Journal of Fungi最新文献

{"title":"Construction of Overexpression Vector with <i>TYR7523</i> Gene and Its Effect on Browning in <i>Macrocybe gigantea</i>.","authors":"Jinyun Gao, Shuqing Song, Xinqian Liu, Zhuanlin Mo, Meihua Mo","doi":"10.3390/jof11030216","DOIUrl":"10.3390/jof11030216","url":null,"abstract":"<p><p><i>Macrocybe gigantea</i> is a rare high-temperature edible fungus known for its resistance to browning. Previous studies suggested that the anti-browning property of the SCAU4 strain might be associated with low expression levels of the <i>TYR7523</i> gene. In this study, an overexpression vector for the <i>TYR7523</i> gene was constructed and introduced into SCAU4 mycelium using an Agrobacterium-mediated transformation method. After three rounds of hygromycin resistance screening, successful transformants were identified through PCR amplification and validated by qRT-PCR analysis, confirming a 3.47-fold upregulation of <i>TYR7523</i> expression. The overexpression strain <i>OE7523</i> was compared with the wild-type SCAU4 strain in terms of growth rate, browning degree, and tyrosinase activity. Although there was no significant difference in growth rate on the mother culture medium, <i>OE7523</i> showed faster growth on the stock culture and mycelium culture medium. In the late storage period, <i>OE7523</i> exhibited a higher browning degree and tyrosinase activity than SCAU4, suggesting a potential role of <i>TYR7523</i> in fruiting body browning. Physiological analyses indicated that low <i>TYR7523</i> expression may contribute to storage tolerance, while high expression influenced postharvest browning and preservation duration. The results provide data support for further study on the function of <i>TYR7523</i> gene of <i>Macrocybe gigantea</i>.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Clinical Features of <i>Candida</i> Bloodstream Infections: A 10-Year Retrospective Study in a Korean Teaching Hospital.","authors":"Shi Nae Yu, Sun In Hong, Jung Wan Park, Min Hyok Jeon, Oh Hyun Cho","doi":"10.3390/jof11030217","DOIUrl":"10.3390/jof11030217","url":null,"abstract":"<p><p><i>Candida</i> species are major pathogens of bloodstream infections (BSIs) in hospitalized patients, with high mortality. This study examined <i>Candida</i> species distribution, clinical characteristics, and the mortality of patients with <i>Candida</i> BSIs. Adult patients (≥16 years) with <i>Candida</i> BSIs at a teaching hospital (2014-2023) were retrospectively reviewed. Over 10 years, 487 <i>Candida</i> isolates were obtained from 462 patients. <i>C. albicans</i> was the most frequent (38.2%), followed by <i>C. glabrata</i> (21.1%), <i>C. parapsilosis</i> (20.5%), and <i>C. tropicalis</i> (13.3%). The annual incidence of <i>Candida</i> BSIs remained stable (<i>p</i> = 0.525). However, non-<i>albicans</i> species BSIs increased 1.61-fold compared to <i>C. albicans</i> (95% CI: 1.19-2.19, <i>p</i> = 0.002). Fluconazole-non-susceptible <i>Candida</i> isolates increased after 2021 (<i>p</i> = 0.040). The overall 30-day mortality was 40.6%. In the multivariate analysis, a high Charlson comorbidity index (aHR: 1.20, 95% CI: 1.07-1.35, <i>p</i> = 0.001) and high SOFA score (aHR: 1.12, 95% CI: 1.02-1.23, <i>p</i> = 0.022) were the strongest predictors of 30-day mortality. Meanwhile, <i>C. parapsilosis</i> BSIs (aHR: 0.46, 95% CI: 0.22-0.99, <i>p</i> = 0.047) and central venous catheter removal at any time (aHR: 0.22, 95% CI: 0.13-0.37, <i>p</i> < 0.001) were associated with reduced 30-day mortality. The mortality of patients with <i>Candida</i> BSIs was mainly determined by disease severity, while catheter removal was associated with improved survival.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Profile of Otomycosis at the Peace Hospital of Ziguinchor (Senegal).","authors":"Abdoulaye Diop, Hussein Younes, Papa Samba Diop, Kalilou Diallo, Youssouph Sambou, Khadim Diongue, Mouhamadou Ndiaye, Mame Ngoné Coly, Habibou Sarr, Evelyne Siga Diom, Daouda Ndiaye","doi":"10.3390/jof11030218","DOIUrl":"10.3390/jof11030218","url":null,"abstract":"<p><p>The investigation of the fungal etiologies of otomycoses is a rare occurrence in Senegal. The present study aspires to ascertain the profile of these mycoses within the confines of Ziguinchor. Conducted from 3 February 2021 to 31 August 2022, this retrospective descriptive study encompassed a total of 82 patients presenting with clinically suspected otomycosis within the otolaryngology (ENT) department of the Ziguinchor Peace Hospital (ZPH). In this study, two samples were collected from the external auditory canal (EAC) of each patient using sterile swabs. These samples were