{"title":"The etymology of liver in ancient Greek and Latin","authors":"John Henry , Marvad Ahad","doi":"10.1016/j.jhep.2024.09.042","DOIUrl":"10.1016/j.jhep.2024.09.042","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 171-173"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vlad Ratziu , Thomas S. Scanlan , Eveline Bruinstroop
{"title":"Thyroid hormone receptor-β analogues for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)","authors":"Vlad Ratziu , Thomas S. Scanlan , Eveline Bruinstroop","doi":"10.1016/j.jhep.2024.10.018","DOIUrl":"10.1016/j.jhep.2024.10.018","url":null,"abstract":"<div><div>The association between suboptimal thyroid function ((sub)clinical hypothyroidism or low-normal thyroid function) and the metabolic syndrome and MASLD (metabolic dysfunction-associated steatotic liver disease) has been clearly established. Furthermore, in MASLD, intracellular thyroid hormone concentrations are low and the activation of the thyroid hormone receptor (THR) is reduced. Administration of thyroid hormone has been shown to reduce liver triglycerides by stimulating fatty acid disposal through lipophagy and beta-oxidation, and to lower LDL-cholesterol. As thyroid hormone exerts its effects in many different organs, including the heart and bone, several drug candidates have been developed as selective thyromimetics for the THR-β nuclear receptor with potent and liver-targeted activity. Importantly, these compounds have reduced affinity for the THR-α nuclear receptor and tissue distribution profiles that differ from endogenous thyroid hormones, thereby reducing unwanted cardiovascular side effects. The most advanced compound, resmetirom, is an oral drug that demonstrated, in a large phase III trial in patients with MASH (metabolic dysfunction-associated steatohepatitis), the ability to reduce liver fat, decrease aminotransferase levels and improve atherogenic dyslipidaemia with a good tolerability profile. This translated into histological improvement that led to accelerated approval of this drug for active fibrotic steatohepatitis, a milestone achievement as a first MASH drug.</div></div>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 375-387"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142450256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Publisher’s note on “The risk-benefit assessment of liver biopsy in times of non-invasive screening for liver fibrosis” by Ivana Ilic and Tamara Milovanovic [J Hepatol 73 (2020) 701–702]","authors":"","doi":"10.1016/j.jhep.2024.09.028","DOIUrl":"10.1016/j.jhep.2024.09.028","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Page 397"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142369124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gut bacterial membrane components as pathogenic signalling molecules in PSC-IBD","authors":"David C. Trampert","doi":"10.1016/j.jhep.2024.11.024","DOIUrl":"10.1016/j.jhep.2024.11.024","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 390-391"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synergy between public health policy and clinicians plays a key role in reducing fracture risk in patients with viral hepatitis","authors":"Jingkai Di , Liying Song , Chuan Xiang","doi":"10.1016/j.jhep.2024.07.024","DOIUrl":"10.1016/j.jhep.2024.07.024","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages e85-e86"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erik A.H. Loeffen, Henkjan J. Verkade, Patrick F. van Rheenen
{"title":"Obtaining first-line induction in autoimmune hepatitis: Aren’t we underestimating prednisolone?","authors":"Erik A.H. Loeffen, Henkjan J. Verkade, Patrick F. van Rheenen","doi":"10.1016/j.jhep.2024.07.020","DOIUrl":"10.1016/j.jhep.2024.07.020","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Page e78"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheng Li , Yali Shen , Zhiping Li , Dan Cao , Yue Hu
{"title":"Is MetALD an independent risk factor of all-cause mortality? A meta-analysis of 164,694 individuals from the real world","authors":"Zheng Li , Yali Shen , Zhiping Li , Dan Cao , Yue Hu","doi":"10.1016/j.jhep.2024.10.022","DOIUrl":"10.1016/j.jhep.2024.10.022","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages e95-e97"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rifaximin in cirrhosis: Is its microbiological spotless record under threat?","authors":"Cornelius Engelmann","doi":"10.1016/j.jhep.2024.11.033","DOIUrl":"10.1016/j.jhep.2024.11.033","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 392-394"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edo J. Dongelmans , Milan J. Sonneveld , Harry L.A. Janssen
{"title":"Increasing functional cure rates after nucleo(s)tide analogue withdrawal: Is peg-IFN the answer?","authors":"Edo J. Dongelmans , Milan J. Sonneveld , Harry L.A. Janssen","doi":"10.1016/j.jhep.2024.10.019","DOIUrl":"10.1016/j.jhep.2024.10.019","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 168-170"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimising the treatment of HDV infection: Efficacy of bulevirtide, HBV-HDV interactions and the importance of statistical methods","authors":"Junkun Zhu","doi":"10.1016/j.jhep.2024.08.018","DOIUrl":"10.1016/j.jhep.2024.08.018","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages e107-e108"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}