Journal of ethnopharmacology最新文献

{"title":"Shisanwei Qinglan Powder attenuates ethanol-induced gastric mucosal injury in association with reduced NF-κB signalling and caspase activation.","authors":"Kanshen Ye, Haoqin Li, Zhizheng Qin, Zichen Zhu, Rui Wang, Jie Dou, Qingjia Ren, Xiaoya Liu, Fei Wang","doi":"10.1016/j.jep.2026.122505","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122505","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Shisanwei Qinglan Powder (SQP) is a marketed Tibetan medicinal formula traditionally used for gastrointestinal disorders associated with \"peigen mubu\", including epigastric distension and pain, gastritis, and ulcer-related symptoms. However, experimental evidence for the complete formula, its systemically exposed constituents, and the mechanisms underlying gastric mucosal protection remains limited.</p><p><strong>Aim of the study: </strong>This study aimed to characterise the serum-associated constituents of SQP and evaluate its protective effects and molecular responses in acute ethanol-induced gastric mucosal injury.</p><p><strong>Materials and methods: </strong>Chemical profiling and serum pharmacochemistry were performed by liquid chromatography-tandem mass spectrometry. Network pharmacology and gastric-tissue transcriptomics were integrated to prioritise treatment-associated pathways. Pharmacological effects were evaluated in mice receiving SQP prophylactically before anhydrous ethanol challenge and in GES-1 cells receiving SQP after ethanol-induced injury, using viability, migration, apoptosis, macroscopic lesion, histological, oxidative-stress, and inflammatory measurements. The IKKβ/IκBα/NF-κB axis and caspase-8/caspase-3 activation were assessed by immunohistochemistry and western blotting. Selected compound-target pairs were further evaluated by molecular docking and 100-ns molecular dynamics simulations.</p><p><strong>Results: </strong>Thirty-two distinct serum-associated constituents were tentatively identified, and 185 targets were shared between SQP- and gastric ulcer-related datasets. Under the post-injury cell-intervention paradigm, SQP improved viability and migration, corrected oxidative and cytokine imbalances, and reduced total apoptosis from approximately 21.9% to 7.9% at 20 μg/mL. Under the prophylactic animal paradigm, SQP alleviated haemorrhage, erosion, and glandular disruption, and 0.52 g/kg significantly reduced both the ulcer index and damaged area. RNA sequencing identified 1,533 differentially expressed genes between the high-dose SQP and model groups, with enrichment in TNF, NF-κB and apoptosis-related pathways. In both models, SQP reduced phosphorylation of IKKβ, IκBα and NF-κB p65, suppressed caspase-8 and caspase-3 cleavage, and decreased gastric TUNEL positivity. Molecular docking and molecular dynamics simulations were used for computational prioritization of the TNF-bicuculline and CASP3-kaempferol pairs; these analyses indicated structural feasibility under the simulated conditions but did not establish direct binding or target engagement.</p><p><strong>Conclusion: </strong>SQP showed prophylactic gastroprote ctive effects in mice and post-injury protective and reparative effects in ethanol-injured GES-1 cells. Across these distinct experimental paradigms, the observed effects were associated with attenuation of oxidative stress, IKK/NF-κB-related inflammati","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122505"},"PeriodicalIF":6.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation\" [J. Ethnopharmacol. 256, (2020), 112824].","authors":"Ying-Nan Jiang, Yong-Zhi Guo, Dan-Hua Lu, Ming-Hai Pan, Hai-Zhi Liu, Gen-Long Jiao, Wei Bi, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He, Xin-Sheng Yao","doi":"10.1016/j.jep.2026.122501","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122501","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122501"},"PeriodicalIF":6.8,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Tianma Gouteng granules decreases the susceptibility of Parkinson's disease by inhibiting ALOX15-mediated lipid peroxidation\" [J. Ethnopharmacol. 