Arsha Kochuvilayil, Hari Sankar, Jaison Joseph, Arun B Nair, Devaki Nambiar
{"title":"Parliamentarily speaking: A thematic analysis of Kerala Legislative Assembly questions relating to health from 2016 to 2021.","authors":"Arsha Kochuvilayil, Hari Sankar, Jaison Joseph, Arun B Nair, Devaki Nambiar","doi":"10.4103/jfmpc.jfmpc_1607_23","DOIUrl":"10.4103/jfmpc.jfmpc_1607_23","url":null,"abstract":"<p><strong>Introduction: </strong>Legislative assemblies often provide a platform for legislators to question the government during question hours, which are crucial for governance However, question hours remain understudied, especially when addressing health policy and systems related issues in lower- and middle-income countries. This study assesses the 14<sup>th</sup> Kerala Legislative Assembly questions, focusing on health-related areas to provide insights for health policy formulation and decision-making processes.</p><p><strong>Materials and methods: </strong>We sourced and transcribed all starred questions (346) related to health that were answered by the health minister in the 14<sup>th</sup> Legislative Assembly between 2016 and 2021 from the archives of the assembly website. We conducted a thematic analysis of these questions and mapped them into various themes, guided by the World Health Organization building blocks framework.</p><p><strong>Results: </strong>About 7.8% of all questions (<i>N</i> = 4404) were related to health (<i>N</i> = 346). Of these questions, the majority were directly related to service delivery (43.4%), followed by health information (16.5%). Health financing, food safety, and human resources were the least discussed topics throughout the assessed period within the state. The legislators primarily focussed on health services and health information, with less attention given to health financing, food safety, and human resources regardless of constituency or political affiliation.</p><p><strong>Discussion: </strong>This study underscores the need for a balanced approach to public health issues, highlighting the importance of legislators to priortizing health services and information, while also addressing health financing, food safety, and human resources. This would enable a robust and resilient public health system to effectively address diverse health concerns.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of hypothyroidism among postmenopausal women in an urbanised village of northern India: A cross-sectional study.","authors":"Priyanka Sharma, Anita Verma","doi":"10.4103/jfmpc.jfmpc_229_24","DOIUrl":"10.4103/jfmpc.jfmpc_229_24","url":null,"abstract":"<p><strong>Introduction: </strong>Hypothyroidism is among the most prevalent endocrine disorders worldwide. Its risk increases with menopause. The prevalence of hypothyroidism among menopausal women in India is unknown, as conclusive data are scarce. The present study was conducted to find out the prevalence of hypothyroidism among menopausal women in Delhi, India, and study the socio-demographic factors associated with it.</p><p><strong>Methods: </strong>This was a cross-sectional community-based study done among 282 menopausal women in an urbanised village in Delhi, India. Women with a previously known history of diagnosed thyroid disorders were also included in the study. Informed written consent was obtained from all participants. A socio-demographic profile was gathered by questionnaire and blood samples were collected and analysed for thyroid hormone levels.</p><p><strong>Results: </strong>The mean age of study participants was 51.1 years. The prevalence of hypothyroidism among postmenopausal women was 27.3% (77) with 19.9% (56) previously diagnosed and 7.3% (21) diagnosed by the present study. Out of 56 previously diagnosed hypothyroid study participants, only 26 (46.4%) participants had thyroid hormones in a normal range. Age, socio-economic status and literacy status were found to be significantly associated with hypothyroidism.</p><p><strong>Conclusion: </strong>About three postmenopausal women out of 10 were found to be hypothyroid. Nation-wide data were required to estimate the true burden of thyroid disorders in this population. The prevalence increased with age underscoring the need for further research to have conclusive evidence regarding this association. Hypothyroid women who are on treatment should undergo regular evaluation of thyroid hormones so that appropriate dose adjustments can be made for pharmacological therapies.