Journal of Feline Medicine and Surgery最新文献

{"title":"Lack of association between inner ear FLAIR suppression on MRI and laterality of clinical signs in feline idiopathic vestibular syndrome.","authors":"Magdalena Putzer, Steven De Decker, Rodrigo Gutierrez Quintana, Anna M Mosel, Holger A Volk","doi":"10.1177/1098612X261445137","DOIUrl":"10.1177/1098612X261445137","url":null,"abstract":"<p><p>ObjectivesThe underlying aetiology of feline idiopathic vestibular syndrome (IVS) remains unclear. In humans, specific MRI sequences are used to demonstrate differences in endolymph composition between unaffected and affected inner ears. A previous study in dogs with IVS reported that in 93% of cases, the clinically affected side exhibited a lower degree of fluid-attenuated inversion recovery (FLAIR) suppression, which may indicate altered endolymph composition, potentially due to increased protein concentration. The objective of this study was to determine whether similar changes can be observed in cats with IVS.MethodsMedical records from three referral hospitals were reviewed. Cats were included if they had a diagnosis of IVS, clear lateralisation of clinical signs and had undergone MRI of the brain. Regions of interest (ROIs) were manually outlined to define the inner ear on T2-weighted and FLAIR images. The FLAIR suppression ratio for each ear was assessed by calculating the average signal intensity across both imaging sequences. Any unilateral reduction in suppression was compared with the direction of clinical signs. ROI size was also measured to evaluate potential swelling or collapse of inner ear structures.ResultsA total of 25 cats met the inclusion criteria. No correlation was found between the clinically affected side and the degree of FLAIR suppression. In 11/25 cats, the identified abnormal side did not correspond to the lateralisation of clinical signs, whereas in 14/25 cats it did. ROI measurements likewise showed no consistent association with the clinically affected side.Conclusions and relevanceIn the present cohort, these findings indicate that cats with IVS did not show a consistent association between clinical lateralisation and MRI-detectable endolymph changes, supporting the possibility of a different underlying pathophysiology compared with dogs.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261445137"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the incidence of haematuria following the placement of subcutaneous ureteral bypass devices in 18 cats (2016-2022).","authors":"Ben Lloyd-Bradley, Rachel Hattersley","doi":"10.1177/1098612X261461615","DOIUrl":"10.1177/1098612X261461615","url":null,"abstract":"<p><p>ObjectivesThe aim of the present study was to evaluate the incidence of postoperative haematuria in cats treated with a subcutaneous ureteral bypass (SUB) device for the management of benign ureteral obstruction.MethodsMedical records from a single referral institute were retrospectively searched for cats that underwent placement of a SUB device for the management of benign ureteral obstruction between June 2016 and June 2022. Signalment, history, diagnostic imaging findings, surgery duration, and pre- and postoperative clinicopathological data were recorded.ResultsIn total, 18 cats presented with placement of de novo SUB devices: 14 unilateral SUBs and four bilateral SUBs. All 18 (100%) cats developed microscopic haematuria postoperatively. Median time to detection of microscopic haematuria was 1 month (range 1-11), with 16/18 (89%) detected on the first postoperative urinalysis. In total, 14 (78%) cats had persistent microscopic haematuria, two (11%) had recurrent microscopic haematuria and a further two (11%) cats had recurrent persistent microscopic haematuria. Severe haematuria (⩾50 red blood cells per high-power field) was identified in 13 (72%) cats; however, gross haematuria as a clinical sign was infrequently reported (n = 2/18, 11%). The median time to first detection of severe haematuria was 1 month (range: 1-31 months). Persistent severe haematuria was documented in seven cats, with a median duration of persistence of 17 months (range 5-31). Haematuria without a positive urine culture at any time point was present in 11/18 (61%) cats.Conclusions and relevanceIn this study population, postoperative persistent microscopic haematuria was a frequent finding in cats after SUB device placement. Further studies are necessary to understand if microscopic haematuria is a clinically relevant finding, and to further understand the aetiology of haematuria in such patients.