Journal of diabetes and its complications最新文献

{"title":"Effectiveness of screening for foot complications in people with diabetes – A systematic review","authors":"Aleksandra Staniszewska ,&nbsp;Amy Jones ,&nbsp;Sarah Rudd ,&nbsp;Frank de Vocht ,&nbsp;Robert Hinchliffe","doi":"10.1016/j.jdiacomp.2024.108865","DOIUrl":"10.1016/j.jdiacomp.2024.108865","url":null,"abstract":"<div><h3>Background</h3><p>A quarter of people with diabetes develop foot ulcer in their lifetime and are six times more likely to require a major lower limb amputation compared to the general population. Risk stratification tools can reliably identify those at the highest risk of ulceration, but it remains unclear if screening for foot complications can prevent limb loss in people with diabetes.</p></div><div><h3>Aims</h3><p>The aim of this systematic review was to determine whether population-based foot screening in people with diabetes reduces lower limb complications as assessed by development of foot ulceration, minor and major lower limb amputations, hospitalisation, or death.</p></div><div><h3>Methods</h3><p>MEDLINE, Embase, Emcare and CINAHL databases were searched to identify randomised and non-randomised controlled trials and observational studies (cohort, case-control and cross-sectional surveys). The screening process, study quality assessment and data extraction were performed by two independent reviewers.</p></div><div><h3>Results</h3><p>Following abstract screening and assessment for eligibility, five out of 10,771 identified studies were included in the analysis. Of these studies, one demonstrated 24 % reduction in development of new ulceration following introduction of screening. Major amputations decreased by between 17 and 96 % in three studies. Hospitalisation rates were contradictory, with one study showing doubling in hospital admissions and another one reduction by 33 %. One study demonstrated no impact of screening on minor or major amputation rates. None of the studies addressed the effect of foot screening on all-cause mortality.</p></div><div><h3>Conclusions</h3><p>The number and quality of studies to support population-based foot screening to prevent lower limb complications in people with diabetes is low. Current evidence suggests variable impact of screening on important clinical outcomes.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108865"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001910/pdfft?md5=6eaa8aa54e8c4b048cdfb2ed1eb34f3e&pid=1-s2.0-S1056872724001910-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating CD31+ Angiogenic T cells are reduced in prediabetes and increase with exercise training","authors":"Callum J. Baker ,&nbsp;Danqing Min ,&nbsp;Felix Marsh-Wakefield ,&nbsp;Elisha Siwan ,&nbsp;James Gerofi ,&nbsp;Xiaoyu Wang ,&nbsp;Samantha L. Hocking ,&nbsp;Stephen Colagiuri ,&nbsp;Nathan A. Johnson ,&nbsp;Stephen M. Twigg","doi":"10.1016/j.jdiacomp.2024.108868","DOIUrl":"10.1016/j.jdiacomp.2024.108868","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate circulating angiogenic cells in adults with prediabetes and the effect of a structured exercise program.</p></div><div><h3>Methods</h3><p>A cohort of adults with overweight/obesity and either normal glucose (NG) or prediabetes were randomised to receive exercise (Exercise) (as twice weekly supervised combined high intensity aerobic exercise and progressive resistance training, and once weekly home-based aerobic exercise) or an unsupervised stretching intervention (Control) for 12 weeks. Circulating angiogenic T cells, muscle strength, and cardiovascular disease risk factors, including blood lipids, arterial stiffness, central haemodynamic responses, and cardiorespiratory fitness (VO₂peak) in those with prediabetes (<em>n</em> = 35, 16 Control, 19 Exercise) and NG (<em>n</em> = 37, 17 Control, 20 Exercise) were analysed at baseline and after the 12-week intervention.