Journal of ethnopharmacology最新文献

{"title":"Corrigendum to \"CYP2C19-mediated metabolic activation and OAT3/P-gp-associated transport contribute to Dioscorea bulbifera L.-induced hepatotoxicity\" [J. Ethnopharmacol. (2026) 122272].","authors":"Yuwei Tian, Liping Deng, Weiyu Guo, Zihao Cheng, Yongjun Li, Dingyan Lu, Shiyu Zhang, Jiang Zheng, Ting Liu","doi":"10.1016/j.jep.2026.122397","DOIUrl":"10.1016/j.jep.2026.122397","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122397"},"PeriodicalIF":6.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Mutton fat-processing enhances the anti-osteoporotic effect of Epimedium koreanum Nakai via regulating the metabolism-inflammation-bone axis\" [J. Ethnopharmacol. 372, (2027), 122153].","authors":"Xinyang Du, Jingran Li, Shuai Qu, Hong Kan, Yingping Wang","doi":"10.1016/j.jep.2026.122437","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122437","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122437"},"PeriodicalIF":6.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Tianwang Buxin Decoction ameliorates neuroinflammation in insomnia via adenosine accumulation-mediated AMPK/SIRT1 pathway\" [J. Ethnopharmacol. (2026), 368, 121790].","authors":"Yaqi Li, Shiyu Ji, Jiecheng Jiang, Zhujiang Li, Zhuo Zhang, Yixuan Wu, Zefeng Zhang, Peipei Qiao, Mingyu Yu, Panpan Huang","doi":"10.1016/j.jep.2026.122387","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122387","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122387"},"PeriodicalIF":6.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment\" [J. Ethnopharmacol. 372, (2027), 122238].","authors":"Hee-Yeon Kwon, Hyesung Lee, Ji-Soo Choi, Seong Hun Lim, Taehyun Kim, Kyeongseok Bae, Young-Sik Park, Eun-Min Kim, Jae-Yeon Lee, Eun-Young Park, Nahyun Choi, Se-Young Choung, Do Sik Min","doi":"10.1016/j.jep.2026.122395","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122395","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122395"},"PeriodicalIF":6.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Er-Chen decoction alleviates spermatogenic dysfunction in obese mice by tuning the SIRT1/p53 axis\" [J. Ethnopharmacol. 356 (2026) 120758].","authors":"Maohui Liu, Jiawei Chen, Zubing Zhou, Jiexin Wang, Guangsen Li, Jinghui Xie, Lingmiao Wen, Huan Wang, Rong Gan, Peihai Zhang, Yanju Gong, Weijun Ding","doi":"10.1016/j.jep.2026.122362","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122362","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122362"},"PeriodicalIF":6.8,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Qinghuang powder ameliorates cellular senescence and energy metabolism abnormalities in bone marrow mesenchymal stem cells of myelodysplastic syndromes\" [J. Ethnopharmacol. 373 (2026) 122323].","authors":"Peizhen Jiang, Daxiang Sun, Yaoyin Zhang, Dexiu Wang, Jiaqi He, Xudong Tang","doi":"10.1016/j.jep.2026.122360","DOIUrl":"10.1016/j.jep.2026.122360","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122360"},"PeriodicalIF":6.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Notoginsenoside R1 interferes with PGAM5-NEK7 interaction to inhibit NLRP3 inflammasome activation in macrophages and ameliorate DSS-induced colitis\" [J. Ethnopharmacol. 370 (2026) 122036].","authors":"Qianqian Du, Zhimei Chen, Xian Ma, Yayu Zhang, Yongqiang Fan","doi":"10.1016/j.jep.2026.122336","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122336","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122336"},"PeriodicalIF":6.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yunpi Xiaoji Formula Restores Gut-Brain Axis Homeostasis in Infantile Anorexia by Targeting the SCFAs-GPR43 Signaling Pathway.","authors":"Binyuan Zhao, Wenxia Tian, Jing Chen, Yuezhen He, Yuxia Li","doi":"10.1016/j.jep.2026.122075","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122075","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Infantile anorexia (IA) represents a complex feeding disorder with limited therapeutic options currently available. The traditional Chinese medicine (TCM) formula Yunpi Xiaoji Formula (YPXJF) has demonstrated clinical efficacy in ameliorating IA symptoms; however, its underlying mechanisms, particularly those associated with the gut-brain axis, remain to be systematically elucidated.