first observed by direct microscopy and then cultured at 30 °C on Sabouraud chloramphenicol with or without cycloheximide. The identification of the isolates was based on their macroscopic, microscopic, and physiological characteristics. The mycological examination was positive in 70 patients, with a prevalence of 85.37%. The most prevalent fungal isolates were <i>Aspergillus section Nigri</i> (30%), <i>Aspergillus section Flavi</i> (20%), and <i>Candida albicans/Candida dubliniensis</i> (10%). Of the clinical signs examined, auricular pruritus (<i>p</i> = 1.7033 × 10^-6) was the only one to demonstrate a positive correlation with the onset of otomycosis. These results indicate that fungal agents play a significant role in the pathogenesis of otitis externa, underscoring the importance of mycological diagnosis in ensuring optimal patient management.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptative Divergence of <i>Cryptococcus neoformans</i>: Phenetic and Metabolomic Profiles Reveal Distinct Pathways of Virulence and Resistance in Clinical vs. Environmental Isolates.","authors":"Camila Botelho Miguel, Geovana Pina Vilela, Lara Mamede Almeida, Mariane Andrade Moreira, Glicélia Pereira Silva, Jamil Miguel-Neto, Melissa Carvalho Martins-de-Abreu, Ferdinando Agostinho, Javier Emilio Lazo-Chica, Mariana Santos Cardoso, Siomar de Castro Soares, Aristóteles Góes-Neto, Wellington Francisco Rodrigues","doi":"10.3390/jof11030215","DOIUrl":"10.3390/jof11030215","url":null,"abstract":"<p><p><i>Cryptococcus neoformans</i> is a life-threatening fungal pathogen that primarily affects immunocompromised individuals. While antiretroviral therapy has reduced incidence in developed nations, fluconazole-resistant strains and virulent environmental isolates continue to pose challenges, especially because they have many mechanisms of adaptability, supporting their survival. This study explores the phenetic and metabolomic adaptations of <i>C. neoformans</i> in clinical and environmental contexts to understand the factors influencing pathogenicity and resistance.</p><p><strong>Methods: </strong>An in silico observational study was conducted with 16 <i>C. neoformans</i> isolates (6 clinical, 9 environmental, and 1 reference) from the NCBI database. Molecular phenetic analysis used MEGA version 11.0.13 and focused on efflux pump protein sequences. Molecular phenetic relationships were assessed via the UPGMA clustering method with 1000 bootstrap replicates. The enzymatic profiling of glycolytic pathways was conducted with dbCAN, and metabolomic pathway enrichment analysis was performed in MetaboAnalyst 6.0 using the KEGG pathway database.</p><p><strong>Results: </strong>Molecular phenetic analysis revealed distinct clustering patterns among isolates, reflecting adaptations associated with clinical and environmental niches. Clinical isolates demonstrated enriched sulfur metabolism and glutathione pathways, likely adaptations to oxidative stress in host environments, while environmental isolates favored methane and glyoxylate pathways, suggesting adaptations for survival in carbon-rich environments.</p><p><strong>Conclusion: </strong>Significant phenetic and metabolomic distinctions between isolates reveal adaptive strategies for enhancing virulence and antifungal resistance, highlighting potential therapeutic targets.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution Pattern and Assembly Process of Fungal Communities Along Altitude Gradient in Sediments of the Yellow River Basin.","authors":"Kang Fang, Guoce Xu, Xin Chen, Jing Li, Yuting Cheng, Yifan Cheng","doi":"10.3390/jof11030214","DOIUrl":"10.3390/jof11030214","url":null,"abstract":"<p><p>Microorganisms have a profound impact on the stability and ecological health of aquatic environments. Fungi, as important components of river ecosystems, play critical roles as decomposers and symbionts. A comprehensive understanding of the mechanisms underlying fungal community assembly is essential for the effective conservation and management of river ecosystems. However, the distribution patterns and assembly process of fungal communities along elevation gradients in river sediments remain poorly understood. In this study, ITS amplicon sequencing, a neutral community model, and a null model were employed to analyze the distribution patterns and assembly processes of fungal communities in sediments along the altitudinal gradient of the Yellow River. The results indicated that Ascomycota (47.79%) and Basidiomycota (15.68%) were identified as the dominant phyla in the sediments, collectively accounting for 63.47% of the total relative abundance of the community. In the three different