Journal of Family Medicine and Primary Care最新文献

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Bridging the gaps in Janani Suraksha Yojana: Addressing challenges through innovative solutions. 弥合Janani Suraksha Yojana的差距:通过创新解决方案应对挑战。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_2121_24
Angeline Hephzibah Pauljoseph, Priyadharshini Ragavane, Priyanga Chandrashekar
{"title":"Bridging the gaps in Janani Suraksha Yojana: Addressing challenges through innovative solutions.","authors":"Angeline Hephzibah Pauljoseph, Priyadharshini Ragavane, Priyanga Chandrashekar","doi":"10.4103/jfmpc.jfmpc_2121_24","DOIUrl":"10.4103/jfmpc.jfmpc_2121_24","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"3082-3083"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Lyme disease presenting as Guillain-Barré syndrome in Jeddah, Saudi Arabia. 病例报告:在沙特阿拉伯吉达出现以格林-巴罗综合征为表现的莱姆病。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_2138_24
Heba Abbas Ezmeirlly
{"title":"Case report: Lyme disease presenting as Guillain-Barré syndrome in Jeddah, Saudi Arabia.","authors":"Heba Abbas Ezmeirlly","doi":"10.4103/jfmpc.jfmpc_2138_24","DOIUrl":"10.4103/jfmpc.jfmpc_2138_24","url":null,"abstract":"<p><p>Lyme disease (LD) is the most common vector-borne disease in the United States; however, it is very rare in Saudi Arabia. If left untreated, the disease can lead to neuroborreliosis, which can rarely present as Guillain-Barré-like syndrome. We propose the possible diagnosis of an unusual presentation of neuroborreliosis in a patient with a previous presumed diagnosis of Guillain-Barré syndrome (GBS) in Jeddah, Saudi Arabia. Early clinical suspicion and accurate testing can lead to proper diagnosis and case management. Cases of LD in Saudi Arabia are limited in the literature. The association between GBS and LD is very uncommon, although there are anecdotal reports in the literature. We would like to raise awareness, among clinicians, including primary care physicians regarding the possibility of LD in Jeddah, Saudi Arabia.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"3032-3036"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological pattern of cleft lip and palate under Rashtriya Bal Swasthya Karyakram project in the state of Bihar: A cross-sectional hospital-based study. 比哈尔邦Rashtriya Bal Swasthya Karyakram项目下唇腭裂的流行病学模式:一项基于医院的横断面研究
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_1643_24
Shria Datta, Veena Kumari Singh
{"title":"Epidemiological pattern of cleft lip and palate under Rashtriya Bal Swasthya Karyakram project in the state of Bihar: A cross-sectional hospital-based study.","authors":"Shria Datta, Veena Kumari Singh","doi":"10.4103/jfmpc.jfmpc_1643_24","DOIUrl":"10.4103/jfmpc.jfmpc_1643_24","url":null,"abstract":"<p><strong>Purpose: </strong>There is a paucity of literature on the incidence and distribution of cleft lip and palate cases in the population of Bihar leading to an unmeasured gap in the status of cleft patients in this part of the country. The present study assessed the pattern of cleft cases in the community reported at the largest cleft center in the state under Rashtriya Bal Swasthya Karyakram (RBSK).</p><p><strong>Methodology: </strong>The study was a questionnaire-based, cross-sectional study conducted over one month at a tertiary care center in Bihar. It included all patients with cleft lip and palate, below the age of 5 years, either isolated or combined, attending the OPD or admitted to the ward in the plastic surgery department.</p><p><strong>Results: </strong>The demographic distribution of cleft lip patients included 16% cleft lip, 6% cleft lip with alveolus, 2% microform, 46% cleft palate, and 30% cleft lip with cleft palate. Bilateral cases contributed to 42% of all cases. Male to female ratio was 3:2 with a ratio of 5:3 in cleft lip, 2:1 in cleft lip with alveolus, 0:1 in microform, 12:11 in cleft palate, and 11:4 in cleft lip with palate patients, respectively.</p><p><strong>Conclusion: </strong>The incidence and distribution of cleft lip and palate were found to be similar to the studies done in other parts of India. Registration of cleft cases under the RBSK project of the central government has led to affordable treatment for poor patients in the state of Bihar.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"2842-2846"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malnutrition: The silent crisis: Collation of anthropometric measures of nutritional status in children under 2 years of age: A hospital-based case-control study. 营养不良:无声的危机:整理2岁以下儿童营养状况的人体测量测量:一项基于医院的病例对照研究。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_296_25
Vibha V Gosalia, Rujal D Bhitora, Harsha M Solanki
