Journal of Hepatology最新文献

{"title":"Beyond Metabolic Benefits: The Underexplored Immunomodulatory Effects of GLP-1/Glucagon Agonists","authors":"Gustav van Niekerk, Johan Fevery, Kai Dallmeier","doi":"10.1016/j.jhep.2025.02.025","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.025","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Gustav van Niekerk drafted the original manuscript and created the figure. Johan Fevery and Kai Dallmeier reviewed and edited this correspondence. All authors approved the final manuscript.</section></section><section><section><h2>Financial support</h2>The authors received no financial support to produce this manuscript.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no conflicts of interest.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"22 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rat hepatitis E virus as an aetiological agent of acute hepatitis of unknown origin","authors":"Javier Caballero-Gómez, María Casares-Jiménez, Marina Gallo-Marín, Sara Pereira-Pardo, Adrián Beato-Benítez, Antonio Poyato, Rafael Guerra, Ana Avellón, Katja Schilling-Loeffler, Carolina Freyre-Carrillo, Ignacio García-Bocanegra, Débora Jiménez-Martín, Diana Corona-Mata, Isabel Viciana, Tomás Fajardo, Milagros Muñoz-Chimeno, Miguel Ángel Quevedo, Lucía Ríos-Muñoz, Ana Belén Pérez, David Cano-Terriza, Antonio Rivero","doi":"10.1016/j.jhep.2025.02.027","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.027","url":null,"abstract":"<h3>Background and Aim</h3>Rat hepatitis E virus (ratHEV) is an emerging cause of acute hepatitis worldwide. The limited number of ratHEV cases may be associated with the lack of a proper molecular diagnosis method; thus, the clinical impact and breadth of ratHEV as a cause of acute hepatitis remain uncertain.<h3>Methods</h3>The study was carried out in four phases. I) Identification: Molecular assays were identified through a literature search. II) Testing: The methods were evaluated in a rodent testing cohort, and the most suitable molecular diagnosis algorithm was established. III) Derivation: The established algorithm was tested in a larger rodent cohort. IV) Clinical validation: The algorithm was used in a cohort of individuals suffering from acute hepatitis of unknown aetiology, thus establishing the frequency of ratHEV as an aetiological agent of acute hepatitis and its clinical impact.<h3>Results</h3>We detected differences in the frequency of positive results among the assays evaluated. After comparing all available molecular methods, we established a molecular diagnostic algorithm, which revealed that 17.5% of the 103 rodents in the validation cohort were infected with ratHEV. In the clinical validation cohort, of 562 patients with acute hepatitis of unknown origin, 8 cases of ratHEV infection were identified during the three years of the study, representing a frequency of 1.4%. One (37.5%) case had severe acute hepatitis; four (50.0%) patients required hospitalization, one of whom (12.5%) died. The strains detected in these patients revealed a close phylogenetic relationship with those found in rats in Spain.<h3>Conclusions</h3>Our study demonstrated that ratHEV is an emerging and underdiagnosed cause of acute hepatitis. The results provide evidence that ratHEV should be monitored and included in the differential diagnosis of acute hepatitis.<h3>Clinical trial number</h3><span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> Identifier: NCT05062967<h3>Impact and Implications</h3>While rat hepatitis E virus (ratHEV) is a newly emerging zoonotic virus worldwide, the results of the present study indicate that the molecular diagnosis methods for this virus may be inappropriate. After establishing a proper molecular diagnostic algorithm using available assays, we demonstrated that ratHEV is an emerging and underdiagnosed aetiological agent of acute hepatitis of unknown origin. The results also expand the knowledge of the diversity of ratHEV strains capable of infecting humans in Europe. These findings strongly suggest that ratHEV should be monitored and included in the differential diagnosis of acute hepatitis.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of non-invasive test dynamics in guiding HCC surveillance decisions after HCV cure in patients with cirrhosis","authors":"Pierre Nahon, Clovis Lusivika-Nzinga, Philippe Merle, Fabien Zoulim, Thomas Decaens, Nathalie Ganne-Carrié, Georges-Philippe Pageaux, Vincent Leroy, Laurent Alric, Jean-Pierre Bronowicki, Marc Bourlière, Jérôme Gournay, Albert Tran, Stanislas Pol, Philippe Mathurin, Véronique Loustaud-Ratti, Sophie Métivier, Victor De Ledinghen, Armand Abergel, Dominique Thabut, Jean-Charles Duclos-Vallée","doi":"10.1016/j.jhep.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.008","url":null,"abstract":"<h3>Background and aims</h3>The objective was to describe the dynamics of noninvasive tests (NITs) in cirrhotic patients following sustained virological response (SVR) and to assess their correlation with hepatocellular carcinoma (HCC) risk.<h3>Methods</h3>The dynamics of NITs (Fib4, APRI and LSM) were described in patients with cirrhosis after SVR included between 2006 and 2015 in two prospective French multicentre cohorts (ANRS CO22 Hepather and CO12 CirVir). To assess their relationship with the risk of HCC, a joint modeling approach was employed using both standard and flexible models adjusted for age and sex. The impacts of NIT current value and slope during follow-up on HCC risk were assessed taking into account competing risks of death.<h3>Results</h3>3067 patients with cirrhosis who achieved SVR were analyzed, among whom 228 (7.4%) developed HCC and 210 (6.9%) died during a 26-month follow-up. All NITs were increased at baseline in patients who ultimately developed HCC, whereas platelet counts were lower. All NITs improved in patients who did not develop HCC. More contrasted changes were observed during the follow-up of patients who ultimately developed HCC. Joint model analyses showed that current values of Fib4, APRI and platelet count at any time impacted HCC risk. Only Fib4 and APRI slopes influenced the same outcome. When considering NIT current value and slope simultaneously, only the current value of NITs impacted HCC risk while the slopes were not informative.<h3>Conclusions</h3>The dynamics of NITs following SVR do not identify cirrhotic patients who could be safely excluded from surveillance programmes. NIT current value is more informative than slope which would necessitate to regularly re-assess HCC risk to design individualized surveillance strategies.