{"title":"Carvacrol-Derived 1,2,3-Triazole Hybrids: Synthesis, Computational Insights, and Targeted Inhibition of EGFR, BRAF V600E, and Tubulin Enzymes.","authors":"Mohamed Enneiymy, Abdellah El Aissouq","doi":"10.1007/s10895-025-04232-y","DOIUrl":"https://doi.org/10.1007/s10895-025-04232-y","url":null,"abstract":"<p><p>This study explores the design and synthesis of innovative triazole-carvacrol hybrid molecules via copper-catalyzed 1,3-dipolar cycloaddition reactions. Leveraging advanced computational drug design tools, the ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiles of these compounds will be meticulously evaluated. Furthermore, molecular docking simulations will unravel the binding interactions and mechanisms with critical cancer therapy targets, including EGFR (PDB ID: 3POZ), BRAF V600E (PDB ID: 1UWJ), and Tubulin (PDB ID: 1SA0). By integrating cutting-edge synthesis and computational techniques, this work aims to uncover potent candidates with significant therapeutic potential in cancer treatment.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Graphene Quantum Dot-Based Gold-Nickel Micromotors for Sensitive Detection of Ferric Ions.","authors":"Gozde Yurdabak Karaca","doi":"10.1007/s10895-025-04238-6","DOIUrl":"https://doi.org/10.1007/s10895-025-04238-6","url":null,"abstract":"<p><p>The development of nano and micromotors has revolutionized the field of nanotechnology, offering innovative solutions for applications in biomedical engineering, environmental monitoring, and chemical sensing. Among these nano/micromotors, graphene quantum dot (GQD)-based micromotors have gained significant attention due to their unique optical and electronic properties. This study presents the synthesis and characterization of novel graphene quantum dot-based gold-nickel (GQD-Au-Ni) micromotors. These micromotors were synthesized using an electrochemical template deposition process, allowing precise control over their composition and structure. The GQD-Au-Ni micromotors exhibit multifunctionality, employing fluorometric, magnetic, and electrochemical methods for the selective and sensitive detection of ferric ions (Fe³⁺), with a remarkable limit of detection (LOD). The study highlights the potential of these micromotors in environmental monitoring paving the way for future research into multifunctional micromotors for a wide range of applications. The findings underscore the promise of GQD-based systems in advancing sensor technology and addressing critical challenges in environmental and health monitoring.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Ratiometric Fluorescent Probe Based on Carbon Dots and Quantum Dots for Glucose Detection.","authors":"Jing Li, Xiaojuan Jin, Sunan Liu, Tongze Lin, Cheng Zhang, Qiutong Chen, Yunsu Ma","doi":"10.1007/s10895-025-04228-8","DOIUrl":"https://doi.org/10.1007/s10895-025-04228-8","url":null,"abstract":"<p><p>Glucose is a critical energy source for human cells, and maintaining stable glucose levels is essential for normal physiological functions. Abnormal glucose levels can lead to health issues such as diabetes, obesity, and hypoglycemia, highlighting the need for precise and rapid glucose detection methods for clinical diagnostics and health management. In this study, a novel ratiometric fluorescent probe was constructed for glucose detection. Using glucose oxidase (GOx) and horseradish peroxidase (HRP) as enzymatic mediators, the probe employs orange-emitting carbon dots (oCDs) as the detection signal and red-emitting quantum dots (rQDs) as the reference signal. Glucose is oxidized by GOx to produce hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), which subsequently generates hydroxyl radicals (·OH) under HRP catalysis. The ·OH interacts electrostatically with oCDs, forming non-fluorescent complexes and quenching the oCDs fluorescence. Glucose concentration is quantified by monitoring the fluorescence intensity ratio (I<sub>590</sub>/I<sub>715</sub>) between oCDs and rQDs. The probe has a limit of detection (LOD) of 0.47 µM and a limit of quantification (LOQ) of 1.58 µM. After methodological validation, it has been successfully applied to the detection of glucose in human serum. This study provides a solid basis for accurate glucose monitoring and holds potential for the early diagnosis and treatment of metabolic diseases such as diabetes.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanshan Liu, Weijie Liu, Xiuhong Chen, Yunping Lai, Tao Zhang
