Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes最新文献

Soil amendments reduced potentially toxic elements (PTEs) in peanuts (Arachis hypogaea L.) grown in farmlands near Cu-Ni mine in Central Botswana. 土壤改良剂降低了博茨瓦纳中部铜镍矿附近农田种植的花生（Arachis hypogaea L.）中的潜在有毒元素（pte）。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-20 DOI: 10.1080/03601234.2026.2749318

Koziba Gaothobogwe, Trust Manyiwa, Izabela Sylwia Oleszek, Izabela Irena Rzeznicka, Venecio Ultra

{"title":"Soil amendments reduced potentially toxic elements (PTEs) in peanuts (Arachis hypogaea L.) grown in farmlands near Cu-Ni mine in Central Botswana.","authors":"Koziba Gaothobogwe, Trust Manyiwa, Izabela Sylwia Oleszek, Izabela Irena Rzeznicka, Venecio Ultra","doi":"10.1080/03601234.2026.2749318","DOIUrl":"https://doi.org/10.1080/03601234.2026.2749318","url":null,"abstract":"This study evaluated the effects of fly ash (FA), compost (COMP), lignite (LIG), and their combination (FA+COMP+LIG) on soil chemical properties, PTE total and available concentrations, PTE uptake by peanut (Arachis hypogaea L.) tissues, and associated human health risks in agricultural soils near BCL Cu-Ni mine. A field experiment was conducted in three farmlands located 2.6 km, 5 km, and 10 km from the BCL Cu-Ni mine in Selibe-Phikwe, Botswana. The experiment consisted of five treatments arranged in a randomized complete block design (RCBD) with three replications: unamended control, FA at 20 t ha-1, COMP at 20 t ha-1, LIG at 10 t ha-1, and FA+COMP+LIG at 20 + 20 + 10 t ha-1. Amendment application increased soil pH and reduced both total and available PTE concentrations in soils across all farms. Additionally, all amendments improved peanut dry matter yield compared to the control treatment. The combined treatment showed the greatest reduction in PTE accumulation in peanut tissues, particularly in kernels, where the reduction exceeded 30% relative to the control. Estimated daily intake (EDI), hazard quotient (HQ), and hazard index (HI) values for both children and adults were significantly reduced following amendment application, indicating lower dietary exposure to PTEs. However, despite the observed reductions, the HQ and HI values for some PTEs remained above the threshold value of 1, suggesting potential health hazards. Overall, the combined application of FA, COMP, and LIG showed the greatest potential for reducing PTE uptake by peanuts and decreasing associated human health risks in mine-affected agricultural soils. Further long-term field studies are recommended to evaluate the sustainability of these remediation effects.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-17"},"PeriodicalIF":2.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary assessment of nicotine and pyridine occurrence in Bok Choy (Brassica rapa subsp. chinensis) following application of a Tobacco waste-derived biopesticide. 白菜（Brassica rapa subsp.）烟碱和吡啶含量初步评价。使用烟草废物衍生的生物农药后，中国（chinensis）。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-19 DOI: 10.1080/03601234.2026.2750534

Edwin Rizki Safitra, Misri Gozan, Idra Herlina, Ikhwanul Muslimin, Mochamad Yusuf Efendi

