环境中接触苯的墨西哥儿童血液毒性和血液恶性肿瘤相关基因的表达。

IF 1.8 4区 农林科学 Q4 ENVIRONMENTAL SCIENCES
Nadia Azenet Pelallo-Martínez, Jesús Magdiel García-Díaz, Jessica Argentina González-Cárdenas, Kelvin Saldaña-Villanueva, Octavio Gaspar-Ramírez
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引用次数: 0

摘要

越来越多的证据表明,环境中接触苯是导致包括白血病在内的某些血液系统疾病的危险因素。本研究的目的是评估暴露于苯和血液学参数的儿童造血基因调控组mRNA表达的变化。在这项研究中,67名年龄在3到12岁之间的健康儿童自愿参与。采用高效液相色谱法分析尿液样本中的反式、反式粘膜酸,采用RT-qPCR法检测血液样本中AhR、BCL2、CD38、PTEN、RUNX1基因表达。我们观察到苯暴露水平升高(GM = 326.3±42.3µg/g肌酐),20%的儿童超过500µg/g肌酐的职业阈值。此外,苯暴露与RUNX1 mRNA表达显著相关(r = 0.27, p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hematotoxicity and expression of genes involved in hematological malignancies in Mexican children environmentally exposed to benzene.

There is growing evidence that environmental benzene exposure is a risk factor for developing some hematological disorders, leukemia included. The aim of this study was to assess the variation in mRNA expression of a regulatory set of hematopoietic genes in children exposed to benzene and hematological parameters. In this study, 67 healthy children between the ages of 3 and 12 voluntarily participated. Trans,trans-muconic acid was analyzed in urine samples using high-performance liquid chromatography, and gene expression of AhR, BCL2, CD38, PTEN, and RUNX1 was assessed in blood samples by RT-qPCR. We observed elevated benzene exposure levels (GM = 326.3 ± 42.3 µg/g creatinine), with 20% of children exceeding the occupational threshold of 500 µg/g creatinine. Additionally, benzene exposure was significantly associated with RUNX1 mRNA expression (r = 0.27, p < 0.05). Our finding show that benzene could contribute to hematopoietic effects developed in highly exposed children. These results highlight the necessity of implementing environmental policies aim at reducing benzene exposure in children.

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来源期刊
CiteScore
4.00
自引率
5.00%
发文量
87
审稿时长
1 months
期刊介绍: 12 issues per year Abstracted/indexed in: Agricola; Analytical Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; BioSciences Information Service of Biological Abstracts (BIOSIS); CAB Abstracts; CAB AGBiotech News and Information; CAB Irrigation & Drainage Abstracts; CAB Soils & Fertilizers Abstracts; Chemical Abstracts Service Plus; CSA Aluminum Industry Abstracts; CSA ANTE: Abstracts in New Technology and Engineering; CSA ASFA 3 Aquatic Pollution and Environmental Quality; CSA ASSIA: Applied Social Sciences Index & Abstracts; CSA Ecology Abstracts; CSA Entomology Abstracts; CSA Environmental Engineering Abstracts; CSA Health & Safety Science Abstracts; CSA Pollution Abstracts; CSA Toxicology Abstracts; CSA Water Resource Abstracts; EBSCOhost Online Research Databases; Elsevier BIOBASE/Current Awareness in Biological Sciences; Elsevier Engineering Information: EMBASE/Excerpta Medica/ Engineering Index/COMPENDEX PLUS; Environment Abstracts; Environmental Knowledge; Food Science and Technology Abstracts; Geo Abstracts; Geobase; Food Science; Index Medicus/ MEDLINE; INIST-Pascal/ CNRS; NIOSHTIC; ISI BIOSIS Previews; Pesticides; Food Contaminants and Agricultural Wastes: Analytical Abstracts; Pollution Abstracts; PubSCIENCE; Reference Update; Research Alert; Science Citation Index Expanded (SCIE); and Water Resources Abstracts.
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