Suresh F Madar, Avinash C Mendhe, Ahmedraza Mavazzan, Babasaheb R Sankapal, Praveen K Bayannavar, Vishwa B Nadoni, K M Mussuvir Pasha, Ravindra R Kamble
{"title":"Synthesis and Photovoltaic Investigation of Novel Triphenylamine- and Phenothiazine-Appended 1H-Pyrazole-3,4-Dicarboxylic Acid Dyes for Dye-Sensitized Solar Cells.","authors":"Suresh F Madar, Avinash C Mendhe, Ahmedraza Mavazzan, Babasaheb R Sankapal, Praveen K Bayannavar, Vishwa B Nadoni, K M Mussuvir Pasha, Ravindra R Kamble","doi":"10.1007/s10895-025-04362-3","DOIUrl":"https://doi.org/10.1007/s10895-025-04362-3","url":null,"abstract":"<p><p>In the present study, we employed a comprehensive multi-step synthetic methodology to design and develop two novel organic dyes, TP-CLN and PT-CLN, using sydnone as a synthon. These compounds feature a donor-π-acceptor (D-π-A) architecture and are classified as chalcones. The resulting molecules were intricately attached to one-dimensional cadmium sulfide nanowires (1D CdS NWs), functioning as highly efficient light energy harvesters for dye-sensitized solar cells (DSSCs). The process of anchoring the dye onto the nano-network of CdS NWs was accomplished using simple solution chemistry, which proved to be both straightforward and efficient. We assessed the sensitizing capabilities of the synthesized materials through various methods, including optical and electrochemical investigations, density functional theory (DFT) simulations, and comprehensive photovoltaic assessments. A detailed analysis of the Dye-Sensitized Solar Cells containing PT-CLN revealed a photovoltaic efficiency 3.35 times higher (0.342%) than that of bare CdS NWs (0.102%) under standard light illumination. Similarly, the use of TP-CLN demonstrated a significant 3.08-fold improvement (0.314%) in photovoltaic efficiency. These results not only provide strong empirical support for the enhancement of external quantum efficiency (EQE) but also show a remarkable consistency with findings from optical examinations.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Annoji Reddy, Vibha, H M Suresh Kumar, M N Ravikantha, J Thipperudrappa
{"title":"Design of Molecular Logic Gates Via pH-dependent Absorption and Fluorescence Transitions in Drug Molecules.","authors":"R Annoji Reddy, Vibha, H M Suresh Kumar, M N Ravikantha, J Thipperudrappa","doi":"10.1007/s10895-025-04375-y","DOIUrl":"https://doi.org/10.1007/s10895-025-04375-y","url":null,"abstract":"<p><p>In this manuscript, we have explored the absorption and fluorescence properties of Sulfamethoxazole (SMX) and Trimethoprim (TMP) in the pH range 1-14. The absorption and fluorescence properties of SMX and TMP exhibit significant variations with changes in pH. These variations in absorption and fluorescence characteristics have been analyzed based on the existence of different species of these molecules in different pH ranges. The variations in absorption and fluorescence intensity of SMX and TMP molecules as a function of pH have been utilized to design two-input molecular logic gates, namely Improved-INHIBIT (I-INHIBIT) and IMPLICATION. Also, the absorption and fluorescence properties at different wavelength maxima have been utilized to design the same molecular logic gates.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rohit V Pawar, Pravin O Patil, Mohammad Khalid, Shadma Wahab, Mohamad Taleuzzaman, Sagar R Pardeshi, Zamir G Khan
{"title":"Design of a Facile Fluorescent Nano-Sensor Using Nitrogen and Sulfur Dual Doped Carbon Quantum Dots for Carbendazim Detection: A Turn-Off-On Approach for Food Safety and Environmental Monitoring.","authors":"Rohit V Pawar, Pravin O Patil, Mohammad Khalid, Shadma Wahab, Mohamad Taleuzzaman, Sagar R Pardeshi, Zamir G Khan","doi":"10.1007/s10895-025-04372-1","DOIUrl":"https://doi.org/10.1007/s10895-025-04372-1","url":null,"abstract":"<p><p>Carbendazim (CBZ), a widely used agricultural fungicide, poses significant health risks due to its potential for endocrine disruption, infertility, and liver damage. Ensuring food safety and compliance with environmental regulations necessitates sensitive and reliable detection methods. This study introduces a novel, ultrasensitive CBZ detection strategy using nitrogen and sulfur co-doped carbon quantum dots (N-S@CQDs) as fluorescent nanosensors. These N-S@CQDs are synthesized via an environmentally friendly hydrothermal process, utilizing citric acid and thiourea as precursors. The detection platform operates through a \"turn-off-on\" fluorescence mechanism. Initially, Fe³⁺ ions quench the fluorescence of N-S@CQDs, which is then restored