altitudinal gradients, the fungal community diversity (Shannon) showed a gradually decreasing trend with increasing altitude. The co-line networks of fungal communities exhibited positive interactions and had more complex and compact networks in the sediments of the Tibetan Plateau area (YRA). Environmental factors in the sediments played an important role in shaping the structure of fungal communities, with lead (Pb), total nitrogen (TN), silt, and total organic carbon (TOC) being the main factors driving changes in community structure, contributing 15.5%, 12.3%, 10.7%, and 10.2%, respectively. In the community assembly process, deterministic processes were found to dominate, with homogenizing selection contributing the most (69.66%). These research results help us understand the distribution patterns of fungal communities along altitudinal gradients and the mechanisms of community assembly, and also provide a scientific basis for biodiversity conservation and the rational use of biological resources.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal Stress Responses and the Importance of GPCRs.","authors":"Daniela Lara-Martínez, Fabiola Estefania Tristán-Flores, Juan Antonio Cervantes-Montelongo, Guillermo Antonio Silva-Martínez","doi":"10.3390/jof11030213","DOIUrl":"10.3390/jof11030213","url":null,"abstract":"<p><p>G-protein-coupled receptors (GPCRs) play a crucial role in the gene regulation of processes related to the response to different types of stress in fungi. These receptors act as sensors of extracellular signals and transmit the information to the interior of the cell through G-proteins. In the presence of different and specific types of stresses, GPCRs activate signaling cascades that culminate in the activation of transcription factors, which regulate the expression of genes associated with the stress response, including those induced by changes in environmental pH. GPCR-mediated gene regulation allows fungi to adapt to adverse conditions such as osmotic, thermal, oxidative, or nutritional stress, as well as fluctuations in environmental pH. This review focuses on the understanding of how GPCRs modulate the stress response in fungi and their crucial role in advancing our knowledge of the physiology and adaptability of these microorganisms in their changing environment.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and Diversity of Fungi and Their Mycotoxin Production in Common Edible and Medicinal Substances from China.","authors":"Ling Chen, Junhui Wu, Shuhong Zhang, Xinqi Liu, Meiping Zhao, Weipeng Guo, Jumei Zhang, Wei Chen, Zhenjie Liu, Meiqing Deng, Qingping Wu","doi":"10.3390/jof11030212","DOIUrl":"10.3390/jof11030212","url":null,"abstract":"<p><p>Edible and medicinal substances can be contaminated by fungi during harvesting, processing, and storage, leading to mycotoxin production and quality deterioration. The distribution of mycotoxigenic fungi in edible and medicinal substances was investigated in this study. Fungi and mycotoxins were detected in 163 commercially available edible and medicinal substances using standard microbiological techniques and high-performance liquid chromatography. A total of 92.0% of samples contained fungi (0.5-5.3 lg colony-forming units (CFU)·g^-1); 208 fungal strains belonging to 16 genera were identified, predominantly <i>Aspergillus</i> and <i>Penicillium. Aspergillus</i> section <i>Nigri</i> (30.3%) produced fumonisin B₂, which was distributed mainly in radix and rhizome samples. Thirteen samples had mycotoxins, of which ochratoxin A was the most common, followed by aflatoxins and zearalenone (ZEN). One <i>Nelumbinis</i> semen sample contained 10.75 μg·kg^-1 AFB₁, and one <i>Raisin tree</i> semen sample contained 484.30 μg·kg^-1 ZEN, which exceeded regulatory limits in Europe and China. These findings highlight the potential risks associated with fungal contamination and mycotoxins in edible and medicinal substances. Enhanced quality control measures are essential to reduce contamination during harvesting, processing, and storage. Expanded mycotoxin screening, improved preservation techniques, and stricter regulatory standards need to be implemented to ensure consumer safety.