<h3>Impact and implications</h3>It has been postulated that that monitoring noninvasive tests (NIT) dynamics following HCV cure may inform on HCC residual risk in patients with cirrhosis, and may allow for the discontinuation of surveillance in certain patient subsets. We analyzed data from over 3,000 patients and found that while all NITs improved in cirrhotic patients who did not develop HCC, those who eventually developed liver cancer showed more contrasted changes in these tests. Specifically, the current values of tests like Fib4 and APRI were linked to an increased risk of HCC. while their slopes did not provide additional useful information, suggesting that dedicated prospective studies are warranted to define how repeated measurement of NIT could be combined with other variables into HCC risk stratification algorithms. Until then, HCC surveillance should be maintained in all patients with cirrhosis following HCV eradication, even in case of decreased NIT.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"27 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Clustering Validity in MELD Subtype Analysis: A Call for Robust Statistical Methods","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.jhep.2025.02.023","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.023","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Yoshiyasu Takefuji completed this research and wrote this article.</section></section><section><section><h2>Financial support</h2>This research has no fund.</section></section><section><section><h2>Declaration of Competing Interest</h2>The author has no conflict of interest.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"15 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: ‘Global survey of stigma among physicians and patients with nonalcoholic fatty liver disease’ [J Hepatol 80 (2024) 419-430]","authors":"Zobair M. Younossi ,&nbsp;Maria Stepanova ,&nbsp;Global NASH Council","doi":"10.1016/j.jhep.2025.01.018","DOIUrl":"10.1016/j.jhep.2025.01.018","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 5","pages":"Page 945"},"PeriodicalIF":26.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Do not leave any ambiguity: alcohol in any amount is harmful","authors":"Jessica Anne Musto, Randall Brown, Michael Ronan Lucey","doi":"10.1016/j.jhep.2025.02.012","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.012","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>All authors contributed equally.</section></section><section><section><h2>Financial support</h2>Michael R. Lucey is supported by R01 AA030966-01</section></section><section><section><h2>Declaration of Competing Interest</h2>None relevant to this paper.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"89 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized risk assessment of advanced liver fibrosis in patients with MASLD","authors":"Arne Åsberg, Ingrid Alsos Lian, Lena Løfblad, Gustav Mikkelsen","doi":"10.1016/j.jhep.2025.02.014","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.014","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Arne Åsberg: Concept and design, data collection, data analysis, draft writing. Others: Conforming data collection and data analysis, writing the article.</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>NonePlease refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Acknowledgements</h2>None.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"51 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on “Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD” - Authors' Reply","authors":"Benedikt Silvester Hofer, Wilhelmus J. Kwanten, Sven Francque","doi":"10.1016/j.jhep.2025.02.019","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.019","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Acknowledgements</h2>The authors wish to thank Rafael Paternostro and Thomas Reiberger for their insights while preparing this letter.</section></section><section><section><h2>Authors' contributions</h2>BS: Analysis of the data; Writing – original draft; Writing – Review and editing;WK: Writing – Review and editing;SF: Writing – Review and editing; Supervision;</section></section><section><section><h2>Financial support</h2>The authors did not receive any financial support for this letter.</section></section><section><section><h2>Declaration of Competing Interest</h2>BS: Travel grant from Ipsen.WK: Co-inventor of a patent on the use lipopigment imaging for disease filed by MIT/MGH; travel grant from Norgine, Ipsen and Abbvie; speakers fee from PanNASH initiative.SF: Senior clinical research mandate from the Fund for Scientific Research (FWO) Flanders (1802154N); advisor and/or lecturer for Roche, Gilead, Abbvie, Bayer, BMS, MSD, Janssen, Actelion, Astellas, Genfit, Inventiva, Intercept, Genentech, Galmed, Promethera, Coherus and NGM Bio.Please refer to the</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"19 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is MELD-Cr an Accurate Predictor of Liver Transplant Outcomes? A Call for Refinement in Allocation Criteria","authors":"Kang He, Liang Chen, Qiang Xia","doi":"10.1016/j.jhep.2025.02.016","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.016","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Data availability statement (delete if not applicable)</h2>Not applicable</section></section><section><section><h2>Authors' contributions</h2>Kang He: Methodology, Formal analysis, Writing - Original Draft; Liang Chen: Writing - Original Draft, Visualization; Qiang Xia: Writing - Review &amp; Editing.</section></section><section><section><h2>Financial support</h2>No fundings were received for this research.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Acknowledgements</h2>This study was supported by Natural Science Foundation of Shanghai (23ZR1438600), the National Natural Science Foundation of China (81972205), and the Project of Shanghai Key Clinical Specialties (shslczdzk05801).</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"25 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: “Procedural bleeding in patients with cirrhosis: from prediction towards prevention”.","authors":"Alberto Zanetto, Elena Campello, Marco Senzolo, Paolo Simioni","doi":"10.1016/j.jhep.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.010","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>AZ: writing of the letter.EC: writing of the letter.MS: revision of the letter.PS: revision of the letter and final approval.</section></section><section><section><h2>Financial support</h2>None.</section></section><section><section><h2>Declaration of Competing Interest</h2>None.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section><section><section><h2>Acknowledgements</h2>None.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"30 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}