upon CBZ binding. This system achieves an ultralow detection limit of 27.84 ng/mL and a linear response range of 0-100 ng/mL, making it ideal for trace-level analysis in food bioscience applications. The sensor was validated on real food samples, yielding impressive recovery rates of 96.9 to 99.36%. The method demonstrates excellent selectivity, rapid response, and cost-efficiency, making it a powerful tool for real-world applications. This study not only advances the field of CBZ detection but also opens doors to safer, more sustainable practices in agriculture and food safety. The developed method offers a sustainable and cost-effective solution for monitoring CBZ residues in food safety programs and environmental surveillance initiatives, addressing critical challenges in pesticide detection.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Ratiometric Fluorescent Probe Based on Carbon Dots and Rhodamine for Rapid Detection of Hg<sup>2+</sup> in Herbal Medicines and Rivers.","authors":"Qian Wang, Qian Zhang, Jiayi Zhang, Jiayi Li, Mengpei Xie, Mengyi Shen, Yuping Tang, Weifang Luo","doi":"10.1007/s10895-025-04367-y","DOIUrl":"https://doi.org/10.1007/s10895-025-04367-y","url":null,"abstract":"<p><p>Ratiometric fluorescent probes have irreplaceable advantages of traditional single fluorescent probes, such as high accuracy, low background interference and high signal-to-noise ratio, which have attracted extensive attention but the preparation process is still a challengment. In this paper, fluorescent carbon dots (CDs) was prepared by hydrothermal treatment of citric acid and triethylamine, and electrostatic adsorption with Rhodamine, which was used to construct ratiometric fluorescent nanoprobes (WZ-L). Among them, rhodamine B was used as the reference signal of the fluorescent probe, which could eliminate part of the error. Carbon dots (CDs) were used as the identification signal for the detection of Hg<sup>2+</sup>. The probe specifically recognized Hg<sup>2+</sup> in a wide pH range and had a well linear range (0-100 µL), which can be used for the quantitative detection of real Chinese herbal medicine samples. including Codonopsis and Codonopsis. In particular, the probe could provide a rapid response to Hg<sup>2+</sup> within 2 min with a detection limit as low as 7.94 µM. It is shown that this probe has a large application potential for future quantitative detection of Hg<sup>2+</sup> in real samples, which provides a new analytical method and strategy for the subsequent detection of heavy metal ions.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microwave Assisted Synthesis of AIEE Responsive Isoniazid Based Schiff Base, DFT Studies and its Fluorometric Response Towards Cd<sup>2+</sup> and Na<sup />.","authors":"Mannat Arora, Navjot Sandhu, Vandana Saraswat","doi":"10.1007/s10895-025-04354-3","DOIUrl":"https://doi.org/10.1007/s10895-025-04354-3","url":null,"abstract":"<p><p>A novel Isoniazid based Schiff base was synthesized utilizing a simple microwave assisted facile one-step method and was analysed using several spectroscopic methods i.e. <sup>1</sup>H NMR, <sup>13</sup>C NMR, HRMS and IR spectroscopy. To illuminate the complexity of electronic structure of an ISB, DFT analysis was conducted. Along with the solvatochromic studies, AIEE analysis of synthesized schiff base was carried out revealing the fluorescence enhancement by eight folds in water: acetonitrile ratio (40:60) in comparison to acetonitrile sample. These results were validated by dynamic light scattering (DLS) analysis. The photophysical analysis unravels the fact that ISB acts as a dual probe for detection of Cd<sup>2+</sup> (trace element) and Na<sup>+</sup> with the limit of detection (LOD) 0.2 µM and 0.15 µM, respectively. The selectivity study divulged that ISB showed selectivity towards Cd<sup>2+</sup>. The DFT studies for the proposed mechanism have been carried out to support the results found in the analysis. For stoichiometry study, Job's plot was examined which revealed 1:1 complexation ratio in case of Cd<sup>2+</sup>: ISB and 3:2 complexation ratio for Na<sup>+</sup>: ISB. Anti interference analysis underpinned the fact that ISB show high selectivity and sensitivity towards Cd<sup>2+</sup> and Na<sup>+</sup> as no other metal interfered during the detection process.