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Leaf Variability of Incubation Period Sheds New Light on the Lifestyle of <i>Cercospora beticola</i> in Sugar Beets.","authors":"Erich-Christian Oerke, Ulrike Steiner","doi":"10.3390/jof11030211","DOIUrl":"10.3390/jof11030211","url":null,"abstract":"<p><p>The length of incubation period, i.e., the time between first contact of host and pathogen and the appearance of symptoms, varies among diseases and depends on environmental conditions. <i>Cercospora beticola</i> is the most important fungal pathogen in sugar beet production worldwide, as Cercospora leaf spot (CLS) reduces the leaf area contributing to yield formation. Using sugar beet cultivars differing in CLS resistance, a single infection period of <i>C. beticola</i> resulted in minor differences in the incubation period among host genotypes and among individual plants of cultivars, greater differences among leaves within plants, and substantial variation within individual leaves. Under greenhouse conditions not suitable for secondary infections, the first CLS lesions appeared 10 days after inoculation; however, the number of leaf spots and CLS severity further increased significantly for another 7 to 17 days. A geographic information system approach enabled the tracking of colony appearance and growth of all CLSs on inoculated leaves for up to 27 days. Asymptomatic colonization of leaves was associated with thick hyphae which switched to thin hyphae or melanization after lesion appearance. The lifestyle of <i>C. beticola</i>-intercellular tissue colonization, triggering of necrotic host reaction-is discussed considering the experimental results as well as literature resources.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Aspergillus</i> in Children and Young People with Cystic Fibrosis: A Narrative Review.","authors":"Emily Chesshyre, Eva Wooding, Emily Sey, Adilia Warris","doi":"10.3390/jof11030210","DOIUrl":"10.3390/jof11030210","url":null,"abstract":"<p><p>Cystic fibrosis is a severe, inherited, life-limiting disorder, and over half of those living with CF are children. Persistent airway infection and inflammation, resulting in progressive lung function decline, is the hallmark of this disorder. <i>Aspergillus</i> colonization and infection is a well-known complication in people with CF and can evolve in a range of <i>Aspergillus</i> disease phenotypes, including <i>Aspergillus</i> bronchitis, fungal sensitization, and allergic bronchopulmonary aspergillosis (ABPA). Management strategies for children with CF are primarily aimed at preventing lung damage and lung function decline caused by bacterial infections. The role of <i>Aspergillus</i> infections is less understood, especially during childhood, and therefore evidence-based diagnostic and treatment guidelines are lacking. This narrative review summarizes our current understanding of the impact of <i>Aspergillus</i> on the airways of children and young people with CF.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Polyacetylenic Deoxyglycosides Isolated from Endophytic Fungus <i>Xylaria</i> sp. VDL4 Associated with <i>Vaccinium dunalianum</i>.","authors":"Jiao Yao, Sai Huang, Lingfeng He, Shengyun Wei, Wei Yang, Qiangxin Zhang, Weihua Wang, Xiaoqin Yang, Sida Xie, Yunxian Li, Ping Zhao, Guolei Zhu","doi":"10.3390/jof11030209","DOIUrl":"10.3390/jof11030209","url":null,"abstract":"<p><p>One novel C₁₀ polyacetylene rhamnoside, 4,6,8-decatriyne-1-<i>O</i>-α-L-rhamnopyranoside, named xylariside A (<b>1</b>), together with two novel C₁₀ polyacetylene quinovopyranosides, 4,6,8-decatriyne-1-<i>O</i>-α-D-quinovopyranoside, xylariside B (<b>2</b>), and 8<i>E</i>-decaene-4,6-diyne-1-<i>O</i>-α-D-quinovopyranoside, xylariside C (<b>3</b>), were obtained from the solid fermentation of <i>Xylaria</i> sp. VDL4, an endophytic fungus isolated from <i>Vaccinium dunalianum</i> wight (Ericaceae). Their chemical structures were elucidated through a combination of spectroscopic techniques. The antifungal activities of these compounds were evaluated in vitro against four phytopathogenic fungi (<i>Fusarium oxysporum</i>, <i>Botrytis cinerea</i>, <i>Phytophthora capsici</i>, and <i>Fusarium solani</i>). Compound <b>2</b> demonstrated significant antifungal activities, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 7.81 μg/mL. Compound <b>2</b>'s effectiveness levels were similar to those of the reference drugs thiabendazole and carbendazim (each MIC = 0.98-15.62 μg/mL). Xylariside B (<b>2</b>) was further evaluated against <i>B. cinerea</i> in vivo. It exhibited remarkable efficacy in both the prevention and treatment of tomato and strawberry gray mold. Molecular docking studies confirmed the antifungal mechanism of compound <b>2</b> by revealing its binding interactions with key enzyme targets in <i>B. cinerea</i>, thereby supporting the observed in vitro and in vivo results. Additionally, compound <b>2</b> showed effective inhibition of α-glucosidase, with IC₅₀ values of 5.27 ± 0.0125 μg/mL.</p>","PeriodicalId":15878,"journal":{"name":"Journal of Fungi","volume":"11 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}