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261461615"},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of analytical characteristics of the Vcheck C10 point-of-care chemistry analyser for feline sera.","authors":"Jae-Ha Jung, Eunseo Goh, Yeji Chun, Hyerin Lee, Jiwoo Baek, Yeongbae Seo, Yoonseo Choi, Yongbaek Kim","doi":"10.1177/1098612X261456678","DOIUrl":"10.1177/1098612X261456678","url":null,"abstract":"<p><p>ObjectivesThe aim of the present study was to characterise the analytical performance of the Vcheck C10 dry chemistry analyser and evaluate its comparability with a reference wet chemistry system (AU480) in feline serum samples.MethodsAnalytical precision was determined by within-run and between-run testing using pooled serum and commercial quality control materials. Agreement between analysers for 16 biochemical analytes was examined using Passing-Bablok regression and Bland-Altman analysis using 57 feline serum samples. Total observed error (TE_obs) was assessed against published allowable total error (TE_a) criteria to evaluate analytical quality.ResultsAcceptable precision was observed for the majority of analytes, although total bilirubin (TBIL) exhibited increased variability at lower concentration ranges. Regression analysis demonstrated strong linear associations for most analytes (<i>r</i> = 0.82-0.99). Bland-Altman analysis indicated that 94.4-98.0% of paired results were within the limits of agreement. Comparison of TE_obs with TE_a limits identified acceptable analytical performance for 10 analytes, whereas blood urea nitrogen, calcium, creatinine, TBIL and total protein exceeded allowable limits.Conclusions and relevanceThe Vcheck C10 demonstrated reliable analytical precision and favourable correlation with the reference analyser for most analytes in feline serum, supporting its utility in point-of-care testing in primary practice. Nevertheless, analyte-specific limitations in agreement with the wet chemistry reference method were identified for certain analytes, emphasising method-consistent interpretation and the use of analyser-specific reference intervals in clinical decision-making and longitudinal monitoring.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261456678"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplex fluorescent immunocytochemistry is a complementary test for the diagnosis of feline infectious peritonitis: a diagnostic clinical trial.","authors":"Samantha Jm Evans, Petra Cerna, Benjamin E Curtis, Wendy M Novicoff, Nile L Stoltz, Laura Ashton, Maggie Valentine, Sophie Epstein, Alora LaVoy, Gregg Dean, Kelly S Santangelo","doi":"10.1177/1098612X261445145","DOIUrl":"10.1177/1098612X261445145","url":null,"abstract":"<p><p>ObjectivesFeline infectious peritonitis (FIP) is a common and treatable viral disease of cats for which there is no single, reliable ante-mortem diagnostic test. The goals of this study were to evaluate the diagnostic accuracy (sensitivity, specificity and positive and negative predictive values) of multiplex fluorescent immunocytochemistry (MF-ICC) for the diagnosis of FIP in clinical patients under field conditions, and to directly compare that accuracy to the diagnostic performance of other commonly used assays.MethodsCats presenting with clinical signs compatible with FIP were enrolled at two academic veterinary teaching hospitals and tested using a combination of complete blood count, biochemistry, fluid analysis, cytology, MF-ICC, serology and RT-PCR. Antibodies against both feline coronavirus and vimentin, as well as a nuclear stain, were used for the MF-ICC assay. Outcomes were determined by necropsy with histopathology and immunohistochemistry, response to antiviral therapy and/or clinical follow-up.ResultsA total of 84 cases comprising 58 cats with FIP and 26 without FIP (control cases) were included in this study. Using a threshold of one dual-expressing mononuclear cell or more, MF-ICC was found to have 77% sensitivity, 81% specificity, 92% positive predictive value and 53% negative predictive value in this cohort. Using a threshold of two or more dual-expressing mononuclear cells improved specificity but reduced both sensitivity and overall diagnostic accuracy. MF-ICC was more sensitive, but less specific, in effusion fluids over tissues. MF-ICC resulted in the highest overall diagnostic accuracy (78%) when compared with serology (75%), RT-PCR (69%) and serum albumin:globulin ratio (76%).Conclusions and relevanceMF-ICC is an imperfect test but is considered complementary to other commonly used ante-mortem diagnostic assays for FIP. It can be used alongside RT-PCR and other minimally invasive tests to build a case for FIP in an individual patient.