</p></div><div><h3>Results</h3><p>At baseline, compared with NG those with prediabetes demonstrated reduced VO₂peak, angiogenic CD31⁺CD8⁺ T cells and VEGFR2⁺CD4⁺ T cells, and increased systolic blood pressure. CD31⁺ T cells were negatively correlated with cardiovascular disease (CVD) risk. Compared with Control, exercise training increased muscle strength, VO₂peak, and CD31⁺CD4⁺ and CD31⁺CD8⁺ T cells in NG and prediabetes.</p></div><div><h3>Conclusions</h3><p>Circulating angiogenic CD31⁺ T cells are decreased in people with prediabetes and are enhanced with exercise training. Exercise increases CD31⁺ T cells, and through this mechanism it is proposed that it may reduce CVD risk.</p></div><div><h3>Trial registration</h3><p>Australian New Zealand Clinical Trials Registry number: ACTRN12617000552381.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108868"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes","authors":"Stephanie Teasdale ,&nbsp;Xin Dong ,&nbsp;Alison Griffin ,&nbsp;Paul James Clark ,&nbsp;Janelle Nisbet ,&nbsp;Adam Morton ,&nbsp;Liza Phillips ,&nbsp;Mitchell Anthony Sullivan ,&nbsp;Graham Galloway","doi":"10.1016/j.jdiacomp.2024.108870","DOIUrl":"10.1016/j.jdiacomp.2024.108870","url":null,"abstract":"<div><h3>Aims</h3><p>Glycogenic hepatopathy is associated with significant psychosocial consequences and health costs. Metabolic Dysfunction-Associated Steatotic Liver Disease and glycogenic hepatopathy are frequently confused as “fatty liver” when seen on ultrasonography. We wished to examine liver fat and glycogen content in groups defined based on metabolic and liver disease phenotypes.</p></div><div><h3>Methods</h3><p>This case-control study undertaken in a tertiary hospital used nuclear proton magnetic resonance spectroscopy (¹H-MRS) to examine liver fat and glycogen content in five clinical groups, each containing five participants: 1. type 1 diabetes with glycogenic hepatopathy, 2. satisfactorily controlled type 1 diabetes with no liver disease, 3. poorly controlled type 1 diabetes without liver disease, 4. a control group of body mass index- and age-matched individuals without diabetes or liver disease, and 5. hepatic steatosis.</p></div><div><h3>Results</h3><p>Fat content was highest in the hepatic steatosis (median 15.4 %, IQR 10.0–19.3) and glycogenic hepatopathy (median 6.5 %, IQR 4.5–9.1) groups and compared to both of these groups was lower in the control group (median 1.0 %, IQR 0.7–1.1, p 0.002 and 0.022), the T1DM group with satisfactory control (median 0.3 %, IQR 0.2–0.6, <em>p</em> &lt; 0.001 and &lt;0.001), and the T1DM group with poor control without liver disease (median 1.1 %, IQR 0.9–1.1, p 0.001 and 0.012).</p><p>No participants from the type 1 diabetes poor control, type 1 diabetes satisfactory control or the no diabetes groups had ¹H-MRS-diagnosed hepatic steatosis.</p><p>¹H-MRS glycogen content could not be interpreted in the majority of those with glycogenic hepatopathy because of interference from the fat signal.</p></div><div><h3>Conclusions</h3><p>In cases diagnosed with glycogenic hepatopathy there may be significant concomitant fat accumulation, compounding the already elevated cardiovascular risk in this cohort.</p><p>The technique of ¹H-MRS has not been demonstrated to be useful for diagnosing glycogenic hepatopathy.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108870"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging treatment strategies for polycystic ovary syndrome women with obesity: Focus on glucagon-like peptide-1 receptor agonists","authors":"Mojca Jensterle ,&nbsp;Manfredi Rizzo ,&nbsp;Andrej Janez","doi":"10.1016/j.jdiacomp.2024.108872","DOIUrl":"10.1016/j.jdiacomp.2024.108872","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108872"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001983/pdfft?md5=bf59c2d5346189bde536705d66936189&pid=1-s2.0-S1056872724001983-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of