{"title":"Malnutrition: The silent crisis: Collation of anthropometric measures of nutritional status in children under 2 years of age: A hospital-based case-control study.","authors":"Vibha V Gosalia, Rujal D Bhitora, Harsha M Solanki","doi":"10.4103/jfmpc.jfmpc_296_25","DOIUrl":"10.4103/jfmpc.jfmpc_296_25","url":null,"abstract":"<p><strong>Background: </strong>Even if malnourishment is a life-threatening condition, there is not a single 'gold standard' anthropometric measurement to diagnose child undernutrition. Hence, this case-control study compared different anthropometric measurements to assess child malnutrition.</p><p><strong>Methodology: </strong>Using WHO's MGRS Criteria 2006, cases and controls were selected and matching was done for age and sex. The calculated sample size was 154 (77 cases and 77 controls), assuming a two-sided confidence level of 95%, power of the study 80% and a case-control ratio of 1:1, 10% nonresponse rate and lack of exclusive breastfeeding taken as an exposure factor. The Z-scores (WFH, HFA, WFA) were calculated using WHO Anthro software. The sensitivity, specificity, and accuracy were calculated for each anthropometric measure. Multiple linear regressions for comparison of MUAC against WFA and HFA Z-scores were performed. The Composite Index of Anthropometric Failure (CIAF) was also calculated.</p><p><strong>Results: </strong>Even among controls, 26% were severely stunted and 14.2% were severely underweight. The sensitivity MUAC to diagnose severely underweight and severely stunted children was 84.2% and 58.5%, respectively. Multiple Linear regression found positive association of WAZ and MUAC. Out of 154 children, 114 (74%) had anthropometric failure.</p><p><strong>Conclusions: </strong>The combined anthropometric measurements approach to screen chronic malnutrition in the community is strongly recommended. There is a need to develop software in the local language that is simple and feasible to use by grass route workers for early diagnosis of SAM children.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"2821-2825"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of enhanced quantitative urine culture technique for isolation of uro-pathogens in children. 强化定量尿液培养技术在儿童尿路病原体分离中的应用。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_260_25
Kavita Gupta, Prashanth Purushotham, Nischitha Vallurupalli, Bilal Malik, Saroj Dash
{"title":"Utility of enhanced quantitative urine culture technique for isolation of uro-pathogens in children.","authors":"Kavita Gupta, Prashanth Purushotham, Nischitha Vallurupalli, Bilal Malik, Saroj Dash","doi":"10.4103/jfmpc.jfmpc_260_25","DOIUrl":"10.4103/jfmpc.jfmpc_260_25","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTIs) are the most common bacterial infection worldwide. Symptoms of UTI in children is vague & non-specific and mostly underdiagnosed Standard urine culture (SUC) is the gold standard for detecting uropathogens but the clinical correlation and its implication in initiating antimicrobial therapy continue to be a question for decision-making. Enhanced quantitative urine culture (EQUC) was developed to overcome these limitations. However, its utility to diagnose paediatric UTI has not been well explored, necessitating the need for new diagnostic methods. The study was conducted to evaluate the utility of EQUC for isolation of bacterial uropathogens in children.</p><p><strong>Method: </strong>A prospective observation study was conducted and urine samples were collected and processed using both SUC and EQUC techniques. Microbial identification was performed using phenotypic characteristics and biochemical tests. VITEK 2 SYSTEM was used for identification and antimicrobial susceptibility testing whenever required.</p><p><strong>Results: </strong>A total of 156 samples were collected from 84 patients and subjected to SUC and EQUC techniques. SUC identified 50 positive samples (32.05%), while EQUC identified 87 positive samples (55.7%). EQUC recovered 25% more organisms compared to SUC. Escherichia coli was the most common organism isolated in both the techniques. Management of patients considering EQUC results showed better recovery in all age groups especially for midstream urine.</p><p><strong>Conclusion: </strong>The EQUC technique demonstrated higher recovery rates of uro-pathogens compared to the SUC, making it a valuable tool for diagnosing paediatric UTIs.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"2837-2841"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-medication - A self-inflicted harm in medical students. 自我治疗-医学生自我伤害。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_1654_24
Sameena Khan, Sahjid Mukhida
{"title":"Self-medication - A self-inflicted harm in medical students.","authors":"Sameena Khan, Sahjid Mukhida","doi":"10.4103/jfmpc.jfmpc_1654_24","DOIUrl":"10.4103/jfmpc.jfmpc_1654_24","url":null,"abstract":"","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"3057-3058"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence studies of human brucellosis in pyrexia of unknown origin (PUO) patients by various diagnostic modalities. 通过各种诊断方式对不明原因发热(PUO)患者布鲁氏菌病的血清患病率进行研究。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_1685_24