{"title":"Preliminary assessment of nicotine and pyridine occurrence in Bok Choy (Brassica rapa subsp. chinensis) following application of a Tobacco waste-derived biopesticide.","authors":"Edwin Rizki Safitra, Misri Gozan, Idra Herlina, Ikhwanul Muslimin, Mochamad Yusuf Efendi","doi":"10.1080/03601234.2026.2750534","DOIUrl":"https://doi.org/10.1080/03601234.2026.2750534","url":null,"abstract":"Tobacco waste-derived biopesticides (TW-DBs) offer a potential approach to combine agricultural-waste valorization with crop protection; however, information on tobacco-derived compounds remaining on edible crops after application is limited. This preliminary study evaluated nicotine- and pyridine-associated analytical signals in bok choy (Brassica rapa subsp. chinensis) following foliar application of a TW-DB prepared by ethanolic heat reflux extraction. The formulation was applied at 2.5, 5.0, and 7.5 mL per 2 L of water, with a commercial pesticide as a reference. Leaf and root extracts were analyzed by GC-MS. Apparent nicotine-associated concentrations ranged from 0.75 to 1.36 mg/kg and pyridine-associated concentrations from 1.06 to 11.17 mg/kg. Signals were generally numerically higher in leaves, particularly for pyridine, but no statistically supported treatment or tissue differences were established, and concentrations showed no monotonic relationship with formulation volume. Given the duplicate biological measurements, absence of an untreated control, unquantified formulation concentrations, single harvest-time sampling, and lack of full matrix-specific analytical validation, these findings should be interpreted as exploratory occurrence data rather than evidence of treatment-derived residues, dose-response behavior, regulatory compliance, or consumer safety. Further confirmatory studies with adequate controls, replication, validated methods, quantified application concentrations, and time-resolved sampling are required.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-6"},"PeriodicalIF":2.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a bioherbicide and a chemical herbicide on soil microbial community structure, diversity, and nitrogen cycling functions. 生物除草剂和化学除草剂对土壤微生物群落结构、多样性和氮循环功能的影响。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-16 DOI: 10.1080/03601234.2026.2745422

Quan Deng, Liangchen Lv, Huaqi Feng, Dongyang Liu, Fanghua Wang, Jie Wang, Xinyu Liu, Shina Sun, Bin Huang

{"title":"Effects of a bioherbicide and a chemical herbicide on soil microbial community structure, diversity, and nitrogen cycling functions.","authors":"Quan Deng, Liangchen Lv, Huaqi Feng, Dongyang Liu, Fanghua Wang, Jie Wang, Xinyu Liu, Shina Sun, Bin Huang","doi":"10.1080/03601234.2026.2745422","DOIUrl":"https://doi.org/10.1080/03601234.2026.2745422","url":null,"abstract":"The fermentation broth of the bioherbicidal fungus Aspergillus versicolor D5 shows efficacy against dicotyledonous weeds in tobacco fields. However, little is known about its impact on the soil ecological environment of tobacco fields, particularly in comparison with chemical herbicides. This study compares the effects of a bioherbicide (BIO) and rimsulfuron (CHE) on tobacco field soil ecology. Both show comparable weed control efficacy and increase urease and dehydrogenase activities, although BIO causes a smaller urease increase. Unlike CHE, BIO does not inhibit nitrite reductase. Metagenomics shows that BIO slightly alters community structure without reducing diversity, whereas CHE decreases it. BIO increases the abundance of Luteitalea (involved in decomposing complex organic carbon and nitrogen cycling) and Chloracidobacterium (light-assisted carbon metabolism) within the phylum Acidobacteria, whereas CHE significantly reduces the abundance of these bacteria. BIO decreases the abundance of arbuscular mycorrhizal fungi Rhizophagus and Funneliformis, while CHE increases them. Nitrogen cycling analysis shows that BIO only significantly reduces the anammox pathway, causing little overall disturbance, whereas CHE strongly promotes dissimilatory/assimilatory nitrate reduction and nitrate/nitrite uptake pathways. These findings indicate that the fermentation extract of A. versicolor D5 affects soil ecology less than rimsulfuron, causing less disturbance to soil microbial diversity in this study.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-13 DOI: 10.1080/03601234.2026.2747489

引用次数: 0

Pesticide residues in date fruits (Phoenix dactylifera L.): a systematic review. 枣果实中农药残留的系统评价。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-12 DOI: 10.1080/03601234.2026.2745418

