner Wedemeyer,&nbsp;Lorenza Rimassa,&nbsp;Annalisa Berzigotti,&nbsp;Tom H. Karlsen,&nbsp;Vlad Ratziu","doi":"10.1016/j.jhep.2025.02.040","DOIUrl":"10.1016/j.jhep.2025.02.040","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Pages 773-776"},"PeriodicalIF":26.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward functional cure of hepatitis B: Is combination therapy the key?","authors":"Lisa Sandmann","doi":"10.1016/j.jhep.2025.03.024","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.03.024","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Background and context</h2>Chronic hepatitis B virus (HBV) infection is a major health burden and it is estimated that 3% of the world’s population are chronically infected.¹ Infected individuals are at risk of developing chronic liver disease leading to cirrhosis, liver-related complications and development of hepatocellular carcinoma (HCC).² Antiviral treatment with nucleos(t)ide analogues (NA) effectively suppresses HBV DNA replication thereby reducing the risk of disease progression and HCC development in patients</section></section><section><section><h2>Objectives, methods and findings</h2>In the phase II study published in the <em>New England Journal of Medicine</em>, 160 patients with chronic HBV infection and established effective NA treatment without clinically significant fibrosis or cirrhosis were randomly assigned to receive (A) xalnesiran 100 mg or (B) 200 mg, (C) xalnesiran 200 mg plus ruzotolimod 150 mg, (D) xalnesiran 200 mg plus pegylated interferon alfa (PEG-IFN), all in addition to continued NA treatment, or (E) NA alone.⁹ The total treatment duration was 48 weeks in all</section></section><section><section><h2>Significance of findings</h2>This study demonstrated that combination treatment with a small-interfering RNA (xalnesiran) and an immune-modulatory agent (ruzotolimod or PEG-IFN) in addition to continued NA treatment led to HBsAg loss in a substantial proportion of patients. Interestingly, response rates were higher in patients receiving PEG-IFN compared to the TLR7 agonist ruzotolimod. The reasons for these differences are unclear but could be due to the broader immunomodulatory activity of IFN, which affects both the</section></section><section><section><h2>Financial support</h2>The authors did not receive any financial support to produce this manuscript.</section></section><section><section><h2>Conflict of interest</h2>The author of this study declares that they do not have any conflict of interest.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"183 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}