Journal of diabetes and its complications最新文献

{"title":"sCD14 as a biomarker for the progression of kidney disease among patients with diabetes","authors":"Oscar Zaragoza-García ,&nbsp;Olivia Briceño ,&nbsp;José Rafael Villafan-Bernal ,&nbsp;Héctor Ugo Rojas-Delgado ,&nbsp;Ilse Adriana Gutiérrez-Pérez ,&nbsp;Cristina Morales-Martínez ,&nbsp;Roma Rubí Rodriguez-Reyes ,&nbsp;Iris Paola Guzmán-Guzmán","doi":"10.1016/j.jdiacomp.2025.108980","DOIUrl":"10.1016/j.jdiacomp.2025.108980","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the association of soluble CD14 (sCD14) with diabetic kidney disease (DKD) and its prediction performance for kidney function staging.</div></div><div><h3>Methods</h3><div>A cross-sectional study of 80 type 2 diabetes (T2D) patients was conducted. Each participant was screened for DKD, and the diagnostic criterion for DKD was a glomerular filtration rate (eGFR) &lt;60 mL/min/1.73m². Serum sCD14 was measured by ELISA technique. Logistic regression models and receiver operating characteristics (ROC) curves were used to assess the association of sCD14 with DKD and its predictive value for disease staging.</div></div><div><h3>Results</h3><div>sCD14 was higher in DKD patients than in T2D patients without kidney disease (<em>p</em> &lt; 0.001). sCD14 was progressively higher in DKD patients according to the kidney function stage (<em>p</em> &lt; 0.001). Also, sCD14 was higher in DKD patients in hemodialysis than those who did not receive renal replacement therapy (<em>p</em> &lt; 0.001). In DKD patients, sCD14 was positively correlated with creatinine (<em>r</em> = 0.282, <em>p</em> = 0.042) and negatively correlated with eGFR (<em>r</em> = −0.365, <em>p</em> = 0.007). The levels of sCD14 were predictive of G3 (AUC = 0.822), G4 (AUC = 0.876), and G5 (AUC = 0.924) stages of kidney function. In a multivariate logistic regression model adjusted for age, sex, and diabetes duration, sCD14 ≥ 1720 ng/mL were associated with G3 stage (OR = 8.92, <em>p</em> = 0.023), G4 (OR = 7.92, <em>p</em> = 0.011) and G5 stage (OR = 18.47, <em>p</em> = 0.017) in DKD patients.</div></div><div><h3>Conclusion</h3><div>Circulating levels of sCD14 are associated with DKD and perform well for kidney function staging. Thus, it is a good candidate for assessing the risk of kidney disease progression.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108980"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of automated insulin delivery (AID) systems on quality of life (QoL): Validation of the AID-QoL questionnaire","authors":"Giuseppe Papa ,&nbsp;Rossella Cannarella ,&nbsp;Concetta Finocchiaro ,&nbsp;Massimiliano Anzaldi ,&nbsp;Gianfranco Gruttadauria ,&nbsp;Donatella Lo Presti ,&nbsp;Rosita A. Condorelli ,&nbsp;Sandro La Vignera ,&nbsp;Aldo E. Calogero","doi":"10.1016/j.jdiacomp.2025.108984","DOIUrl":"10.1016/j.jdiacomp.2025.108984","url":null,"abstract":"<div><h3>Background and aim</h3><div>Evidence supports the efficacy of automated insulin delivery (AID) systems in improving glycometabolic outcomes. However, limited data are available on their impact on quality of life (QoL). This study aimed to develop and validate a questionnaire to assess QoL in subjects with type 1 diabetes mellitus (T1DM) using AID system (AID-QoL).</div></div><div><h3>Patients and methods</h3><div>A questionnaire was developed and validated following a standardized procedure and administered to 219 subjects with T1DM who were using AID systems for insulin therapy.</div></div><div><h3>Results</h3><div>Analysis of inter-expert agreement for internal consistency showed a Cronbach's alpha coefficient of 0.720, suggesting an acceptable level of consistency across the 29 items of the AID-QoL. The infraclass correlation coefficient for retest agreement was 0.745, demonstrating “substantial” reliability. Administration of the questionnaire to the 219 subjects with T1DM showed that AID systems contributed to high satisfaction with glycometabolic management, a slightly lower satisfaction with the technical aspects of the AID systems, a positive impact on psychological and social well-being, and a high level of confidence in the technology.</div></div><div><h3>Conclusion</h3><div>The AID-QOL questionnaire is a newly validated, reliable, easy-to-use tool for measuring QoL and satisfaction in subjects with T1DM who are receiving insulin treatment via AID systems.