Journal of diabetes and its complications最新文献

{"title":"REAL life study of subcutaneous SEMaglutide in patients with type 2 diabetes in SPain: Ambispective, multicenter clinical study. Results in the GLP1-experienced cohort","authors":"Jersy Jair Cárdenas-Salas ,&nbsp;Roberto Miguel Sierra Poyatos ,&nbsp;Bogdana Luiza Luca ,&nbsp;Begoña Sánchez Lechuga ,&nbsp;Naiara Modroño Móstoles ,&nbsp;Teresa Montoya Álvarez ,&nbsp;María de la Paz Gómez Montes ,&nbsp;Jorge Gabriel Ruiz Sánchez ,&nbsp;Diego Meneses González ,&nbsp;Raquel Sánchez-Lopez ,&nbsp;Carlos Casado Cases ,&nbsp;Víctor Pérez de Arenaza Pozo ,&nbsp;Clotilde Vázquez Martínez","doi":"10.1016/j.jdiacomp.2024.108874","DOIUrl":"10.1016/j.jdiacomp.2024.108874","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of switching to once-weekly subcutaneous semaglutide in patients with type 2 diabetes mellitus (T2DM) who were previously treated with other glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in a real-world setting in Spain.</div></div><div><h3>Methods</h3><div>The REAL Life study of SEMaglutide in Patients with Type 2 diabetes in Spain (REALSEM-SP) was conducted in four endocrinology departments in Madrid, Spain. Adult patients with T2DM who were prescribed once-weekly (OW) subcutaneous semaglutide and had been previously treated with other GLP-1 RAs were included. Baseline characteristics, including demographic, anthropometric, and laboratory variables, were recorded at baseline and at 6 ± 3 and 12 ± 3 months of follow-up. The primary outcome was the change in HbA_1c at 12 ± 3 months of follow-up, with secondary outcomes including changes in weight, BMI, and other glycemic parameters.</div></div><div><h3>Results</h3><div>A total of 267 patients were included in the analysis, with a mean age of 61.6 years and a mean T2DM duration of 11.3 years. The majority of patients had grade 1 or 2 obesity at baseline. Switching to OW-semaglutide was associated with a significant reduction in HbA_1c from baseline to 13 months (−0.35 % ± 0.81). Patients who reached the 1.0 mg OW-dose showed a significant reduction in HbA_1c compared to those on the ≤0.5 mg OW-dose. Significant reductions in weight, BMI, and fasting plasma glucose were also observed. Adverse events were mostly gastrointestinal and led to treatment withdrawal in few cases.</div></div><div><h3>Conclusion</h3><div>Switching to OW-subcutaneous semaglutide in patients with T2DM previously treated with other GLP-1 RAs was associated to improvements in glycemic control and weight management in a real-world setting in Spain. These findings support the use of OW-semaglutide as an effective option for patients with T2DM who require additional glycemic control and weight management.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108874"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of longitudinal estimated glomerular filtration rate trajectories in Canadian adults with type 1 diabetes","authors":"Kristen Favel ,&nbsp;Jeffrey N. Bone ,&nbsp;Tom Elliott ,&nbsp;Constadina Panagiotopoulos ,&nbsp;Cherry Mammen","doi":"10.1016/j.jdiacomp.2024.108864","DOIUrl":"10.1016/j.jdiacomp.2024.108864","url":null,"abstract":"<div><h3>Aims</h3><div>Type 1 diabetes (T1D) increases the risk of chronic kidney disease (CKD) development. The aims of this study were to classify trajectories of estimated glomerular filtration rate (eGFR) in a cohort of Canadian adults with T1D, and to describe the risk factors associated with declining eGFR trajectories.</div></div><div><h3>Methods</h3><div>In this retrospective cohort of adults with T1D, data was collected between 1996 and 2020. CKD was defined as eGFR &lt;60 mL/min/1.73 m². Latent class mixed models were used to categorize eGFR trajectories. Multinomial logistic regression was used to identify factors associated with declining eGFR trajectories.</div></div><div><h3>Results</h3><div>In this study, 304 adults were analyzed, with baseline measurements at a median duration of T1D of 15.3 (5.4–24.2) years. Eight percent of the cohort developed CKD over a median duration of 24.3 (13.7–34.8) years. Four classes of longitudinal eGFR trajectories were identified, broadly categorized as steeply declining (SD1, SD2) and gradual declining (GD1, GD2). Female sex, poor glycemic control, elevated body mass index, and albuminuria were associated with a steeply declining trajectory.</div></div><div><h3>Conclusion</h3><div>In this cohort, four distinctive eGFR trajectories were identified, including a subtype with steeply declining eGFR. Given the complex nature of CKD progression, further prospective study of this model for identification of individuals at risk for CKD based on their trajectory of kidney function may support clinicians in their decision-making.