Journal of Fluorescence最新文献_第7页

Novel Silicon-Based Fluorescent Nanocomposite Drug Carriers for Natural Compound Delivery in Melanoma Treatment.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-24 DOI: 10.1007/s10895-025-04182-5

Fei Gao, Lei Li, Linbo Liu, Guangshuai Li, Jianan Zhang, Wang Zhan, Wenjian You, Xia Lin, Yun Liu, Jiayao Wang, Denglin Chen

{"title":"Novel Silicon-Based Fluorescent Nanocomposite Drug Carriers for Natural Compound Delivery in Melanoma Treatment.","authors":"Fei Gao, Lei Li, Linbo Liu, Guangshuai Li, Jianan Zhang, Wang Zhan, Wenjian You, Xia Lin, Yun Liu, Jiayao Wang, Denglin Chen","doi":"10.1007/s10895-025-04182-5","DOIUrl":"https://doi.org/10.1007/s10895-025-04182-5","url":null,"abstract":"Melanoma, a highly aggressive cancer, is closely associated with an elevated tumor mutation burden (TMB) and an active tumor microenvironment (TME). Melanin synthesis, a key feature of melanoma progression, is primarily regulated by tyrosinase (TYR), the rate-limiting enzyme controlled by the microphthalmia-associated transcription factor (MITF). Resveratrol (Res), a natural polyphenol known for its antioxidant and anticancer properties, faces limitations including poor solubility, low bioavailability, and rapid metabolism. To overcome these challenges, a three-dimensional Co(II) coordination polymer {[Co(bpdado)(bpe)(H₂O)₂]·2DMF·2 H₂O}n (1) was synthesized and incorporated into a composite material, 1@CP1, for Res delivery (1@CP1@Res). The system exhibited enhanced solubility, pH-sensitive release, and improved biological activity. Fluorescence assays demonstrated significant quenching in the presence of Cu²⁺ ions, indicating a high sensitivity of 1@CP1@Res to metal ion interactions. The pH-responsive drug release profile was confirmed by in vitro studies showing accelerated release at lower pH values, mimicking the acidic tumor microenvironment. Cell viability assays revealed that 1@CP1@Res significantly inhibited the proliferation of murine B16-F10 melanoma cells, with cell survival rates of 72.4%, 58.2%, and 43.6% at 24, 48, and 72 h of incubation, respectively, at a concentration of 100 µM. Molecular docking studies further revealed multiple binding interactions between Res and the coordination polymer, suggesting a promising therapeutic strategy for melanoma treatment by integrating advanced materials with bioactive compounds.","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectively Controlling NIR Emissive Property and the ESIPT Behavior of Modified Styryl Dyes by Atomic Substituent: DFT/TD-DFT Approach.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-24 DOI: 10.1007/s10895-025-04197-y

Shilpa Taneja, Selva Kumar Ramasamy, Bhawna Pareek, Geetha Venkatesan, Govindasami Periyasami, Dineshkumar Sengottuvelu

{"title":"Effectively Controlling NIR Emissive Property and the ESIPT Behavior of Modified Styryl Dyes by Atomic Substituent: DFT/TD-DFT Approach.","authors":"Shilpa Taneja, Selva Kumar Ramasamy, Bhawna Pareek, Geetha Venkatesan, Govindasami Periyasami, Dineshkumar Sengottuvelu","doi":"10.1007/s10895-025-04197-y","DOIUrl":"https://doi.org/10.1007/s10895-025-04197-y","url":null,"abstract":"Recent literature on biosensing and bioimaging has explored excited state intramolecular proton transfer (ESIPT) cyanide dyes. These classes of fluorescence dyes generally use the classical pyridinium or indolium cations acceptor units' styrene with the ESIPT core. This work studied the photophysical and ESIPT kinetics of novel flavylium cation as an acceptor unit styrene with an ESIPT core using DFT/TD-DFT calculations. Two new ESIPT cyanine dyes, namely (E)-4-(3-(benzo[d]thiazol-2-yl)-2-hydroxystyryl)-7-(dimethylamino)-2-phenyl chromenylium (PSS) and (E)-4-(3-(benzo[d]oxazol-2-yl)-2-hydroxystyryl)-7-(dimethylamino)-2-phenylchromenylium (PSO) were designed and fully studies. This is concerned with studying changes in intramolecular hydrogen bonds, molecular orbitals at the frontier of the ESIPT process, absorption and fluorescence spectra, and excited state energy barriers. As a result, both the systems considered here can undergo an ultrafast ESIPT reaction with PSS and then PSO. Furthermore, ESIPT is more accessible in the normal enol-form first excited singlet (S1) state, with shorter hydrogen bonds. The intersystem crossing between the S1 state and the triplet (T1) state greatly influences the fluorescence efficiency of PSO and PSS. The potential energy curve and transition state energy profiles of PSS and PSO show that ultrafast ESIPT occurs in the state. Furthermore, the PSS shows less energy barriers, which leads to faster proton transfer than PSO. The current study will advance knowledge of the mechanism behind the ESIPT process and help enhance the qualities of the cyanine dye used in ESIPT.","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Structure and Luminescence Properties of Novel Red-Emitting Na₂SrSi₂O₆:Eu³⁺ Phosphors.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-24 DOI: 10.1007/s10895-025-04196-z

