Journal of Fluorescence最新文献

{"title":"Molecular Design and DFT Analysis of High-performance Dyes Based on Pyrene with Different Donor Parts and Their Optoelectronic Applications","authors":"Faeq A. AL-Temimei, Muntadher Talib Awayiz, Hamid I. Abbood","doi":"10.1007/s10895-024-03936-x","DOIUrl":"https://doi.org/10.1007/s10895-024-03936-x","url":null,"abstract":"<p>The performance and efficacy of dyes, which are crucial photon-harvesting components in dye-sensitized solar cells (DSSCs), must be meticulously analysed at the molecular level. This research focuses on a theoretical investigation of dye characteristics rather than the synthesis of novel compounds. Using Density Functional Theory (DFT) and Time-Dependent DFT (TD-DFT), we have analysed six D-π-A structure dyes designed with pyrene as the π-bridge and various functional groups as donors. Our study examines their geometrical, electronic, optical, electronic localization, and electrochemical properties. The findings reveal that these theoretically designed D-π-A dyes show significant improvements in light-harvesting efficiency, open-circuit photovoltage, electron injection efficiency, and overall photovoltaic performance. The analysis indicates effective electron injection from each dye into the conduction band of TiO₂, followed by efficient regeneration and enhanced intra- and intermolecular charge transfer properties. The incorporation of pyrene as a π-bridge and the use of different functional groups as donors are crucial for facilitating electron transfer from the donor to the acceptor region. Among the dyes studied, the D-π-D modified dye demonstrates superior theoretical performance, attributed to its higher energy levels of the lowest unoccupied molecular orbital and greater oscillator strengths for excited states. This results in improved intramolecular electron transfer and electron injection into the conduction band of TiO₂, followed by effective regeneration. Overall, our study highlights the potential of these theoretically modeled dyes as highly promising sensitizers for DSSCs, due to their exceptional optical and electronic properties and impressive photovoltaic parameters. These findings position these molecular structures as strong candidates for future applications in organic DSSCs.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent, pH, and UCST Responsive Polymer Nanomaterials for Treatment of Recurrent Miscarriage","authors":"Xuanping Lu, Weiqin Zhou, Caiping Mao","doi":"10.1007/s10895-024-03883-7","DOIUrl":"https://doi.org/10.1007/s10895-024-03883-7","url":null,"abstract":"<p>Recurrent miscarriage (RM), defined as three or more consecutive spontaneous miscarriages, affects many women of childbearing age. The pathological basis of RM is an imbalance in apoptosis, with the MDM2-p53 pathway playing a crucial role. In this study, we synthesized poly(6-acetoxyl-ε-caprolactone)-graft-(4-amino-benzimidazole) (PCCL-4-ABI) by modifying poly(6-acetoxyl-ε-caprolactone) (PCCL) with 4-amino-benzimidazole (4-ABI). The introduction of carboxyl and 4-ABI groups endowed the PCL backbone with fluorescence, pH responsiveness, and UCST responsiveness. The temperature-dependent release behavior of compound 1-loaded PCCL-4-ABI nanofluorescent materials was attributed to UCST transition. We successfully developed a novel nanofluorescent polymer drug delivery platform, PCCL-4-ABI@1, and evaluated its regulatory effects on p53 and MDM2 in trophoblast cells (HTR-8/SVneo). The results showed that the system loaded with low molecular weight heparin increased MDM2 and decreased p53 expression in a dose-dependent manner, thereby inhibiting trophoblast cell apoptosis. This study developed a biodegradable poly(ε-caprolactone) with UCST behavior, significant for the advancement of thermoresponsive fluorescent nanoparticle systems.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes: Classification and Analytical Applications – A Review","authors":"Kurdo A. Abdullah, Tara F. Tahir, Aryan F. Qader, Rebaz A. Omer, Khdir A. Othman","doi":"10.1007/s10895-024-03930-3","DOIUrl":"https://doi.org/10.1007/s10895-024-03930-3","url":null,"abstract":"<p>The recent discovery of a new class of nanomaterials called nanozymes, which have the action of enzymes and are thus of tremendous significance, has altered our understanding of these previously believed to be biologically inert nanomaterials. As a significant and exciting class of synthetic enzymes, nanozymes have distinct advantages over natural enzymes. They are less expensive, more stable, and easier to work with and store, making them a viable substitute. This practical advantage of nanozymes over natural enzymes reassures us about the potential of this new technology. Peroxidase-like nanozymes have been investigated for the