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary care perspectives on leptin and adiponectin in north Indian families with metabolic syndrome.","authors":"Arjun Kumar Singhal, Gaurav Singh, Shravan Kumar Singh, Busi Karunanand, Merajul Haque Siddique, Naveen Kumar","doi":"10.4103/jfmpc.jfmpc_1942_23","DOIUrl":"10.4103/jfmpc.jfmpc_1942_23","url":null,"abstract":"<p><strong>Background: </strong>Urbanization, sedentary lifestyles, and dietary changes have all contributed to an increase in the prevalence of metabolic syndrome (MetS) in Indian populations during the past 10 years. Numerous markers have been investigated to determine if a person is at risk for developing MetS, with the bulk of them having to do with adipose tissue. Recently, adiponectin and leptin, two biomarkers with a high correlation to cardiometabolic health or disease, are of particular interest.</p><p><strong>Methods: </strong>In the general population of India, 100 persons were included. Body mass index (BMI), waist circumference, systolic and diastolic blood pressure, fasting blood glucose, plasma lipids, adiponectin, leptin, insulin, and the homeostasis model were measured to assess insulin resistance. We used binary logistic regression analysis to determine the connection between the researched factors and MetS and Spearman's analyses to evaluate correlations.</p><p><strong>Results: </strong>In all, 200 participants (100 men and 100 women) were enrolled in the study. Men's and women's median ages were 53 and 48, respectively (<i>P</i> < 0.05). Men had significantly greater WHR, SBP, and DBP (<i>P</i> < 0.05, respectively). Women had significantly higher levels of triglycerides, LDL, insulin, adiponectin, leptin, and HOMA-IR (<i>P</i> < 0.05, respectively). Leptin-to-adiponectin ratio was significantly and positively correlated with BMI (r = 0.597, <i>P</i> < 0.001), waist circumference (r = 0.576, <i>P</i> < 0.001), triglycerides (r = 0.190, <i>P</i> = 0.001), insulin levels (r = 0.329, <i>P</i> < 0.000), and HOMA-IR (r = 0.301, <i>P</i> < 0.000).</p><p><strong>Conclusion: </strong>In this study, higher levels of LAR, together with higher levels of leptin and lower levels of adiponectin, were found to be significantly linked with MetS. To properly determine whether LAR can be a predictor of MetS, independent of confounding factors, research with adequate design must be conducted.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Alanazy, Abdullah Alruwaili, Hassan H Al-Hassan, Abdullah Almulhim, Nawaf A Altaher, Abdulraouf S Alhomoud, Mohammed Alduhaish, Sultan N Alanazi, Turki M Alanazi
{"title":"Awareness of first aid among adults in Al-Ahsa City, Saudi Arabia: A cross-sectional study.","authors":"Ahmed Alanazy, Abdullah Alruwaili, Hassan H Al-Hassan, Abdullah Almulhim, Nawaf A Altaher, Abdulraouf S Alhomoud, Mohammed Alduhaish, Sultan N Alanazi, Turki M Alanazi","doi":"10.4103/jfmpc.jfmpc_1952_23","DOIUrl":"10.4103/jfmpc.jfmpc_1952_23","url":null,"abstract":"<p><strong>Background: </strong>First-aid knowledge among the general public is critical for saving lives in medical emergencies before expert care arrives. However, studies show persistent gaps in layperson first-aid capacity worldwide. This study assessed first-aid knowledge and awareness among adults in Al-Ahsa City, Saudi Arabia, to identify strengths and weaknesses to guide tailored interventions.</p><p><strong>Materials and methods: </strong>A cross-sectional survey was conducted among 716 adults recruited through convenience sampling. A structured questionnaire collected sociodemographics and assessed knowledge across 12 first-aid scenarios involving bleeding control, burns, seizures, choking, and cardiopulmonary resuscitation (CPR).</p><p><strong>Results: </strong>Just 59.2% correctly identified direct pressure to stop bleeding, and 61.2% knew proper burn first aid. Only 52% recognized the pediatric CPR compression-to-ventilation ratio (15:2), and 36.2% identified the chest compression rate of 100/min. For choking, 73.9% endorsed abdominal thrusts for children, but only 60.9% knew backslaps for infants. Females scored higher on bleeding (94.5% vs 92.8% correct) and abdominal thrusts (83.6% vs 66.1%), while males were more knowledgeable on burns (70.4% vs 53.8%) and infant choking (81.1% vs 44.7%). Younger and more educated respondents had higher scores.