{"title":"Impact of selected novel plant bioactives on improvement of impaired gut barrier function using human primary cell intestinal epithelium","authors":"D. Bolster, L. Chae, J. Klinken, S. Kalgaonkar","doi":"10.31665/jfb.2022.18324","DOIUrl":"https://doi.org/10.31665/jfb.2022.18324","url":null,"abstract":"Gut barrier function is compromised in the obese state. The N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT), two naturally occurring bioactive compounds in hemp hulls, identified using in silico approaches, have the potential to improve gut barrier function and their effects were studied here in vitro. Proliferative human transverse colon epithelial cells were plated and co-cultured with tumor necrosis factor (TNF) along with NCT, NFT or NCT/NFT (2.2 ratio) post-differentiation, over a 48-hour period to induce inflammation and to observe the effects of NCT and NFT. A decrease in transepithelial electrical resistance (TEER) and increase in the intestinal permeability were observed with increased addition of TNF. Co-administration of NCT and NFT demonstrated a dose-dependent and statistically significant reversal of impaired TEER and intestinal permeability. NCT and NFT demonstrated a physiologically relevant reversal of impaired gut barrier function in the setting of inflammation via significant improvement in TEER and percent permeability.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84074808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacological bioactivity of enzymatically bio-transformed ginsenosides","authors":"Wei-Sheng Lin, Dhriti Choudhary, Y. Lo, M. Pan","doi":"10.31665/jfb.2022.18331","DOIUrl":"https://doi.org/10.31665/jfb.2022.18331","url":null,"abstract":"Many ginsenosides have shown positive effects, including anti-cancer potential and anti-inflammatory effects. Of note, protopanaxadiol (PPD) and protopanaxatriol (PPT) are not easily absorbed by the body through the digestive tract due to their hydrophilicity. From this point of view, the cytotoxic potencies of the hydrolysates of PPD and PPT on CRC are much stronger than their source compounds. Moreover, several minor ginsenosides that are absent naturally but have high disease ameliorative efficacy can be obtained from major ginsenoside by enzymatic hydrolysis. Therefore, the first aim of this study was to determine the effectiveness of the biotransformation of ginsenosides via enzymatic hydrolysis to improve their bioactivity. Second, the anti-inflammatory and anti-cancer effects of the raw and bio-transformed ginseng metabolites were determined in vitro. The results suggest that enzymes can effectively biotransform major ginsenosides (i.e., PPD and PPT) into minor ginsenosides (i.e., compound K) by hydrolyzing the β-glucosidic linkage. Moreover, the bio-transformed ginsenosides were effective in inhibiting the proliferation of HCT-116 cells and suppressing lipopolysaccharide-induced nitric oxide production in RAW 264.7 murine macrophages. Therefore, the enzymatic hydrolysis of ginsenosides can be employed to functionally produce hydrolysates with increased bioactivity.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75866810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic fate of peptides in a rice protein hydrolysate in rat intestine and blood after oral administration","authors":"Satoshi Miyauchi, Shiro Kajiwara, Kenji Sato","doi":"10.31665/jfb.2022.18327","DOIUrl":"https://doi.org/10.31665/jfb.2022.18327","url":null,"abstract":"The objective of this study was to elucidate the metabolic fate of peptides in a rice protein hydrolysate (RPH) in rats. Peptides present in RPH and its in vitro exopeptidase digest were identified using liquid chromatography–tandem mass spectrometry. One hour after an oral administration of RPH (250 mg/kg body weight), the levels of in vitro exopeptidase-resistant pyroglutamyl peptides in the lumen and ileal tissue significantly increased, whereas those of exopeptidase-susceptible peptides remained unchanged. Among them, the concentrations of pyroGlu-Leu, pyroGlu-Val, and pyroGlu-Lys significantly yet slightly increased in portal blood, while those of other hydrophilic ones (pyroGlu-Gln, pyroGlu-Glu, etc.) remained unchanged. However, all of the pyroglutamyl peptides were stable in rat ileal extract and blood plasma. These findings indicate that the pyroglutamyl peptides can enter enterocytes and resist to peptidases, while small amounts are transported to the blood, suggesting that pyroglutamyl peptides in enterocytes might be returned to the lumen.