purpose of creating adaptable biosensors via the use of molecularly imprinted polymers (MIPs) or particular bio recognition ligands, including enzymes, antibodies, and aptamers. This review delves into the distinctions between synthetic and natural enzymes, explaining their structures and analytical applications. It primarily focuses on carbon-based nanozymes, particularly those that contain both carbon and hydrogen, as well as metal-based nanozymes like Fe, Cu, and Au, along with their metal oxide (FeO, CuO), which have applications in many fields today. Analytical chemistry finds great use for nanozymes for sensing and other applications, particularly in comparison with other classical methods in terms of selectivity and sensitivity. Nanozymes, with their unique catalytic capabilities, have emerged as a crucial tool in the early diagnosis of COVID-19. Their application in nanozyme-based sensing and detection, particularly through colorimetric and fluorometric methods, has significantly advanced our ability to detect the virus at an early stage.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon Dots Employed for the Detection of Ranitidine and Elaborating the Detecting Mechanism","authors":"Mei Zhang, Jingwen Zhao, Yingying Long, Changsong Li, Xiaoming Yang","doi":"10.1007/s10895-024-03912-5","DOIUrl":"https://doi.org/10.1007/s10895-024-03912-5","url":null,"abstract":"<p>Carbon dots (CDs) has been widely utilized in multiple fields, especially towards kinds of drug analyses, owing to its superior optical properties and satisfactory stability. Herein, we rapidly synthesized one kind of soluble bright-blue fluorescent CDs through a facile microwave method, while disodium ethylenediaminetetraacetic acid and phosphoric acid served as the raw materials. Importantly, introducing ranitidine into these CDs resulted in its decreased fluorescence, and thus an innovative method of detecting ranitidine was successfully established, which showed the favorable selectivity and anti-interference ability. With the optimal conditions, the standard curve diagram of F₀/F against concentration of ranitidine was linear in the range of 6-2000 µM with a correlation coefficient of 0.9833, and the limit of detection (LOD) was calculated to be 4.2 µM. Meanwhile, we also explored the detecting mechanism of ranitidine by CDs, and elaborated that as the internal filtration effect. Consequently, we may broaden the avenues of detecting ranitidine on the basis of CDs.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perylene Diimide-based Fluorescent Aptasensor for Quantitative Analysis of Pb2+ Based on Terminal Deoxynucleotidyl Transferase-assisted Formation of Elongated Aptamer and Gold Nanoparticles","authors":"Masoomeh Esmaelpourfarkhani, Mahdi Yaghmaei, Mohammad Ramezani, Mona Alibolandi, Khalil Abnous, Seyed Mohammad Taghdisi","doi":"10.1007/s10895-024-03923-2","DOIUrl":"https://doi.org/10.1007/s10895-024-03923-2","url":null,"abstract":"<p>Due to the exceedingly poisonous properties of Pb²⁺, it is imperative to conduct a thorough assessment of its quantity in both biological and environmental samples, as this is crucial for safeguarding public health. This study describes an economic turn-off fluorescent aptasensor for the quantitative analysis of Pb²⁺ employing 3,4,9,10-perylenetetracarboxylic acid diimide (PTCDI) as a cost-effective fluorophore, gold nanoparticles (AuNPs) as separating agent and an elongated aptamer as both targeting agent and PTCDI loading site. The fundamental principle of the suggested fluorescent aptasensor, which is based on PTCDI, relies on detecting variations in the fluorescence intensity of PTCDI when an elongated aptamer (as single-stranded DNA) is present or absent. The advanced aptasensor is advantageous due to the elongation of the lead aptamer sequence length induced by terminal deoxynucleotidyl transferase (TdT), resulting in enhanced sensitivity. The presence of Pb²⁺ and the centrifugation process causes the separation of the poly A-modified aptamer/Pb²⁺ conjugate from the poly T sequence. Hence, the interaction of PTCDI with the poly A moiety in the modified aptamer leads to a decrease in its fluorescence emission. The findings showcased that the fluorescent aptasensor exhibited exceptional specificity towards Pb²⁺ ions, while the biosensing platform accomplished an impressive detection limit of 3.7 pM. Moreover, the suggested aptasensor utilizing PTCDI exhibits a commendable capability in quantitatively analyzing Pb²⁺ within human serum samples and mineral water.