</p><p><strong>Conclusions: </strong>Major gaps exist in implementing proper first-aid techniques, especially differentiation by age. Deficits in direct bleeding control, high-quality CPR, and tailored pediatric care represent high-risk knowledge weaknesses in this population. Targeted education programs focused on skill-building in these areas, particularly for higher-risk demographics like the elderly and less educated, are critically needed to strengthen public preparedness and save lives. Findings provide key insights to inform evidence-based interventions.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bacteriological profile and antibiotic sensitivity pattern of bloodstream infections from a teaching institution in Eastern Uttar Pradesh, North India.","authors":"Shefali Gupta, Mukesh Shukla, Mahendra Meena, Soumyabrata Nag, Sana Islahi, Sweta Singh, Akshat Srivastav, Anirudh Mukherjee","doi":"10.4103/jfmpc.jfmpc_1994_23","DOIUrl":"10.4103/jfmpc.jfmpc_1994_23","url":null,"abstract":"<p><strong>Introduction: </strong>Bloodstream infections (BSIs), encompassing both self-limiting bacteremia and potentially fatal septicaemia, make up the majority of healthcare-associated ailments worldwide. The organisms encountered are mostly multidrug-resistant (MDROs), leading to increased hospital stays. Our study aims to collect data about blood culture isolates from a medical college in eastern Uttar Pradesh, India.</p><p><strong>Materials and methods: </strong>A retrospective analysis of blood culture isolates obtained at our laboratory for ten months from patients with clinical suspicion of sepsis or infection with the possibility of haematogenous spread was done. We only considered consecutive and patient-specific, non-duplicate isolates. Blood samples were initially incubated in BacT/ALERT® and then manually processed once they flagged positive.</p><p><strong>Results: </strong>A total of 1,033 blood samples were received, of which 217 (21%) showed the growth of a pathogenic organism. The positivity rate varied significantly across different age groups, locations, and departments (<i>P</i> value < 0.001). It was higher among in-patients, those with central venous access, and patients with diabetes mellitus (DM). <i>Staphylococcus aureus</i> [n <i>=</i> 105, 48.38%] was isolated most commonly, with a high prevalence of methicillin resistance (83%). <i>Enterococcus</i> demonstrated a high degree of resistance. MDROs accounted for 68% of the detected Gram-negatives.</p><p><strong>Discussion: </strong>This study comprehensively analyses blood culture results from a diverse group of patients and emphasizes the association between risk factors and positive blood cultures. Gram-positive and Gram-negative isolates demonstrated low sensitivity to common antibiotics, urging vigilant monitoring and specific therapy.</p><p><strong>Conclusion: </strong>Our study reveals important insights guiding clinical practices, antimicrobial stewardship, and infection control strategies.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delivering comprehensive and integrated care in India.","authors":"Harish Gupta, Ajay K Patwa","doi":"10.4103/jfmpc.jfmpc_352_24","DOIUrl":"10.4103/jfmpc.jfmpc_352_24","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jayesh D Solanki, Rahul Vaghasiya, Isha Sharma, Jagdish B Patel
{"title":"Determination of SRPA and adiposity measures and its association with glycemic status in type 2 diabetics having high mean HbA1c in a private clinic of a city in west India.","authors":"Jayesh D Solanki, Rahul Vaghasiya, Isha Sharma, Jagdish B Patel","doi":"10.4103/jfmpc.jfmpc_205_24","DOIUrl":"10.4103/jfmpc.jfmpc_205_24","url":null,"abstract":"<p><strong>Introduction: </strong>Indian type 2 diabetics (T2D) is known for poor disease control on which self-reported physical activity (SRPA) and optimum body composition have positive impact. We determined prevalence of SRPA and general/visceral obesity and its impact on HbA1c-based glycemia.