neuropathy in children and adolescents with type 1 diabetes evaluated with bedside modalities","authors":"Julie A. Damm ,&nbsp;Amalie Dalgas-Madsen ,&nbsp;Christian Stevns Hansen ,&nbsp;Kasper A. Pilgaard ,&nbsp;Flemming Pociot ,&nbsp;Tine W. Hansen ,&nbsp;Jesper Johannesen","doi":"10.1016/j.jdiacomp.2024.108873","DOIUrl":"10.1016/j.jdiacomp.2024.108873","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the prevalence of diabetic polyneuropathy (DPN), cardiac autonomic neuropathy (CAN) and sudomotor dysfunction in children and adolescents with type 1 diabetes using bedside modalities. Secondly, to evaluate the co-existence of these types of diabetes neuropathies.</p></div><div><h3>Methods</h3><p>Cross-sectional study including 221 children and adolescents with type 1 diabetes. DPN was assessed by vibration sensation threshold and sural nerve conductance, CAN by cardiac reflex tests and sudomotor function by electrochemical skin conductance.</p></div><div><h3>Results</h3><p>Median (interquartile range) age was 14.2 (11.9, 16.5) years, diabetes duration 4.8 (2.7, 7.7) years and Hba1c 7.1 (6.6, 7.9) %, (54: 49, 63 mmol/mol). Three had retinopathy; all had normal albuminuria. DPN was present in 40 %, early CAN in 17 %, established CAN in 3 % and sudomotor dysfunction in the feet in 5 %. Of these, 60 % had one type of neuropathy, while 35 % had two types. Only 1 participant manifested all three types of neuropathies.</p></div><div><h3>Conclusions</h3><p>Bedside modalities demonstrated a high prevalence of neuropathy in children and adolescents with type 1 diabetes, despite good glycemic outcome, short diabetes duration and absence of complications. A lack of co-existing neuropathies was shown, underscoring the need for multiple screening modalities.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108873"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between patients with type 2 diabetes mellitus and chronic microvascular complications during the glucose peak time","authors":"Yanqiu Jiang ,&nbsp;Xinlei Wang ,&nbsp;Xiaoqin Zhao ,&nbsp;Yi Sun ,&nbsp;Ping Huang ,&nbsp;Qianfeng Que ,&nbsp;Rongfeng Shi ,&nbsp;Xuying Zhao ,&nbsp;Honghong Lu ,&nbsp;Yunjuan Gu","doi":"10.1016/j.jdiacomp.2024.108866","DOIUrl":"10.1016/j.jdiacomp.2024.108866","url":null,"abstract":"<div><h3>Introduction</h3><div>To assess the Type 2 Diabetes Mellitus (T2DM) patients in association with Chronic Microvascular Complications at Glucose Peak Time and the association among chronic microvascular complications in T2DM patients and the glucose peak period in the typical steamed bread meal test.</div></div><div><h3>Methods</h3><div>Overall 1095 T2DM patients were classified as three groups: (1) Group G1: glucose peak time ≤ 1 h (<em>n</em> = 84), Group G2: 1 h &lt; glucose peak time ≤ 2 h (<em>n</em> = 648) and Group G3: glucose peak time &gt; 2 h (<em>n</em> = 363). The clinical characteristics, insulin characteristics and glucose peak time and chronic microvascular complications markers of patients in each group was analyzed and compared. Statistical analyses were performed using SPSS 23.0, employing chi-square tests, Kruskal-Wallis tests, one-way ANOVA, and binary logistic regression analysis, with significance set at <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Age, length of disease, glycated hemoglobin (HbA1c), urine albumin-creatinine ratio (UACR), and the number of patients with diabetic retinopathy (DR) increased (all <em>P</em> &lt; 0.05) in those with postponed glucose peak time, while insulinogenic indexes, the AUC for C-p (AUCC-p), fasting, and 120-min C-peptide (C-p) decreased (all <em>P</em> &lt; 0.05). Only age was connected to patients with diabetic kidney disease (DKD) independently in binary logistic regression analysis, although delayed glucose peak time was related to the presence of patients with DR. (all <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Delayed glucose peak time contributed to DR. Attention should be paid to condition of chronic microvascular complications in T2DM patients with a postponed peak glucose timing.