Journal of Food Bioactives最新文献

A comprehensive characterization of phenolics, amino acids and other minor bioactives of selected honeys and identification of botanical origin markers 选定蜂蜜中酚类、氨基酸和其他次要生物活性物质的综合表征以及植物来源标记的鉴定

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18369

Yan Zhu, Ronghua Liu, Lili Mats, Honghui Zhu, Joy Roasa, Tauseef Khan, Amna Ahmed, Yolanda Brummer, Steve Cui, John Sievenpiper, D. Ramdath, Rong Tsao

{"title":"A comprehensive characterization of phenolics, amino acids and other minor bioactives of selected honeys and identification of botanical origin markers","authors":"Yan Zhu, Ronghua Liu, Lili Mats, Honghui Zhu, Joy Roasa, Tauseef Khan, Amna Ahmed, Yolanda Brummer, Steve Cui, John Sievenpiper, D. Ramdath, Rong Tsao","doi":"10.31665/jfb.2024.18369","DOIUrl":"https://doi.org/10.31665/jfb.2024.18369","url":null,"abstract":"Phenolic and amino acid profiles along with organic acid, vitamin and mineral contents, major and minor sugars and enzyme activities of selected honey samples collected in North America were analyzed using different methods and potential markers of their botanical origin were identified. Among the 29 detected phenolic compounds, and some were found to be a good chemical markers to distinguish a genuine honey given its propolis origin. Quantitative data and principal component analysis showed that hesperidin, caffeic acid/isoferulic acid, and p-hydroxybenzoic acid/p-coumaric acid have the most positive relationship to the orange, alfalfa, and buckwheat honey, respectively, indicating their potential roles as chemical markers of these floral honeys. Free amino acid profiles were similar in all other honeys except buckwheat which not only had significantly higher branched-chain amino acids but was the only floral honey that contained L-norvaline that was identified for the first time. The enzyme activities and the major and rare sugar composition helped explain the presence of the various organic acids in the honeys. Compositional data of these bioactives and other nutrients will not only serve as database information for honey derived from North America but also provide insightful knowledge for the underlining potential health benefits.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"29 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140358407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico ADME and Molecular Simulation Studies of Pharmacological Activities of Phytoconstituents of Annona muricata (L.) Fruit 关于鼠李子（Annona muricata (L.)）果实中植物成分药理活性的 In Silico ADME 和分子模拟研究

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18374

Iseoluwa Isaac Ajayi, T. Fatoki, Ayodele Sunday Alonge, C. D. Famusiwa, I. Saliu, O. S. Akinlolu, C. Onodugo, Rachel Temitop Ojo

{"title":"In Silico ADME and Molecular Simulation Studies of Pharmacological Activities of Phytoconstituents of Annona muricata (L.) Fruit","authors":"Iseoluwa Isaac Ajayi, T. Fatoki, Ayodele Sunday Alonge, C. D. Famusiwa, I. Saliu, O. S. Akinlolu, C. Onodugo, Rachel Temitop Ojo","doi":"10.31665/jfb.2024.18374","DOIUrl":"https://doi.org/10.31665/jfb.2024.18374","url":null,"abstract":"Annona muricata Lin is known for its ethnomedicinal uses as food, decoctions, or infusions to address various conditions like skin infections, fever, diabetes, insomnia, malaria, hypertension, nervous disorders, diarrhea, and cancer. The study aimed to analyze the phytochemicals such as acetogenins, alkaloids, cyclopeptides, and flavonoids, present in A. muricata fruit, evaluate their pharmacokinetics, and understand binding dynamics with key molecular targets relevant to human well-being. Results indicated a mix of high and low gastrointestinal absorption (GIA) among A. muricata phytochemicals, with some demonstrating blood-brain barrier (BBB) permeability. Molecular target prediction highlighted frequent interactions with Programmed cell death protein 4 (PDCD4). Protein-protein interaction analysis revealed central connectivity of tyrosinase (TYR), Tyrosine 3-monooxygenase (TH), interleukin 2 (IL2), and others. Molecular docking results identified Luteolin 3´7-di-O-glucoside with the highest binding affinity for PDCD4 (-7.65 kcal.mol-1), followed by Annonaine (-7.294 kcal.mol-1); meanwhile, Dexamethasone (standard compound) exhibited a binding affinity of -6.682 kcal.mol-1. Molecular dynamic simulation indicated a stable binding energy ΔGbind (Total) for the Annonaine - PDCD4 complex (-11.240 kcal.mol-1) and Dexamethasone - PDCD4 complex (-18.909 kcal.mol-1). In conclusion, this study suggests potential anticancer properties of A. muricata based on modulation of PDCD4 protein, influencing the CDK/Akt/STAT3 pathway. Further in vivo investigations are necessary to validate these findings.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140359749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sesamolin has the ability to induce longevity effects on the Caenorhabditis elegans, and the mechanism depends on the SIR-2.1 and AAK-2 芝麻素能够诱导秀丽隐杆线虫产生长寿效应，其机制取决于 SIR-2.1 和 AAK-2

