Journal of diabetes and its complications最新文献

{"title":"A randomised controlled trial of additional bolus insulin using an insulin-to-protein ratio compared with insulin-to-carbohdrate ratio alone in people with type 1 diabetes following a carbohydrate-restricted diet","authors":"Rosemary M. Hall ,&nbsp;Hannah J. Marshall ,&nbsp;Amber Parry-Strong ,&nbsp;Brian Corley ,&nbsp;Jeremy D. Krebs","doi":"10.1016/j.jdiacomp.2024.108778","DOIUrl":"10.1016/j.jdiacomp.2024.108778","url":null,"abstract":"<div><h3>Aims</h3><p>Postprandial hyperglycemia can be problematic for people with type 1 diabetes (T1DM) following carbohydrate-restricted diets. Bolus insulin calculated for meal protein plus carbohydrate may help. This study evaluated the effect of additional bolus insulin using an insulin-to-protein ratio (IPR) on glycaemic control.</p></div><div><h3>Materials and methods</h3><p>Participants with T1DM aged ≥18-years were randomly allocated (1:1) to either carbohydrate and protein-based, or carbohydrate-based insulin dosing alone for 12 weeks while following a carbohydrate-restricted diet (50-100 g/day). Measurement of HbA1c and continuous glucose monitoring occurred at baseline and 12 weeks, with assessment of participant experience at 12 weeks.</p></div><div><h3>Results</h3><p>Thirty-four participants were randomised, 22 female, mean(SD): age 39.2 years (12.6) years; diabetes duration 20.6 years (12.9); HbA1c 7.3 % (0.8), 56.7 mmol/mol (9.2). Seven in each group used insulin pump therapy. HbA1c reduced at 12 weeks with no difference between treatments: mean (SD) control 7.2 % (1.0), 55.7 mmol/mol (10.6); intervention 6.9 % (0.7), 52.3 mmol/mol (7.2) (<em>p</em> = 0.65). Using additional protein-based insulin dosing compared with carbohydrate alone, there was no difference in glycaemic variability, time spent in euglycemic range (TIR), or below range. Participants using IPR reported more control of their diabetes, but varying levels of distress.</p></div><div><h3>Conclusions</h3><p>Additional bolus insulin using an IPR did not improve glycaemic control or TIR in patients with well controlled T1DM following a carbohydrate-restricted diet. Importantly, the use of the IPR does not increase the risk of hypoglycemia and may be preferred.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 7","pages":"Article 108778"},"PeriodicalIF":3.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001041/pdfft?md5=13eb4814a2a0664ef5dd4c6d37fa3efd&pid=1-s2.0-S1056872724001041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIB-4 as a screening and disease monitoring method in pre-fibrotic stages of metabolic dysfunction-associated fatty liver disease (MASLD)","authors":"Stewart G. Albert,&nbsp;Emily M. Wood","doi":"10.1016/j.jdiacomp.2024.108777","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108777","url":null,"abstract":"<div><h3>Aims</h3><p>Guidelines emphasize screening high-risk patients for metabolic dysfunction-associated steatotic liver disease (MASLD) with a calculated FIB-4 score for therapy to reverse fibrosis. We aimed to determine whether FIB-4 can effectively screen and monitor changes in steatohepatitis (MASH).</p></div><div><h3>Methods</h3><p>Data were retrieved from the NIDDK-CR R4R central repository, of the CRN/PIVENS (pioglitazone vs vitamin E vs placebo) trial of adult patients without diabetes mellitus and with MASLD.</p></div><div><h3>Results</h3><p>220 patients with MASLD had alanine transaminase (ALT), aspartate aminotransferase (AST) and platelet count, to calculate FIB-4, and repeat liver biopsies for histological MASLD activity scores (NAS). Compared to NAS score of 2, Fib-4 was higher at NAS 5) (<em>p</em> = 0.03), and NAS score of 6 (<em>p</em> = 0.02). FIB-4 correlated with cellular ballooning (<em>r</em> = 0.309, <em>p</em> &lt; 0.001). Levels of ALT (ANOVA, <em>p</em> = 0.016) and AST (ANOVA <em>p</em> = 0.0008) were associated with NAS. NAS improved with pioglitazone by 39 %, <em>p</em> &lt; 0.001 and with vitamin E by 36 %, <em>p</em> &lt; 0.001. Pioglitazone and vitamin E both improved histological sub-scores for steatosis, and inflammation, without statistical changes in fibrosis grade. Changes in FIB-4 correlated with changes in NAS (<em>r</em> = 0.237, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>In this post hoc analysis, changes in FIB-4 were associated with changes of steatohepatitis. Medication known to treat steatohepatitis, may be considered, before the onset of advanced fibrosis.