Journal of Hepatology最新文献

{"title":"Post-Transplant Hepatitis D Breakthrough Driven by Integrant-Derived HBsAg from an Extrahepatic HCC Metastasis","authors":"Lorenza Di Marco,Nicola De Maria,Daniele Lombardo,Giovanni Raimondo,Teresa Pollicino,Maria Paola Anolli,Giacomo Ciusa,Antonio Colecchia,Elisabetta Degasperi,Fabrizio Di Benedetto,Stefano Di Sandro,Giovanni Dolci,Massimo Dominici,Domenico Giosa,Giovanni Guaraldi,Pietro Lampertico,Marco Maggioni,Cristina Musolino,David James Pinato,Alessandra Pivetti,Adriana Romanzi,Massimiliano Salati,Andrea Spallanzani","doi":"10.1016/j.jhep.2026.08.029","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.029","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"3 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of aged liver regeneration by youthful systemic factors via LTβ-driven hepatocyte reprogramming","authors":"Jiang Chenhao,Han Lu,Liu Yasong,Zhang Jianhao,Chen Huaxin,Wen Xinyun,Chi Xianda,Fan Linda,Li Tianyi,Shi Shaojun,Chen Sunrui,Xiao Jiaqi,Lv Xing,Zhang Jiebin,Zhao Xuegang,Zhang Yujun,Liu Jianrong,Zhang Xu,Lv Guo,Qiu Yuan,Yao Jia,Zeng Kaining,Li Haibo,Lu Tongyu,Ye Linsen,Fu Binsheng,Li Hua,Yi Shuhong,Liu Wei,Zhang Qi,Chen Guihua,Cai Jianye,Xiang Andy Peng,Zhang Yingcai,Sui Xin,Yang Yang","doi":"10.1016/j.jhep.2026.08.036","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.036","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"54 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision support requires modifiable targets and inclusive reach in STOP-C","authors":"Fangyou Wei","doi":"10.1016/j.jhep.2026.08.035","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.035","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"7 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall and Line-Specific Impact of Targeted Therapies in Advanced Biliary Tract Cancer After Chemoimmunotherapy Failure","authors":"Margherita Rimini,Masafumi Ikeda,Oluseyi Abidoye,Jessica Lucchetti,Lorenzo Antonuzzo,Jin Won Kim,Arndt Vogel,Angela Lamarca,Federico Nichetti,Anna Saborowski,Tiziana Pressiani,Caterina Vivaldi,Ilario Giovanni Rapposelli,Frederik Peeters,Chiara Braconi,David J. Pinato,Emiliano Tamburini,Chiara Pircher,Stefano Tamberi,Florian Castet,Monica Verrico,Alessandro Parisi,Nuno Couto,Hong Jae Chon,Andrea Martirena,Matteo Landriscina,Fabian Fimkelmeier,Ester Oneda,Antonio Avallone,Emanuela Dell’Aquila,Lukas Perkhofer,Il Hwan Kim,Vincenzo Formica,Cidalia Maria de Sousa Pinto,Ingrid Garajova,Beodeul Kang,Salvatore Corallo,Elisabetta Fenocchio,Giovanni Farinea,Alessandro Pastorino,Anna Diana,Changhoon Yoo,Marta Schirripa,Maria Grazia Rodriquenz,Mario Scartozzi,Lucrezia Zumstein,Michele Ghidini,Gerald W. Prager,Giuseppe Aprile,Gian Paolo Spinelli,Su Yung-Yeh,Stephen Chan,Emily Warmington,Alessia Lancianese,Tomoyuki Satake,Tanios Bekaii-Saab,Daniele Lavacchi,Laura Passeri,Michele Ferrara,Minsu Kang,Alessandra Anna Prete,Silvia Bozzarelli,Mara Persano,Gianluca Masi,Rita Balsano,Monica Niger,Sara Lonardi,Francesca Salani,Silvia Camera,Lorenzo Fornaro,Lorenza Rimassa,Andrea Casadei-Gardini","doi":"10.1016/j.jhep.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.012","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"71 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “From definitions to phenotyping: a response to the illusion of harmonisation”","authors":"Rajiv Jalan,Nipun Verma","doi":"10.1016/j.jhep.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.007","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"17 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-target blood test for hepatocellular carcinoma early detection: a cross-sectional analysis of the prospective ALTUS study","authors":"Binu V. John,Mark Camardo,Amit G. Singal,Neehar D. Parikh,Ju Dong Yang,Lewis R. Roberts,Alvin C. Silva,Naga Chalasani,Reena Salgia,John B. Kisiel,Kyle Porter,Paul Z. Elias,Elle Kielar-Grevstad,Janelle J. Bruinsma,Marilyn C. Olson,Jorge Garces,Paul J. Limburg","doi":"10.1016/j.jhep.2026.09.011","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.011","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"269 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spleen stiffness measurement rules out high-risk varices in patients with chronic portal vein thrombosis without cirrhosis.","authors":"Lucile Moga, Audrey Payancé, Luis Téllez, Dario Saltini, Lucia Giuli, Asunción Ojeda, Elton Dajti, Ekaterina Liusina, Francisco Capinha, Dominik Bettinger, Teresa Monllor-Nunell, Arathi