</p><p><strong>Aim of the study: </strong>This study aimed to determine the association between anorexia and the SCFAs-GPR43-PYY/GLP-1 pathway, to investigate whether YPXJF ameliorates IA via modulation of this pathway, and to elucidate its role in gut-brain axis crosstalk.</p><p><strong>Materials and methods: </strong>The phytochemical profile of YPXJF and its absorbed serum constituents was characterized using UHPLC-MS. An integrative approach combining in vivo IA rat models and in vitro cell systems was employed. Interventions included the GPR43 agonist 4-CMTB and antagonist GLPG0974. Genetic techniques involved GPR43 knockdown and overexpression in GLUTag L-cells. Gut-brain axis communication was modeled using a Transwell co-culture system of GLUTag L-cells and POMC neurons. Analytical methods comprised H&E staining, immunohistochemistry, immunofluorescence, Western blotting, RT-PCR, and ELISA.</p><p><strong>Results: </strong>A total of 883 compounds were detected in YPXJF, with 130 absorbed constituents (82 prototypes and 48 metabolites) identified in serum, primarily phenolic acids, alkaloids, and flavonoids. The pathogenesis of IA was driven by aberrant activation of the gut-brain axis. In IA rats, elevated levels of fecal SCFAs (acetate, propionate, and butyrate) activated G protein-coupled receptor 43 (GPR43) on colonic L-cells, leading to excessive secretion of the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). These hormones subsequently acted on the hypothalamus to upregulate anorexigenic POMC/CART neurons and downregulate orexigenic NPY/AGRP neurons, ultimately resulting in anorexia. YPXJF treatment effectively reversed this dysregulation by normalizing fecal SCFA profiles and downregulating colonic GPR43 expression, which reduced GLP-1 and PYY secretion. Consequently, YPXJF suppressed hypothalamic POMC neuronal activity and enhanced NPY neuronal activity, restoring appetite and body weight. These findings were confirmed by molecular assays showing that YPXJF efficacy was blunted by GPR43 overexpression or agonist co-administration.</p><p><strong>Conclusion: </strong>YPXJF ameliorates IA by modulating the SCFAs-GPR43 pathway and restores gut-brain axis homeostasis by attenuating pathological anorexigenic signaling and restoring physiological appetite regulation. This study provides a mechanistic basis for YPXJF's clinical application and identifies GPR43 as a promising therapeutic target.</p>","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122075"},"PeriodicalIF":6.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Areca catechu L. procyanidins alleviate pulmonary fibrosis by suppressing the TGF-β/Smad/ERK cascade: Validation of traditional herbal medicine\". [J. Ethnopharmacol. 372 (2027) 122236].","authors":"Bin Liu, Yueru Zhao, Mengxia Zhu, Lei Liu","doi":"10.1016/j.jep.2026.122337","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122337","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122337"},"PeriodicalIF":6.8,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Traditional Mongolian medicine Batri-7 exhibits chemopreventive activity in colitis-associated colorectal cancer through microbiota modulation and NLRP3 inflammasome targeting\" [J. Ethnopharmacol. 355 (2026) 120696/ JETHNO-D-25-09107].","authors":"Jiaxin Sun, Jialin Shi, Jie Zhang, Xuemeng Sun, Shengyao Du, Xianjue Wang, Gang Liu, Xian Li, Xuemin Feng, Jia Wang, Mingxing Hou, Ying Wei, Liya Su","doi":"10.1016/j.jep.2026.122319","DOIUrl":"https://doi.org/10.1016/j.jep.2026.122319","url":null,"abstract":"","PeriodicalId":15761,"journal":{"name":"Journal of ethnopharmacology","volume":" ","pages":"122319"},"PeriodicalIF":6.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}