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Cardiometabolic risk factors and alcohol use among adults aged 20-25: a nationally representative US study 20-25岁成年人的心脏代谢危险因素和酒精使用：一项具有全国代表性的美国研究
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-22 DOI: 10.1016/j.jhep.2025.08.014
Emmanuelle Hodara PhD, Jennifer L. Dodge MPH, Norah A. Terrault MD MPH, Brian P. Lee MD MAS
{"title":"Cardiometabolic risk factors and alcohol use among adults aged 20-25: a nationally representative US study","authors":"Emmanuelle Hodara PhD, Jennifer L. Dodge MPH, Norah A. Terrault MD MPH, Brian P. Lee MD MAS","doi":"10.1016/j.jhep.2025.08.014","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.08.014","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Uncited reference</h2>2.; 2..</section></section><section><section><h2>Authors' contributions</h2>Emmanuelle Hodara had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.Concept and design: Hodara, Dodge, Lee.Acquisition, analysis, or interpretation of data: All authors.Drafting of the manuscript: Hodara.Critical revision of the manuscript for important intellectual content: Dodge, Lee, Terrault.Statistical analysis: Hodara, Dodge.Administrative, technical, or material support: Lee.Supervision: Lee, Dodge</section></section><section><section><h2>Data availability statement (delete if not applicable)</h2>Study protocol, statistical code and datasets are available upon request from Dr. Hodara (email: <span><span>ehodara@usc.edu</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section><section><section><h2>Financial support</h2>Support for this study comes from Dr. Lee’s K23AA029752 grant from the National Institute on Alcohol Abuse and Alcoholism. In addition, Dr. Emmanuelle Hodara is supported by training grant F30 CA257401 from the National Institute of Health.</section></section><section><section><h2>Declaration of Competing Interest</h2>EH, JLD, BPL have no disclosures. NAT receives institutional grant support from clinical trial from GSK, Genentech-Roche, Helio Health, Durect Corp Gilead Sciences, has received one-time consulting fees from Enyo Pharmaceuticals, Exigo, Saol Therapeutics, Eiger Biopharmaceutics and participate on data safety monitoring board of Moderna.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"15 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond a Single Snapshot: Considerations for PEth-Guided Subclassification of Steatotic Liver Disease 超越单一快照：peth引导下脂肪变性肝病亚分类的考虑
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-21 DOI: 10.1016/j.jhep.2025.08.015
Tao Zhang M.D
{"title":"Beyond a Single Snapshot: Considerations for PEth-Guided Subclassification of Steatotic Liver Disease","authors":"Tao Zhang M.D","doi":"10.1016/j.jhep.2025.08.015","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.08.015","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Tao Zhang is the only author of this letter and made all contributions.</section></section><section><section><h2>Financial support</h2>This letter receives no financial support.</section></section><section><section><h2>Declaration of Competing Interest</h2>There is no conflict of interest.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"79 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemodynamic Graft-Recipient Matching in Pediatric Liver Transplantation: Just Graft with the Flow 儿童肝移植的血流动力学移植物-受体匹配：只是移植物的流动
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.07.035
Guillaume Rossignol, Xavier Muller, Remi Dubois, Kayvan Mohkam, Jean-Yves Mabrut
{"title":"Hemodynamic Graft-Recipient Matching in Pediatric Liver Transplantation: Just Graft with the Flow","authors":"Guillaume Rossignol, Xavier Muller, Remi Dubois, Kayvan Mohkam, Jean-Yves Mabrut","doi":"10.1016/j.jhep.2025.07.035","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.07.035","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial support</h2>No funding was received for this work.</section></section><section><section><h2>Data availability statement (delete if not applicable)</h2>The data supporting the conclusions of this article are not publicly available but will be made available by the corresponding author upon reasonable request.</section></section><section><section><h2>Authors' contributions</h2>GR and XM contributed equally as first authors, acquired the data, performed the statistical analysis, interpreted the data, and wrote the manuscript. RD, JYM and KM interpreted the data, critically reviewed the data, and drafted a final version of the manuscript.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors have no conflicts of interest to disclosePlease refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"50 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From parts to portal: Recapitulating hepatobiliary microarchitecture using multicellular organoids 从局部到门静脉：用多细胞类器官概括肝胆微结构
IF 33 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.07.010
David C. Trampert
{"title":"From parts to portal: Recapitulating hepatobiliary microarchitecture using multicellular organoids","authors":"David C. Trampert","doi":"10.1016/j.jhep.2025.07.010","DOIUrl":"10.1016/j.jhep.2025.07.010","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"83 5","pages":"Pages 1226-1228"},"PeriodicalIF":33.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Efficacy or Illusion?” Interpreting Null Results in the Rifaximin Trial “功效还是幻觉？”利福昔明试验无效结果的解释
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.08.012
Zhihao Lei
{"title":"“Efficacy or Illusion?” Interpreting Null Results in the Rifaximin Trial","authors":"Zhihao Lei","doi":"10.1016/j.jhep.2025.08.012","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.08.012","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial support</h2>The author received no funding for this work.</section></section><section><section><h2>Authors' contributions</h2>Zhihao Lei — Conceptualization, Investigation, Writing – Original Draft, Writing – Review &amp; Editing.</section></section><section><section><h2>Declaration of Competing Interest</h2>The author declares no conflicts of interest.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"27 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-Related Variations in Liver Homeostasis and Disease: From Zonation Dynamics to Clinical Implications 肝脏内稳态和疾病的性别相关变异：从分区动力学到临床意义
