Journal of Hepatology最新文献

{"title":"A consensus definition for ACLF - The need of the hour?","authors":"Sagnik Biswas, Arnav Aggarwal, Shalimar","doi":"10.1016/j.jhep.2024.06.020","DOIUrl":"10.1016/j.jhep.2024.06.020","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":"e52-e53"},"PeriodicalIF":26.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor long-term outcome in patients with porto-sinusoidal vascular disease (PSVD): fact or disease misclassification?","authors":"Shiv K Sarin, Ansgar W Lohse, Patrick S Kamath","doi":"10.1016/j.jhep.2024.09.015","DOIUrl":"10.1016/j.jhep.2024.09.015","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":"4-6"},"PeriodicalIF":26.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile acid metabolism and signalling in liver disease.","authors":"Claudia D Fuchs, Benedikt Simbrunner, Maximillian Baumgartner, Clarissa Campbell, Thomas Reiberger, Michael Trauner","doi":"10.1016/j.jhep.2024.09.032","DOIUrl":"10.1016/j.jhep.2024.09.032","url":null,"abstract":"<p><p>Bile acids (BAs) serve as signalling molecules, efficiently regulating their own metabolism and transport, as well as key aspects of lipid and glucose homeostasis. BAs shape the gut microbial flora and conversely are metabolised by microbiota. Disruption of BA transport, metabolism and physiological signalling functions contribute to the pathogenesis and progression of a wide range of liver diseases including cholestatic disorders and MASLD (metabolic dysfunction-associated steatotic liver disease), as well as hepatocellular and cholangiocellular carcinoma. Additionally, impaired BA signalling may also affect the intestine and kidney, thereby contributing to failure of gut integrity and driving the progression and complications of portal hypertension, cholemic nephropathy and the development of extrahepatic malignancies such as colorectal cancer. In this review, we will summarise recent advances in the understanding of BA signalling, metabolism and transport, focusing on transcriptional regulation and novel BA-focused therapeutic strategies for cholestatic and metabolic liver diseases.</p>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":" ","pages":"134-153"},"PeriodicalIF":26.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Rethinking Methodology and Data Integrity in Mendelian Randomization: Insights from Air Pollution and MASLD Research","authors":"Shanshan Ran, Jingyi Zhang, Hualiang Lin","doi":"10.1016/j.jhep.2024.12.042","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.12.042","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>CRediT authorship contribution statement</h2>Shanshan Ran: Formal analysis, writting – original draft, writting – review &amp; editing. Jingyi Zhang: Formal analysis, writting – review &amp; editing. Hualiang Lin: Conceptualization, writting – original draft, writting – review &amp; editing.</section></section><section><section><h2>Financial support statement</h2>This work was supported by the National Natural Science Foundation of China (82373534).</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"348 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Timing To Initiate Antiviral Prophylaxis of MTCT: More Required to Be Done","authors":"Ruixuan Hong, Xiaoyun Liu, Xueru Yin","doi":"10.1016/j.jhep.2024.12.043","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.12.043","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Ruixuan Hong and Xiaoyun Liu contributed to writing the manuscript. Xueru Yin critically revised the manuscript and reviewed the manuscript for important content. All authors approved the final manuscript submitted.</section></section><section><section><h2>Financial support</h2>Funding by Science and Technology Projects in Guangzhou (2023A04J2299).</section></section><section><section><h2>Declaration of Competing Interest</h2>All authors have no conflicts of interest to declare. Please refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Acknowledgements</h2>We thank all the investigators and participants of the SHIELD program, with the commitment to eliminate HBV MTCT.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"34 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Tumour Endothelial Cells in Liver Cancer: The end of beginning","authors":"Xiaohang Long, Tsz Tung Kwong, Alfred Sze-Lok Cheng, Stephen Lam Chan","doi":"10.1016/j.jhep.2024.12.032","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.12.032","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Declaration of Competing Interest</h2>SLC serves an advisory member for AstraZeneca, MSD, Eisai, Elevar, Roche, Ipsen, and Hengrui, received research funds from MSD, Eisai, Ipsen, SIRTEX, and Zailab, and honoraria from AstraZeneca, Eisai, Roche, Ipsen, and MSD.</section></section><section><section><h2>Acknowledgements</h2>This work is partially supported by the General Research Fund (14118424 and 14109122), the Li Ka Shing Foundation (CUHK_2021) and the CUHK Strategic Seed Funding for Collaborative Research Scheme (NL/SSFCRS2022/0672/22en).</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"32 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New evidence of cross-disease communication between heart and liver","authors":"Thomas Marjot","doi":"10.1016/j.jhep.2024.11.034","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.11.034","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Background and context</h2>Much is known about the cardiovascular implications of metabolic dysfunction-associated steatohepatitis (MASH). Cardiovascular disease (CVD) represents the leading cause of mortality in patients with MASH and despite overlapping risk factors for both conditions, the presence of hepatic steatosis and inflammation are generally regarded as independent risk factors for ischaemic heart disease (IHD).¹^,² This is likely to occur through a combination of liver-derived systemic inflammation,</section></section><section><section><h2>Objectives, methods and findings</h2>This work predominantly involved subjecting rodents with and without MASH to acute MI (via ligating the left anterior descending coronary artery) or sham surgery. Authors then characterised the liver phenotype, hepatic cell infiltrate, and systemic immune response to intervention, before using a range of treatment conditions to offer mechanistic insights into the cellular and soluble mediators of post-MI liver damage. Firstly, MI was found to exacerbate liver injury in three different models of</section></section><section><section><h2>Scientific importance and translational relevance</h2>There is still some way to go before the concept of accelerated liver damage after MI is considered a major shift in our understanding of human MASH. The mechanistic components of the current work are performed entirely in preclinical models and further investigation is now required as part of clinical studies, not least because both lipid metabolism and cardiovascular structure differ between rodents and humans.