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability of Bile Baseline Excitation-emission Fluorescence of Two Tropical Freshwater Fish Species","authors":"Diego Mora-Solarte, Rodrigo Jimenez, Ivonne Calderón-Delgado, Alvaro Duarte-Ruiz, Markus Brinkmann, Yohana Velasco-Santamaría","doi":"10.1007/s10895-024-03871-x","DOIUrl":"https://doi.org/10.1007/s10895-024-03871-x","url":null,"abstract":"<p>The quantification of pollutant metabolites in fish bile is an efficient approach to xenobiotic pollution monitoring in freshwaters since these measurements directly address exposure. Fluorescence excitation-emission matrix spectroscopy (EEMS) has demonstrated to be a highly specific and cost-effective technique for polycyclic aromatic hydrocarbon (PAH) and PAH-metabolite identification and quantification. EEMS ability to quantify these compounds strongly depends on the intensity and variability of the bile baseline fluorescence (BBF). We found large differences in BBF among <i>Aequidens metae</i> (AME) individuals and of these with <i>Piaractus orinoquensis</i> (PIO). Moreover, BBF was large enough that solvent dilutions of over 1:400 were needed to avoid inner filter effects. We used parallel factor analysis (PARAFAC) to model the intra- and inter-species BBF variability. PARAFAC successfully decomposed the EEMS set into three fluorophores present in all samples, although in concentrations spreading over ~ 3 orders of magnitude. One of the factors was identified as tryptophan. Tryptophan and Factor 2 were covariant and much more abundant in AME than in PIO, while Factor 3 was ~ 6 times more abundant in PIO than in AME. Also, tryptophan was ~ 10x more abundant in AME specimens immediately caught in rivers than in their laboratory-adapted peers. The PARAFAC decomposition effectiveness was confirmed by the positive proportionality of scores to dilution ratios. A large inner filter indicates that Factor 2 is as strong a light absorber as tryptophan. Our results stress the need to include bile matrix variable components for the detection and quantification of pollutant metabolites using PARAFAC.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing ESIPT-Capable α-Cyanostilbene Luminogens: Influence of Different Aromatic Substitutions Tethered to H-Acceptor (CH = N) on Photophysical Properties, Cu2+ and Fe3+ Detection","authors":"Meihui Chen, Yulin Zhou, Yi Li, Donghong Xie, Yuanbin Wu, Huihua Gong, Zhenye Wang, Yue Yu, Jianqiang Chen, Mingguang Zhu","doi":"10.1007/s10895-024-03920-5","DOIUrl":"https://doi.org/10.1007/s10895-024-03920-5","url":null,"abstract":"<p>Herein, two excited-state intramolecular proton transfer (ESIPT)-capable α-cyanostilbene luminogens were synthesized by Schiff base reaction of salicylaldehyde-like α-cyanostilbene candidate with 1-naphthylamine and 3-biphenylamine, respectively. We systematically analyzed their photophysical properties compared with their analogue, and demonstrated that their fluorescence behaviors could be elaborately modulated by different aromatic substitutions tethered to H-acceptor (CH = N). In virtue of the outstanding solid fluorescence, the 3-biphenylamine-decorated fluorophore was applied for monitoring Cu²⁺/Fe³⁺ qualitatively on the TLC-based test strip in real time and sensing Cu²⁺/Fe³⁺ quantitatively in the THF/H₂O medium (<i>f</i>_w = 90%, pH = 7.4). When the probe chelated with Cu²⁺/Fe³⁺, similar “turn-off” fluorescence signal outputs were triggered. From the fluorescence titration experiments, the detection limits were evaluated as 7.97 × 10^− 8 M for Cu²⁺ and 8.24 × 10^− 8 M for Fe³⁺, and the binding constant (<i>K</i>_α) values of the complexes were found to be 7.80 × 10⁴ M^-1 for Cu²⁺ and 9.06 × 10⁴ M^-1 for Fe³⁺. Job’s plots indicated that probe complexed with Cu²⁺/Fe³⁺ in a 2:1 binding stoichiometry ratio. Furthermore, the probe was used to accurately quantify the Fe³⁺ spiked in real water specimens. This study offered a new perspective to construct ESIPT-capable α-cyanostilbene luminogen as the potential luminescent probe.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence Carbon Dots from Blood-Berries for Sensing Cr6+ Ions in Water and Application in White Light Emitting Diode","authors":"V. Kamalarasan, C. Venkateswaran","doi":"10.1007/s10895-024-03916-1","DOIUrl":"https://doi.org/10.1007/s10895-024-03916-1","url":null,"abstract":"<p>Conventional techniques for identifying heavy metal ions in water are laborious and time-consuming. Therefore, it is necessary to create innovative sensing technologies that can detect with greater sensitivity and speed. Although there have been reports of optical-based assays utilising fluorescent nanomaterials, these assays usually rely on variations in signal strength. However, this approach has significant drawbacks when it comes to environmental monitoring. Fluorescence carbon dots (CDs) have been prepared by facile synthesis from Blood berries. A homemade heavy metal optical detector is constructed to accurately identify heavy metal ions, exclusively Cr⁶⁺ ions in a water medium. Their optical emission signature varies based on the specific chromium ions in solution, and the emission intensity also changes depending on its concentration. The quenching behaviour is attributed to the interaction between the metallic cations and the fluorescent surface states of the carbon dots. Another application is the encapsulation of CDs in PVDF polymer to form a flexible film and use it as a phosphor for LED conversion.