Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes最新文献_第10页

Dissipation, residue and dietary risk assessment of difenoconazole in Rosa roxburghii. 苯醚甲环唑在刺梨中的消散、残留和饮食风险评估。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2023-10-12 DOI: 10.1080/03601234.2023.2263325

Qingshan Feng, Lei Han, Qiong Wu, Xiaomao Wu

{"title":"Dissipation, residue and dietary risk assessment of difenoconazole in Rosa roxburghii.","authors":"Qingshan Feng, Lei Han, Qiong Wu, Xiaomao Wu","doi":"10.1080/03601234.2023.2263325","DOIUrl":"10.1080/03601234.2023.2263325","url":null,"abstract":"Rosa roxburghii is a medicinal and edible plant, which is favored by consumers due to its rich vitamin C content. Residues and potential health risks of difenoconazole in the R. roxburghii ecosystem has aroused a concern considering its extensive use for controlling the powdery mildew of R. roxburghii. In this study, the residue of difenoconazole in R. roxburghii and soil was extracted by acetonitrile, purified by primary secondary amine and detected by liquid chromatography-tandem triple quadrupole mass spectrometry. The average recoveries in R. roxburghii and soil matrix varied from 82.59% to 99.63%, with relative standard deviations (RSD) of 1.14%-8.23%. The limit of quantification (LOQ) and detection (LOD) of difenoconazole in R. roxburghii and soil samples were 0.01 mg/kg. The dissipation of difenoconazole followed well the first-order kinetic, with a half-life of 3.99-5.57 d in R. roxburghii and 4.94-6.23 d in soil, respectively. And the terminal residues were <0.01-2.181 mg/kg and 0.014-2.406 mg/kg, respectively. The chronic and acute risk quotient values of difenoconazole were respectively 0.42% and 4.1%, which suggests that the risk was acceptable and safe to consumers. This study provides a reference for the safe and reasonable use of difenoconazole in R. roxburghii production.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"651-658"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41134550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic genomic assessment of dietary ingestion of 2-aminoanthracene in Sprague Dawley rats. 大鼠饮食摄取2-氨基蒽的肝脏基因组评估。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 DOI: 10.1080/03601234.2023.2185023

Awa M Cisse, Jody E Erber, Brittany J McHale, Worlanyo E Gato

{"title":"Hepatic genomic assessment of dietary ingestion of 2-aminoanthracene in Sprague Dawley rats.","authors":"Awa M Cisse, Jody E Erber, Brittany J McHale, Worlanyo E Gato","doi":"10.1080/03601234.2023.2185023","DOIUrl":"https://doi.org/10.1080/03601234.2023.2185023","url":null,"abstract":"This research aims to investigate the effects of 2-aminoanthracene (2-AA), a polycyclic aromatic hydrocarbon (PAH), on the liver. PAH is a by-product of the incomplete combustion of fossil fuels. Specifically, the impact of 2-AA on different body tissues in animals has been reported. The liver is an organ central to the metabolism of PAHs, including 2-AA. Sprague Dawley rats ingested a well-defined dose of 2-AA in their diet (0, 50, and 100 mg/kg 2-AA) for 12 weeks. Hepatic global gene expression using Affymetrix Rat Genome 230 2.0 microarray was performed. Overall, more than 17,000 genes were expressed. Approximately 70 genes were upregulated, while 65 were downregulated when control rats were compared with low-dose animals. Similarly, 103 genes were upregulated and 49 downregulated when the high-concentration 2-AA group was compared with the control group rats. This result suggests that the magnitude of gene expression fold change depends on the dose of 2-AA ingested. Several differentially expressed genes are involved in biological processes such as gene transcription, cell cycle, and immune system function, indicating that the ingestion of 2-AA could impact these processes. The over-expression of genes related to liver inflammation, nonalcoholic liver disease, hepatic glucose processing, and PAH metabolism were noted.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":"58 3","pages":"229-238"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9211951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress induced by soil contamination with heavy metals and their effects on some biomarkers and DNA damage in maize plants at the vicinity of Ferronikel smelter in Drenas, Kosovo. 科索沃德雷纳斯Ferronikel冶炼厂附近土壤重金属污染引起的胁迫及其对玉米植物某些生物标志物和DNA损伤的影响。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2023-09-06 DOI: 10.1080/03601234.2023.2253114

