Journal of Hepatology最新文献

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The etymology of liver in ancient Greek and Latin 古希腊语和拉丁语中 "肝 "的词源
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.09.042
John Henry , Marvad Ahad
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引用次数: 0
Thyroid hormone receptor-β analogues for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) 治疗代谢功能障碍相关性脂肪性肝炎(MASH)的甲状腺激素受体-β类似物
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.10.018
Vlad Ratziu , Thomas S. Scanlan , Eveline Bruinstroop
{"title":"Thyroid hormone receptor-β analogues for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)","authors":"Vlad Ratziu ,&nbsp;Thomas S. Scanlan ,&nbsp;Eveline Bruinstroop","doi":"10.1016/j.jhep.2024.10.018","DOIUrl":"10.1016/j.jhep.2024.10.018","url":null,"abstract":"<div><div>The association between suboptimal thyroid function ((sub)clinical hypothyroidism or low-normal thyroid function) and the metabolic syndrome and MASLD (metabolic dysfunction-associated steatotic liver disease) has been clearly established. Furthermore, in MASLD, intracellular thyroid hormone concentrations are low and the activation of the thyroid hormone receptor (THR) is reduced. Administration of thyroid hormone has been shown to reduce liver triglycerides by stimulating fatty acid disposal through lipophagy and beta-oxidation, and to lower LDL-cholesterol. As thyroid hormone exerts its effects in many different organs, including the heart and bone, several drug candidates have been developed as selective thyromimetics for the THR-β nuclear receptor with potent and liver-targeted activity. Importantly, these compounds have reduced affinity for the THR-α nuclear receptor and tissue distribution profiles that differ from endogenous thyroid hormones, thereby reducing unwanted cardiovascular side effects. The most advanced compound, resmetirom, is an oral drug that demonstrated, in a large phase III trial in patients with MASH (metabolic dysfunction-associated steatohepatitis), the ability to reduce liver fat, decrease aminotransferase levels and improve atherogenic dyslipidaemia with a good tolerability profile. This translated into histological improvement that led to accelerated approval of this drug for active fibrotic steatohepatitis, a milestone achievement as a first MASH drug.</div></div>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 375-387"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142450256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher’s note on “The risk-benefit assessment of liver biopsy in times of non-invasive screening for liver fibrosis” by Ivana Ilic and Tamara Milovanovic [J Hepatol 73 (2020) 701–702] 伊万娜-伊利奇(Ivana Ilic)和塔玛拉-米洛瓦诺维奇(Tamara Milovanovic)撰写的 "无创肝纤维化筛查时期肝活检的风险效益评估"[J Hepatol 73 (2020) 701-702] 出版人注释
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.09.028
{"title":"Publisher’s note on “The risk-benefit assessment of liver biopsy in times of non-invasive screening for liver fibrosis” by Ivana Ilic and Tamara Milovanovic [J Hepatol 73 (2020) 701–702]","authors":"","doi":"10.1016/j.jhep.2024.09.028","DOIUrl":"10.1016/j.jhep.2024.09.028","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Page 397"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142369124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut bacterial membrane components as pathogenic signalling molecules in PSC-IBD 肠道细菌膜组分在PSC-IBD中的致病信号分子作用
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.11.024
David C. Trampert
{"title":"Gut bacterial membrane components as pathogenic signalling molecules in PSC-IBD","authors":"David C. Trampert","doi":"10.1016/j.jhep.2024.11.024","DOIUrl":"10.1016/j.jhep.2024.11.024","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 390-391"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142809537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergy between public health policy and clinicians plays a key role in reducing fracture risk in patients with viral hepatitis 公共卫生政策与临床医生之间的协同作用在降低病毒性肝炎患者骨折风险方面发挥着关键作用。
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.07.024
Jingkai Di , Liying Song , Chuan Xiang
{"title":"Synergy between public health policy and clinicians plays a key role in reducing fracture risk in patients with viral hepatitis","authors":"Jingkai Di ,&nbsp;Liying Song ,&nbsp;Chuan Xiang","doi":"10.1016/j.jhep.2024.07.024","DOIUrl":"10.1016/j.jhep.2024.07.024","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages e85-e86"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obtaining first-line induction in autoimmune hepatitis: Aren’t we underestimating prednisolone? 获得自身免疫性肝炎的一线诱导:我们是否低估了泼尼松龙?
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.07.020
Erik A.H. Loeffen, Henkjan J. Verkade, Patrick F. van Rheenen
{"title":"Obtaining first-line induction in autoimmune hepatitis: Aren’t we underestimating prednisolone?","authors":"Erik A.H. Loeffen,&nbsp;Henkjan J. Verkade,&nbsp;Patrick F. van Rheenen","doi":"10.1016/j.jhep.2024.07.020","DOIUrl":"10.1016/j.jhep.2024.07.020","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Page e78"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is MetALD an independent risk factor of all-cause mortality? A meta-analysis of 164,694 individuals from the real world MetALD 是全因死亡率的独立风险因素吗?对现实世界中 164,694 人进行的荟萃分析
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.10.022
Zheng Li , Yali Shen , Zhiping Li , Dan Cao , Yue Hu
{"title":"Is MetALD an independent risk factor of all-cause mortality? A meta-analysis of 164,694 individuals from the real world","authors":"Zheng Li ,&nbsp;Yali Shen ,&nbsp;Zhiping Li ,&nbsp;Dan Cao ,&nbsp;Yue Hu","doi":"10.1016/j.jhep.2024.10.022","DOIUrl":"10.1016/j.jhep.2024.10.022","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages e95-e97"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rifaximin in cirrhosis: Is its microbiological spotless record under threat? 利福昔明在肝硬化中的应用:它在微生物方面一尘不染的记录是否受到威胁?
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.11.033
Cornelius Engelmann
{"title":"Rifaximin in cirrhosis: Is its microbiological spotless record under threat?","authors":"Cornelius Engelmann","doi":"10.1016/j.jhep.2024.11.033","DOIUrl":"10.1016/j.jhep.2024.11.033","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 392-394"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing functional cure rates after nucleo(s)tide analogue withdrawal: Is peg-IFN the answer? 提高核苷酸类似物停药后的功能性治愈率:peg-IFN 是答案吗?
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.10.019
Edo J. Dongelmans , Milan J. Sonneveld , Harry L.A. Janssen
{"title":"Increasing functional cure rates after nucleo(s)tide analogue withdrawal: Is peg-IFN the answer?","authors":"Edo J. Dongelmans ,&nbsp;Milan J. Sonneveld ,&nbsp;Harry L.A. Janssen","doi":"10.1016/j.jhep.2024.10.019","DOIUrl":"10.1016/j.jhep.2024.10.019","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages 168-170"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimising the treatment of HDV infection: Efficacy of bulevirtide, HBV-HDV interactions and the importance of statistical methods 优化 HDV 感染的治疗:布来维肽的疗效、HBV-HDV 相互作用以及统计方法的重要性。
IF 26.8 1区 医学
Journal of Hepatology Pub Date : 2025-02-01 DOI: 10.1016/j.jhep.2024.08.018
Junkun Zhu
{"title":"Optimising the treatment of HDV infection: Efficacy of bulevirtide, HBV-HDV interactions and the importance of statistical methods","authors":"Junkun Zhu","doi":"10.1016/j.jhep.2024.08.018","DOIUrl":"10.1016/j.jhep.2024.08.018","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 2","pages":"Pages e107-e108"},"PeriodicalIF":26.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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