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Orange-Emitting YPO4:Sm3+/Polymer Nanocomposite Phosphor Films for LED Applications","authors":"Lamine Mebarki, Badis Kahouadji, Abdelhalim Zoukel, Lyes Benharrat, Jai Prakash, Salim Ouhenia, Abdelhafid Souici, Maxime Delaey, Lakhdar Guerbous, Dirk Poelman, Hendrik C. Swart","doi":"10.1007/s10895-024-03915-2","DOIUrl":"https://doi.org/10.1007/s10895-024-03915-2","url":null,"abstract":"<p>A polymer based nanocomposite (NC) material embedded with highly luminescent nanopowders could be promising for replacing traditional luminescent materials from a technological point of view. In this study, we have successfully obtained YPO₄: Sm³⁺ /Polymer nanocomposite phosphor films by embedding YPO₄: Sm³⁺ luminescent nanoparticles (NPs) for orange-light emitting diode (LED) applications. These luminescent NPs were synthesized using the sol gel method in different polymer matrices i.e. polystyrene (PS) and poly (methyl methacrylate) (PMMA) by using direct solution mixing. The structural, morphological, and photoluminescence characteristics of the nano-phosphors and resulting NC films were examined and discussed. The emission spectra of YPO₄: Sm³⁺ (x at.%) nano-phosphors under near-UV excitation at 404 nm were dominated by orange emission attributed to ⁶H_5/2 <span>(rightarrow)</span> ⁴F_7/2 (601 nm) luminescence of Sm³⁺ ions. The optimum doping concentration of activator Sm³⁺ in YPO₄ matrix was found to be 5 at.%. When the doping concentration of Sm³⁺ was higher than 5 at.%, concentration quenching occurred. The incorporation of YPO₄: Sm³⁺ NPs into polymer matrices indicated that the NCs retained the original luminescence properties of the luminescent NPs, although a decrease in their emission intensity was observed for the NC films, attributable to a polymer matrix effect, which dominated in PS matrix. The fluorescence decay times of NPs in the NC films were measured and compared to those of proper YPO₄: Sm³⁺ nano-phosphors. A decrease in decay time in NC film was observed due the effective refractive index effect. Temperature-dependent photoluminescence (TDPL) of PMMA NC film was studied in 100–400 K range, investigating the thermal stability of the film. Additionally, CIE coordinates confirmed the red–orange light emission of the prepared phosphors and NC films. The obtained results indicate that the synthesized polymer-nanophosphor NC films are promising candidates for orange-LED applications.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Methanol Sensing: Integrating Chemical Insights of Optical Sensors for Enhanced Detection.","authors":"Amit K Deoghoria, Nilanjan Dey","doi":"10.1007/s10895-024-03860-0","DOIUrl":"https://doi.org/10.1007/s10895-024-03860-0","url":null,"abstract":"<p><p>Methanol has become a very important part of many industries, ranging from chemical production and pharmaceuticals to automotive and electronics manufacturing as a result of which methanol usage has spiked in recent years. But this exponential increase asks for precise detection methods as methanol has not only detrimental effects on environment but it is very dangerous to human health even if consumed in a minute amount .This paper will explore the unique physical and chemical properties of methanol which can be exploited to make it a target for different mechanisms such as H-Bonding, induced self-assembly, Internal Charge Transfer (ICT), Aggregation-induced emission (AIE), conformational flexibility, keto-enol tautomerization, adsorption etc. by various small molecule and nano-particles. Informative studies on small molecules involves functionalized pentacenequinone derivatives, luminogens, ligands and fluorescent probes which can be used to detect methanol by change in color or intensity which can be easily detected in real time and is portable. On the other hand, nanoparticle-based probes reveal the use of materials like chitosan/zinc, sulfide composites, Quantum Dots (QDs) hybrids, graphene polyoxides, Ag-LaFeO₃ etc. which provides with selective and sensitive methanol optical and conductometric sensing. This paper acknowledges the contributions of various studies and researchers who contributed to advancing the field of methanol sensing, providing a foundation for future developments.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}