Usha Verma, Prabhu Prakash
{"title":"Seroprevalence studies of human brucellosis in pyrexia of unknown origin (PUO) patients by various diagnostic modalities.","authors":"Usha Verma, Prabhu Prakash","doi":"10.4103/jfmpc.jfmpc_1685_24","DOIUrl":"10.4103/jfmpc.jfmpc_1685_24","url":null,"abstract":"<p><strong>Background: </strong>Brucellosis is a re-emerging zoonosis with global distribution. In India, it remains common but often neglected. In Rajasthan, where agriculture is prevalent, frequent contact with infected animals such as goats, sheep, and cattle leads to brucellosis-like clinical symptoms. This study aims to determine the seroprevalence of brucellosis in patients presenting with PUO (Pyrexia of Unknown Origin).</p><p><strong>Materials and methods: </strong>This cross-sectional observational study was conducted on 170 suspected PUO patients from January 2019 to December 2019 in Western Rajasthan to detect the seroprevalence of Brucella. Patients with Widal, MP, and RA test positive were kept in exclusion criteria. All samples were tested by using screening test: Stained Febrile Antigen for Brucella abortus and Brucella melitensis by using, RBPT, Standard tube Agglutination Method (STAT). All samples were processed for ELISA IgM and ELISA IgG titers using Cal biotech kit, and the results were analyzed statistically.</p><p><strong>Results: </strong>Out of 170 samples, 9 (5.29%), 8 (4.70%), and 11 (6.47%) were positive by RBPT, SAT and STAT, respectively, while 14 (8.23%) positive by ELISA. Positivity was higher in males 9 out of 14, urban area 8 out of 14, >60 years 5 (22.72%) of age, occupational risk of animal contact was in 10 (15.55%). Out of 170 cases had histories of animal contact 170 (100%), consumption of raw dairy products 23 (13.52%), and meat consumption 17 (10%). The most common clinical feature was fever 125 (73.52%) followed by headache and back pain. ELISA IgM and IgG antibodies were positive in 3 (1.76%) and 7 (4.11%) patients, respectively, and both ELISA IgM and IgG were positive in 4 (2.35%) patients.</p><p><strong>Conclusion: </strong>Brucellosis is prevalent in Western Rajasthan, due to its dry climatic conditions. It should be considered in PUO diagnosis, with all preventive measures applied. A safe and effective vaccine in human is not yet available. Prevention relies on public awareness, safe livestock practices, and health-veterinary cooperation.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"2810-2814"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep hygiene practices and its impact on sleep quality and mood. 睡眠卫生习惯及其对睡眠质量和情绪的影响。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_133_25
Ruchi Singh, Moutrisha M Roy, Anzar Alvi, Sunil Chouhan, Abhishek Goyal, Nirendra K Rai
{"title":"Sleep hygiene practices and its impact on sleep quality and mood.","authors":"Ruchi Singh, Moutrisha M Roy, Anzar Alvi, Sunil Chouhan, Abhishek Goyal, Nirendra K Rai","doi":"10.4103/jfmpc.jfmpc_133_25","DOIUrl":"10.4103/jfmpc.jfmpc_133_25","url":null,"abstract":"<p><strong>Introduction: </strong>Shift in circadian clock of adolescence with delayed bedtime and early awakening to catch morning school effects their sleep. Present study elucidated sleep hygiene practices of school-going adolescents and explored its association with their sleep quality and mood.</p><p><strong>Methods: </strong>Students of 6<sup>th</sup> to 12<sup>th</sup> grade were enrolled after requisite permissions, parental consent, and written informed assent from students. Standardized questionnaires were used to evaluate for sleep hygiene practices-Adolescent Sleep Hygiene Scale (ASHS), sleep quality- Pittsburgh Sleep Quality Index (PSQI), daytime sleepiness-Pediatric Daytime Sleepiness Scale (PDSS) and mood (DASS-21-Depression Anxiety Stress Scale-21). CTRI/2022/06/043556 is the study number in Clinical Trial Registry of India.</p><p><strong>Results: </strong>Adolescents with mean age 14.28 ± 1.86 years, including 48.7% (479) males and 51.2% (503) females participated in this study. Mean sleep hygiene score was 4.37 ± 0.60, with no difference between males and females. On ASHS subscales comparison, females had poorer sleep quality (0.009), higher daytime sleepiness (<i>P</i> = 0.001), poorer cognitive/emotional factor (<i>P</i> = 0.001) and higher depression, anxiety, and stress (DASS-21). Young adolescents (10-14 years; N = 528) had better total sleep hygiene scores (<i>P</i> = 0.016), better bedtime routine, cognitive/emotional factor (<i>P</i> = 0.001), but had poor sleep environment factor (<i>P</i> = 0.001). Younger adolescents also exhibited better quality of sleep (<i>P</i> = 0.003), lesser daytime sleepiness, and lesser mood derangements compared to older adolescents (15-19 years; N = 453). Sleep hygiene scores showed a significantly negative correlation with mood and sleep quality.