Journal of Hepatology最新文献

{"title":"Subtypes of MASLD confer distinct clinical trajectories","authors":"Panu K. Luukkonen","doi":"10.1016/j.jhep.2025.02.032","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.032","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Background and context</h2>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major global health concern, affecting up to one-third of the population.¹ It can progress from simple hepatic steatosis to more severe stages such as steatohepatitis and cirrhosis, and ultimately liver-related mortality, often as a result of hepatic decompensation.¹ Additionally, MASLD is strongly associated with extrahepatic complications, including cardiovascular disease and various malignancies, which further contribute</section></section><section><section><h2>Objectives, methods, and findings</h2>The primary aim of the study was to identify distinct subtypes of MASLD with similar histological severity but differing biological profiles and associated cardiovascular risk. To achieve this, the authors employed a data-driven clustering approach to classify a cohort of 1,389 bariatric surgery patients from France. The cohort was stratified into clusters based on six clinical variables: age, body mass index, plasma triglycerides, hemoglobin A1c, alanine aminotransferase (ALT), and LDL</section></section><section><section><h2>Significance of findings</h2>The study by Raverdy <em>et al.</em> advances our understanding of the clinical heterogeneity observed in MASLD. By applying a data-driven clustering approach, the authors identified two distinct subtypes of MASLD – ‘cardiometabolic’ and ‘liver-specific’ – that carry different prognostic implications for liver and cardiovascular disease. Both subtypes are associated with an increased risk of liver disease, but only the ‘cardiometabolic’ subtype is linked to a significantly higher risk of cardiovascular</section></section><section><section><h2>Declaration of AI-assisted technologies in the writing process</h2>During the preparation of this work the author used GPT-4 in order to proofread the manuscript. After using this tool, the author reviewed and edited the content as needed and takes full responsibility for the content of the publication.</section></section><section><section><h2>Financial support</h2>Dr. Luukkonen was supported by the <span>Academy of Finland</span> (<span>350545</span>), the Sigrid Jusélius Foundation, the <span>Novo Nordisk Foundation</span> (<span>NNF22OC0074397</span>), the <span>Emil Aaltonen Foundation</span>, the <span>Finnish Medical Foundation</span>, the Wilhelm and Else Stockmann's Foundation and the Early Career Investigator fund of the <span>University of Helsinki</span>.</section></section><section><section><h2>Conflict of interest</h2>The author of this study declares that they do not have any conflict of interest.Please refer to the accompanying ICMJE disclosure forms for further details.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"50 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norway rat hepacivirus resembles hepatitis C virus in terms of intra-host evolution and escape from neutralizing antibodies","authors":"Caroline E. Thorselius, Raphael Wolfisberg, Ulrik Fahnøe, Troels K.H. Scheel, Kenn Holmbeck, Jens Bukh","doi":"10.1016/j.jhep.2025.02.044","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.044","url":null,"abstract":"<h3>Background and Aims</h3>Norway rat hepacivirus 1 (NrHV) is an attractive surrogate model for evaluating vaccine strategies against hepatitis C virus (HCV). Yet the immune response in NrHV infections remains poorly understood, particularly the role of neutralizing antibodies (nAbs). Here, we explore nAb development and viral evolution during chronic NrHV infection of inbred rats to understand neutralization and viral escape dynamics.<h3>Methods</h3>Lewis rats inoculated with the NrHV RHV-rn1 strain were monitored for &gt;52 weeks. Viremia was quantified by RT-qPCR, and NrHV nAbs were characterized by infectious cell culture-based neutralization assays and challenge experiments. Viral evolution was followed over time by whole open reading frame deep sequencing.<h3>Results</h3>In most animals, high levels of nAbs appeared after 20 to 45 weeks of infection, coinciding with the emergence of numerous mutations in the envelope proteins. Incorporation of these E1/E2 mutations into cell-culture-adapted RHV-rn1 reduced sensitivity to neutralization by autologous contemporary serum. Five key recurrent E1/E2 substitutions (E209K, R224Q, V275I, T500K, and L569P) were identified, collectively impairing serum neutralization, with E209K in E1 alone proving sufficient to confer neutralization escape. In contrast, NrHV-infected rats devoid of nAbs displayed fewer envelope mutations. Finally, pretreatment of cells with rat serum with high-titer nAbs led to partial control of NrHV-infection, and passive immunization with such sera protected SCID mice from subsequent challenge.