256, (2020), 112824].","authors":"Ying-Nan Jiang, Yong-Zhi Guo, Dan-Hua Lu, Ming-Hai Pan, Hai-Zhi Liu, Gen-Long Jiao, Wei Bi, Hiroshi Kurihara, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He, Xin-Sheng Yao","doi":"10.1016/j.jep.2026.122456","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122456","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122456"},"PeriodicalIF":6.8,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"CYP2C19-mediated metabolic activation and OAT3/P-gp-associated transport contribute to Dioscorea bulbifera L.-induced hepatotoxicity\" [J. Ethnopharmacol. (2026) 122272].","authors":"Yuwei Tian, Liping Deng, Weiyu Guo, Zihao Cheng, Yongjun Li, Dingyan Lu, Shiyu Zhang, Jiang Zheng, Ting Liu","doi":"10.1016/j.jep.2026.122397","DOIUrl":"10.1016/j.jep.2026.122397","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122397"},"PeriodicalIF":6.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Mutton fat-processing enhances the anti-osteoporotic effect of Epimedium koreanum Nakai via regulating the metabolism-inflammation-bone axis\" [J. Ethnopharmacol. 372, (2027), 122153].","authors":"Xinyang Du, Jingran Li, Shuai Qu, Hong Kan, Yingping Wang","doi":"10.1016/j.jep.2026.122437","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122437","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122437"},"PeriodicalIF":6.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Tianwang Buxin Decoction ameliorates neuroinflammation in insomnia via adenosine accumulation-mediated AMPK/SIRT1 pathway\" [J. Ethnopharmacol. (2026), 368, 121790].","authors":"Yaqi Li, Shiyu Ji, Jiecheng Jiang, Zhujiang Li, Zhuo Zhang, Yixuan Wu, Zefeng Zhang, Peipei Qiao, Mingyu Yu, Panpan Huang","doi":"10.1016/j.jep.2026.122387","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122387","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122387"},"PeriodicalIF":6.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment\" [J. Ethnopharmacol. 372, (2027), 122238].","authors":"Hee-Yeon Kwon, Hyesung Lee, Ji-Soo Choi, Seong Hun Lim, Taehyun Kim, Kyeongseok Bae, Young-Sik Park, Eun-Min Kim, Jae-Yeon Lee, Eun-Young Park, Nahyun Choi, Se-Young Choung, Do Sik Min","doi":"10.1016/j.jep.2026.122395","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122395","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122395"},"PeriodicalIF":6.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1/p53 axis\" [J. Ethnopharmacol. 356 (2026) 120758].","authors":"Maohui Liu, Jiawei Chen, Zubing Zhou, Jiexin Wang, Guangsen Li, Jinghui Xie, Lingmiao Wen, Huan Wang, Rong Gan, Peihai Zhang, Yanju Gong, Weijun Ding","doi":"10.1016/j.jep.2026.122362","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122362","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122362"},"PeriodicalIF":6.8,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Qinghuang powder ameliorates cellular senescence and energy metabolism abnormalities in bone marrow mesenchymal stem cells of myelodysplastic syndromes\" [J. Ethnopharmacol. 373 (2026) 122323].","authors":"Peizhen Jiang, Daxiang Sun, Yaoyin Zhang, Dexiu Wang, Jiaqi He, Xudong Tang","doi":"10.1016/j.jep.2026.122360","DOIUrl":"10.1016/j.jep.2026.122360","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122360"},"PeriodicalIF":6.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Notoginsenoside R1 interferes with PGAM5-NEK7 interaction to inhibit NLRP3 inflammasome activation in macrophages and ameliorate DSS-induced colitis\" [J. Ethnopharmacol. 370 (2026) 122036].","authors":"Qianqian Du, Zhimei Chen, Xian Ma, Yayu Zhang, Yongqiang Fan","doi":"10.1016/j.jep.2026.122336","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122336","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122336"},"PeriodicalIF":6.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}