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108866"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001922/pdfft?md5=3cecf78c66379e34d13552b9178491be&pid=1-s2.0-S1056872724001922-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REAL life study of subcutaneous SEMaglutide in patients with type 2 diabetes in SPain: Ambispective, multicenter clinical study. Results in the GLP1-experienced cohort","authors":"Jersy Jair Cárdenas-Salas ,&nbsp;Roberto Miguel Sierra Poyatos ,&nbsp;Bogdana Luiza Luca ,&nbsp;Begoña Sánchez Lechuga ,&nbsp;Naiara Modroño Móstoles ,&nbsp;Teresa Montoya Álvarez ,&nbsp;María de la Paz Gómez Montes ,&nbsp;Jorge Gabriel Ruiz Sánchez ,&nbsp;Diego Meneses González ,&nbsp;Raquel Sánchez-Lopez ,&nbsp;Carlos Casado Cases ,&nbsp;Víctor Pérez de Arenaza Pozo ,&nbsp;Clotilde Vázquez Martínez","doi":"10.1016/j.jdiacomp.2024.108874","DOIUrl":"10.1016/j.jdiacomp.2024.108874","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of switching to once-weekly subcutaneous semaglutide in patients with type 2 diabetes mellitus (T2DM) who were previously treated with other glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in a real-world setting in Spain.</div></div><div><h3>Methods</h3><div>The REAL Life study of SEMaglutide in Patients with Type 2 diabetes in Spain (REALSEM-SP) was conducted in four endocrinology departments in Madrid, Spain. Adult patients with T2DM who were prescribed once-weekly (OW) subcutaneous semaglutide and had been previously treated with other GLP-1 RAs were included. Baseline characteristics, including demographic, anthropometric, and laboratory variables, were recorded at baseline and at 6 ± 3 and 12 ± 3 months of follow-up. The primary outcome was the change in HbA_1c at 12 ± 3 months of follow-up, with secondary outcomes including changes in weight, BMI, and other glycemic parameters.</div></div><div><h3>Results</h3><div>A total of 267 patients were included in the analysis, with a mean age of 61.6 years and a mean T2DM duration of 11.3 years. The majority of patients had grade 1 or 2 obesity at baseline. Switching to OW-semaglutide was associated with a significant reduction in HbA_1c from baseline to 13 months (−0.35 % ± 0.81). Patients who reached the 1.0 mg OW-dose showed a significant reduction in HbA_1c compared to those on the ≤0.5 mg OW-dose. Significant reductions in weight, BMI, and fasting plasma glucose were also observed. Adverse events were mostly gastrointestinal and led to treatment withdrawal in few cases.</div></div><div><h3>Conclusion</h3><div>Switching to OW-subcutaneous semaglutide in patients with T2DM previously treated with other GLP-1 RAs was associated to improvements in glycemic control and weight management in a real-world setting in Spain. These findings support the use of OW-semaglutide as an effective option for patients with T2DM who require additional glycemic control and weight management.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108874"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of longitudinal estimated glomerular filtration rate trajectories in Canadian adults with type 1 diabetes","authors":"Kristen Favel ,&nbsp;Jeffrey N. Bone ,&nbsp;Tom Elliott ,&nbsp;Constadina Panagiotopoulos ,&nbsp;Cherry Mammen","doi":"10.1016/j.jdiacomp.2024.108864","DOIUrl":"10.1016/j.jdiacomp.2024.108864","url":null,"abstract":"<div><h3>Aims</h3><div>Type 1 diabetes (T1D) increases the risk of chronic kidney disease (CKD) development. The aims of this study were to classify trajectories of estimated glomerular filtration rate (eGFR) in a cohort of Canadian adults with T1D, and to describe the risk factors associated with declining eGFR trajectories.