Journal of Family Medicine and Primary Care最新文献

{"title":"Comparative study of the early predictive values of the heart rate variability parameters, neurophysiological and metabolic markers for the early detection of type two diabetic visceral autonomic neuropathy.","authors":"Omar A Alfaifi, Syed S Habib, Khalid Al-Regaiey, Muhammad Iqbal, Thamir Al-Khlaiwi, Aida A Korish, Mohamed M Khalifa","doi":"10.4103/jfmpc.jfmpc_320_26","DOIUrl":"10.4103/jfmpc.jfmpc_320_26","url":null,"abstract":"<p><strong>Background: </strong>Early detection of diabetic neuropathy is crucial for both health and economic stability. Clinically, timely diagnosis and intervention can prevent the progression to severe complications, significantly preserving a patient's quality of life and mobility. Economically, this proactive approach reduces the long-term burden on healthcare systems.</p><p><strong>Objective: </strong>To assess and compare the early predictive value of different heart rate variability (HRV) parameters for the early detection of type 2 diabetes mellitus (T2DM)-induced neuropathy. And to evaluate their correlation with the novel serum parameters, Brain-Derived Neurotrophic Factor (BDNF), and Nesfatin-1.</p><p><strong>Results: </strong>HRV parameters showed early changes in type 2 diabetics, even before the development of overt neuropathy. We investigated early changes in heart rate variability parameters in a cohort of type 2 diabetic patients compared to age-matched healthy controls. We found that heart rate variability changes occur even before the development of neuropathic symptoms, suggesting that it can be used as an early detection measure in diabetic neuropathy. Also, we measured serum brain-derived neurotrophic factor and Nesfatine-1 in all study subjects and found brain-derived neurotrophic factor to show a stronger correlation with the HRV parameters than Nesfatine-1. This correlation was more significant in the diabetic patients than the healthy controls.</p><p><strong>Conclusion: </strong>We concluded that the HRV metrics can serve as sensitive early biomarkers for detecting type 2 diabetes mellitus-induced neuropathy, especially cardiac autonomic neuropathy, even in T2DM patients without clinical signs of neuropathy. Additionally, BDNF is superior to Nesfatin-1 for early detection of visceral autonomic neuropathy.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2267-2276"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: A study on knowledge, attitude and practices (KAP) towards adult immunizations among health care professionals.","authors":"Akhil R Nair","doi":"10.4103/jfmpc.jfmpc_417_26","DOIUrl":"10.4103/jfmpc.jfmpc_417_26","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2359-2360"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teleconsultation and proxy visits, and tele-diabetes education: The need of the hour for managing gestational diabetes mellitus.","authors":"Felix K Jebasingh, Nihal Thomas","doi":"10.4103/jfmpc.jfmpc_2172_25","DOIUrl":"10.4103/jfmpc.jfmpc_2172_25","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2349-2350"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of dapsone nonjudicially in acne: Can this lead to resistance in leprosy? Comments on safety and effectiveness of topical dapsone in acne treatment: A review.","authors":"Sahjid Mukhida, Prachi Athavale","doi":"10.4103/jfmpc.jfmpc_505_26","DOIUrl":"10.4103/jfmpc.jfmpc_505_26","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2355-2356"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Almutairi <i>et al</i>.-Understanding the boundaries of Human papillomavirus vaccine protection.","authors":"Jay Sakore, Suman Ray","doi":"10.4103/jfmpc.jfmpc_2094_25","DOIUrl":"10.4103/jfmpc.jfmpc_2094_25","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2372-2373"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Can depression, anxiety, and stress predict smoking?","authors":"Parthkumar Dhameliya","doi":"10.4103/jfmpc.jfmpc_530_26","DOIUrl":"10.4103/jfmpc.jfmpc_530_26","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2353-2354"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escalating threat of multidrug-resistant bacteria: Insights from a low-middle income country setting.","authors":"Amarpreet Kaur, Veenu Gupta, Menal Gupta, Parshotam Lal Gautam","doi":"10.4103/jfmpc.jfmpc_2138_25","DOIUrl":"10.4103/jfmpc.jfmpc_2138_25","url":null,"abstract":"<p><strong>Background: </strong>Infections due to multidrug-resistant bacteria have become a global threat, increasing morbidity, mortality and healthcare costs. The main drivers for antimicrobial resistance are indiscriminate antimicrobial use, poor drug quality and lack of antimicrobial stewardship programs.</p><p><strong>Aim: </strong>This one-year prospective study aimed to determine the prevalence of multidrug-resistant bugs among hospital-acquired infections (HAI) in a low-middle income country.</p><p><strong>Methods: </strong>Depending on the clinical suspicion, various samples were processed as per standard protocols. Multiple antibiotic resistance (MAR) index was calculated, and isolates were characterized into multi-/extensively/pan-drug resistant isolates (MDR/ XDR/ PDR).</p><p><strong>Results: </strong>Nosocomial bacterial infections were identified in 13% patients which yielded 165 isolates (85% Gram-negative). 89.6% of these GN isolates were MDR, 77.5% of which were XDR and 2.8% PDR.</p><p><strong>Conclusion: </strong>By prioritizing infection control measures, early detection and judicious empirical antimicrobial use, healthcare facilities can significantly reduce the risk of HAIs and ensure a safer environment for patients.