Zoubeyda Chettouh, Anissa Zergui, Mohamed Amine Kerdoun

{"title":"Pesticide residues in date fruits (Phoenix dactylifera L.): a systematic review.","authors":"Zoubeyda Chettouh, Anissa Zergui, Mohamed Amine Kerdoun","doi":"10.1080/03601234.2026.2745418","DOIUrl":"https://doi.org/10.1080/03601234.2026.2745418","url":null,"abstract":"Introduction: The date palm (Phoenix dactylifera L.) is a vital nutritional and economic resource in tropical and subtropical regions. However, the intensive use of agrochemicals to combat diverse pests has led to growing concerns regarding pesticide residues. This review aims to systematically evaluate the prevalence of these residues in date fruits and assess their compliance with global safety standards.Methodology: Following PRISMA guidelines and a PECOT-based strategy, a systematic search was conducted in Scopus, PubMed, and Google Scholar for studies published between January 2000-September 2024. Out of 4,172 identified records, 7 original studies were selected for final analysis. These studies involved 597 samples, primarily from the MENAP region, utilizing advanced chromatographic techniques often paired with QuEChERS extraction.Results: The findings indicate the presence of various pesticide classes, including organophosphates, carbamates, and fungicides. While the majority of samples met international standards established by the Codex Alimentarius and European Food Safety Authority, specific instances were identified where pesticide concentrations significantly exceeded established Maximum Residue Levels.Conclusion: Although compliance with international safety thresholds is generally high, localized MRL exceedances demonstrate the need for continuous residue surveillance across date-producing regions to maintain global food safety standards.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-12"},"PeriodicalIF":2.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico and in vitro evaluation of compatibility between papain and agricultural pesticides. 木瓜蛋白酶与农用农药相容性的室内及体外评价。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-09 DOI: 10.1080/03601234.2026.2740984

Adriane Toledo Batista da Silva, Isabela Aparecida Militani, Nivia Kelly Lima Sales, Amanda do Carmo Alves, Alexandre Alves de Castro, Rosangela Cristina Marucci, Teodorico Castro Ramalho, Filippe Elias de Freitas Soares

{"title":"In silico and in vitro evaluation of compatibility between papain and agricultural pesticides.","authors":"Adriane Toledo Batista da Silva, Isabela Aparecida Militani, Nivia Kelly Lima Sales, Amanda do Carmo Alves, Alexandre Alves de Castro, Rosangela Cristina Marucci, Teodorico Castro Ramalho, Filippe Elias de Freitas Soares","doi":"10.1080/03601234.2026.2740984","DOIUrl":"https://doi.org/10.1080/03601234.2026.2740984","url":null,"abstract":"Brazil is a major consumer of pesticides, which raises concerns in the context of One Health. In this sense, new biotechnological alternatives for pest and disease control are fundamental. The use of relevant biomolecules, such as papain, a cysteine protease present in Carica papaya latex, has shown great potential. In this context, this study investigated in silico, through molecular docking with 130 pesticides authorized by MAPA and through experimental assays, the interactions between pesticides and papain, in addition to evaluating the combined action on Tenebrio molitor larvae. Metaflumizone and etiprole were selected for biochemical analysis, with proteolytic activity determined by the caseinolytic method and the effects on larvae evaluated in vitro. By docking analysis, metaflumizone presented the lowest binding energy (-8.6 kcal mol-1), indicating high affinity for the active site; however, in experimental tests, there was no significant change in papain activity (p > 0.05). On the other hand, etiprole reduced enzymatic activity by 64%, but only at a concentration four times higher than that used in the spray (p < 0.01).","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-10"},"PeriodicalIF":2.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidimensional behavioral profiling uncovers centrifugal hyperactivity induced by the neonicotinoid dinotefuran in Drosophila melanogaster. 多维行为分析揭示了新烟碱类杀虫剂呋虫胺诱导黑腹果蝇的离心多动。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-05 DOI: 10.1080/03601234.2026.2740562