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 7","pages":"Article 108777"},"PeriodicalIF":3.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(24)00096-5","DOIUrl":"https://doi.org/10.1016/S1056-8727(24)00096-5","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 6","pages":"Article 108770"},"PeriodicalIF":3.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724000965/pdfft?md5=efb7de8983eb608c663ce64f984926ed&pid=1-s2.0-S1056872724000965-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common carotid artery intima media thickness (CIMT) in patients with prediabetes and newly diagnosed type 2 diabetes mellitus","authors":"Antoaneta Gateva,&nbsp;Yavor Assyov,&nbsp;Vera Karamfilova,&nbsp;Zdravko Kamenov","doi":"10.1016/j.jdiacomp.2024.108766","DOIUrl":"10.1016/j.jdiacomp.2024.108766","url":null,"abstract":"<div><h3>Aim</h3><p>To evaluate the relationship between common carotid artery intima media thickness (CIMT) in patients with prediabetes and new-onset diabetes mellitus without proven cardiovascular disease and some classic cardio-metabolic risk factors.</p></div><div><h3>Patients and methods</h3><p>The study included 461 obese patients with an average age of 53.2 ± 10.7 years, divided into three groups - group 1 without carbohydrate disturbances (<em>n</em> = 182), group 2 with prediabetes (<em>n</em> = 193) and group 3 with newly diagnosed diabetes mellitus (<em>n</em> = 86).</p></div><div><h3>Results</h3><p>The patients with new-onset diabetes had significantly higher mean CIMT values compared to those with prediabetes or without carbohydrate disturbances and a higher frequency of abnormal IMT values. CIMT correlated significantly with age, systolic BP, diastolic BP and fasting blood glucose and showed a high predictive value for the presence of diabetic neuropathy and sudomotor dysfunction. Patients with abnormal CIMT values had a higher incidence of arterial hypertension, dyslipidemia, metabolic syndrome, peripheral neuropathy, and sudomotor dysfunction. Patients who developed type 2 diabetes during follow-up had a significantly higher initial mean CIMT, which showed the highest predictive value for the risk of new-onset diabetes, with CIMT≥0.7 mm having 53 % sensitivity and 83 % specificity for the risk of progression to diabetes mellitus.</p></div><div><h3>Conclusion</h3><p>Patients with new-onset diabetes mellitus had significantly greater intima media thickness of the common carotid artery and a greater frequency of abnormal CIMT values compared to those with normoglycemia and prediabetes. CIMT has a high predictive value for the presence of diabetic neuropathy, sudomotor dysfunction and the risk of new onset diabetes.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 7","pages":"Article 108766"},"PeriodicalIF":3.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724000928/pdfft?md5=b77882eaecbff998f8560566d926c8aa&pid=1-s2.0-S1056872724000928-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular matrix turnover proteins as risk markers in people with type 2 diabetes and microalbuminuria","authors":"Anne-Cathrine Skriver-Møller ,&nbsp;Alexandra L. Møller ,&nbsp;Martin B. Blond ,&nbsp;Daniel G.K. Rasmussen ,&nbsp;Federica Genovese ,&nbsp;Henrik Reinhard ,&nbsp;Bernt J. von Scholten ,&nbsp;Peter K. Jacobsen ,&nbsp;Hans-Henrik Parving ,&nbsp;Morten A. Karsdal ,&nbsp;Tine W. Hansen ,&nbsp;Peter Rossing","doi":"10.1016/j.jdiacomp.2024.108765","DOIUrl":"10.1016/j.jdiacomp.2024.108765","url":null,"abstract":"<div><h3>Background</h3><p>This post-hoc study investigated whether biomarkers reflecting extracellular matrix (ECM) turnover predicted cardiovascular disease (CVD), mortality, and progression of diabetic kidney disease (DKD) in individuals with type 2 diabetes (T2D) and microalbuminuria.