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18370

Chia-Yu Chin, Pei-Jing Lee, Nae-Cherng Yang

{"title":"Sesamolin has the ability to induce longevity effects on the Caenorhabditis elegans, and the mechanism depends on the SIR-2.1 and AAK-2","authors":"Chia-Yu Chin, Pei-Jing Lee, Nae-Cherng Yang","doi":"10.31665/jfb.2024.18370","DOIUrl":"https://doi.org/10.31665/jfb.2024.18370","url":null,"abstract":"Sesamolin, one of the prominent lignans in sesame seeds, offers diverse physiological benefits. However, the longevity effects and mechanisms of sesamolin remain unclear. We hypothesized that sesamolin can exert the longevity effects in the Caenorhabditis (C.) elegans when prepared with the γ-cyclodextrin to form an inclusion complex (named γCD-SM). In this study, the γCD-SM was prepared, and the lifespan assays, health indexes, and loss-of-function assays in the C. elegans or mutants were conducted. The results demonstrated that the γCD-SM significantly extended the C. elegans’ lifespan and improved the health indexes, such as the pharyngeal pumping and body bends. The longevity effects of the γCD-SM were found to depend on the signaling of the SIR-2.1 and AAK-2. In conclusion, the γ-CD inclusion is a crucial step for assessing the sesamolin's longevity effects in the C. elegans. This study confirms that sesamolin exhibits the longevity effects, and its mechanism relies on the signaling of the SIR-2.1 and the AAK-2 proteins, suggesting its potential as a health-promoting ingredient.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"28 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140360554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the anti-inflammatory effect of clove water extract in lipopolysaccharide-stimulated RAW264.7 cells and mouse peritoneal macrophages 探索丁香水提取物在脂多糖刺激的 RAW264.7 细胞和小鼠腹腔巨噬细胞中的抗炎作用

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18373

Sellen Gurusmatika, M. Ishida, K. Nishi, Takuya Sugahara

引用次数: 0

Fuji apple (Malus domestica Borkh. cv. Red Fuji) pomace extracts as a source of antimicrobial and antioxidant polyphenols 作为抗菌和抗氧化多酚来源的富士苹果（Malus domestica Borkh.

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18371

Jiankang Wang, Zhengchun Liu, Lina Wei, Changyan Shao, Jing Wang, Yanan Zhu, Yujiao Sun

{"title":"Fuji apple (Malus domestica Borkh. cv. Red Fuji) pomace extracts as a source of antimicrobial and antioxidant polyphenols","authors":"Jiankang Wang, Zhengchun Liu, Lina Wei, Changyan Shao, Jing Wang, Yanan Zhu, Yujiao Sun","doi":"10.31665/jfb.2024.18371","DOIUrl":"https://doi.org/10.31665/jfb.2024.18371","url":null,"abstract":"This study aimed to assess the antibacterial and antioxidant properties of both crude polyphenol extract (CPE) and purified polyphenol extract (PPE) obtained from Fuji apple pomace. The antibacterial capacity of both extracts against Staphylococcus aureus was investigated by evaluating the inhibition zones, minimum bactericidal concentrations (MBC), growth curves and bacterial morphology of S. aureus treated with CPE or PPE, as well as the performance in simulated food systems. The antioxidant activity of CPE or PPE was assessed using the ABTS radical scavenging and ferric reducing antioxidant power (FRAP) assays. The results showed that PPE exhibited potent antibacterial activity against S. aureus, which was further confirmed by the bacterial morphology. It was revealed that PPE only exerted strong antibacterial effect in starch-based food system while CEP did not show such effect in all systems. The results of the ABTS and FRAP assays indicated that both PPE and CPE possess strong antioxidant activity, from which PPE showed much higher capacity than that of CPE. Therefore, PPE from Fuji apple pomace can be used as a novel antibacterial agent for food preservation and natural antioxidant for functional food and nutraceutical products.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140359207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebration of the lifetime achievements of Professor Chi-Tang Ho on the occasion of his 80th birthday 庆祝何志堂教授八十寿辰，表彰其毕生成就