Rui Wu, Jie Shen

{"title":"Multidimensional behavioral profiling uncovers centrifugal hyperactivity induced by the neonicotinoid dinotefuran in Drosophila melanogaster.","authors":"Rui Wu, Jie Shen","doi":"10.1080/03601234.2026.2740562","DOIUrl":"10.1080/03601234.2026.2740562","url":null,"abstract":"Dinotefuran is a widely used third-generation neonicotinoid insecticide, yet its sublethal effects on non-target insect behavior remain poorly resolved. We used the deep-learning tracking framework SLEAP to quantify locomotor and spatial responses of Drosophila melanogaster larvae after 72 h of exposure to nominal dinotefuran concentrations of 0, 10, 50, and 100 μM. Kinematics, velocity distributions, trajectory geometry, spatial redistribution, inter-individual spacing, and principal component analysis (PCA) were integrated. Compared with control larvae, larvae exposed to 50 and 100 μM dinotefuran showed increases in mean linear velocity, respectively, spent a greater proportion of the recording time in the high-speed range, and explored a larger area. Although mean angular velocity did not differ significantly among groups, exposed larvae spent more time at low angular velocities and less time at medium-to-high angular velocities. Exposure increased trajectory straightness, radius of gyration, mean squared displacement, outward redistribution, and inter-individual spacing. PCA supported this multivariate response: PC1 and PC2 explained 52.1% and 16.6% of the variance, and the higher-concentration groups shifted toward higher PC1 scores associated with locomotor activity and spatial exploration. These findings show that dinotefuran alters multiple dimensions of larval behavior and support high-resolution behavioral profiling for assessing sublethal pesticide effects.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-11"},"PeriodicalIF":2.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytotoxicity of pyroxasulfone and pendimethalin, individually and in combination, in non-target vegetable crops. 吡咯砜和对二甲脒单独和组合对非目标蔬菜作物的植物毒性。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-10-01 DOI: 10.1080/03601234.2026.2740391

Ramandeep Kaur, Pervinder Kaur, Navjyot Kaur, Manmohan Dhkal

{"title":"Phytotoxicity of pyroxasulfone and pendimethalin, individually and in combination, in non-target vegetable crops.","authors":"Ramandeep Kaur, Pervinder Kaur, Navjyot Kaur, Manmohan Dhkal","doi":"10.1080/03601234.2026.2740391","DOIUrl":"https://doi.org/10.1080/03601234.2026.2740391","url":null,"abstract":"Herbicides are increasingly used in modern agriculture, yet their unintended effects on adjacent non-target vegetable crops remain insufficiently investigated. This study evaluated the individual and combined phytotoxic effects of two pre-emergence herbicides, pyroxasulfone and pendimethalin, on nine non-target vegetable crops during early seedling development, integrating dose-response modeling (GR50), toxicity index (TI) assessment and onion root-tip cytological analysis. All treatments produced significant dose-dependent suppression of seedling growth, with dry weight emerging as the most sensitive indicator of herbicidal stress. Pendimethalin caused stronger growth inhibition (7.87 ± 1.41 to 60.76 ± 1.54%) than pyroxasulfone (3.27 ± 1.81 to 52.17 ± 0.68%), while combined exposure produced the greatest reductions across crops (11.02 ± 0.79 to 71.55 ± 1.22%). Highest Single Agent (HSA) analysis showed that fixed-ratio mixture produced greater growth inhibition than the individual herbicides, whereas Bliss independence indicated crop- and dose-dependent interaction outcomes. Onion was the most sensitive crop based on GR50, while metha and pea were comparatively more tolerant. Cytological analysis revealed reduced mitotic index and increased chromosomal abnormalities, particularly under combined treatment. These findings demonstrate that herbicide mixtures may produce greater phytotoxic responses than individual compounds, highlighting the importance of species-specific ecological risk assessment and herbicide stewardship.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic dissipation of kresoxim methyl from soil using zinc oxide nanoparticles: synthesis, characterization, and kinetic studies. 利用氧化锌纳米颗粒光催化土壤中甲基甲咯辛的耗散：合成、表征和动力学研究。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-09-30 DOI: 10.1080/03601234.2026.2740548