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carbon Dots: Synthesis, Characterization, and Applications in the Detection of Bilirubin - Recent Advances and Challenges.","authors":"Kawan F Kayani","doi":"10.1007/s10895-025-04366-z","DOIUrl":"https://doi.org/10.1007/s10895-025-04366-z","url":null,"abstract":"<p><p>Bilirubin (BR) is a yellow tetrapyrrole compound present in digestive juice, formed from the breakdown of hemoglobin (Hb). Normal serum bilirubin levels range from 0.30 to 1.20 mg/dL. Elevated BR levels act as a crucial biomarker for diagnosing and managing liver diseases, underscoring the importance of its accurate measurement. In recent decades, carbon dots (CDs) have garnered significant attention for their exceptional properties, including strong compatibility and ease of synthesis. These attributes have driven extensive research into developing highly efficient CD-based probes for the rapid and selective detection of bilirubin. This review presents a thorough introduction to CDs and bilirubin metabolism, systematically categorizes the synthetic methodologies for CDs, outlines key characterization techniques, and critically analyzes various sensing approaches, including fluorescence-based and colorimetric sensors. Furthermore, it discusses current challenges and highlights potential future research directions to advance the development of high-performance CDs and enhance bilirubin detection technologies.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Donor-π-Donor Type Ratiometric Chromogenic Molecular Optode for Efficient Recognition of Sarin Analog, Diethylchlorophosphate.","authors":"Shraddha Rai, Shubham Lama, Subekchha Pradhan, Upika Darnal, Jyoti Chourasia, Sabbir Ahamed, Najmin Tohora, Sudhir Kumar Das","doi":"10.1007/s10895-025-04365-0","DOIUrl":"https://doi.org/10.1007/s10895-025-04365-0","url":null,"abstract":"<p><p>The extremely toxic G-series nerve agents are synthetic chemical compounds developed for making synthetic weapons for terrorist attacks and mass destruction in war. So, for these dangerous nerve agents, quick and precise detection is needed to rescue nature and public health. In this study, we have developed a colorimetric probe [(E)-N1-((E)-3-(4-(dimethylamine) phenyl) allylidene)-N4, N4-dimethylbenzene-1,4-diamine] (DPAD) with high selectivity and sensitivity for the on-spot identification of lethal sarin gas surrogate diethylchlorophosphate (DCP) in both the solid and liquid phase individuality. Upon contact with DCP, the probe exhibits a distinctly purple color, visible with bare eyes. After the addition of triethylamine (TEA) to our sensor, DPAD-DCP solution reversed the color back to pale yellow. To enable rapid detection and quantification of our colorimetric probe demonstrates exceptional selectivity for DCP within the nM range (3.2 nM). For an instant observation and quantification of DCP, we also experimented using paper strip-based kits. To further enhance detection, we also conducted a dip-vial conical flask and dip-stick experiment to recognize DCP in the vapor stage across the numerous inorganic phosphate (IPs), organic phosphate (OPs), and other deadly analytes. Additionally, for real-time and practical application, we employed a smartphone-based readout technique to facilitate on-the-spot detection for DCP.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fluorometric Detection of Sodium Ion Using Bis(2,4-dihydroxyphenylmethylene)Thiocarbohydrazone; Crystal Structure, DFT Studies, Anti-Cancer Assay, ADMET Study and Molecular Docking.","authors":"Lakshmi V Menon, E Manoj","doi":"10.1007/s10895-025-04363-2","DOIUrl":"https://doi.org/10.1007/s10895-025-04363-2","url":null,"abstract":"<p><p>A simple fluorescent sensor, 1,5-bis(2,4-dihydroxyphenylmethylene)thiocarbohydrazone (H<sub>6</sub>L), was designed for the selective detection of sodium ions amidst other cations. The molecular structure of H<sub>6</sub>L was confirmed using the SCXRD method, which reveals significant hydrogen bonding interactions in the lattice. Hirshfeld surface analysis also confirms asubstantial contribution of O⋅⋅⋅H/H⋅⋅⋅O interactions (23.3%) to the total Hirshfeld surface. H<sub>6</sub>L exhibited enhanced fluorescence emission in response to Na<sup>+</sup> with a detection limit of 40 × 10<sup>- 8</sup> M, facilitated by the inhibition of the C = N based isomerisation and inhibition of the excited-state intramolecular proton transfer mechanism. The sensing capability of H<sub>6</sub>L towards Na<sup>+</sup> ions was confirmed by electronic and IR spectra, theoretical studies, Job's plot and Benesi-Hildebrand method, collectively demonstrating ground-state complex formation and a 1:2 binding stoichiometry between H<sub>6</sub>L and Na<sup>+</sup> ions. The sensor's practical application for detecting Na<sup>+</sup> ions was demonstrated by creating sensor-coated paper strips. Additionally, the compound was evaluated for its in vitro anticancer activity against MCF7 breast cancer and A549 lung adenocarcinoma cell lines. The IC<sub>50</sub> values indicate excellent cytotoxic activity against MCF7 cells (40.37 µg/mL) compared to A549 cells (82.30 µg/mL). To further explore the mechanisms underlying its anticancer activity, molecular docking studies were performed against enzyme targets 4IGK and 2ITO, which validate the in vitro findings.