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.08.007
Madlen Matz-Soja, Thomas Berg, Thomas Kietzmann
{"title":"Sex-Related Variations in Liver Homeostasis and Disease: From Zonation Dynamics to Clinical Implications","authors":"Madlen Matz-Soja, Thomas Berg, Thomas Kietzmann","doi":"10.1016/j.jhep.2025.08.007","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.08.007","url":null,"abstract":"The liver exhibits pronounced sexual dimorphism, characterised by sex-specific differences in structure, metabolic function, and susceptibility to disease. Although traditionally considered homogeneous, the liver exhibits significant zonal heterogeneity, with periportal and pericentral regions differing considerably in terms of oxygen availability, metabolic activity and partially cell composition. In recent years, new technologies such as single-cell RNA sequencing and spatial proteomics have revealed numerous sex-specific differences in gene and protein expression that align with the spatial heterogeneity of liver functions. These spatial and functional dynamics are largely influenced by sex hormones, including estrogens, androgens, and growth hormone, and their downstream endocrine signalling pathways. Consequently, men and women not only differ in their susceptibility to various liver diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD), hepatocellular carcinoma (HCC), and autoimmune liver diseases but also in the rate and pattern of disease progression, including fibrogenesis. For instance, men are more prone to develop MASLD and HCC, whereas women have a higher prevalence of autoimmune liver diseases and are at increased risk of accelerated fibrosis progression after menopause. New methods, such as digital twin models and innovative computer-assisted approaches, continue to advance our understanding of liver dimorphism, offering the prospect of personalised diagnosis and treatment strategies.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"13 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis Claudin-1是原发性硬化性胆管炎的中介和治疗靶点
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.08.005
Fabio Del Zompo, Emilie Crouchet, Tessa Ostyn, Zeina Nehme, Mélissa Messé, Frank Juehling, Romain Désert, Angelica T. Vieira, Julien Moehlin, Diana Nakib, Tallulah Andrews, Catia Perciani, Sai Chung, Gary Bader, Ian McGilvray, Chiara Caime, Miki Scaravaglio, Marco Carbone, Pietro Invernizzi, Sheraz Yaqub, Trine Folseraas, Tom H. Karlsen, Gautam Shankar, Mark Primeaux, Punita Dhawan, Jesus M. Banales, Natascha Roehlen, Roberto Iacone, Geoffrey Teixeira, Mathias Heikenwälder, Laurent Mailly, Sonya MacParland, Tania Roskams, Olivier Govaere, Catherine Schuster, Thomas F. Baumert
{"title":"Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis","authors":"Fabio Del Zompo, Emilie Crouchet, Tessa Ostyn, Zeina Nehme, Mélissa Messé, Frank Juehling, Romain Désert, Angelica T. Vieira, Julien Moehlin, Diana Nakib, Tallulah Andrews, Catia Perciani, Sai Chung, Gary Bader, Ian McGilvray, Chiara Caime, Miki Scaravaglio, Marco Carbone, Pietro Invernizzi, Sheraz Yaqub, Trine Folseraas, Tom H. Karlsen, Gautam Shankar, Mark Primeaux, Punita Dhawan, Jesus M. Banales, Natascha Roehlen, Roberto Iacone, Geoffrey Teixeira, Mathias Heikenwälder, Laurent Mailly, Sonya MacParland, Tania Roskams, Olivier Govaere, Catherine Schuster, Thomas F. Baumert","doi":"10.1016/j.jhep.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.08.005","url":null,"abstract":"Primary sclerosing cholangitis (PSC) is a cholangiopathy associated with high risk of development into end-stage liver disease and hepatobiliary cancer. The pathogenesis is poorly understood, and current clinical care offers limited therapeutic options, primarily relying on liver transplantation. Claudin-1 (CLDN1), a transmembrane protein highly expressed in liver epithelial cells, plays a crucial role in cell-cell communication and signaling. Here we aimed to investigate the functional role of CLDN1 as a mediator and therapeutic target for PSC using patient cohorts combined with murine and patient-derived intervention models.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"12 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rifaximin and Survival in Cirrhosis: An Unmet Clinical Promise 利福昔明和肝硬化患者的生存：一个未实现的临床承诺
IF 25.7 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.08.011
Lorenzo Ridola, Oliviero Riggio
{"title":"Rifaximin and Survival in Cirrhosis: An Unmet Clinical Promise","authors":"Lorenzo Ridola, Oliviero Riggio","doi":"10.1016/j.jhep.2025.08.011","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.08.011","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors' contributions</h2>Lorenzo Ridola and Oliviero Riggio: conceptualization and manuscript writing, critical revision for important intellectual content, final approval</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>NonePlease refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"15 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trientine-induced enteritis in Wilson’s disease treatment 曲恩汀致肠炎在肝豆状核变性治疗中的应用
IF 33 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.08.009
Rachel Orbuch , Amanda Cheung
{"title":"Trientine-induced enteritis in Wilson’s disease treatment","authors":"Rachel Orbuch ,&nbsp;Amanda Cheung","doi":"10.1016/j.jhep.2025.08.009","DOIUrl":"10.1016/j.jhep.2025.08.009","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"83 5","pages":"Pages e227-e228"},"PeriodicalIF":33.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cirrhosis recompensation: What it is and what it ought to be — insights from the philosophy of science 肝硬化补偿：它是什么，它应该是什么——来自科学哲学的见解。
IF 33 1区 医学
Journal of Hepatology Pub Date : 2025-08-20 DOI: 10.1016/j.jhep.2025.08.013
Mario Romero-Cristobal
{"title":"Cirrhosis recompensation: What it is and what it ought to be — insights from the philosophy of science","authors":"Mario Romero-Cristobal","doi":"10.1016/j.jhep.2025.08.013","DOIUrl":"10.1016/j.jhep.2025.08.013","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"83 5","pages":"Pages e245-e246"},"PeriodicalIF":33.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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