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261445145"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new generic feline quality of life (FelQoL) questionnaire: part 1 - development and validation.","authors":"Luca Albergante, Anna Harding, Tammie King, Tanya Schoeman, Emily Blackwell, Nathaniel Spofford, Nicole Einerson, Ellie Davey, Janet Patterson-Kane, Luisa De Risio","doi":"10.1177/1098612X261448700","DOIUrl":"10.1177/1098612X261448700","url":null,"abstract":"<p><p>ObjectivesThe central aim of this study was to develop a questionnaire that can be used to assess the combined emotional and physical wellbeing of pet cats - that is, to evaluate their quality of life (QoL). Using answers to this questionnaire, we then aimed to develop a statistically validated and robust algorithm (an instrument) to derive a set of reproducible QoL dimensions for evaluating and comparing the wellbeing of cats.MethodsResponses from 1324 cat owners in the USA and UK were collected and used to identify key cat QoL dimensions using well-established approaches. Statistical analysis was used to evaluate the extent to which our algorithm produced comparable results when used across different populations of cats (validity and robustness). Furthermore, data from 385 cats were collected again after 2 weeks to evaluate the extent to which scores of the QoL dimensions varied over time (reliability).ResultsA data-driven analysis was used to develop an instrument with seven QoL dimensions across daytime and mealtime behaviours: Active, Talkative, Satisfied, Relaxed, Mobile, Appetite and Sociable. Statistical analysis confirmed the robustness, validity and reliability of the instrument.Conclusions and relevanceThe Feline Quality of Life questionnaire and its associated instrument evaluated cat QoL across seven dimensions and allowed exploration of wellbeing across different cat demographics and health conditions. The questionnaire can be used by pet owners interested in better understanding the wellbeing of their cat and by veterinary professionals to gather information that complements in-clinic health assessments.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"28 6","pages":"1098612X261448700"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective study of axial pattern and subdermal plexus skin flaps in cats: clinical indications, surgical sites, complications and outcomes.","authors":"Nithida Boonwittaya, Naris Thengchaisri","doi":"10.1177/1098612X261450116","DOIUrl":"10.1177/1098612X261450116","url":null,"abstract":"<p><p>ObjectivesThe aim of the present study was to report the outcome and postoperative complications of wound reconstruction in cats using axial pattern flaps (APFs) and subdermal plexus flaps (SPFs), and to assess associations between location, indication, flap type, postoperative complications and outcomes.MethodsThe surgical records of 52 cats undergoing 62 SPF or APF reconstructions were retrospectively reviewed between 2014 and 2025. Data collected included signalment, indication, location, flap type, postoperative complications and outcomes. Descriptive analyses and associations between variables were assessed.ResultsChronic wounds were the most common indication (n = 53/62, 85.5%), followed by mass removal and acute wounds. Among APFs, the lateral caudal flap was the most employed (n = 7/30, 23.3%), while the skin fold flap was the most frequent SPF (n = 19/32, 59.4%). A significant association was observed between anatomical location and clinical indication (<i>P</i> = 0.028). Overall complication rates did not differ significantly between APFs and SPFs. The most frequently observed complications were necrosis (45.2%) in all flaps. No significant associations were identified between clinical indication and wound dehiscence. Flap dehiscence was significantly more prevalent in SPFs applied to the dorsal body (n = 7/8, 87.5%; <i>P</i> = 0.032).Conclusions and relevanceAPFs and SPFs demonstrated comparable overall complication rates in feline wound reconstruction, with chronic wounds being the most common indication. Anatomical location was associated with wound dehiscence only in the dorsal body, with more wound dehiscence in SPFs than APFs, emphasising the importance of careful flap selection for each body area.