</p><p><strong>Conclusion: </strong>A clear relationship between sleep hygiene practices, mood and sleep quality has been observed among adolescents. Young adolescents who followed better sleep hygiene practices had lesser mood derangements and better sleep quality. Though ASHS scores were same among both genders but females had poor sleep quality, higher daytime sleepiness and mood.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"2966-2973"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To study effects of metformin on thyroid functions in type-2 diabetes mellitus in patients attending OPD at Government Medical College, Bidar. 目的:探讨二甲双胍对2型糖尿病门诊患者甲状腺功能的影响。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_75_25
Prashant Patil, Sachin Gudage, Mahesh B Tondare, Sangamesh B Tondare, Praveen Ganganahalli
{"title":"To study effects of metformin on thyroid functions in type-2 diabetes mellitus in patients attending OPD at Government Medical College, Bidar.","authors":"Prashant Patil, Sachin Gudage, Mahesh B Tondare, Sangamesh B Tondare, Praveen Ganganahalli","doi":"10.4103/jfmpc.jfmpc_75_25","DOIUrl":"10.4103/jfmpc.jfmpc_75_25","url":null,"abstract":"<p><strong>Introduction: </strong>Metformin is one of the most used diabetes treating agents and has proved to be very effective, with a wide spectrum of efficacy, safety as well as being as agent that works at different spots in diabetes pathogenesis paradigm. Recently it has been reported that metformin is able to interfere with thyroid hormone profile, by decrease in the serum levels of thyrotropin (TSH) to subnormal levels in hypothyroid patients in stable levothyroxine (L-T4) treatment.</p><p><strong>Objectives: </strong>To study and compare the effect of metformin and non-metformin composed treatment of type-2 diabetes mellitus on thyroid functions.</p><p><strong>Methods: </strong>Comparative observational study was conducted among diabetic patients taking metformin as study and taking antidiabetic other than metformin as control group and analysed for the thyroid profile (TSH, fT3, fT4). Total 70 patients including both group from tertiary care teaching hospital were enrolled in to the study after taking informed verbal consent.</p><p><strong>Observations: </strong>The present study demonstrates that while the study group's fT3 and fT4 levels were lower than those of the control group, diabetic patients on non-metformin medication had statistically higher TSH (2.05 ± 0.15 mIU/mL vs. 2.35 ± 0.18 mIU/mL) levels than those taking metformin.</p><p><strong>Conclusion: </strong>Thyroid-stimulating hormone (TSH) levels may be somewhat or not at all decreased by metformin. Thyroid function monitoring is crucial for diabetic patients using metformin, particularly if they already have thyroid problems.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"2941-2944"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A curious case of hypercalcemic crisis in sarcoidosis: The missing link beyond 1,25(OH)2D. 结节病高钙血症危象的一个奇怪病例:125 (OH)2D以外的缺失环节。
IF 1
Journal of Family Medicine and Primary Care Pub Date : 2025-07-01 Epub Date: 2025-07-21 DOI: 10.4103/jfmpc.jfmpc_203_25
Ajaz Qadir, Raiz A Misgar, Ankit Chhabra, Javid A Sofi
{"title":"A curious case of hypercalcemic crisis in sarcoidosis: The missing link beyond 1,25(OH)<sub>2</sub>D.","authors":"Ajaz Qadir, Raiz A Misgar, Ankit Chhabra, Javid A Sofi","doi":"10.4103/jfmpc.jfmpc_203_25","DOIUrl":"10.4103/jfmpc.jfmpc_203_25","url":null,"abstract":"<p><p>Sarcoidosis is a chronic granulomatous disease affecting various organs and is one of the causes of parathyroid hormone (PTH)-independent hypercalcemia. However, sarcoidosis <i>per se</i> presenting with severe hypercalcemia is very rare. We present a case with an initial presentation of hypercalcemic crisis (corrected calcium of 16.8 mg/dl) and suppressed iPTH (7.2 pg/ml). Upon thorough evaluation, including biochemical, radiology, and histopathology, of the right inguinal lymph node biopsy, extrapulmonary sarcoidosis was diagnosed. The patient was initiated on glucocorticoid therapy, leading to clinical and biochemical improvement. This case is characterized by hypophosphatemia and inappropriately normal 1,25-dihydroxy vitamin D level, a finding rarely reported in the literature. Hypercalcemia may be due to the overproduction of bone-resorbing cytokines, INF-α, IL-6, IL-1β, and PTHrP.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"14 7","pages":"3028-3031"},"PeriodicalIF":1.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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