Yunxiang Du, Yingchao Xu, Subin Wang, Junhuang Hong, Jing Li, Yuxuan Wei, Zhifang Liu

{"title":"Synthesis, Structure and Luminescence Properties of Novel Red-Emitting Na2SrSi2O6:Eu3+ Phosphors.","authors":"Yunxiang Du, Yingchao Xu, Subin Wang, Junhuang Hong, Jing Li, Yuxuan Wei, Zhifang Liu","doi":"10.1007/s10895-025-04196-z","DOIUrl":"https://doi.org/10.1007/s10895-025-04196-z","url":null,"abstract":"The novel red phosphors Na2SrSi2O6:xEu3+(x = 0.1 ~ 0.5) were successfully prepared using the high-temperature solid-state synthesis method. The phase morphology, luminescence properties, fluorescence quenching, thermal stability, fluorescence lifetime, quantum efficiency, and CIE chromaticity coordinates of the phosphors were characterized. Experimental results show that the Na2SrSi2O6:Eu3+ phosphors are capable of emitting intense red light when illuminated by 393 nm excitation wavelength. By studying the fluorescence emission spectra at different doping concentrations, a doping concentration of x = 0.3 was determined. The concentration quenching mechanism of Na2SrSi2O6:Eu3+ phosphor was identified as electric dipole-electric dipole (d-d) interactions. At temperatures of 313 K, 373 K, and 433 K, the emission intensity was maintained at 99.2%, 94.6%, and 90.8% of the room temperature value, respectively. Furthermore, the samples displayed high quantum efficiency, extended fluorescence lifetime, superior color purity, and low correlated color temperature. Consequently, the Na2SrSi2O6:Eu3+ red phosphor shows significant potential for applications in the realm of white light LEDs.","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Covalent Organic Networks Confined in Molecularly Imprinted Polymers for Optosensing of Histamine in Fish Products.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-24 DOI: 10.1007/s10895-025-04205-1

Dianwei Zhang, Yuanchen Ma, Shengnan Wang, Ping Xiao, Shiza Nawaz, Fenghuan Wang, Huilin Liu

{"title":"Ionic Covalent Organic Networks Confined in Molecularly Imprinted Polymers for Optosensing of Histamine in Fish Products.","authors":"Dianwei Zhang, Yuanchen Ma, Shengnan Wang, Ping Xiao, Shiza Nawaz, Fenghuan Wang, Huilin Liu","doi":"10.1007/s10895-025-04205-1","DOIUrl":"https://doi.org/10.1007/s10895-025-04205-1","url":null,"abstract":"Histamine is a naturally occurring alkaloid that is an important indicator of meat spoilage, and excessive levels in food can lead to food poisoning or trigger allergic reactions. Therefore, accurate detection of histamine in meat is crucial for evaluating freshness and ensuring meat quality. In this study, a fluorescence probe based on ionic covalent organic networks confined with molecularly imprinted polymers (iCON@MIPs) was developed for detecting histamine in aquatic products. The probe was utilized iCOFs as the light-emitting element to improve the selectivity of the system for histamine by ion attraction reaction, and its anti-interference ability enhanced through molecular imprinting technology. The maximum emission wavelength of iCON@MIPs was at 570 nm, giving it a bright yellow emission and endowing it with the ability for on-site detection. The detection limit of iCON@MIPs for histamine was 0.516 µg L- 1, with a good recovery rate of 87.29-102.26% in fish samples. The fluorescence probe developed in this study provides an effective and rapid detection method for harmful substances in food, agriculture, environment and even medicine.","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose as Source and Matrix for Fluorescent Chemo-Sensors.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-24 DOI: 10.1007/s10895-025-04200-6

Sicily Rilu Joseph, Jith C Janardhanan, Sithara Radhakrishnan, Honey John, Ushamani Mythili

引用次数: 0

Development of a Peptide Aptamer-Based TRFIA for the Quantitive Detection of SARS-CoV-2 Nucleocapsid Protein.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-22 DOI: 10.1007/s10895-025-04199-w

Hongfang Chen, Tonggong Liu, Xiaona Zhao, Xi Chen, Liwen Zhu, Tingting Jiang, Huawen Li, Dayong Gu