</div></div><div><h3>Methods</h3><div>In this retrospective cohort of adults with T1D, data was collected between 1996 and 2020. CKD was defined as eGFR &lt;60 mL/min/1.73 m². Latent class mixed models were used to categorize eGFR trajectories. Multinomial logistic regression was used to identify factors associated with declining eGFR trajectories.</div></div><div><h3>Results</h3><div>In this study, 304 adults were analyzed, with baseline measurements at a median duration of T1D of 15.3 (5.4–24.2) years. Eight percent of the cohort developed CKD over a median duration of 24.3 (13.7–34.8) years. Four classes of longitudinal eGFR trajectories were identified, broadly categorized as steeply declining (SD1, SD2) and gradual declining (GD1, GD2). Female sex, poor glycemic control, elevated body mass index, and albuminuria were associated with a steeply declining trajectory.</div></div><div><h3>Conclusion</h3><div>In this cohort, four distinctive eGFR trajectories were identified, including a subtype with steeply declining eGFR. Given the complex nature of CKD progression, further prospective study of this model for identification of individuals at risk for CKD based on their trajectory of kidney function may support clinicians in their decision-making.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108864"},"PeriodicalIF":2.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001909/pdfft?md5=aac55bae3236f38653c8b2d2808019c5&pid=1-s2.0-S1056872724001909-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(24)00185-5","DOIUrl":"10.1016/S1056-8727(24)00185-5","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108859"},"PeriodicalIF":2.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001855/pdfft?md5=d067c4de3b819fb03a4ed850e9729b85&pid=1-s2.0-S1056872724001855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inter-relationship between Helicobacter pylori infection, dementia and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase I","authors":"Timothy M.E. Davis ,&nbsp;David G. Bruce ,&nbsp;Katrin Schimke ,&nbsp;S.A. Paul Chubb ,&nbsp;Wendy A. Davis","doi":"10.1016/j.jdiacomp.2024.108854","DOIUrl":"10.1016/j.jdiacomp.2024.108854","url":null,"abstract":"<div><h3>Background</h3><p>Given sparse relevant data, the aim of this study was to determine whether <em>Helicobacter pylori</em> infection, including cytotoxin-associated gene-A (CagA) producing strains, is associated with dementia in type 2 diabetes (T2DM).</p></div><div><h3>Methods</h3><p>Longitudinal data from 1115 participants in the community-based Fremantle Diabetes Study Phase I (mean age 64.0 years, 48.0 % males; 38.0 % <em>H. pylori</em> seronegative, 24.3 % <em>H. pylori</em> seropositive/CagA seronegative, and 37.7 % <em>H. pylori</em>/CagA seropositive at baseline) were analyzed.</p></div><div><h3>Results</h3><p>During up to 19 years of follow-up, 50.3 % and 83.5 % of participants without and with incident dementia, respectively, died. In Cox proportional hazards models, <em>H. pylori</em>/CagA seropositivity (hazard ratio (95 % CI) 1.68 (1.15, 2.46), <em>P</em> = 0.008), but not <em>H. pylori</em> seropositivity/CagA seronegativity (<em>P</em> = 0.541) was an independent predictor of incident dementia, but neither <em>H. pylori</em> seropositivity/CagA seronegativity nor <em>H. pylori</em>/CagA seropositivity were significant predictors in competing risks models (<em>P</em> ≥ 0.280).</p></div><div><h3>Conclusions</h3><p>Although CagA seropositivity in T2DM may have a contributory etiologic role in the risk of dementia, this may be through its association with reduced cardiovascular/all-cause mortality.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108854"},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001806/pdfft?md5=fbebd4a96986440b0e993c6aff90ce7f&pid=1-s2.0-S1056872724001806-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}