{"title":"Bioactive Peptides as Antioxidants and Antimicrobials: Fundamentals and Applications","authors":"Sarika Kumari, Fereidoon Shahidi","doi":"10.31665/jfb.2024.18367","DOIUrl":"https://doi.org/10.31665/jfb.2024.18367","url":null,"abstract":"Bioactive peptides are well-known for their remarkable tissue affinity, specificity, and effectiveness in promoting health. Extracted from food proteins, these bioactive peptides have displayed significant potential as functional foods and nutraceuticals. Throughout the years, numerous potential bioactive peptides derived from food sources have been documented. These bioactive peptides offer a wide range of crucial functions within the human body, including acting as antioxidants, antimicrobial agents, anti-inflammatory compounds, anti-hypertensive substances, and immunomodulators. More recently, extensive research has been conducted to investigate the origins, bioavailability, potential physiological effects and functionality, as well as the mechanisms of action of bioactive peptides in rendering health benefits. Researchers have also delved into various technological methods for preparing, purifying, and characterizing these peptides. This contribution primarily centers on exploring the antioxidant and antimicrobial aspects of bioactive peptides.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140358663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research progress on separation and characterization of bioflavonoids from Coreopsis tinctoria Nutt.","authors":"Limin Guo, Wenyu Zhang, Yina Meng, Shiming Li","doi":"10.31665/jfb.2023.18362","DOIUrl":"https://doi.org/10.31665/jfb.2023.18362","url":null,"abstract":"Coreopsis tinctoria Nutt (C. tinctoria) or a common name ‘Snow chrysanthemum’ because of its growing condition at high altitude,is one of the popular medicinal-food plants, mainly grows in the northwest area of China. Because of its rich nutrients, particularly polyphenols (majorly flavonoids), and volatile oils among others, C. tinctoria has become a research hotspot in recent years. In addition, the flavonoids of C. tinctoria, especially the flavanomarein, marein, okanin and other bioactive phytochemicals, have effective biological activity. They possess good antioxidant and anti-inflammatory effects, also have significant effects on lowering blood pressure, hypoglycemia and reducing levels of triglycerides and cholesterol. However, at present, studies on the bioactivity of C. tinctoria are mainly focused on crude extracts or total flavonoids. The study of monomer components is largely limited to the isolation and purification process, which is difficult for a systematic study because of the chemical-physical nature of marein, flavanomarein and other compounds in C. tinctoria. Therefore, to have an updated isolation of C. tinctoria bioactive components, this paper reviewed the current research status of the separation and purification methods of flavonoids from C. tinctoria, by analyzing and comparing the technical characteristics of these methods, and providing prospects on the development and application of the separation and purification methods of C. tinctoria.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"60 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Binding of carotenoids to proteins: A review","authors":"Fereidoon Shahidi, Chandrika Sewwandi Dissanayaka","doi":"10.31665/jfb.2023.18360","DOIUrl":"https://doi.org/10.31665/jfb.2023.18360","url":null,"abstract":"Carotenoids are lipophilic natural pigments distributed in plants, certain types of algae, fungi and animals. The extensive conjugated double bond system in carotenoids is responsible for their unique color, antioxidant capacity and provide health benefits. However, the hydrophobic nature of carotenoids impacts their color and bioactivity during the development of food products due to their low solubility in aqueous media. The complexation of these molecules with proteins has proven to be an efficient approach for enhancing carotenoid’s solubility and protection against oxidative degradation and hence improving their functional properties and biological activities. This review compiles the molecular interactions between carotenoids and proteins, their physiological relevance, potential applications and characterization of their binding affinities, stabilities, and activities in terms of in-silico analysis and beyond. Overall, the deep understanding and interpretation of binding at the molecular level provide fundamental aspects for the inclusion of carotenoid bioactive compounds in fortified foods and pharmaceuticals.