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261450116"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13270014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral lotilaner in 21 cats with naturally acquired harvest mite infestation.","authors":"Carlotta Filippini, Marion Etter, Elisa Maina","doi":"10.1177/1098612X261450016","DOIUrl":"10.1177/1098612X261450016","url":null,"abstract":"<p><p>Case series summaryThis case series describes 21 client-owned cats with naturally acquired harvest mite infestation treated with a single oral dose of lotilaner. All cats were diagnosed at baseline by visual identification of characteristic orange larvae on the skin. A total of 12 cats underwent microscopic parasitological evaluation, including semi-quantitative mite scoring and assessment of mite viability, while nine cats were assessed clinically by visual inspection only. At baseline, inflammatory skin lesions and pruritus were present in 16/21 (76.2%) cats, whereas 5/21 (23.8%) were clinically healthy despite visible larvae. Lesions predominantly affected the head and neck region (n = 18/21, 85.7%). In the microscopically evaluated subgroup, live mites were detected in all cats on day 0, in 2/12 cats on day 7 and in none on day 14. Complete clinical resolution was observed in all cats by day 7 or, when applicable, day 14. No adverse events were reported.Relevance and novel informationThis case series provides clinical and parasitological observations in cats with naturally acquired harvest mite infestation treated with oral lotilaner. Although the absence of an untreated sentinel group precludes stronger efficacy claims, the consistent temporal association between treatment and clinical/parasitological improvement supports the practical use of lotilaner in affected cats and highlights harvest mite infestation as an important differential diagnosis in cats with seasonal head and neck dermatoses.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261450016"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new generic feline quality of life (FelQoL) questionnaire: part 2 - initial evaluation of clinical utility.","authors":"Luca Albergante, Anna Harding, Tammie King, Tanya Schoeman, Emily Blackwell, Nathaniel Spofford, Nicole Einerson, Ellie Davey, Janet Patterson-Kane, Luisa De Risio","doi":"10.1177/1098612X261447559","DOIUrl":"10.1177/1098612X261447559","url":null,"abstract":"<p><p>ObjectivesThe aim of this study was to analyse how demographics (breed, age, sex, neutering status), health and the environment (access to environmental features, weather and emotional state of the owner) affect the quality of life (QoL) of cats as measured by the Feline Quality of Life (FelQoL) questionnaire and its associated instrument. The result of this analysis was used to investigate the validity of the FelQoL questionnaire and instrument to inform pet owners and clinicians on the quantitative effects of different factors on feline wellbeing.MethodsResponses from 1324 cat owners in the USA and UK were collected and used to compute the wellbeing dimensions characterised by FelQoL and to identify the demographics, health and environment of pet cats. Participants were clients of Banfield Pet Hospital, participants in the Bristol Cat Study or Mars employees. Statistical analysis was used to assess how demographics, health and environment affect the wellbeing scores and to further evaluate the validity of FelQoL.ResultsResults showed the effects of sex, age, health and environment on feline QoL that were compatible with clinical expectations and previous findings. Reference intervals that can be used to identify expected feline QoL across different circumstances and highlight potential causes of reduced wellbeing were also produced.Conclusions and relevanceOur analysis suggests that FelQoL may be able to provide guidance on factors causing reduced feline wellbeing. FelQoL can also be used by cat owners to track QoL at home, instigating more intentional veterinary consultations when the wellbeing of a cat decreases even without obvious illness or injury. Further research, including targeted analysis of specific diseases and the exploration of longitudinal changes in FelQoL scores within individual cats over time will have the potential to assist with screening and quantification of effects of various factors on wellbeing and monitoring of targeted health plan interventions.