Liridon Buqaj, Bekim Gashi, Muhamet Zogaj, Ramë Vataj, Valbona Sota, Metin Tuna

{"title":"Stress induced by soil contamination with heavy metals and their effects on some biomarkers and DNA damage in maize plants at the vicinity of Ferronikel smelter in Drenas, Kosovo.","authors":"Liridon Buqaj, Bekim Gashi, Muhamet Zogaj, Ramë Vataj, Valbona Sota, Metin Tuna","doi":"10.1080/03601234.2023.2253114","DOIUrl":"10.1080/03601234.2023.2253114","url":null,"abstract":"The Ferronikel smelter in Drenas is one of the main industrial areas in the Kosovo and pollution by heavy metals causes serious threat for all living organisms on this area. The objective of this study was to determine the concentration of some heavy metals (Fe, Cu, Mn, Cr, Cd, Ni and Pb) in agricultural soils and in maize plants, and their potential toxic effects on this plant through some sensitive biochemical and molecular markers. Maize seedlings growth in nine soil samples from different locations of this area. The highest concentrations of heavy metals in soils and maize leaves were conducted close to the Ferronikel smelter, and in some locations, the nickel and chromium concertation in soils exceeded 800 mg kg-1. A significant effects of heavy metals induced toxicity resulted in the, build-up aminolevulinic acid and reduced activity of δ-aminolevulinic acid dehydratase, and chlorophyll content in the maize leaves. In general, maize seedlings growth in polluted locations showed an increase in nuclear DNA content and in G2M phase. We concluded that locations close to the smelter are affected by soil heavy metals pollution and these biochemical and molecular analysis would be a powerful ecotoxicological tool in biomonitoring of heavy metal pollution.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"617-627"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10163323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel moisture retaining dustable powder containing Steinernema abbasi effectively controls damage of subterranean termite in wheat and chickpea. 一种新型保水剂，能有效控制小麦和鹰嘴豆地下白蚁的危害。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2023-10-12 DOI: 10.1080/03601234.2023.2264743

Arkadeb Mukhopadhyay, Shubham Chaudhary, Jyoti Antil, Vishal S Somvanshi, Suresh M Nebapure, Neeraj Patanjali, Anirban Dutta, Subhash Babu, Chellapilla Bharadwaj, Susama Sudhishri, Man Singh, Tirthankar Banerjee, Anil Kumar, Anupama Singh

{"title":"Novel moisture retaining dustable powder containing Steinernema abbasi effectively controls damage of subterranean termite in wheat and chickpea.","authors":"Arkadeb Mukhopadhyay, Shubham Chaudhary, Jyoti Antil, Vishal S Somvanshi, Suresh M Nebapure, Neeraj Patanjali, Anirban Dutta, Subhash Babu, Chellapilla Bharadwaj, Susama Sudhishri, Man Singh, Tirthankar Banerjee, Anil Kumar, Anupama Singh","doi":"10.1080/03601234.2023.2264743","DOIUrl":"10.1080/03601234.2023.2264743","url":null,"abstract":"The application of biocontrol agents in farm operations for pest control programs is gaining priority and preference globally. Effective delivery, infectivity of the biocontrol agents, and quality shelf-life products containing these bioagents are vital parameters responsible for the success of biopesticides under field conditions. In the present study, moisture-retaining bio-insecticidal dustable powder formulation (SaP) of Steinernema abbasi (Sa) infective juveniles (IJs) was developed and assessed for its shelf life, physicochemical profile, and bio-efficacy against subterranean termite under field conditions. Formulation exhibited free-flowing character, with pH of 6.50-7.50, and apparent density in the range 0.50-0.70 g cm-3. The bioefficacy study for two rabi seasons (2020-2021, and 2021-2022) in wheat and chickpea grown in an experimental farm heavily infested with subterranean termites (Odontotermes obesus) revealed a significant reduction in plant damage due to pest attack in formulation-treated plots, monitored in terms of relative number of infested tillers in wheat and infested plants in chickpea fields. The reduced damage to the crop caused by termite was reflected in the relative differences in the growth and yield attributes as well. The study establishes the potential of the developed product as a biopesticide suitable for organic farming and integrated pest management operations.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"679-688"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resonance Rayleigh scattering technique-using chitosan-capped gold nanoparticles, approaches spectrofluorimetric method for determination of Bentazone residual in water samples. 采用壳聚糖包覆金纳米粒子共振瑞利散射技术，采用荧光光谱法测定水样中苯达松的残留量。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2023-10-05 DOI: 10.1080/03601234.2023.2262348