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 4","pages":"Article 108984"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline-directed medical therapies (GDMTs) for chronic kidney disease with type 2 diabetes (CKD + T2D): Translation of lessons learned from the management of heart failure","authors":"Jonathan Rollins ,&nbsp;Alison L. Hong ,&nbsp;Bridgette Schroader ,&nbsp;Sheldon X. Kong ,&nbsp;Barb Lennert ,&nbsp;Jennifer Cameron ,&nbsp;Rakesh Singh ,&nbsp;Yuxian Du ,&nbsp;Todd Williamson","doi":"10.1016/j.jdiacomp.2025.108985","DOIUrl":"10.1016/j.jdiacomp.2025.108985","url":null,"abstract":"<div><div>Although guideline-directed medical therapy (GDMT) is an evidence-based, proven approach to manage chronic kidney disease and type 2 diabetes (CKD + T2DM), adherence is low and multifactorial. Opportunities exist to improve care delivery, thus delaying disease progression, avoiding unnecessary costs, and potentially improving quality of life for patients both diagnosed and yet to be diagnosed.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 4","pages":"Article 108985"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(25)00043-1","DOIUrl":"10.1016/S1056-8727(25)00043-1","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108990"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of adding glucagon-like peptide-1 receptor agonist on diabetes complications and mortality among basal insulin-treated people with type 2 diabetes: A real-world Korean study","authors":"Kyoung Hwa Ha ,&nbsp;Won Kim ,&nbsp;Dong Han Kim ,&nbsp;Dae Jung Kim","doi":"10.1016/j.jdiacomp.2025.108983","DOIUrl":"10.1016/j.jdiacomp.2025.108983","url":null,"abstract":"<div><h3>Aims</h3><div>To compare the effectiveness of adding a glucagon-like peptide-1 receptor agonist (GLP-1RA) on composite of diabetes-related complications and mortality with that of adding short-acting insulin (SAI) or shifting to premixed insulin among basal insulin (BI)-treated individuals with type 2 diabetes mellitus (T2DM) in South Korea.</div></div><div><h3>Methods</h3><div>From the Health Insurance Review and Assessment Service database, individuals with T2DM who initiated BI treatment and had advanced their treatment regimen from July 1, 2012, to December 31, 2018.</div></div><div><h3>Results</h3><div>A total of 38,634 individuals with T2DM were included in this study. Compared to adding SAI to BI, adding GLP-1RA was associated with decreased risks of cardiovascular complications (hazard ratio 0.56; 95 % confidence interval 0.43–0.72), severe microvascular complications (0.30; 0.19–0.48), diabetes-related hospitalization (0.62; 0.53–0.73), and all-cause mortality (0.27; 0.13–0.57). Compared to switching to premixed insulin, adding GLP-1RA was also associated with lower risk of cardiovascular complications (0.65; 0.51–0.84), severe microvascular complications (0.36; 0.22–0.58), diabetes-related hospitalization (0.62; 0.53–0.73), and all-cause mortality (0.32; 0.15–0.67).</div></div><div><h3>Conclusions</h3><div>In this real-world Korean study, adding GLP-1RA to BI reduced risks of diabetes complications and all-cause mortality than adding SAI or shifting to premixed insulin.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 5","pages":"Article 108983"},"PeriodicalIF":2.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the treatment of vascular complications in type 2 diabetes by finerenone in combination with RAS inhibitors/SGLT-2i","authors":"Ruoqi Liu ,&nbsp;Zhuomin Qu ,&nbsp;Yizhuo Feng ,&nbsp;Lu Bai ,&nbsp;Xueqian Liu ,&nbsp;Xuemei Fan ,&nbsp;Xiaoqi Liu ,&nbsp;Lingxia Zhao","doi":"10.1016/j.jdiacomp.2025.108981","DOIUrl":"10.1016/j.jdiacomp.2025.108981","url":null,"abstract":"<div><h3>Background</h3><div>Currently, the prevalence of diabetes is rising. Patients with diabetes often face high risks of kidney disease, cardiovascular disease, and retinal disease. Cardiovascular complications are the primary cause of morbidity and mortality in patients with type 2 diabetes mellitus. Finerenone is a novel non-steroidal mineralocorticoid receptor antagonist. Research has shown that finerenone provides renal, cardiac, and retinal protection in patients with type 2 diabetes. Currently, various drugs (angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, sodium-glucose co-transporter 2 inhibitors) are effective in treating diabetic vascular complications, but each has its limitations. Combining finerenone with RAS Inhibitors/SGLT-2i may yield better clinical outcomes.</div></div><div><h3>Methods</h3><div>This review aggregates research on the mechanisms and clinical efficacy of finerenone, RAS Inhibitors, and SGLT-2i used individually, as well as in combination, for the treatment of vascular complications in diabetes from various databases.