</p></div><div><h3>Methods</h3><p>Serum levels of specific ECM turnover biomarkers were assessed in 192 participants with T2D and microalbuminuria from an observational study conducted at Steno Diabetes Center Copenhagen from 2007 to 2008. Endpoints included CVD events, mortality, and DKD progression, defined as decline in estimated glomerular filtration rate (eGFR) of &gt;30 %.</p></div><div><h3>Results</h3><p>Participants had a mean age of 59 years, with 75 % males. Over a median follow-up of 4.9 to 6.3 years, the study recorded 38 CVD events, 24 deaths, and 40 DKD events. Elevated levels of a degradation fragment of collagen type I (C1M) were associated with an increased risk of &gt;30 % eGFR decline, although this association was not independent of other risk factors. No significant associations were found between other ECM turnover biomarkers and DKD progression, mortality, or CVD risk.</p></div><div><h3>Conclusion</h3><p>Elevated C1M levels were linked to DKD progression in individuals with T2D and microalbuminuria, but not independently of other risk factors. None of the ECM turnover biomarkers were associated with CVD or mortality.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 6","pages":"Article 108765"},"PeriodicalIF":3.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of insulin responses and insulin sensitivity with cognition in adults with pre-diabetes: The Diabetes Prevention Program Outcomes Study","authors":"Allison L.B. Shapiro ,&nbsp;Ashley H. Tjaden ,&nbsp;Sharon L. Edelstein ,&nbsp;Steven E. Kahn ,&nbsp;Preethi Srikanthan ,&nbsp;William C. Knowler ,&nbsp;Elizabeth M. Venditti ,&nbsp;Sherita H. Golden ,&nbsp;Owen Carmichael ,&nbsp;José A. Luchsinger ,&nbsp;DPP Research Group","doi":"10.1016/j.jdiacomp.2024.108764","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108764","url":null,"abstract":"<div><h3>Objective</h3><p>Dysglycemia is a significant risk factor for cognitive impairment. However, which pathophysiologic determinant(s) of dysglycemia, impaired insulin sensitivity (ISens) or the islet β-cell's response (IResp), contribute to poorer cognitive function, independent of dysglycemia is not established. Among 1052 adults with pre-diabetes from the Diabetes Prevention Program Outcomes Study (DPPOS), we investigated the relationship between IResp, ISens and cognitive function.</p></div><div><h3>Research design and methods</h3><p>IResp was estimated by the insulinogenic index (IGI; pmol/mmol) and ISens as 1/fasting insulin from repeated annual oral glucose tolerance tests. The mean IResp and mean ISens were calculated over approximately 12 years of follow-up. Verbal learning (Spanish-English Verbal Learning Test [SEVLT]) and executive function (Digital Symbol Substitution Test [DSST]) were assessed at the end of the follow-up period. Linear regression models were run for each cognitive outcome and were adjusted for dysglycemia and other factors.</p></div><div><h3>Results</h3><p>Higher IResp was associated with poorer performance on the DSST (−0.69 points per 100 unit increase in IGI, 95 % CI: −1.37, −0.01). ISens was not associated with DSST, nor were IResp or ISens associated with performance on the SEVLT.</p></div><div><h3>Conclusions</h3><p>These results suggest that a greater β-cell response in people at high risk for type 2 diabetes is associated with poorer executive function, independent of dysglycemia and ISens.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 6","pages":"Article 108764"},"PeriodicalIF":3.