Elham Pournamdari, Leila Niknam

引用次数: 0

Residues of pyrethroids and triazoles pesticides in water and sediment of certain Egyptian watercourses: assessing their influence on fungal diversity. 拟除虫菊酯类和三唑类杀虫剂在埃及某些水道的水和沉积物中的残留：评估其对真菌多样性的影响。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2023-10-05 DOI: 10.1080/03601234.2023.2263191

Marwa Tamim A Abdel-Wareth, Rania M Abd El-Hamid

{"title":"Residues of pyrethroids and triazoles pesticides in water and sediment of certain Egyptian watercourses: assessing their influence on fungal diversity.","authors":"Marwa Tamim A Abdel-Wareth, Rania M Abd El-Hamid","doi":"10.1080/03601234.2023.2263191","DOIUrl":"https://doi.org/10.1080/03601234.2023.2263191","url":null,"abstract":"Contamination of water and sediment with pyrethroids and triazoles residues can affect fungal diversity, and hence the aquatic system functioning. The aim of the present study is to investigate the effect of water and sediment contamination with pyrethroids and triazoles on fungal diversity. Water and sediment samples were seasonally collected along 2019 from water bodies representing Gharbeya and Qualubeya governorates. Concentrations of pyrethroids and triazoles were determined, and fungal species in water and sediment samples were molecularly identified. The results indicated that temperature and pH varied according to the season. Permethrin, deltamethrin, lambda-cyhalothrin and esfenvalerate showed the highest pyrethroids concentrations, whereas tetraconazole, tebuconazole and difenconazole were of the highest triazoles concentrations. Aspergillus niger was one of the most frequent species, in addition to Trichoderma capillare, Fusarium oxysporum, Penicillium commune and Penicillium polonicum. Principal component analysis indicated a positive correlation between temperature and different Aspergillus spp., and between pH and each of pyrethroids and triazoles. Moreover, a negative correlation was observed between triazoles and Trichoderma asperellum, Penicillium griseofulvum and Aspergillus fumigatus. In conclusion, contamination of water with pesticides affected fungal diversity. This disturbance in fungal assemblages might result in a reduction of some key organisms, or an increase and emergence of new pathogens.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":"58 10","pages":"637-650"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening bacterial isolates for biocontrol of sheath blight in rice plants. 筛选用于生物防治水稻鞘枯病的细菌分离物。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2023-06-14 DOI: 10.1080/03601234.2023.2220644

Akintunde Abiodun Ajulo, Princewill Chukwuma Asobia, Rodrigo Silva de Oliveira, Gustavo de Andrade Bezerra, Ariany Rosa Gonçalves, Marta Cristina Corsi de Filippi