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18366

Min-Hsiung Pan

{"title":"Celebration of the lifetime achievements of Professor Chi-Tang Ho on the occasion of his 80th birthday","authors":"Min-Hsiung Pan","doi":"10.31665/jfb.2024.18366","DOIUrl":"https://doi.org/10.31665/jfb.2024.18366","url":null,"abstract":"Prof. Chi-Tang Ho was an illuminating thread, woven with unparalleled brilliance through the realms of food science and more. I recount the transformative experience under his guidance and a distinguished mentor.” \u0000He continues to say “Our academic camaraderie blossomed through scholarly discussions, unveiling numerous research avenues, and fostering intellectual curiosity. At every turning point, as new information or research direction surfaced, Prof. Ho promptly shared and discussed with me potential developments of each new project. Our collaboration persisted in my tenure at Taiwan, transcending the challenges of a 12-hour time difference. Prof. Ho remained my trusted confidant, and the first to consult on intriguing research and cutting-edge technologies.” He then adds “To date, the countless individuals who have collaborated with Prof. Ho attest to his continuous willingness to mentor and contribute to the flourishing development of the field of food science. Prof. Ho's distinguished outstanding in the academic community is underscored by numerous honours, including election as a Fellow of the American Chemical Society in 2010, the Royal Society of Chemistry in the UK in 2014, the International Academy of Food Science & Technology in 2006, the Institute of Food Technologists in 2003, and the International Society for Nutraceuticals & Functional Foods in 2018","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel combination against skin aging via promoting the synthesis of biological collagen 通过促进生物胶原蛋白的合成来防止皮肤老化的新型组合疗法

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18372

Bei-Bei Dong, Peng-Fei Zhang, Wu-Yan Guo, Heng-Yu Zheng, You-Nan Kou, Huan Zhang, Ying-Chao Ma, Bo Zhang

{"title":"A novel combination against skin aging via promoting the synthesis of biological collagen","authors":"Bei-Bei Dong, Peng-Fei Zhang, Wu-Yan Guo, Heng-Yu Zheng, You-Nan Kou, Huan Zhang, Ying-Chao Ma, Bo Zhang","doi":"10.31665/jfb.2024.18372","DOIUrl":"https://doi.org/10.31665/jfb.2024.18372","url":null,"abstract":"Supplementing collagen is considered to contribute to delaying skin aging. In this work, we developed a novel combination for improving skin aging by stimulating the biosynthesis of collagen. By screening a library of Chinese herbal medicines (CHM), we found that Angelicae Dahuricae Radix (Baizhi), Lilii bulbus (Baihe), Glycyrrhizae radix et rhizoma (Gancao), and Jujubae fructus (Dazao) substantially increased the mRNA expression levels of type I collagen, suggesting their potential anti-skin-aging activity. To keep the structural integrity of collagen, prolyl 4-hydroxylase (P4H), a key enzyme in collagen synthesis, was recombinantly expressed in Escherichia coli. In addition, the transfersome with added P-4H was prepared to improve the transdermal absorption of combination. Vitamin C (VC), the substrate required for the activity of P4H, was also incorporated into the combination. Eventually, an optimal combination, consisting of Baizhi, Baihe, Gancao, P4H transfersome and VC, was obtained by a series of combination experiments. Based on traditional CHM and modern biological agents, we developed a novel combination against skin aging by promoting the synthesis of collagen. Collectively, the combination show the high potential of application to delay skin aging","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"28 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140359544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the phytochemical composition and pharmacological effects of fermented turmeric using the isolated strain Lactobacillus rhamnosus FN7 利用分离菌株鼠李糖乳杆菌 FN7 探索发酵姜黄的植物化学成分和药理作用