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Benzoxazole-Functionalized Conjugated Mesoporous Polymer for Highly Sensitive and Selective Detection of Fe<sup>2+</sup> and Fe<sup>3</sup>.","authors":"Huaiyi Zhang, Guang Wang","doi":"10.1007/s10895-025-04377-w","DOIUrl":"https://doi.org/10.1007/s10895-025-04377-w","url":null,"abstract":"<p><p>Conjugated micro/mesoporous polymers (CMPs) have emerged as versatile platforms for designing advanced functional materials. In this study, a novel benzoxazole-functionalized CMP, TFPA-DBD, was rationally synthesized, featuring a spherical morphology, well-defined mesoporous structure and robust thermal/chemical stability. When dispersed in DMF, TFPA-DBD exhibits a selective \"turn-off\" fluorescence response toward Fe<sup>2+</sup> and Fe<sup>3+</sup> ions, achieving low detection limits (LOD) of 0.56 µM and 0.72 µM, respectively. Importantly, TFPA-DBD demonstrates rapid response, high selectivity and strong anti-interference capability during sensing process. The fluorescence quenching mechanism originates from synergistic effects between Fe<sup>2+</sup>/Fe<sup>3+</sup> ions and the nitrogen/oxygen sites within the benzoxazole units, and combines with absorption competition quenching (ACQ) sensing mechanism. Additionally, TFPA-DBD enables the straightforward visual identification of Fe<sup>2+</sup> and Fe<sup>3+</sup> ions using test paper mode, detectable by the naked eye. Practical applicability was validated through reliable recovery performance in real water samples, highlighting its potential for environmental monitoring applications. This work expands the library of functional CMPs and underscores their utility in developing high-performance sensing systems for transition metal ion detection.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esraa Ibrahim, Yara E Mansour, Sameh Soror, Hesham Haffez
{"title":"New Fluorescent Synthetic Retinoids as Potential RAR Agonists with Anticancer, Molecular Docking and ADME Assessments.","authors":"Esraa Ibrahim, Yara E Mansour, Sameh Soror, Hesham Haffez","doi":"10.1007/s10895-025-04343-6","DOIUrl":"https://doi.org/10.1007/s10895-025-04343-6","url":null,"abstract":"<p><p>Natural and synthetic retinoids are derivatives of vitamin A that mediate different transcriptional activities. Synthesis of fluorescent probes can be a useful tool in cellular imaging and understanding different regulatory signaling pathways. In this study, new fluorescent synthetic retinoid analogues (3a, 3b, 4a, and 4b) were prepared and biologically screened against six different cancer and normal cell lines for assessment of their anticancer and fluorescent activities. A combination of biological assays, such as MTT, flow cytometry, gene and protein expression analysis, DNA fragmentation, and ATPase activity assays, as well as in-silico and ADME studies, was performed. All new compounds showed anti-proliferative activity (2.09-132.70 µM) against different cancer cell types with minimal cytotoxicity (SI > 1), and the Caco-2 cancer cell line was selected for further in vitro investigation. All compounds showed cell cycle arrest at the SubG<sub>0</sub>-G<sub>1</sub> phase with induction of early apoptosis and necrosis. Compound 4b showed a significant apoptotic effect by overexpression of Caspase-3 and Cyt-c genes, followed by compound 3a. All compounds showed anti-inflammatory activity by significantly down-regulating the IL-10 pro-inflammatory marker, while compounds 3b, 4a, and 4b specifically down-regulated IL-6. Retinoic acid receptors (RARs) were suggested as molecular targets confirmed by their overexpression of both gene and protein levels with molecular docking and molecular dynamic simulation studies. All fluorescent compounds showed intracellular fluorescent emission spectra with intracellular lipophilic properties. The new fluorescent synthetic retinoids showed dual activities as anticancer agents with fluorescence properties and can be used as useful probes in a variety of cellular imaging investigations.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}