</div></div><div><h3>Results</h3><div>This review shows that combining finerenone with RAS inhibitors/ SGLT-2 inhibitors can further reduce proteinuria, the urinary albumin-to-creatinine ratio, and the risk of hyperkalemia, slow CKD progression, reduce atherosclerosis, myocardial fibrosis, and hypertrophy, and lower the incidence of atrial fibrillation, myocardial infarction, and heart failure. It can also reduce retinal neovascularization, macular edema, and inflammation. Overall, combining can further lower the risk of complications in type 2 diabetic patients.</div></div><div><h3>Conclusions</h3><div>In summary, combining finerenone with RAS inhibitors and SGLT-2i is a promising treatment strategy. However, the molecular mechanisms and interactions are not fully understood, necessitating more basic research and clinical trials to provide evidence. Combining finerenone with existing treatments may yield better clinical outcomes.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 4","pages":"Article 108981"},"PeriodicalIF":2.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIB-4 predicts events in compensated advanced chronic liver disease and type 2 diabetes treated with GLP-1-receptor-agonists","authors":"Wiebke van Beurden ,&nbsp;Yuly P. Mendoza ,&nbsp;Naomi F. Lange ,&nbsp;Jaime Bosch ,&nbsp;Annalisa Berzigotti ,&nbsp;Susana G. Rodrigues","doi":"10.1016/j.jdiacomp.2025.108978","DOIUrl":"10.1016/j.jdiacomp.2025.108978","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Patients with compensated advanced chronic liver disease (cACLD) and treated type 2 diabetes have an increased risk for liver-related events, but data regarding this population is lacking, particularly, taking into account novel treatments. We assessed the role of Fibrosis-4 index and other variables to predict events.</div></div><div><h3>Methods</h3><div>First hepatic decompensation, liver transplantation (OLT), death, hepatocellular carcinoma (HCC) and bacterial infections over a follow-up period of 28.7 (16–49.4) months were retrospectively identified from 106 patients with treated type 2 diabetes and liver stiffness measurement &gt;10 kPa suggesting ACLD. We identified predictors of events using Cox regression. Additionally, we evaluated treatment effect with add-on GLP-1 receptor agonists (GLP-1-RA) compared to other antidiabetic medications.</div></div><div><h3>Results</h3><div>FIB-4 was associated with hepatic decompensation, OLT and death (HR 1.517, 95%CI 1.226–1.879, <em>p</em> ≤ 0.001), HCC (HR 1.369, 95%CI 1.046–1.791, <em>p</em> = 0.022) and bacterial infections (HR 1.379, 95%CI 1.118–1.702, <em>p</em> = 0.003). Propensity score adjusted analysis for GLP-1-RA treatment did not show an effect (HR 0.240, 95%CI 0.044–1.315, <em>p</em> = 0.1). Survival was worse in those with more advanced disease defined by FIB-4 &gt; 2.67 (<em>p</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>FIB-4 is a strong prognostic tool to screen patients and refer them to specialists, in cACLD patients and pharmacologically treated type 2 diabetes, irrespective of treatment.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108978"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological effect of ZYGK1, a novel glucokinase activator, in hyperglycemic and sulfonylurea-resistant type 2 diabetes in mice models","authors":"Kalpesh Patani ,&nbsp;Amit Joharapurkar ,&nbsp;Rajesh Sundar ,&nbsp;Samadhan Kshirsagar ,&nbsp;Sunil Metiya ,&nbsp;Ashutosh Kumar ,&nbsp;Mukul Jain","doi":"10.1016/j.jdiacomp.2025.108977","DOIUrl":"10.1016/j.jdiacomp.2025.108977","url":null,"abstract":"<div><h3>Objectives</h3><div>Type 2 diabetes is caused due to inadequate glucose utilization in the liver and pancreas due to insulin resistance. Glucokinase enzyme plays a key role in metabolism of glucose and insulin release and hence glucokinase activation can be a useful therapeutic target for treatment of type 2 diabetes.</div></div><div><h3>Methods</h3><div>Present study was conducted to investigate the effect of a novel glucokinase activator ZYGK1 in the preclinical models of diabetes in mice. The activity of ZYGK1 was evaluated using recombinant glucokinase, and isolated islets and hepatocytes. Acute effect on glucose disposal was evaluated in C57 mice and repeated dose effect was assessed in db/db mice, along with the evaluation in sulfonylurea-resistance db/db mice.