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2238-2242"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical epidemiology and outcome of paraquat poisoning - A 12-year patient record based observational study.","authors":"Abinash Panda, Anand Acharya","doi":"10.4103/jfmpc.jfmpc_2044_24","DOIUrl":"10.4103/jfmpc.jfmpc_2044_24","url":null,"abstract":"<p><strong>Introduction: </strong>Paraquat (dipyridylium) is1-methyl-4-(1-methylpyridin-1-ium-4-yl) pyridin-1-ium a quaternary ammonium herbicide. It is a highly toxic herbicide primarily used to control grass and weeds. World health organization Recommended Classification of Pesticides by Hazard identifies paraquat as class II moderately hazardous herbicide. Due to the lack of effective treatments to be used in humans for paraquat poisoning the mortality is high ranges from 60% to 80%. Present study has been designed to analyses all cases of paraquat poisoning admitted in department of emergency medicine Konaseema institute of medical science Amalapuram Andhra Pradesh, to know the clinicoepidemiological pattern and outcome of treatment.</p><p><strong>Material and method: </strong>This is a retrospective case record-based study conducted in the department of emergency medicine and general medicine Konaseema institute of medical science and research foundation Amalapuram India.</p><p><strong>Result: </strong>The amount of poison consumed was significantly higher among non-survivor (22.2 ± 12.2 ml vs 154.4 ± 99.0 ml). Fatality was more common, who has consumed paraquat with alcohol then those who has consumed without alcohol that was 72% patients.</p><p><strong>Discussion and conclusion: </strong>From present study we can conclude that amount of paraquat consumed and time required to visit to the hospital (hrs) was significantly associate with higher incidence of death. Elevated liver enzyme and lung damage as visible in chest x ray is important predictor for mortality.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2215-2219"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of dentist as a patient towards restorative dental treatment; A caries risk assessment study-Case report.","authors":"Khalid L Alrashedi","doi":"10.4103/jfmpc.jfmpc_355_26","DOIUrl":"10.4103/jfmpc.jfmpc_355_26","url":null,"abstract":"<p><p>A patient aged around 52 years visited Faculty dental centre, Al Baha University with pain and discomfort in chewing. He was dentist by profession with multiple restoration with a perception of deep caries and further to root canal treatment. He had a complaint of pain or discomfort while chewing, as he was dentist in profession, he had teeth restored due to caries from many years back. On assessment of caries risk, it was observed there was no new incidence of caries which was supportive with his lifestyle changes with disciplined eating and balanced diet with micro and macro nutrients. The patient's perception was changed later with self-evaluation of caries status. There was cessation of caries or further progress in many teeth which is a good indication for oral and general health.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2328-2330"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13466069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices toward screening of colorectal cancer among adults in Kuwait primary health care centers.","authors":"Mahmood Alawainati, Sara N Alshtaily, Rawan A Almutairi, Aisha Alshammari, Ghalla Alotaibi, Sarah Kh Alrashidi, Salma Alotaibi, Lujain Alotaibi, Eissa Althefairi, Khaled Alsubaiei","doi":"10.4103/jfmpc.jfmpc_2264_25","DOIUrl":"10.4103/jfmpc.jfmpc_2264_25","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of colorectal cancer has been increasing both globally and in Kuwait. Early identification and treatment are essential to reduce its morbidity and mortality. This study aimed to assess the knowledge, attitudes, and practices toward screening of colorectal cancer among adults in Kuwait.</p><p><strong>Methods: </strong>A cross-sectional study was conducted across six governorates in Kuwait, including patients aged 18 years and above. Data were collected using an interview-administered questionnaire. Descriptive and inferential analyses were performed to evaluate participants' knowledge, attitudes, and practices regarding colorectal cancer screening.</p><p><strong>Results: </strong>A total of 367 respondents were included; most were females (59.7%), Kuwaiti (85.4%), and university graduates (63.2%). Regarding the knowledge about colorectal cancer, although 60.8% of participants had heard of colorectal cancer screening, 35.7% of the respondents showed poor knowledge and only 22.6% had good knowledge. Older patients (<i>P</i> = 0.040), patients with higher educational levels (<i>P</i> < 0.001), and those with prior awareness of screening (<i>P</i> < 0.001) showed better knowledge about colorectal cancer. Participants who had heard of screening showed significantly higher behaviors (<i>P</i> = 0.006) and attitude scores (<i>P</i> = 0.008). Less than 10% underwent colon cancer screening (9.5%), with embarrassment (37.1%) and perceived cultural constraints (17%) being the most common barriers to colonoscopy.</p><p><strong>Conclusion: </strong>The study demonstrated low levels of knowledge and screening uptake, particularly among younger participants, those with lower educational levels, and individuals who had not undergone screening. Nonetheless, participants showed positive attitudes toward colorectal cancer screening. Enhancing knowledge through awareness campaigns and targeted public health initiatives is essential.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"15 6","pages":"2284-2289"},"PeriodicalIF":1.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13465746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}