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18368

Kai-Jiun Lo, Sandeep Choudhary, Chi-Tang Ho, Min-Hsiung Pan

{"title":"Exploring the phytochemical composition and pharmacological effects of fermented turmeric using the isolated strain Lactobacillus rhamnosus FN7","authors":"Kai-Jiun Lo, Sandeep Choudhary, Chi-Tang Ho, Min-Hsiung Pan","doi":"10.31665/jfb.2024.18368","DOIUrl":"https://doi.org/10.31665/jfb.2024.18368","url":null,"abstract":"Turmeric (Curcuma longa), widely used in Asia as a spice, preservative, and colorant, contains curcuminoids known for diverse pharmacological benefits, including antimicrobial properties. However, their hydrophobic nature hampers bioavailability. Addressing this, we hypothesized that Lactic Acid Bacteria (LAB) fermentation could enhance curcuminoid content and bioactivity. This study isolated LAB strains to ferment turmeric and investigated the phytochemical and pharmacological outcomes. Twelve LAB strains from various sources were tested for fermenting 3% turmeric in MRS broth. L. rhamnosus FN7 emerged as a robust strain, tolerating turmeric's antibacterial properties and increasing curcuminoid content and anti-inflammatory effects. Fermented turmeric exhibited higher phenolic and flavonoid contents and improved radical scavenging activity than its non-fermented counterpart. Additionally, L. rhamnosus FN7 survived under simulated gastrointestinal conditions, indicating probiotic potential. Our findings suggest that L. rhamnosus FN7 fermentation significantly boosts turmeric's biochemical attributes, positioning it as a promising functional food.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"37 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140358487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Peptides as Antioxidants and Antimicrobials: Fundamentals and Applications 作为抗氧化剂和抗菌剂的生物活性肽：基础知识与应用

Journal of Food Bioactives Pub Date : 2024-03-31 DOI: 10.31665/jfb.2024.18367

Sarika Kumari, Fereidoon Shahidi

引用次数: 1

Research progress on separation and characterization of bioflavonoids from Coreopsis tinctoria Nutt. 从拟南芥中分离和鉴定生物类黄酮的研究进展

Journal of Food Bioactives Pub Date : 2023-12-31 DOI: 10.31665/jfb.2023.18362

Limin Guo, Wenyu Zhang, Yina Meng, Shiming Li

{"title":"Research progress on separation and characterization of bioflavonoids from Coreopsis tinctoria Nutt.","authors":"Limin Guo, Wenyu Zhang, Yina Meng, Shiming Li","doi":"10.31665/jfb.2023.18362","DOIUrl":"https://doi.org/10.31665/jfb.2023.18362","url":null,"abstract":"Coreopsis tinctoria Nutt (C. tinctoria) or a common name ‘Snow chrysanthemum’ because of its growing condition at high altitude，is one of the popular medicinal-food plants, mainly grows in the northwest area of China. Because of its rich nutrients, particularly polyphenols (majorly flavonoids), and volatile oils among others, C. tinctoria has become a research hotspot in recent years. In addition, the flavonoids of C. tinctoria, especially the flavanomarein, marein, okanin and other bioactive phytochemicals, have effective biological activity. They possess good antioxidant and anti-inflammatory effects, also have significant effects on lowering blood pressure, hypoglycemia and reducing levels of triglycerides and cholesterol. However, at present, studies on the bioactivity of C. tinctoria are mainly focused on crude extracts or total flavonoids. The study of monomer components is largely limited to the isolation and purification process, which is difficult for a systematic study because of the chemical-physical nature of marein, flavanomarein and other compounds in C. tinctoria. Therefore, to have an updated isolation of C. tinctoria bioactive components, this paper reviewed the current research status of the separation and purification methods of flavonoids from C. tinctoria, by analyzing and comparing the technical characteristics of these methods, and providing prospects on the development and application of the separation and purification methods of C. tinctoria.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"60 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0