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"51 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The enzymatic hydrolysates of Andrias davidianus mucus alleviates UVA-induced photoaging in the HSF cell and mouse skin","authors":"Li-Hua Zhou, Peng-Fei Zhang, Huan Zhang, Bei-Bei Gong, You-Nan Kou, Qing-Hua Luo, Wu-Yan Guo, Bo Zhang","doi":"10.31665/jfb.2023.18365","DOIUrl":"https://doi.org/10.31665/jfb.2023.18365","url":null,"abstract":"Photoaging is the premature aging of skin caused by long-term exposure to ultraviolet radiation. The skin mucus of Andrias davidianus has anti-photoaging activity, but its active ingredients and mechanisms are not clear. In this study, we first investigated the photoprotective effect of enzymatic hydrolysates from Andrias davidianus mucus (AD-APRO) on UVA-irradiated responses in human skin fibroblasts (HSF) cells and mice. AD-APRO hindered the UVA induced activation of reactive oxygen species (ROS) and increased the activity of antioxidase in HSF cells. Furthermore, topical application of AD-APRO ameliorated skin photoaging in a mouse model by suppressing oxidative stress. CAMP and Peptide Ranker, two online tools, were used to predict the active peptides of AD-APRO against photoaging. The active peptides of AD-APRO were predicted to be KDACCNLVLHFNPRF, NLVLHFNPRF, FEWKP, and CNLVLHFNPRF. These results provide a basis for the study of the photoprotective effect of AD-APRO and suggest that it can be potentially used as an agent against UVA-induced skin photoaging in humans.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"51 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingzhang Geng, Jinhui Wu, Huiying Wang, Yanfei Liu, Bin Du, Yuedong Yang
{"title":"Effects of ultra-fine micronization on the structure, rheological and functional properties of dietary fiber from Laminaria ja-ponica","authors":"Jingzhang Geng, Jinhui Wu, Huiying Wang, Yanfei Liu, Bin Du, Yuedong Yang","doi":"10.31665/jfb.2023.18363","DOIUrl":"https://doi.org/10.31665/jfb.2023.18363","url":null,"abstract":"Laminaria japonica is known to be a rich source of dietary fiber (DF). The DF in L. japonica was extracted by combined enzymatic and chemical method in this study. The effect of ultra-fine pulverization on structural and functional properties of DF fractions were also investigated. The results displayed that the molecular weight of DF was 2.22 × 107 Da. After ultra-fine grinding, the viscosity of soluble dietary fiber (SDF) suspension increased from 4.65 ± 0.08 to 6.89 ± 0.24 mPa·s. In addition, ultra-fine grinding significantly reduced the particle size of DF with higher insoluble dietary fiber (IDF) yields. L. japonica IDF exhibited significant enhancement on absorption capacities of nitrite ion absorption, cholesterol and glucose, which could be utilized as potential ingredients in several DF intensified foods. This work could provide understanding into the influence of micronization on the structure-function relationship of food materials rich in dietary fiber.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"112 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139135179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pomelo Peel Extract induces ROS-mediated DNA Double Stand Break and Apoptotic Death Pathway in Caco-2 Colon Cancer Cells","authors":"Vo Thi Hong Tham, Hsiao-Chi Wang, Yung-Lin Chu","doi":"10.31665/jfb.2023.18364","DOIUrl":"https://doi.org/10.31665/jfb.2023.18364","url":null,"abstract":"Colorectal cancer (CRC) ranks among the top ten leading causes of death in the world. Beyond chemical therapy or targeted therapy, finding an alternative approach to colorectal cancer therapy is necessary. Citrus grandis (L.) Osbeck is a popular fruit cultivated worldwide; the peel is mainly discarded after consuming the fruit. However, it has also been commonly reported as folk medicine for treating several illnesses, such as cough and indigestion. In this study, Caco-2 cells were treated with different concentrations of pomelo peel extract (PPE). PPE suppressed cell viability in a dose-dependent manner at 24 and 48 h. The PPE extract showed condensed chromatin and apoptotic cells at 12, 24, and 48 h under the microscope in DAPI (4′,6-diamidino-2-phenylindole) staining. Moreover, PPE activated the apoptosis pathway by increasing the protein expression of cleaved caspase-3. In addition, it also expressed elevation of pro-apoptotic Bax and degradation of anti-apoptotic Bcl-2. In addition, it enhanced the p-Chk2 protein in arresting the cell cycle and increased the protein expression of p-Histone H2A.X. Those results suggest that PPE can reduce cell viability in Caco-2 cells through ROS production and DNA damage.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"104 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential role of nobiletin in Alzheimer's disease","authors":"Huilin Fang, Lingling Zhang, Hui Zhao","doi":"10.31665/jfb.2023.18361","DOIUrl":"https://doi.org/10.31665/jfb.2023.18361","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles. At present, there is no specific drugs for the prevention and treatment of AD, so it is urgent to find natural products contributing to alleviation of AD. Nobiletin is one of polymethoxyflavones (PMFs) extracted mainly from citrus peels. Nobiletin has multiple bioactivities, good bioavailability and low side effects. Studies have shown that nobiletin improves cognitive impairment and pathological features in animal models of AD and exerts neuroprotective effects. In addition, 5-demethylnobiletin (5-DN), the main derivative of nobiletin, achieves neuroprotection through anti-inflammatory, neurotrophic and cholinergic effects for the treatment of neurodegenerative diseases. Other PMFs (for example tangeretin) also have the potential to prevent neurodegenerative diseases due to their anti-inflammatory and neuroprotective effects similar to nobiletin. Taken together, PMFs, including nobiletin, have potential as therapeutic agents for AD.