{"title":"Hydrothermal Synthesis of Nitrogen-Doped Carbon Dots for Selective Fe<sup>3+</sup> Detection.","authors":"Shanshan Liu, Weijie Liu, Xiuhong Chen, Yunping Lai, Tao Zhang","doi":"10.1007/s10895-025-04230-0","DOIUrl":"https://doi.org/10.1007/s10895-025-04230-0","url":null,"abstract":"<p><p>Carbon dots (CDs) have recently regarded as an attractive fluorescent sensor for water quality detection. However, the actual detection application of CDs is limited owing to the low fluorescence quantum yield (QY) and unclear ion detection mechanism. Here, nitrogen doped CDs (N-CDs) with abundant amide groups, which were easy to prepare using urea and citric acid under mild reaction conditions and displayed great light absorption and strong fluorescence performance with a fluorescence QY of up to 26.6%. More importantly, N-CDs could achieve selective detection of iron ion (Fe<sup>3+</sup>) and its concentrations as low as 0.47 µM in water. Meanwhile, N-CDs exhibited a good linear relationship within the concentration range of 0.5-500 µM of Fe<sup>3+</sup>. This mainly because the introduction of amide groups of N-CDs not only could serve as both donors (NH-), but also acceptors (C = O) for hydrogen bonding, which consequently increased multifunctional fluorescent recognition sites and formed coordination interactions with metal ions, and ultimately achieved fluorescence detection of ions. Therefore, the preparation of N-CDs rich in amide groups provides a promising strategy for rapid and efficient detection of Fe<sup>3+</sup> ions for water quality detection applications.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ratio Fluorescence Sensor Based on Bimetal MOFs for the Detection of Hg<sup>2+</sup>and H<sub>2</sub>O<sub>2</sub>.","authors":"Bo-Ming Han, Hao-Rui Zhang, Wen-Jie Gao, Xi-Wen He, Wen-You Li, Yu-Kui Zhang","doi":"10.1007/s10895-025-04234-w","DOIUrl":"https://doi.org/10.1007/s10895-025-04234-w","url":null,"abstract":"<p><p>In this work, a dual-emission material based on lanthanide metals was synthesized and used as a ratio fluorescence sensor to respond to Hg<sup>2+</sup> and H<sub>2</sub>O<sub>2</sub>, respectively. Tb-BDC-NH<sub>2</sub> as a bimetal MOFs had double ligands and exhibited double fluorescence emission peaks at 550 nm and 450 nm. The two emission peaks of Tb-BDC-NH<sub>2</sub> can be quenched by Hg<sup>2+</sup> and H<sub>2</sub>O<sub>2</sub> respectively, forming a built-in calibration signal for ratio fluorescence detection. Based on the different detection conditions of the Hg<sup>2+</sup> and H<sub>2</sub>O<sub>2</sub>, the simultaneous detection of the two detection substances can be achieved with simple operation. This detection system had good stability and anti-interference ability. Under optimal conditions, the detection limit for Hg<sup>2+</sup> detection was 0.2 µM. Meanwhile, for the detection of H<sub>2</sub>O<sub>2</sub>, the detection limit was 11 µM and large linear ranges were obtained. Through actual sample testing, it had been proven that the ratio fluorescence sensor based on Tb-BDC-NH<sub>2</sub> had good application prospects. And the work also provided a new idea for double substances detection.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diéricon Sousa Cordeiro, Eduardo Sérgio de Souza, Cássia Alessandra Marquezin