{"title":"Screening bacterial isolates for biocontrol of sheath blight in rice plants.","authors":"Akintunde Abiodun Ajulo, Princewill Chukwuma Asobia, Rodrigo Silva de Oliveira, Gustavo de Andrade Bezerra, Ariany Rosa Gonçalves, Marta Cristina Corsi de Filippi","doi":"10.1080/03601234.2023.2220644","DOIUrl":"10.1080/03601234.2023.2220644","url":null,"abstract":"Sheath blight (Rhizoctonia solani) causes significant yield losses in rice (Oryza sativa L.). Its sustainable management needs an efficient biocontrol agent. The objective was to screen bacterial isolates as an antagonist to R. solani and identify the most efficient ones as sheath blight suppressors under greenhouse conditions. Two assays (E1 and E2) were performed in a completely randomized design with three replications. E1 tested 21 bacterial isolates antagonists to R. solani in vitro. E2 was conducted under greenhouse conditions, with rice cultivar BRS Pampeira sown in plastic pots (7 kg) containing fertilized soil. Sixty old plants were inoculated with a segment of a toothpick containing fragments of R. solani, followed by spray inoculation of a bacterial suspension (108 CFU/mL). The severity of the disease was determined by calculating the relative lesion size formed on the colm. Isolates BRM32112 (Pseudomonas nitroreducens), BRM65929 (Priestia megaterium), and BRM65919 (Bacillus cereus) reduced R. solani colony radial growth by 92.8, 77.56, and 75.56%, respectively while BRM63523 (Serratia marcescens), BRM65923 and BRM65916 (P. megaterium) and BRM65919 (B. cereus) with 23.45, 23.37, 23.62, and 20.17 cm, respectively were effective at suppressing sheath blight in greenhouse, indicating their potential as a biofungicide for sheath blight suppression.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":"58 5","pages":"426-435"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9776152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous silica nanoparticles adsorb aflatoxin B₁ and reduce mycotoxin-induced cell damage. 介孔二氧化硅纳米颗粒吸附黄曲霉毒素B1，减少霉菌毒素诱导的细胞损伤。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 DOI: 10.1080/03601234.2022.2161251

Geovana Dagostim Savi, Elton Torres Zanoni, Rahisa Scussel, Emily da Silva Córneo, Bianca Guimarães Furtado, Domingos Lusitâneo Pier Macuvele, Janaína Nones, Paulo Emilio Feuser, Ricardo Andrez Machado-de-Ávila, Elidio Angioletto

{"title":"Mesoporous silica nanoparticles adsorb aflatoxin B1 and reduce mycotoxin-induced cell damage.","authors":"Geovana Dagostim Savi, Elton Torres Zanoni, Rahisa Scussel, Emily da Silva Córneo, Bianca Guimarães Furtado, Domingos Lusitâneo Pier Macuvele, Janaína Nones, Paulo Emilio Feuser, Ricardo Andrez Machado-de-Ávila, Elidio Angioletto","doi":"10.1080/03601234.2022.2161251","DOIUrl":"https://doi.org/10.1080/03601234.2022.2161251","url":null,"abstract":"The present study examined the effects of mesoporous silica nanoparticles (MSNs) on its adsorption capacity of aflatoxin B1 (AFB1). Moreover, the study evaluated the toxicity of MSNs with AFB1 using NIH3T3 cells and hemolysis test. The obtained MSNs were spherical, irregular-like in shape, having a mean size of 39.97 ± 7.85 nm and a BET surface area of 1195 m2/g. At 0.1 mg mL-1 concentration of MSN, the AFB1 adsorption capacity was 30%, which reached 70% when the MSN concentration increased to 2.0 mg mL-1. Our findings showed that AFB1 was adsorbed (∼67%) in the first few minutes on being in contact with MSNs, reaching an adsorption capacity of ∼70% after 15 min. Thereafter, the adsorption capacity remained constant in solution, demonstrating that the MSNs adsorbed toxins even beyond overnight. MSN treatment (0.5-2.0 mg mL-1) using NIH3T3 cells did not result in any reduction in cell viability. In addition, MSN treatment completely reversed the cytotoxic effect of AFB1 at all concentrations. Hemolysis test also revealed no hemolysis in MSNs evaluated alone and in those combined with AFB1. To the best of our knowledge, this study is the first to demonstrate that MSN can reduce cell toxicity produced by AFB1 due to its potential to adsorb mycotoxins.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":"58 1","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9095588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of acute toxicity and histology effect on liver of glyphosate and atrazine in the African catfish Clarias gariepinus (Burchell 1822). 草甘膦和阿特拉津对非洲鲶鱼（Claris gariepinus (Burchell 1822)）肝脏急性毒性和组织学影响的评估。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 Epub Date: 2022-12-30 DOI: 10.1080/03601234.2022.2162797