</p><p><strong>Methodology: </strong>By a cross-sectional study conducted on 200 T2Ds in a private clinic, HbA1c-based glycemic status, WHO questionnaire-based SRPA, BMI-based general obesity, and bipolar bioelectrical impedance-based visceral obesity were evaluated. SRPA and obesity were compared and associated with glycaemic status keeping mean HbA1c as cutoff.</p><p><strong>Result: </strong>Mean age, male%, mean duration of T2D, mean BMI, mean HbA1c, and SRPA prevalence were 54 years, 42.5%, 4.82 years, 25.49, 8.69%, and 61.5%, respectively. Comparison of groups based on either SRPA or BMI (cutoff 25) showed better HbA1c with the presence of SRPA and BMI <25. Physical inactivity imposed odds risk of 3.44 for visceral fat (VF) ≥10% and odds risk of 2.6 for more than mean HbA1c with statistical significances. VF ≥10% imposed odds risk of 4 for higher than mean HbA1c. Physical inactivity and visceral obesity together imposed ⅓rd prevalence of better glycaemic value, while physical activity and controlled visceral obesity yielded ¾th prevalence of good glycaemic value.</p><p><strong>Conclusion: </strong>In T2D with poor glycaemic status and moderately prevalent physical activity, we found strongly significant association of SRPA and controlled body adiposity with HbA1c-based glycaemic status. It reaffirms physical activity and control of central obesity as forerunners of better glycaemic status and calls for further studies having vertical follow-up.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk and protective factors of miscarriage: Evidence from a nationally representative sample of women in India.","authors":"H S Sonu, Sumit Kumar Das, Roshni Tony, V S Binu","doi":"10.4103/jfmpc.jfmpc_329_24","DOIUrl":"10.4103/jfmpc.jfmpc_329_24","url":null,"abstract":"<p><strong>Context: </strong>Miscarriage is the most distressing complication in early pregnancy, with one in every five pregnant women ending in a miscarriage, and its causes are multifactorial.</p><p><strong>Aim: </strong>This study aimed to find the risk and protective factors of miscarriage among women aged 15-49 years in India by using the National Family Health Survey (NFHS-5) data.</p><p><strong>Methods and material: </strong>The data were taken from NFHS-5; 53,560 women aged 15-49 years who had reported either a miscarriage (n = 5104) or livebirth (n = 48,456) during the last 12 months preceding the survey were included in the study.</p><p><strong>Statistical analysis used: </strong>Various sociodemographic, lifestyle, comorbid, and fertility-related factors were considered in the Poisson regression analysis, and adjusted prevalence ratios were obtained.</p><p><strong>Results: </strong>Significant sociodemographic risk factors were age less than 20 years or more than 34 years, urban residence, primary and higher education levels, wealth index middle and above, and occupation as employed. Muslim religion, Scheduled Tribe, and Other Backward Class castes were statistically significant protective factors. Obesity, severe anemia, hypertension, and thyroid disorder were the significant comorbid risk factors, whereas tobacco chewing was the only significant lifestyle risk factor. A higher number of ever-born children was the fertility-related risk factor, whereas the use of intrauterine devices was a significant protective factor for miscarriage.</p><p><strong>Conclusions: </strong>To reduce the incidence of miscarriage in developing countries like India, the respective governments and healthcare providers should develop intervention programs targeting women in well-educated and high-income families.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anju Damu Ade, Visweswara Rao Guthi, Nagaraj Kondagunta, D S Sujith Kumar, Ravisankar Deekala, Chandrasekhar Vallepalli, T V D Prathyusha