¹¹^,¹² In addition, a single assessment of liver pathology was made at 14 days after</section></section><section><section><h2>Financial support</h2>T.M. is supported by a <span>National Institute for Health Research (NIHR) Academic Clinical Lectureship</span>. The views expressed are those of the author and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health.</section></section><section><section><h2>Conflict of interest</h2>T.M. has no conflicts of interest to declare.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Acknowledgements</h2>T.M. would like to thank Dr Paul N Brennan (University of Dundee, UK) for an informal check of the initial article draft.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"25 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “ALT to qHBsAg ratio predicts HBsAg seroclearance in HBeAg-negative hepatitis B patients with Peg-IFNα based therapy”","authors":"Rex Wan-Hin Hui, Lung-Yi Mak, Man-Fung Yuen","doi":"10.1016/j.jhep.2024.12.036","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.12.036","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>AUTHOR CONTRIBUTIONS</h2>RWH Hui was involved in manuscript design and drafting of manuscript. LY Mak was involved in critical revision of manuscript. MF Yuen was involved in critical revision of manuscript and overall study supervision. The authors declare that they have participated in the preparation of the manuscript and have seen and approved the final version.</section></section><section><section><h2>DATA AVAILABILITY STATEMENT</h2>The data from this study is available from the corresponding author upon reasonable request.</section></section><section><section><h2>Funding</h2>Innovative Research Fund of the State Key Laboratory of Liver Research, The University of Hong Kong (ref. no.: SKLLR/IRF/2018/07) and the S. K. Yee Medical Foundation Grant (ref. no.: 2141213). The funders had no involvement in study design, data collection/ analysis/ interpretation, writing of the manuscript or decision to submit the article for publication.</section></section><section><section><h2>Declaration of Competing Interest</h2>MF Yuen is an advisory board member and/or received research funding from AbbVie, Arbutus Biopharma, Assembly Biosciences, Bristol Myer Squibb, Dicerna Pharmaceuticals, GlaxoSmithKline, Gilead Sciences, Janssen, Merck Sharp and Dohme, Clear B Therapeutics, Springbank Pharmaceuticals; and received research funding from Arrowhead Pharmaceuticals, Fujirebio Incorporation and Sysmex Corporation. The remaining authors have no conflict of interests.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"11 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Plasma Exchange in Acute Liver Failure: can the data be trusted?","authors":"Alaa Daoud, Kim Peder Dalhoff, Tonny Studsgaard Petersen","doi":"10.1016/j.jhep.2024.12.035","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.12.035","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>All authors contributed to the concept of the manuscript. AD wrote the first draft. KPD and TSP reviewed and approved the final manuscript.</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>None</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"149 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roux-en-Y gastric bypass in a patient with Wilson’s disease and obesity","authors":"Alexandre Balaphas, Christine Sempoux, Caroline F. Samer, Haithem Chtioui, Alend Saadi","doi":"10.1016/j.jhep.2024.12.034","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.12.034","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Clinical case presentation</h2>A 29-year-old woman with a body mass index (BMI) of 38.4 kg/m², glucose intolerance, and irregular menstrual cycles was referred to our specialized obesity center. Two years earlier, she was diagnosed with WD. The patient presented without any neurological or psychiatric complications. The initial liver biopsy revealed a pattern of steatohepatitis with periportal and perisinusoidal fibrosis and some copper deposits (Fig. S1). Intrahepatic copper concentration was 911 μg per g of liver dry</section></section><section><section><h2>Discussion and conclusion</h2>DPA absorption is strongly influenced by malabsorption states[2]. Ammitzboll <em>et al.</em> evaluated the bioavailability of DPA in patients with progressive systemic sclerosis[8]. The bioavailability was reduced by more than half in the presence of gastrointestinal involvement following impaired drug absorption and/or increased degradation in the gastrointestinal tract. Copper absorption primarily occurs in the duodenum and the small bowel, and malabsorptive bariatric surgery may reduce dietary copper</section></section><section><section><h2>Consent</h2>The patient provided written informed consent to this report.</section></section><section><section><h2>Data availability</h2>Not applicable</section></section><section><section><h2>Authors contributions</h2>DM, CS, HC, and AS were implicated in the management of the patient before and after the surgery. AB, CS and AS acquired the data. All authors analysed and interpreted the data. AB, DM and AS contributed to the writing of the first draft of the manuscript. All authors contributed to the critical revision of the manuscript. All authors approved the final version of the manuscript.</section></section><section><section><h2>Funding</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>None</section></section><section><section><h2>Acknowledgments</h2>The authors are grateful to the late Professor Peter Ferenci for sharing his expertise in the preoperative evaluation of this patient. The authors thank Cécile Stéphan Moulin, Romina Capoccia Brugger, and SolenneNguyen Gia Can for their dedicated work. Moreover, the authors wish to express their sincere appreciation to Basma Benhaddou and Guy Temporal for the professional proof editing of the manuscript.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"2 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}