Journal of Hepatology最新文献

{"title":"Reply to: \"Alcohol abstinence and recompensation - time to understand the 'how?'\".","authors":"Benedikt Silvester Hofer, Georg Semmler, Thomas Reiberger","doi":"10.1016/j.jhep.2026.09.008","DOIUrl":"10.1016/j.jhep.2026.09.008","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBV-reactive KIR+ CX3CR1+ CD8+ T cells mediate liver transplantation tolerance.","authors":"Yongbo Liu, Bingran Wang, Di Sun, Aiwei Zhou, Zimeng Cai, Tao Zhou, Sen Yang, Qi Pan, Yunmu Gao, Jiaqi Song, Zhipeng Zong, Wanglong Xiao, Hongyuan Liu, Taihua Yang, Zhicong Zhao, Yi Luo, Jianjun Zhang, Jianchen Fang, Zhenzhen Zhan, Linrong Lu, Yuan Liu, Qiang Xia","doi":"10.1016/j.jhep.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.004","url":null,"abstract":"<p><strong>Background & aims: </strong>Immune tolerance after transplantation reduces immunosuppression-related complications and improves the overall survival rates. The unique tolerogenic microenvironment of the liver enables a proportion of liver transplantation (LT) recipients to develop tolerance with intact liver function. However, the underlying immunological mechanisms remain unclear.</p><p><strong>Method: </strong>s: We integrated single-cell transcriptome/TCR profiling, flow cytometry, in vitro killing assays, HLA-E peptidome from a retrospective cohort including 347 LT recipients, murine LT models, and a 20-participant prospective immunosuppressant withdrawal trial in pediatric LT recipients with median 26 months follow-up.</p><p><strong>Results: </strong>We demonstrated that Epstein-Barr virus (EBV)-derived peptides can be presented by HLA-E on alloreactive CD4⁺ T cells to prime KIR⁺ CX3CR1⁺ CD8⁺ T cells, thereby promoting immune tolerance after LT. As a subset of CD8⁺ T_EMRA cells, KIR⁺ CX3CR1⁺ CD8⁺ T cells utilize perforin and granzyme B to suppress alloreactive CD4⁺ T cells after LT. In vitro analysis unveiled that the EBV-derived peptide SQAPLPCVL could stabilize HLA-E expression on alloreactive CD4⁺ T cells and mediate recognition and elimination by KIR⁺ CX3CR1⁺ CD8⁺ T cells through a TCR-dependent mechanism. Furthermore, BATF was indispensable for induction of KIR⁺ CX3CR1⁺ CD8⁺ T cells. In the prospective immunosuppressant withdrawal clinical trial, the peripheral ratio of CD8⁺ T_EMRA and KIR⁺ CX3CR1⁺ CD8⁺ T cells were suggested to be potentially useful in identifying tolerant recipients.</p><p><strong>Conclusions: </strong>Our study demonstrated a new immune tolerance mechanism mediated by KIR⁺ CX3CR1⁺ CD8⁺ T cells and established the connection between viral infection and tolerance formation, providing new insights into tolerance-inductive strategies after transplantation.</p>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation instead of depletion: Rethinking B cell-targeted therapies in IgG4-related cholangitis.","authors":"David C Trampert","doi":"10.1016/j.jhep.2026.08.012","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.012","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curative conversion and confounding in a bevacizumab dose comparison.","authors":"Jiaju Zhao, Bin Qiao","doi":"10.1016/j.jhep.2026.08.030","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.030","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Surveillance of patients at risk of liver cancer: Expert Opinions.","authors":"Maria Qurashi, Jessica Howell, Rohini Sharma","doi":"10.1016/j.jhep.2026.08.031","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.031","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging strategies for hepatocellular carcinoma surveillance: Abbreviated MRI, biomarkers and benefit stratification.","authors":"George N Ioannou, Peter Jepsen, Ian A Rowe","doi":"10.1016/j.jhep.2026.08.027","DOIUrl":"10.1016/j.jhep.2026.08.027","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) surveillance with semi-annual ultrasound and alpha-fetoprotein is recommended in clinical practice guidelines for patients with cirrhosis and selected patients with chronic hepatitis B. However, this strategy has suboptimal sensitivity for early-stage HCC and poor real-world adherence; moreover, randomised trial evidence demonstrating reduced HCC-related or all-cause mortality in patients