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":"28 6","pages":"1098612X261447559"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum amyloid A: A biomarker to aid in assessing cats with acute pyelonephritis and monitoring response to antibiotic therapy.","authors":"Katrina Viviano, Vanessa Bruneau, Shefali Kaul, Faye Hartmann, William H Whitehouse, Kenneth Waller","doi":"10.1177/1098612X261451465","DOIUrl":"10.1177/1098612X261451465","url":null,"abstract":"<p><p>ObjectivesSerum amyloid A (SAA), the major acute-phase protein in cats, has potential, as in humans, to aid in the diagnosis and treatment of bacterial infections. This study compared SAA concentrations in cats with acute pyelonephritis (APN) with stable chronic kidney disease (CKD) and healthy cats. In cats with APN, SAA concentrations were monitored during antibiotic treatment to assess whether they correlated with clinical scores.MethodsA multicenter study recruited client-owned cats with APN (n = 9), with stable CKD (n = 10) or healthy cats (n = 10). Cats with APN were monitored for 21 days during antibiotic therapy to assess SAA concentrations along with clinical scores.ResultsThe majority of cats with APN were older (>10 years) and spayed females (8/10), with 5/9 having pre-existing CKD. Median SAA concentrations were significantly higher in cats with APN (235.3 mg/l, range 9.1-810) than in healthy cats (1.85 mg/l, range 1-2.7; <i>P</i> = 0.0008) and cats with stable CKD (1.45 mg/l, range 0.1-8.9; <i>P</i> = 0.0002). Cats with APN reached peak SAA concentrations (412 mg/l, range 18.6-810) within 48 h of presentation. In addition, with treatment and clinical recovery, median SAA concentrations returned to normal (3.1 mg/l, range 1-7.2) within 14 days. SAA concentrations were moderately correlated with clinical scores (<i>r</i>_s = 0.650).Conclusions and relevanceThe results of this study offer additional insights into the potential benefits and limitations of monitoring SAA concentrations in cats with APN. Cats with APN experience increased SAA concentrations, supporting SAA as a diagnostic tool for identifying affected cats. Serial SAA monitoring may help assess clinical recovery or determine treatment failure.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261451465"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D metabolites do not differ between cats with chronic kidney disease and healthy cats.","authors":"Valerie J Parker, Lauren J Reynolds, Jessica M Quimby","doi":"10.1177/1098612X261457854","DOIUrl":"10.1177/1098612X261457854","url":null,"abstract":"<p><p>ObjectiveThe aim of the present study was to characterize comprehensive vitamin D metabolite profiles in cats with chronic kidney disease (CKD) compared with healthy cats.MethodsA total of 33 healthy cats and 66 cats with CKD (six International Renal Interest Society [IRIS] stage 1, 36 IRIS stage 2, 18 IRIS stage 3, six IRIS stage 4) were prospectively enrolled. Serum vitamin D metabolites, including 25-hydroxyvitamin D₃ (25[OH]D₃), 3-epi-25-hydroxyvitamin D₃ (3-epi-25[OH]D₃), 1,25-dihydroxyvitamin D₃ (1,25[OH]₂D₃; calcitriol) and 24,25-dihydroxyvitamin D₃ (24,25[OH]₂D₃), were analyzed via liquid chromatography-tandem mass spectrophotometry. Vitamin D metabolites, clinicopathologic parameters, age, body weight and body condition score were compared between groups using a Mann-Whitney U-test or <i>t</i>-test as appropriate. Correlations between vitamin D metabolites and clinicopathologic parameters, age and weight were assessed using Spearman's rank test.ResultsThere was no significant difference in any vitamin D metabolite between groups. Median 25(OH)D₃ concentrations in cats with CKD and healthy cats were 28.9 ng/ml (range 12.2-68.8) and 26.3 ng/ml (range 11.5-55.9), respectively. Median 3-epi-25(OH)D₃ concentrations in cats with CKD and healthy cats were 9.1 ng/ml (range 2.2-30.4) and 7.2 ng/ml (range 1.9-22.9), respectively. Median calcitriol concentrations in cats with CKD and healthy cats were 141.3 pg/ml (range 38.6-367.8) and 127.9 pg/ml (range 71.5-235.8), respectively. Median 24,25(OH)₂D₃ concentrations in cats with CKD and healthy cats were 9.8 ng/ml (range 2.5-32.5) and 8.8 ng/ml (range 1.2-38.4), respectively. There was no correlation between any vitamin D metabolite and age or serum creatinine concentration, and no correlation between 25(OH)D and hematocrit, blood pressure or urine protein:creatinine ratio.Conclusions and relevanceVitamin D metabolites were not significantly different in cats with CKD, which could have implications for recommendations regarding calcitriol supplementation.</p>","PeriodicalId":15851,"journal":{"name":"Journal of Feline Medicine and Surgery","volume":" ","pages":"1098612X261457854"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}