{"title":"Rod-like SDS Micelles in High Ionic Strength: A Fluorescence Quenching Investigation.","authors":"Diéricon Sousa Cordeiro, Eduardo Sérgio de Souza, Cássia Alessandra Marquezin","doi":"10.1007/s10895-025-04227-9","DOIUrl":"https://doi.org/10.1007/s10895-025-04227-9","url":null,"abstract":"<p><p>In this study, the sphere-to-rod transition in sodium dodecyl sulfate (SDS) micelles was induced by increasing the ionic strength of the medium. This transition was monitored through the fluorescence of the lipophilic probe 2-amino-N-hexadecyl-benzamide (AHBA), which has a 16-carbon hydrocarbon chain and aggregates in aqueous solution. AHBA fluorescence parameters, such as emission intensity, spectral position, lifetime, and steady-state anisotropy, were monitored to understand the probe's behavior in aqueous solution as a function of ionic strength. The results showed that the addition of NaCl induces a spectral red shift in AHBA fluorescence, suggesting a repositioning of the probe within its aggregate. Fluorescence quenching experiments were also conducted using the Co<sup>2+</sup> ion as a quencher of AHBA fluorescence, both when free in aqueous solution and at different salt concentrations. The quenching results revealed the presence of two distinct AHBA populations, each with different access to Co<sup>2+</sup>. The Stern-Volmer plots for low Co<sup>2+</sup> concentrations, where quenching primarily affects the population most exposed to Co<sup>2+</sup>, indicated that NaCl slightly reduces the accessibility of this population to the quencher. Finally, the sphere-to-rod transition in SDS micelles was monitored through fluorescence quenching assays. The Stern-Volmer plots showed a dependence on the ionic strength of the medium, indicating that the change in the micelle shape occurs between 0.2 M and 0.3 M NaCl. Once the rod shape is reached, the quenching constant assumes lower values, suggesting that AHBA becomes more inserted into the micelles, with reduced access to Co<sup>2+</sup>.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kawan F Kayani, Sewara J Mohammed, Nian N Mohammad, Mohammed K Rahim, Muhammad S Mustafa, Harez Rashid Ahmed, Wrya O Karim, Mohammed K Sidiq, Shujahadeen B Aziz
{"title":"Exploring Green Practices: a Review of Carbon Dot-Based Sustainable Sensing Approaches.","authors":"Kawan F Kayani, Sewara J Mohammed, Nian N Mohammad, Mohammed K Rahim, Muhammad S Mustafa, Harez Rashid Ahmed, Wrya O Karim, Mohammed K Sidiq, Shujahadeen B Aziz","doi":"10.1007/s10895-025-04254-6","DOIUrl":"https://doi.org/10.1007/s10895-025-04254-6","url":null,"abstract":"<p><p>The increasing demand for sustainable and eco-friendly technologies has driven significant interest in carbon dots (CDs) due to their unique optical properties, low toxicity, and versatile applications in sensing. The aim of this review is to provide a comprehensive analysis of the current advancements in CD-based sensing approaches, with a focus on their environmental sustainability based on greenness evaluation tools. We begin by discussing the principles and methodologies of greenness evaluation, including various assessment tools and metrics used to measure the environmental impact of CD synthesis and applications. Key applications of CD-based sensors in detecting pollutants, biomolecules, and other analytes are examined, emphasizing their potential in environmental monitoring, biological, and food analysis. The review concludes with a discussion on future research directions aimed at overcoming these challenges and enhancing the sustainability of CD-based sensing technologies. Through this detailed exploration, we aim to provide valuable insights into the greenness of CDs, fostering their development as a cornerstone of sustainable sensing technologies. The evaluation tools applied for future probes confirmed their superior environmental friendliness.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Advances in Colorimetric and Fluorescent Chemosensors for Cu<sup>2</sup>⁺ Ions: Trends, Challenges, and Future Directions.","authors":"Duraisamy Udhayakumari","doi":"10.1007/s10895-025-04253-7","DOIUrl":"https://doi.org/10.1007/s10895-025-04253-7","url":null,"abstract":"<p><p>The detection of copper ions (Cu<sup>2</sup>⁺) through colorimetric and fluorometric methods has garnered significant attention due to the biological, environmental, and medical importance of Cu<sup>2</sup>⁺. These detection techniques have proven to be highly effective due to their simplicity, cost-efficiency, high sensitivity, and suitability for bioimaging applications. This critical review begins by briefly addressing the sources, applications, and toxicity of copper ion sensors. It then provides an in-depth classification of fluorescent and colorimetric Cu<sup>2</sup>⁺ sensors based on their receptors, organizing them into various categories such as anthracene, pyridine, pyrazole, pyrrole, naphthalene, imidazole, and quinoline functionalized sensing systems, with a focus on developments since 2016.