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring potential correlations between HLA class II and the risk of microvascular complications in Japanese patients with type 1 diabetes","authors":"Eijiro Yamada,&nbsp;Risa Kajita,&nbsp;Haruna Takahashi,&nbsp;Kazuhiko Horiguchi,&nbsp;Satoshi Yoshino,&nbsp;Shunichi Matsumoto,&nbsp;Shuichi Okada,&nbsp;Masanobu Yamada","doi":"10.1016/j.jdiacomp.2024.108763","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108763","url":null,"abstract":"<div><p>Managing complications in Type 1 diabetes (T1D) remains challenging. HLA genes, particularly DR and DQ, are linked to T1D susceptibility. We studied 48 Japanese T1D inpatients and revealed associations between DRB1*04:05-DQB1*04:01 and DRB1*09:01-DQB1*03:03 haplotypes and complications, offering a new perspective for future research.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 6","pages":"Article 108763"},"PeriodicalIF":3.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724000898/pdfft?md5=4500e1a4416d9eabd4aa7ea80f1fe7c4&pid=1-s2.0-S1056872724000898-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient albuminuria in the setting of short-term severe hyperglycemia in type 1 diabetes","authors":"Jia Xin Huang ,&nbsp;Timothy P. Copeland ,&nbsp;Casey E. Pitts ,&nbsp;Sage R. Myers ,&nbsp;Marissa J. Kilberg ,&nbsp;Elaine Ku ,&nbsp;Nicole Glaser","doi":"10.1016/j.jdiacomp.2024.108762","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108762","url":null,"abstract":"<div><p>In a cohort of 1817 children with type 1 diabetes (T1D), short-term hyperglycemia was associated with transient albuminuria (11 % during new-onset T1D without diabetic ketoacidosis (DKA), 12 % during/after DKA, 6 % during routine screening). Our findings have implications regarding future risk of diabetic kidney disease and further investigation is needed.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 6","pages":"Article 108762"},"PeriodicalIF":3.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(24)00077-1","DOIUrl":"https://doi.org/10.1016/S1056-8727(24)00077-1","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 5","pages":"Article 108751"},"PeriodicalIF":3.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724000771/pdfft?md5=ee3a4f00ea98b867a2267c760605d0a8&pid=1-s2.0-S1056872724000771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a Danish tertiary outpatient clinic","authors":"Hatice Isik Mizrak ,&nbsp;Huda Kufaishi ,&nbsp;Sofie Korsgaard Hecquet ,&nbsp;Tine Willum Hansen ,&nbsp;Rodica Pop-Busui ,&nbsp;Peter Rossing ,&nbsp;Birgitte Brock ,&nbsp;Christian Stevns Hansen","doi":"10.1016/j.jdiacomp.2024.108761","DOIUrl":"10.1016/j.jdiacomp.2024.108761","url":null,"abstract":"<div><h3>Background</h3><p>Population-based prevalence estimates of distal symmetric polyneuropathy (DPN) and diabetic autonomic neuropathy (DAN) are scares. Here we present neuropathy estimates and describe their overlap in a large cohort of people with type 1 and type 2 diabetes.</p></div><div><h3>Methods</h3><p>In a large population of outpatient participants, DPN was assessed using vibration perception threshold, sural nerve function, touch, pain and thermal sensation. Definite DPN was defined by the Toronto Consensus Criteria. Painful DPN was defined by Douleur Neuropathique 4 Questions. DAN measures were: cardiovascular reflex tests, electrochemical skin conductance, and gastroparesis cardinal symptom index.</p></div><div><h3>Results</h3><p>We included 822 individuals with type 1 (mean age (±SD) 54 ± 16 years, median [IQR] diabetes duration 26 [15–40] years) and 899 with type 2 diabetes (mean age 67 ± 11 years, median diabetes duration 16 [11−22] years).</p><p>Definite DPN was prevalent in 54 % and 68 %, and painful DPN was in 5 % and 15 % of type 1 and type 2 participants, respectively. The prevalence of DAN varied between 6 and 39 % for type 1 and 9–49 % for type 2 diabetes. DPN without other neuropathy was present in 45 % with T1D and 50 % with T2D.</p></div><div><h3>Conclusion</h3><p>The prevalence of DPN and DAN was high. DPN and DAN co-existed in only 50 % of cases.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 6","pages":"Article 108761"},"PeriodicalIF":3.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}