<h3>Conclusions</h3>This study demonstrates the correlation between nAbs and viral evolution during long-term NrHV infection. The observed humoral immunity for NrHV infection closely resembles that of chronic HCV infection, where late-emerging high-level nAbs fail to clear evolving viral populations, thereby contributing to the evasion of the adaptive immune response. Preexisting antibodies do, however, protect from infection.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"214 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: ‘Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis’ [J Hepatol (2024) 80:268-281]","authors":"Ahmed Ghallab, Daniela González, Ellen Strängberg, Ute Hofmann, Maiju Myllys, Reham Hassan, Zaynab Hobloss, Lisa Brackhagen, Brigitte Begher-Tibbe, Julia C. Duda, Carolin Drenda, Franziska Kappenberg, Joerg Reinders, Adrian Friebel, Mihael Vucur, Monika Turajski, Abdel-latief Seddek, Tahany Abbas, Noha Abdelmageed, Samy A.F. Morad, Jan G. Hengstler","doi":"10.1016/j.jhep.2025.02.031","DOIUrl":"https://doi.org/10.1016/j.jhep.2025.02.031","url":null,"abstract":"In this article, owing to a typesetter error, the supplementary video files were incorrectly named. This has now been updated online. The publisher apologises for any inconvenience caused.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"24 1","pages":""},"PeriodicalIF":25.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EASL-ERN Clinical Practice Guidelines on Wilson’s disease","authors":"European Association for the Study of the Liver","doi":"10.1016/j.jhep.2024.11.007","DOIUrl":"10.1016/j.jhep.2024.11.007","url":null,"abstract":"<div><div>Wilson’s disease is an autosomal recessive disorder of copper metabolism which affects the liver, brain and other organs. Diagnosis is based on: clinical features; biochemical tests, including plasma ceruloplasmin concentration, 24-h urinary copper excretion, copper content in the liver; and molecular analysis. Leipzig score and additionally relative exchangeable copper determination are recommended for diagnosis. Pharmacological therapy comprises chelating agents (penicillamine, trientine) and zinc salts, while only chelators are recommended for significant liver disease. Monitoring is based on clinical symptoms, liver tests and copper metabolism (urinary copper excretion, exchangeable copper) to detect poor compliance and over/under-treatment. Acute liver failure is challenging as making a diagnosis is difficult and pharmacological therapy may not be sufficient to save life. Liver transplantation has a well-defined role in Wilsonian acute hepatic failure but may also be considered in neurological disease.</div></div>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Pages 690-728"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Register now for the EASL Congress 2025, 7-10 May in Amsterdam!","authors":"","doi":"10.1016/S0168-8278(25)00103-5","DOIUrl":"10.1016/S0168-8278(25)00103-5","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Page iii"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JHEP at a glance (April 2025)","authors":"","doi":"10.1016/S0168-8278(25)00128-X","DOIUrl":"10.1016/S0168-8278(25)00128-X","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Pages e157-e167"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Join the community and become an EASL member today!","authors":"","doi":"10.1016/S0168-8278(25)00105-9","DOIUrl":"10.1016/S0168-8278(25)00105-9","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Page v"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Editor’s Desk…","authors":"Philip Newsome,&nbsp;Frank Tacke,&nbsp;Heiner Wedemeyer,&nbsp;Lorenza Rimassa,&nbsp;Annalisa Berzigotti,&nbsp;Tom H. Karlsen,&nbsp;Vlad Ratziu","doi":"10.1016/j.jhep.2025.01.037","DOIUrl":"10.1016/j.jhep.2025.01.037","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Pages 549-552"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrate World Liver Day on 19 April! Read more and see how you can get involved.","authors":"","doi":"10.1016/S0168-8278(25)00102-3","DOIUrl":"10.1016/S0168-8278(25)00102-3","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Page ii"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EASL Guidelines app is your indispensable mobile companion for accessing comprehensive and up-to-date clinical practice guidelines in hepatology. Download it now!","authors":"","doi":"10.1016/S0168-8278(25)00104-7","DOIUrl":"10.1016/S0168-8278(25)00104-7","url":null,"abstract":"","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"82 4","pages":"Page iv"},"PeriodicalIF":26.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}