{"title":"Improving access to utilize the healthcare services facilitated by ASHAs, ANMs and medical officers of PHC among scheduled tribe pregnant women: An interventional study.","authors":"Anju Damu Ade, Visweswara Rao Guthi, Nagaraj Kondagunta, D S Sujith Kumar, Ravisankar Deekala, Chandrasekhar Vallepalli, T V D Prathyusha","doi":"10.4103/jfmpc.jfmpc_44_24","DOIUrl":"10.4103/jfmpc.jfmpc_44_24","url":null,"abstract":"<p><strong>Introduction: </strong>Early marriages, early childbirth, low BMI and high incidence of anaemia are known factors for high maternal mortality among tribal pregnant women.</p><p><strong>Materials and methods: </strong>This was a mixed method study (qualitative and quantitative) undertaken to evaluate educational intervention package among tribal pregnant women in Chittoor District of Andhra Pradesh State in South India. A baseline household survey with the help of a semi-structured questionnaire was conducted in both intervention group (n = 109) and control group (n = 119) of ST habitations. An educational intervention was implemented through health education approach to bring about awareness and behavioural change among pregnant women regarding healthcare practices and utilization of health services. Qualitative data collection tool included semi-structured FGD. Quantitative data was analysed using SPSS version 26.0. Content analysis was done for qualitative data.</p><p><strong>Results: </strong>The findings of this study show that awareness and utilization with respect to various services facilitated by ASHAs, ANMs and medical officers are improved postintervention among tribal pregnant women, and the various reasons for non-utilization of services were lack of awareness, long distance of health facility, no transportation, poor socio-economic status, inadequate facilities at PHC, etc.</p><p><strong>Conclusion: </strong>This study shows that intervention to improve awareness and health services utilization, and continuous health education should be imparted to all the pregnant mothers. For this healthcare providers like ASHA and ANM and medical officers should be trained and motivated to educate the community.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manash P Baruah, Pankaj Aneja, Shailesh Pitale, Abhijit Bhograj, Ritesh K Agrawala, Ajay Aggarwal, Prasad G Mahadev, Deepaklal C Madhavdas, Sanjay Shah, Mathew John, Muzammil Khan A Pathan, Manjunatha Revanna, Manu Chandrappa, Kiran P Singh
{"title":"Initiation or switch to insulin degludec/insulin aspart in adults with type 2 diabetes in India: Results from a prospective, non-interventional, real-world study.","authors":"Manash P Baruah, Pankaj Aneja, Shailesh Pitale, Abhijit Bhograj, Ritesh K Agrawala, Ajay Aggarwal, Prasad G Mahadev, Deepaklal C Madhavdas, Sanjay Shah, Mathew John, Muzammil Khan A Pathan, Manjunatha Revanna, Manu Chandrappa, Kiran P Singh","doi":"10.4103/jfmpc.jfmpc_1401_23","DOIUrl":"10.4103/jfmpc.jfmpc_1401_23","url":null,"abstract":"<p><strong>Aim: </strong>To investigate clinical outcomes in adults with type 2 diabetes (T2D) after insulin degludec/insulin aspart (IDegAsp) treatment in a real-world setting.</p><p><strong>Methods: </strong>The 26 weeks study involved 1102 adults with T2D who were either initiated with or switched to IDegAsp according to local practice in six countries. It was an open-label, non-interventional study. The primary endpoint was the change in glycosylated haemoglobin (HbA1c) levels from baseline to the end of study (EOS).</p><p><strong>Results: </strong>From India, 185 adults participated in this study with mean age of 58.1 (10.3) years and 14.4 (8.1) years of mean duration of T2D. Mean HbA1c decreased from 9.8% (1.8) at baseline to 8.2% (0.1) at the EOS; change in HbA1c from baseline [95% CI]: -1.6% (0.1) [-1.8; -1.4], <i>P</i> < 0.0001. There was a significant reduction in mean fasting plasma glucose (FPG) level from 190.0 (65.8) mg/dl at baseline to 141.9 (4.3) mg/dl at EOS; change in FPG from baseline [95% CI]: -52.2 (4.3) mg/dl [-60.7; -43.7], <i>P</i> < 0.0001. There was a numerical reduction in resource utilization related to diabetes and its complications and hypoglycaemic episodes. From baseline to EOS, the participants with outpatient visits (72 to 32) and workdays missed (2 to 0) decreased. Additionally, the number of patient-reported non-severe hypoglycaemic (47 to 8) and severe hypoglycaemic (4 to 1) episodes decreased as well.</p><p><strong>Conclusion: </strong>Initiation or switching to IDegAsp led to improvement in glycaemic control in real-world population of Indian adults with T2D. This was accompanied by a numerical reduction in resource utilization and patient-reported hypoglycaemia. <b>Clinical trial registration:</b> NCT04042441.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}