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"118 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139133350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges hindering the commercialization of nutraceuticals derived from agri-food by-products","authors":"Renan Danielski","doi":"10.31665/jfb.2023.18358","DOIUrl":"https://doi.org/10.31665/jfb.2023.18358","url":null,"abstract":"Several agri-food by-products carry a significant amount of bioactive compounds and could potentially be transformed into nutraceuticals within the circular economy framework. However, the full realization of this potential is hindered by logistics, technological, biological, and regulatory challenges, slowing down the development of a robust nutraceutical market. The present article discusses the need for innovative solutions to optimize waste collection and transportation. The technological challenges in extracting and preserving bioactive compounds call for advancements in unconventional extraction methods and encapsulation approaches. Biological challenges, particularly regarding the bioaccessibility and bioavailability of bioactive compounds, underscore the importance of tailoring delivery methods for optimal efficacy. In addition, selected regulatory aspects need to be highlighted in order to clarify the need for harmonization in ensuring the safety and efficacy of nutraceuticals. Despite challenges, the potential rewards include health benefits, economic growth, and environmental sustainability, driven by the pivotal role of scientific research and interdisciplinary collaboration to realize the vision of a circular economy in the agri-food sector.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"8 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139130326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do date codes cause food waste? Smart packaging might tackle the problem","authors":"Abul Hossain","doi":"10.31665/jfb.2023.18359","DOIUrl":"https://doi.org/10.31665/jfb.2023.18359","url":null,"abstract":"Food waste is a multifaceted problem that occurs across various sectors of the food supply chain, causing significant repercussions on the environment, food security, and both global and regional/national economies. One of the most common reasons for food waste is the misunderstanding of food dating (e.g., best-before date), leading to the throwing away of food more frequently. Consumers tend to discard food products as they approach the best-before date due to potential health and safety concerns. Many argue that the diversity of date labels employed by food manufacturers contributes to confusion among consumers regarding both food quality and safety, thus causing food waste. Removing/ supplementing date codes requires the adoption of alternative methods to maintain the freshness and safety of food. Recent advancements in smart packaging have the potential to extend the shelf life and maintain the safety of products equipped with a range of features, which allow the monitoring of the condition of packaged products and provide information. Given the global concern over food waste, this review emphasizes the implementation of smart (active and intelligent) packaging in order to supplement the date labels and assist consumers in reducing their waste and maintain the integrity of its bioactive components.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"120 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Qin, Nannan Wang, Jiaojiao Han, Chenyang Lu, Jun Zhou, Jiajie Xu, Xiurong Su
{"title":"Antihyperglycemic and hypolipidemic properties of Acaudina leucoprocta peptides in type II diabetic mice","authors":"Yang Qin, Nannan Wang, Jiaojiao Han, Chenyang Lu, Jun Zhou, Jiajie Xu, Xiurong Su","doi":"10.31665/jfb.2023.18357","DOIUrl":"https://doi.org/10.31665/jfb.2023.18357","url":null,"abstract":"This study aimed to investigate the protective mechanism of Acaudina leucoprocta peptides (ALPs) in the kidney of type II diabetes mice (db/db mice). Serum lipid and glucose indexes were detected in diabetes mice after ALPs treatment. The two-dimensional gel electrophoresis was used to study the kidney protein of diabetic mice. The differential protein screening, GO function annotation, and metabolic pathways were used to determine the protective mechanism of ALPs in the kidney of diabetic mice. The symptoms of db/db mice were alleviated after 10 weeks of treatment with ALPs. The content of TC, TG, and LDL-C in the ALPs group was significantly decreased and the level of HDL-C was increased. After ALPs treatment, the urine glucose and fasting blood glucose of diabetes mice were significantly reduced. The expression of Haptoglobin was up-regulated, it plays a role in anti-inflammatory and immune regulation. And the expression of alpha-2-HS-glycoproteins was down-regulated, then the insulin signal pathway was restored to normal condition, to improve the symptoms of diabetes. This study provided a new strategy that will help treat diabetes.","PeriodicalId":15882,"journal":{"name":"Journal of Food Bioactives","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136336317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}