{"title":"Development of a Peptide Aptamer-Based TRFIA for the Quantitive Detection of SARS-CoV-2 Nucleocapsid Protein.","authors":"Hongfang Chen, Tonggong Liu, Xiaona Zhao, Xi Chen, Liwen Zhu, Tingting Jiang, Huawen Li, Dayong Gu","doi":"10.1007/s10895-025-04199-w","DOIUrl":"https://doi.org/10.1007/s10895-025-04199-w","url":null,"abstract":"This study, we employed computer-aided design to develop 27 peptide aptamers, and initially screened 11 candidates with binding energies less than - 6.0 kcal/mol. Subsequently, three peptide aptamers with strong specificity were selected using a direct time-resolved fluorescence immunoassay (TRFIA). Peptide aptamer B3, in combination with monoclonal antibody R001, was used to construct a TRFIA-based sandwich assay system. The performance of this system was evaluated concerning sensitivity, specificity, and reproducibility, and was further tested using 20 simulated pharyngeal swab samples. The dominant peptide aptamer, B3(RGQGVPI), was identified as the most promising candidate. This peptide demonstrated high specificity for the SARS-CoV-2 nucleocapsid (N) protein, with the lowest detectable concentration of 203.78 pg/mL. Importantly, the peptide had no cross-reactions with other potential interferents, including RSV, Flu A, and MP, confirming its specificity. The assay also exhibited good reproducibility, with coefficients of variation of 11.33% and 8.00% at different concentrations in pharyngeal swab samples. Additionally, the LOB and LOD in clinical samples were 31.59 pg/mL and 243.70 pg/mL and the correlation coefficient R2 was 0.9784, which indicated that the method had good resistance to clinical interference. In this study, we successfully developed a sandwich TRFIA method based on the peptide aptamer B3-R001, which can be used to quantitatively measure the SARS-CoV-2 N protein level in pharyngeal swabs. Compared to antibodies, peptide aptamers are easily synthesized, inexpensive, and show great potential for clinical applications. This method provides a novel approach for rapidly detecting viral pathogens, contributing to the advancement of diagnostic tools.","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing the Excited State Photophysics of an Anthraquinone Based Dye in Solution and LB Films.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-22 DOI: 10.1007/s10895-025-04188-z

Sutapa Deb, Ranendu Kumar Nath, Arghyadeep Bhattacharyya

引用次数: 0

A Highly Sensitive Fluorescent Probe for the Detection of Zn²⁺ and Water as Well as Application in Alcoholic Beverages.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-22 DOI: 10.1007/s10895-025-04186-1

Hao Hu, Lei Xue, Haibin Wang

引用次数: 0

Synergistic Interactions of Metals and Quantum Dots: Expanding Frontiers in Fluorescent Sensing. 金属与量子点的协同作用：拓展荧光传感的前沿。

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-22 DOI: 10.1007/s10895-025-04144-x

P K Archana, Suni Vasudevan, Unnikrishnan Gopalakrishna Panicker

引用次数: 0

Fluorescent Nanocomposite Materials with Synergistic Effects for Enhanced Fenelidone Delivery in Diabetic Nephropathy Treatment.

IF 2.6 4区化学

Journal of Fluorescence Pub Date : 2025-02-22 DOI: 10.1007/s10895-025-04195-0

Suyu Wang, Yanyan Wu, Bingru Fei, Mei Zhang

{"title":"Fluorescent Nanocomposite Materials with Synergistic Effects for Enhanced Fenelidone Delivery in Diabetic Nephropathy Treatment.","authors":"Suyu Wang, Yanyan Wu, Bingru Fei, Mei Zhang","doi":"10.1007/s10895-025-04195-0","DOIUrl":"https://doi.org/10.1007/s10895-025-04195-0","url":null,"abstract":"In this study, we designed and synthesized a novel thio-purine analog, compound 1, which exhibits significant fluorescence properties due to its extended conjugated system, heteroatom incorporation (O, S, N), and rigid three-dimensional molecular framework, enabling its use as a fluorescence probe for real-time drug tracking and release monitoring. To enhance the solubility, biocompatibility, and therapeutic efficacy of compound 1, we synthesized a copper(II)-based coordination polymer (CP1) via hydrothermal methods, featuring a three-dimensional framework formed by 1,4-ttb and auxiliary ligand 4,4'-bpdc, as confirmed by comprehensive characterization techniques. Leveraging the synergistic therapeutic effects of compound 1 and fenelidone, we developed a composite drug delivery system, mPEG-PSU@CP1@1@fenelidone, which combines an amphiphilic mPEG-PSU shell with a CP1 core co-encapsulating both drugs. Notably, the fluorescence properties of compound 1 allow for real-time monitoring of drug release, as its fluorescence is quenched when encapsulated in CP1 and restored upon release. This system optimizes controlled drug release while enhancing the synergistic effects of compound 1 and fenelidone in reducing inflammation and renal fibrosis, as demonstrated in diabetic nephropathy (DN) model mice. Overall, the composite system integrates real-time fluorescence monitoring with improved therapeutic efficacy, offering a promising strategy for diabetic nephropathy treatment.","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0