</div></div><div><h3>Results</h3><div>ZYGK1 has potent glucokinase stimulating activity with EC50 of 43 nM and increased glucokinase activity in islets and hepatocytes in a dose-related manner. Oral administration of ZYGK1 (0.1 to 10 mg/kg) showed dose dependently improved glucose disposal and glucose dependent insulin secretion in oral glucose tolerance test (OGTT) in C57 mice. Repeated dose administration of ZYGK1 improved glucose homeostasis and nondiabetic as well as diabetic mice and sulfonylurea-resistant db/db mice.</div></div><div><h3>Conclusion</h3><div>ZYGK1 appears to be a potential therapeutic option for the treatment of type 2 diabetes owing to its action in the liver and pancreas, and in conditions resistant to sulfonylurea therapy.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108977"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liraglutide improves senescence and ameliorating diabetic sarcopenia via the YAP-TAZ pathway","authors":"Qian Xu ,&nbsp;Xuan Qiu ,&nbsp;Hailing Di ,&nbsp;Zhongkang Li ,&nbsp;Zanchao Liu ,&nbsp;Kuanzhi Liu","doi":"10.1016/j.jdiacomp.2025.108975","DOIUrl":"10.1016/j.jdiacomp.2025.108975","url":null,"abstract":"<div><h3>Objective</h3><div>Beyond its established glucose-lowering and weight-reducing benefits, glucagon-like peptide-1 receptor agonists (GLP-1RAs) such as liraglutide may also mitigate sarcopenia. This study investigates the effects of liraglutide on diabetic sarcopenia and its underlying mechanisms.</div></div><div><h3>Methods</h3><div>A type 2 diabetic SD rat model was induced using a high-fat, high-sugar diet supplemented with a low dose of streptozotocin. Comparisons were made among control (Con), diabetic (DM), and liraglutide-treated (Li) groups for gastrocnemius muscle wet weight and length, histology (HE staining), immunofluorescence for muscle fiber typing, and Western blotting for aging-related proteins and YAP/TAZ pathway components. Concurrently, C2C12 myoblasts were differentiated into myotubes, treated with 60 mM glucose to model diabetic conditions, and assessed for morphological changes, senescence (SA-β-gal staining), and protein expression dynamics.</div></div><div><h3>Results</h3><div>Diabetic rats displayed significant reductions in muscle mass, length, and cross-sectional area, along with disorganized fiber architecture, all of which were improved by liraglutide. In vitro, C2C12 myotubes showed accelerated aging and atrophy under high-glucose conditions, which were significantly reduced by liraglutide. Analysis revealed increased expression of aging markers P53 and P21 and decreased YAP/TAZ/TEAD and Cyclin D1 levels in diabetic conditions, which were reversed following liraglutide treatment. The inhibition of YAP significantly negated the protective effects of liraglutide.</div></div><div><h3>Conclusion</h3><div>High glucose promotes muscle cell aging and sarcopenia, processes that liraglutide can attenuate by modulating the YAP/TAZ signaling pathway. This study underscores liraglutide's potential to alleviate muscle degeneration in diabetic sarcopenia through its regulatory impact on critical aging pathways.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108975"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral edaravone ameliorates myocardial fibrosis in type 2 diabetic rats by TGF-β1/Smad signaling pathway","authors":"Xiao-Yan Zhang ,&nbsp;Yong-xuan Xu ,&nbsp;Si-Quan Xue ,&nbsp;Yue-Qin Zeng ,&nbsp;Juan-Hua Gu ,&nbsp;Xin-Fu Zhou ,&nbsp;Hai-Yun Luo ,&nbsp;Li-Jin Pu","doi":"10.1016/j.jdiacomp.2025.108976","DOIUrl":"10.1016/j.jdiacomp.2025.108976","url":null,"abstract":"<div><div>Myocardial fibrosis, characterized by increased reactive oxygen species (ROS), is a key pathological feature of diabetic cardiomyopathy (DCM). Although oral edaravone (EDA) shows therapeutic potential in ameliorating myocardial fibrosis in DCM, the precise mechanisms remain unclear. Transcriptome analysis of myocardial tissues revealed a dramatic up-regulation of the TGF-β1/Smad pathway, which was reversed by oral EDA treatment. In vitro studies showed that oral EDA attenuated myocardial fibrosis by inhibiting the TGF-β1/Smad signaling pathway and its downstream fibrosis key factors, Col3a1 and α-SMA. These findings suggest that oral EDA improves myocardial fibrosis in Type 2 diabetes mellitus (T2DM) by inhibiting the TGF-β1/Smad signaling pathway and holds promise as an effective treatment for myocardial fibrosis in DCM.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108976"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}