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanane Etabti, Mohammed Er-Rajy, Asmae Fitri, Arunkumar Ammasi, Mohd Shkir, Adil Touimi Benjelloun, Mohammed Benzakour, Mohammed Mcharfi
{"title":"Computational Analysis of Triazolone-Based Dyes in DSSCs: Exploring Acceptor Terminal for Enhanced Photovoltaic Performance.","authors":"Hanane Etabti, Mohammed Er-Rajy, Asmae Fitri, Arunkumar Ammasi, Mohd Shkir, Adil Touimi Benjelloun, Mohammed Benzakour, Mohammed Mcharfi","doi":"10.1007/s10895-025-04231-z","DOIUrl":"https://doi.org/10.1007/s10895-025-04231-z","url":null,"abstract":"<p><p>We designed and built several triazolone-based dyes (TPA1-TPA5 and PTZ1-PTZ5) by modifying the structure around At-D-π-A. We studied how different donating and accepting groups affect the shape, energy levels, absorption spectra and photovoltaic behavior of these sensitizers using DFT and TDDFT calculations. We used selected functional methods to optimize the ground state of these sensitizer molecules. Our quantum chemistry calculations revealed vital molecular properties such as absorption properties, HOMO-LUMO orbital configurations, energy differences, and chemical properties indicators. The light absorption patterns and quantum data show useful evidence for applying these sensitizers in photonic systems. The performance data obtained from LHE, <math><mrow><mi>▵</mi> <msub><mi>G</mi> <mrow><mi>inject</mi></mrow> </msub> </mrow> </math> , and <math><msub><mtext>V</mtext> <mrow><mi>OC</mi></mrow> </msub> </math> metrics indicates these dyes are suitable for upcoming experimental tests which guide improvements to dye-sensitized solar cells. The study analyzes structural adjustments and electronic properties of these chromophores to show how they perform in photonic devices. These results help researchers plan new dye-sensitized solar cell experiments while supporting them in creating better solar energy devices.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spectrofluorophotometric Analysis of Phytoconstituents, Biomarkers, Enzyme Kinetics and Trace Metals: A Comprehensive Review.","authors":"Amol Warokar, Bhagyashree Dahake, Purushottam Gangane, Swapnil Samrit","doi":"10.1007/s10895-025-04241-x","DOIUrl":"https://doi.org/10.1007/s10895-025-04241-x","url":null,"abstract":"<p><p>Spectrofluorophotometry is a highly sensitive and selective analytical technique widely employed in pharmaceutical, biomedical, and environmental sciences. This review provides a comprehensive application for detecting and quantifying phytoconstituents, biomarkers, enzyme kinetics, and trace metals. This technique offers detection of analyte in the femtomolar (fM) range. Phytochemicals such as flavonoids, alkaloids, and polyphenols were analyzed with high precision and accuracy, and the reported analytical method can be adopted for quality control analysis. Spectrofluorophotometry has been utilized to estimate biomarkers, which plays a critical role in disease diagnostics and therapeutic monitoring. It also facilitates the monitoring of enzyme kinetics, offering insights into metabolic processes and drug development. Additionally, its ability to detect trace metals through chelation and fluorescence quenching mechanisms proves vital for environmental and toxicological analysis. Despite challenges such as fluorescence quenching and environmental susceptibility, advancements in miniaturization, automation, and hybrid analytical techniques continue to enhance their capabilities. This review underscores the transformative impact of spectrofluorophotometry and its expanding role in modern analytical sciences.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}