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81032228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formation of furanoic compounds in model systems with saccharides, amino acids, and fatty acids, analyzed with headspace-solid phase micro-extraction-gas chromatography–tandem mass spectrometry","authors":"A. Schöpf, C. Oellig, M. Granvogl","doi":"10.31665/jfb.2022.18329","DOIUrl":"https://doi.org/10.31665/jfb.2022.18329","url":null,"abstract":"Furan and furan derivatives are processing contaminants found in thermally processed food, such as coffee or canned products. For the determination of furan and ten derivatives, a sensitive headspace-solid phase micro-extraction-gas chromatography–tandem mass spectrometry method with stable isotope dilution analysis was developed. Different precursors such as saccharides, saccharide/amino acid mixtures, polyunsaturated fatty acids (PUFA), and oils were heat processed to investigate the formation of furanoic compounds via Maillard reaction and lipid oxidation. Therefore, a low moister (silica gel with 10% water content) and an aqueous (phosphate buffer, pH 4.5, 7, and 9) model system were chosen to study the effect of water content and pH value on the formation process. The formation of different furan derivatives could be attributed to distinct precursors; furfuryl alcohol was highly formed from 1,4-linked disaccharides, whereas PUFA formed the highest amounts of 2-ethylfuran and 2-pentylfuran.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90609597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia-hong Sun, Xuejiao Li, Zhuo Qu, Shengjie Dong, H Zhao
{"title":"Optimization of ultrasonic-assisted extraction of bioactive compounds from Bupleuri Radix by response surface methodology and HPLC analysis","authors":"Jia-hong Sun, Xuejiao Li, Zhuo Qu, Shengjie Dong, H Zhao","doi":"10.31665/jfb.2022.18321","DOIUrl":"https://doi.org/10.31665/jfb.2022.18321","url":null,"abstract":"A simple and efficient ultrasonic-assisted extraction of bioactive compounds from raw Bupleuri Radix and vinegar-baked Bupleuri Radix was developed and optimized by using quantitative analysis of multi-components by a single-marker combined with response surface methodology approaches. The quantitative analysis of multi-components by a single-marker analytical method based on high-performance liquid chromatography coupled with a photodiode array detector was established and applied to determine the contents of six bioactive compounds in raw Bupleuri Radix and vinegar-baked Bupleuri Radix. In order to maximize extraction of six bioactive compounds in raw Bupleuri Radix and vinegar-baked Bupleuri Radix, the ultrasonic-assisted extraction conditions were obtained by the response surface methodology coupled with Box–Behnken design. The conditions of ultrasonic-assisted extraction were found to be effective for the extraction of bioactive compounds from raw Bupleuri Radix and vinegar-baked Bupleuri Radix. The test results showed that the difference in saikosaponins contents in these samples was obvious; a quantitative analysis of saikosaponins will contribute significantly to improving the quality control of raw Bupleuri Radix and vinegar-baked Bupleuri Radix. In conclusion, the designed protocol is suitable for the quality control of raw Bupleuri Radix and vinegar-baked Bupleuri Radix.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81153675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review on fruits bioactive potential: An Insight into phytochemical traits and their extraction methods","authors":"A. Gautam, Sonia Morya, A. Neumann, F. Menaa","doi":"10.31665/jfb.2022.18318","DOIUrl":"https://doi.org/10.31665/jfb.2022.18318","url":null,"abstract":"In recent years the uptake of fruits is increased due to bioactive compounds present in it. Given this, the purpose of the review is to give information about the extraction process of phytochemicals and the method of their determination. The systematic review comprised recent year papers to bring the knowledge about the bio actives and techniques of their extraction and determination. Most of the fruits contain bioactive compounds and provides various health benefits. Studies included in this paper indicate the infusion of bioactive compounds in fruits and could benefit in improving consumer health. The present review aims to analyze the different phytochemicals that are present in fruits and their mode of extraction and determination.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84724258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Doum fruit (Hyphaene thebaica (L.) Mart.) supplementation improves glycemic index of wheat flour bread in apparent healthy volunteers","authors":"Khadijah Aminu, Aminu Mohammed, D. A. Ameh","doi":"10.31665/jfb.2022.18322","DOIUrl":"https://doi.org/10.31665/jfb.2022.18322","url":null,"abstract":"The increasing demand for plant-based enriched diet has encouraged the food industry to produce fiber-supplemented products such as composite breads using locally available plants products. In the present study, composite breads from doum (Hyphaene thebaica Mart.) fruit and wheat flours were produced. Control bread (0% doum fruit) and four different composite breads (10%, 20%, 30% and 40% doum fruit) were produced. The physical properties, sensory evaluation, shelf-life, proximate composition, antinutrients content and glycemic index (GI) of the composite breads were investigated. Supplementation of wheat bread with doum fruit improved the nutritional content by increasing the fiber and mineral contents with reduction in phytate content. The composite bread, especially at 40% doum fruit inclusion was moderately accepted by the product testing panels. Inclusion of doum fruit further improved the shelf-life of the composite breads at both ambient and refrigerated temperatures. Similarly, the GI was observed to improve with doum fruit inclusion at all the concentration used. Conclusively, inclusion of doum fruit to the wheat flour produced composite breads with improved physical and nutrients quality with moderate overall acceptability and lower GI.