Venu, Gowripriya Nair, Laure Elkrief, Joel Silva, Magdalena Meszaros, Markus Peck-Radosavljevic, Sara Reinartz Groba, Christiane Stern, Laurent Castéra, Michael Praktiknjo, Boris Guiu, Arun Valsan, José Ferrusquía-Acosta, Carlos Noronha Ferreira, Maria Nadinskaya, Federico Ravaioli, Fanny Turon, Francesco Santopaolo, Filippo Schepis, Agustin Albillos, Pierre-Emmanuel Rautou, Aurélie Plessier","doi":"10.1016/j.jhep.2026.08.026","DOIUrl":"10.1016/j.jhep.2026.08.026","url":null,"abstract":"<p><strong>Background & aims: </strong>Screening endoscopy can be spared in patients with compensated cirrhosis when spleen stiffness measurement (SSM) by vibration-controlled transient elastography (VCTE) is ≤40 kPa, as these patients have a low probability of high-risk varices (HRV). Conversely, endoscopy is required in all patients with chronic portal vein thrombosis (PVT) without cirrhosis. The objective was to evaluate the performance of SSM-VCTE for excluding HRV in patients with chronic PVT.</p><p><strong>Methods: </strong>We retrospectively included patients with chronic PVT without cirrhosis who underwent upper endoscopy within 2 years before or after SSM-VCTE at 16 VALDIG centres. Patients were divided into derivation and validation cohorts.</p><p><strong>Results: </strong>A total of 159 patients were included in the derivation cohort; 43% had HRV. A total of 187 patients were included in the validation cohort; 32% had HRV. On univariable analysis, myeloproliferative neoplasm, ascites, hemoglobin, bilirubin, albumin, splenomegaly, portosystemic collaterals, liver stiffness-spleen diameter-to-platelet ratio score, liver stiffness measurement and SSM-VCTE were associated with HRV in both cohorts. On multivariable binary logistic regression analysis, only SSM-VCTE (p <0.005) remained associated with HRV in both cohorts. In the derivation cohort, SSM-VCTE ≤ 40 kPa had a sensitivity of 97% to rule out HRV, and could spare 41% of endoscopies, with 3% of HRV missed, and a 97% negative predictive value (NPV). In the validation cohort, SSM-VCTE ≤40 kPa could spare 43% of endoscopies, with 5% of HRV missed, and a 96% NPV.</p><p><strong>Conclusions: </strong>In this study of 346 patients with chronic PVT without cirrhosis, SSM-VCTE ≤40 kPa identified patients at low risk of HRV, allowing endoscopy to be spared in approximately 40% of patients while missing ≤5% of HRV.</p><p><strong>Impact and implications: </strong>Patients with chronic portal vein thrombosis who do not have cirrhosis usually have low liver stiffness measurement values; the liver stiffness cut-offs used to rule out high-risk varices in patients with cirrhosis cannot therefore be used in this population. We show here that spleen stiffness measurement by vibration-controlled transient elastography ≤40 kPa is able to identify patients with chronic portal vein thrombosis with a very low probability of high-risk varices, in whom screening endoscopy can be spared. Annual surveillance of spleen stiffness measurement could reduce the need for repeated screening endoscopies throughout a person's lifetime. This approach could enhance quality of life while also reducing risks associated with endoscopic procedures, particularly those related to anesthesia.</p>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":""},"PeriodicalIF":40.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When containment fails: β-adrenergic disruption of the gut–liver barrier in cirrhosis","authors":"Schalk Van der Merwe,Hannelie Korf","doi":"10.1016/j.jhep.2026.09.010","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.010","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"52 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confounded Time Intervals and Artificial Variance Suppression in MASLD Biomarker Reproducibility","authors":"Mengchu Ke,Yanbao Ding","doi":"10.1016/j.jhep.2026.08.033","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.08.033","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"163 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148895798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-cells on the rise: Serum IgA Identifies a High-Risk Biological Phenotype in MASLD","authors":"Mathias Heikenwalder,Yasuko Iwakiri","doi":"10.1016/j.jhep.2026.09.006","DOIUrl":"https://doi.org/10.1016/j.jhep.2026.09.006","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"110 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149050287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}