Prudencio Agbohessi, Laurence Olowo, Bodelaire Degila, Gisèle Houedjissi, Ibrahim Imorou Toko

{"title":"Evaluation of acute toxicity and histology effect on liver of glyphosate and atrazine in the African catfish Clarias gariepinus (Burchell 1822).","authors":"Prudencio Agbohessi, Laurence Olowo, Bodelaire Degila, Gisèle Houedjissi, Ibrahim Imorou Toko","doi":"10.1080/03601234.2022.2162797","DOIUrl":"10.1080/03601234.2022.2162797","url":null,"abstract":"Aquatic organisms are exposed to chemical pesticides including glyphosate (Sharp 480 SL) and atrazine (Atraforce), two phytocidal molecules used for agriculture purposes in Benin. In this study, we assessed the acute toxicity of these two herbicides with emphasis on their histopathological effects on the liver of catfish Clarias gariepinus. One hundred and eighty juveniles of C. gariepinus (mean length 7.26 ± 0.59 cm and mean weight 5.21 ± 3.22 g) were exposed over 96 h to increasing concentrations of each phytocide. The values of 96 h-LC50 were 6.175 × 103 and 3.165 ppm, respectively for Sharp 480 SL and Atraforce. This indicates that Sharp 480 SL was nontoxic, while Atraforce displayed a moderate toxicity to C. gariepinus juveniles. During the tests, the behavioral responses (hyperexcitation, lethargy, loss of balance, discoloration of skin, etc.) that usually precede death were observed in exposed fishes, confirming the neurotoxicity of these phytocides. Histological alterations observed in liver of contaminated fishes were regressive changes, such as necrosis, hepatocyte vacuolation, nuclear degeneration, hepatocytes degeneration, sinusoids dilatation, etc. These results indicate that exposure to these herbicides had destructive effects on the liver of C. gariepinus.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":"58 1","pages":"21-30"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9102140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons. 毒死蜱诱导大鼠海马神经元突触可塑性失调。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2023-01-01 DOI: 10.1080/03601234.2023.2171236

Wenjuan Zhou, Chen Zhang, Peipei Wang, Yuanying Deng, Hongmei Dai, Jing Tian, Guojiao Wu, Lingling Zhao

{"title":"Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons.","authors":"Wenjuan Zhou, Chen Zhang, Peipei Wang, Yuanying Deng, Hongmei Dai, Jing Tian, Guojiao Wu, Lingling Zhao","doi":"10.1080/03601234.2023.2171236","DOIUrl":"https://doi.org/10.1080/03601234.2023.2171236","url":null,"abstract":"Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Increasing evidence has shown that exposure to CPF in early life might induce neurodevelopmental disorders, but the pathogenesis remains uncertain. Synaptic plasticity plays a crucial role in neurodevelopment. This study aimed to investigate the effect of CPF on synaptic plasticity in hippocampal neurons and establish the cellular mechanism underlying these effects. Using CPF-exposed rat and primary hippocampal neurons model, we analyzed the impact of CPF on the synaptic morphology, the expression level of a presynaptic protein, a postsynaptic protein and ionotropic glutamate receptors (iGluRs), as well as the effects on the Wnt/β-catenin pathway. We found that the synapses were shortened, the spines were decreased, and the expression of synaptophysin (Syp), postsynaptic density-95 (PSD-95), GluN1, GluA1 and Wnt7a, as well as active β-catenin in primary hippocampal neurons was decreased. Our study suggests that CPF exposure induced dysregulation of synaptic plasticity in rat hippocampal neurons, which might provide novel information regarding the mechanism of CPF-induced neurodevelopmental disorders.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":"58 2","pages":"100-109"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1