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80986968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Natural nutraceuticals, especially functional foods, their ma-jor bioactive components, formulation, and health benefits for disease prevention - An overview","authors":"Chinaza Godswill Awuchi, C. Okpala","doi":"10.31665/jfb.2022.18317","DOIUrl":"https://doi.org/10.31665/jfb.2022.18317","url":null,"abstract":"Nutraceuticals play wide range of important roles, from health promotion, increasing life expectancy, maintaining body cell integrity, to reducing the risks of many diseases. As consumers continue to be attracted to nutraceuticals, such as superfoods, vegetables, fruits, high-protein foods, eating healthy intertwines with finding the right balance. Nowadays, the nutraceutical industries are among the many that target to meet the growing and dynamic consumers’ expectations. Adding to their increasing interest and general acceptability, consumers continue to be attracted to nutraceuticals. How nutraceuticals, especially functional foods, etc., help in tackling health challenges increase the interest among several researchers in this subject area, and given the ever-growing need across communities around the globe for healthy living, strengthens the need for continued synthesis of published information to supplement existing knowledge. This overview, therefore, discusses natural nutraceuticals, especially functional foods, their major bioactive components, formulation, health benefits for disease prevention.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82773739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md. Abdul Wazed, Jinat Rabeya, E. F. Ansary, Md Abdul Awale, M. Farid
{"title":"Food selection and processing: Can we blend science with engineering to address Chronic Kidney Disease (CKD)?","authors":"Md. Abdul Wazed, Jinat Rabeya, E. F. Ansary, Md Abdul Awale, M. Farid","doi":"10.31665/jfb.2022.18315","DOIUrl":"https://doi.org/10.31665/jfb.2022.18315","url":null,"abstract":"Chronic kidney disease (CKD) alters the function and structure of the kidney irreversibly, over months or years. The rising incidence of CKD has become a leading global health problem and therefore a number of multi-field investigations are being carried on. In general, diabetes and high blood pressure (hypertension) are the most common causes of CKD. However, the importance of functional food selection and less consumption of ultra-processed food is at the forefront of the current research domain to manage CKD. To address this threat, experts suggest and recommend adopting a science-based dietary pattern, for instance, the Dietary Approaches to Stop Hypertension (DASH). Moreover, food bioactive compounds are non-nutrients that typically occur in small quantities in foods, and hence, the selection of proper food (source) and subsequent processing is of paramount importance to attenuate the magnitude of CKD. The role of food science in managing chronic diseases could be coupled with the advancement of food engineering to minimize the detrimental effect of food processing along with the delivery of target bioactive molecules. This potentially indicates bold ambitions to innovate holistic solutions to address CKD through a proper selection of food and processing parameters.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"146 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91506769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Quek, Dai Chuan Tan, Pei Cee Lim, N. Kassim, A. Ismail, K. Shaari, Nuraisyah Mohd Shuib
{"title":"Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components","authors":"Alexandra Quek, Dai Chuan Tan, Pei Cee Lim, N. Kassim, A. Ismail, K. Shaari, Nuraisyah Mohd Shuib","doi":"10.31665/jfb.2022.18320","DOIUrl":"https://doi.org/10.31665/jfb.2022.18320","url":null,"abstract":"Melicope glabra (Blume) T. G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect of M. glabra leaves extract on diabetic rats and identify its bioactive components. The induction of diabetes in Sprague-Dawley rats was done by a combination of high-fat diet and low-dose streptozotocin injection. The M. glabra extracts and standard sitagliptin were orally administered once daily to the diabetic rats for 28 days. The diabetic rats showed drastic weight loss, hyperglycemia, poor glucose tolerance, hyperlipidemia, and disturbances in the liver and kidney functions. However, oral administration of M. glabra extracts to the diabetic rats significantly lowered the DPP-4 level and increased glucagon-like peptide-1 (GLP-1) level. Scopoletin, pachypodol, and stigmasterol were revealed as the active DPP-4 and α-amylase inhibitors. This study revealed novel findings which suggest the","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89295161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}