with cirrhosis is lacking. In this expert opinion, we evaluate two emerging categories of HCC surveillance tests - abbreviated magnetic resonance imaging (aMRI) protocols and blood-based biomarker panels - and propose that, if validated, their future clinical implementation should be guided not only by HCC risk, but by expected surveillance benefit. Protocols for aMRI seek to preserve the high diagnostic accuracy of full liver-protocol MRI while reducing scan time, cost, and patient burden. Dynamic contrast-enhanced aMRI (DCE-aMRI) can establish a definitive HCC diagnosis without recall imaging and may match the accuracy of full liver-protocol MRI. Non-contrast aMRI (NC-aMRI) avoids intravenous contrast and has demonstrated superior sensitivity and specificity compared with ultrasound in recent trials. Blood-based biomarker panels, including protein-based tests (GALAD, HES 2.0) and circulating tumour DNA-based assays (Oncoguard, HelioLiver) may improve adherence, but face methodological challenges and require rigorous, prospective longitudinal evaluation to determine whether they result not only in earlier actionable detection but also better clinical outcomes. We argue that selecting which patients should receive enhanced surveillance requires moving beyond risk stratification towards benefit stratification, i.e. basing surveillance recommendations not only on the patient's risk of developing HCC, but also on the probability that earlier-stage detection and receipt of effective treatment enabled by surveillance will improve clinical outcomes. Patients at the highest HCC risk do not necessarily stand to gain the most from earlier detection, underscoring the need for pragmatic frameworks and prediction tools that estimate individualised surveillance benefit.</p>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent but persistent: Failure of continuous tenofovir based ART to prevent HBV and HDV reactivation under chemotherapy in an HBsAg-negative patient living with HIV.","authors":"Lisa Sophie Pflüger, Katja Giersch, Julian Schulze Zur Wiesch, Marc Lütgehetmann","doi":"10.1016/j.jhep.2026.08.010","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.010","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mouse models of acute and chronic hepatitis E virus infection","authors":"Tianxu Liu,Xinyue Yang,Baixun Li,Qing Fan,Zihao Yu,Dong Ying,Yuebao Li,Wei Zhang,Jiajing Wu,Peiyu Jiang,Liwei Zheng,Hongzhen Mao,Guochao Wei,Yanning Liu,Xin Yin,Fengmin Lu,Zizheng Zheng,Weigang Zhang,Cheng-Feng Qin,André Gömer,Nicola Frericks,Eike Steinmann,Lei Qin,Yunjie Lu,Bei Jiang,Lin Wang","doi":"10.1016/j.jhep.2026.08.034","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.034","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"24 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Transplant Hepatitis D Breakthrough Driven by Integrant-Derived HBsAg from an Extrahepatic HCC Metastasis","authors":"Lorenza Di Marco,Nicola De Maria,Daniele Lombardo,Giovanni Raimondo,Teresa Pollicino,Maria Paola Anolli,Giacomo Ciusa,Antonio Colecchia,Elisabetta Degasperi,Fabrizio Di Benedetto,Stefano Di Sandro,Giovanni Dolci,Massimo Dominici,Domenico Giosa,Giovanni Guaraldi,Pietro Lampertico,Marco Maggioni,Cristina Musolino,David James Pinato,Alessandra Pivetti,Adriana Romanzi,Massimiliano Salati,Andrea Spallanzani","doi":"10.1016/j.jhep.2026.08.029","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.029","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"3 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of aged liver regeneration by youthful systemic factors via LTβ-driven hepatocyte reprogramming","authors":"Jiang Chenhao,Han Lu,Liu Yasong,Zhang Jianhao,Chen Huaxin,Wen Xinyun,Chi Xianda,Fan Linda,Li Tianyi,Shi Shaojun,Chen Sunrui,Xiao Jiaqi,Lv Xing,Zhang Jiebin,Zhao Xuegang,Zhang Yujun,Liu Jianrong,Zhang Xu,Lv Guo,Qiu Yuan,Yao Jia,Zeng Kaining,Li Haibo,Lu Tongyu,Ye Linsen,Fu Binsheng,Li Hua,Yi Shuhong,Liu Wei,Zhang Qi,Chen Guihua,Cai Jianye,Xiang Andy Peng,Zhang Yingcai,Sui Xin,Yang Yang","doi":"10.1016/j.jhep.2026.08.036","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.036","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"54 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}