Shruti Pathak, Anjana Srivastava, P C Srivastava

{"title":"Photocatalytic dissipation of kresoxim methyl from soil using zinc oxide nanoparticles: synthesis, characterization, and kinetic studies.","authors":"Shruti Pathak, Anjana Srivastava, P C Srivastava","doi":"10.1080/03601234.2026.2740548","DOIUrl":"https://doi.org/10.1080/03601234.2026.2740548","url":null,"abstract":"Kresoxim methyl fungicide is commonly used to prevent fungal diseases in fruits, vegetables, and other plants. However, its toxicity and persistence in soil and water raise significant environmental concerns. Reducing its concentration in soil is essential to limit its movement to surface and ground water systems. In this context, semiconductor metal nanoparticles; specifically, ZnO nanoparticles, have emerged as promising agents for rapid degradation of organic pollutants, including pesticides. However, their photocatalytic performance in soil systems remains underexplored compared with that in aqueous environment due to the natural complexity and heterogeneity of soil matrices. The present study investigates the photocatalytic dissipation of Kresoxim methyl in two different soils with ZnO nanoparticles as a catalyst. The synthesized nanoparticles were characterized using SEM-EDX, XRD, BET, etc., revealing the formation of pure hexagonal wurtzite phase ZnO nanoparticles (15.75 nm) with a BET surface area of 29.8 m2/g and a band gap of 3.228 eV. The dissipation was examined at three ZnO nanoparticle doses, with optimum performance observed at 0.3%. Dissipation followed second order kinetics with half-lives of 19.8 hr (SH1) and 17.1 hr (IG3). LC-MS analysis identified five transformation products, including three novel compounds, providing insights into the degradation pathway for Kresoxim methyl.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-16"},"PeriodicalIF":2.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma. mc - lr相关性肝细胞癌的网络毒理学和机器学习分析。

IF 2 4区农林科学

Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes Pub Date : 2026-09-29 DOI: 10.1080/03601234.2026.2736267

Zhipeng Xu, Ji Luo, Jiaming Liang, Jianwen Deng, Minju He, Tongfen Cao, Guangzhao Chen

{"title":"Network toxicology and machine learning analysis of MC-LR-associated hepatocellular carcinoma.","authors":"Zhipeng Xu, Ji Luo, Jiaming Liang, Jianwen Deng, Minju He, Tongfen Cao, Guangzhao Chen","doi":"10.1080/03601234.2026.2736267","DOIUrl":"https://doi.org/10.1080/03601234.2026.2736267","url":null,"abstract":"Microcystin-LR (MC-LR), a hepatotoxic aquatic contaminant classified by IARC as a Group 2B carcinogen, was investigated using an integrated network toxicology and machine learning framework to explore potential molecular mechanisms underlying MC-LR-related hepatocarcinogenesis. By integrating GEO transcriptomic datasets, differential expression analysis, WGCNA, and predicted MC-LR targets, we identified 24 candidate genes potentially associated with MC-LR-related HCC. Functional enrichment analyses implicated these genes mainly in complement and coagulation cascades and metabolic processes. Machine learning consensus analysis prioritized five core genes-AKR1C3, FABP5, CA2, ADH1B, and EPHX2-each showing an AUC greater than 0.79 and suggesting moderate discriminatory potential. Single-gene GSEA linked these genes mainly to ribosome-related pathways, while single-cell transcriptomic analysis revealed cell-type-specific expression heterogeneity within the HCC microenvironment. Molecular docking provided exploratory structural evidence for possible in silico compatibility between MC-LR and the encoded proteins. However, further experimental validation is required to confirm this hypothesis. Overall, these findings establish a multidimensional framework for investigating MC-LR-associated hepatotoxicity and nominate candidate molecular nodes for future biomarker assessment, functional validation, and environment-related HCC risk evaluation.","PeriodicalId":15720,"journal":{"name":"Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes","volume":" ","pages":"1-16"},"PeriodicalIF":2.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0