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108864"},"PeriodicalIF":2.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001909/pdfft?md5=aac55bae3236f38653c8b2d2808019c5&pid=1-s2.0-S1056872724001909-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(24)00185-5","DOIUrl":"10.1016/S1056-8727(24)00185-5","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108859"},"PeriodicalIF":2.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001855/pdfft?md5=d067c4de3b819fb03a4ed850e9729b85&pid=1-s2.0-S1056872724001855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inter-relationship between Helicobacter pylori infection, dementia and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase I","authors":"Timothy M.E. Davis ,&nbsp;David G. Bruce ,&nbsp;Katrin Schimke ,&nbsp;S.A. Paul Chubb ,&nbsp;Wendy A. Davis","doi":"10.1016/j.jdiacomp.2024.108854","DOIUrl":"10.1016/j.jdiacomp.2024.108854","url":null,"abstract":"<div><h3>Background</h3><p>Given sparse relevant data, the aim of this study was to determine whether <em>Helicobacter pylori</em> infection, including cytotoxin-associated gene-A (CagA) producing strains, is associated with dementia in type 2 diabetes (T2DM).</p></div><div><h3>Methods</h3><p>Longitudinal data from 1115 participants in the community-based Fremantle Diabetes Study Phase I (mean age 64.0 years, 48.0 % males; 38.0 % <em>H. pylori</em> seronegative, 24.3 % <em>H. pylori</em> seropositive/CagA seronegative, and 37.7 % <em>H. pylori</em>/CagA seropositive at baseline) were analyzed.</p></div><div><h3>Results</h3><p>During up to 19 years of follow-up, 50.3 % and 83.5 % of participants without and with incident dementia, respectively, died. In Cox proportional hazards models, <em>H. pylori</em>/CagA seropositivity (hazard ratio (95 % CI) 1.68 (1.15, 2.46), <em>P</em> = 0.008), but not <em>H. pylori</em> seropositivity/CagA seronegativity (<em>P</em> = 0.541) was an independent predictor of incident dementia, but neither <em>H. pylori</em> seropositivity/CagA seronegativity nor <em>H. pylori</em>/CagA seropositivity were significant predictors in competing risks models (<em>P</em> ≥ 0.280).</p></div><div><h3>Conclusions</h3><p>Although CagA seropositivity in T2DM may have a contributory etiologic role in the risk of dementia, this may be through its association with reduced cardiovascular/all-cause mortality.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108854"},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001806/pdfft?md5=fbebd4a96986440b0e993c6aff90ce7f&pid=1-s2.0-S1056872724001806-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary counseling, meal patterns, and diet quality in patients with type 2 diabetes mellitus with/without chronic kidney disease","authors":"Erika F. Gómez-García ,&nbsp;Alfonso M. Cueto-Manzano ,&nbsp;Héctor R. Martínez-Ramírez ,&nbsp;Laura Cortés-Sanabria ,&nbsp;Carla M. Avesani ,&nbsp;Claudia N. Orozco-González ,&nbsp;Enrique Rojas-Campos","doi":"10.1016/j.jdiacomp.2024.108853","DOIUrl":"10.1016/j.jdiacomp.2024.108853","url":null,"abstract":"<div><h3>Background</h3><p>Aim to this study is to investigate the association of Dietary Counseling, Meal Patterns, and Diet Quality (DietQ) in Patients with Type 2 Diabetes Mellitus (T2DM) with/without chronic kidney disease (CKD) in primary healthcare.</p></div><div><h3>Methods</h3><p>Cross-sectional study acquired data on dietary counseling and meal patterns by direct interview with a food-frequency questionnaire and one 24-h food-recall. The Healthy Eating Index (HEI) was used to classify DietQ [“good” DietQ (GDietQ, score ≥ 80) and “poor” DietQ (PDietQ, score &lt; 80)].</p></div><div><h3>Participants/setting</h3><p>This study included 705 patients with T2DM: 306 with normal kidney function; 236 with early nephropathy, and 163 with overt nephropathy (ON).</p></div><div><h3>Statistical analyses performed</h3><p>Multivariate linear-regression models for predicting HEI and χ² tests for qualitative variables and one-way ANOVA for quantitative variables were employed. Mann-Whitney U and independent Student t were performed for comparisons between GDietQ and PDietQ.</p></div><div><h3>Results</h3><p>Only 18 % of the population was classified as GDietQ. Patients with ON and PDietQ <em>vs.</em> with GDietQ received significantly less dietary counseling from any health professional in general (45 % <em>vs</em> 72 %, respectively), or from any nutrition professional (36 % <em>vs.</em> 61 %, respectively). A better HEI was significantly predicted (F = 42.01; <em>p</em> = 0.0001) by lower HbA_1C (β −0.53, <em>p</em> = 0.0007) and better diet diversity (β 8.09, <em>p</em> = 0.0001).</p></div><div><h3>Conclusions</h3><p>Patients with more advanced stages of CKD had less nutritional counseling and worse dietary patterns, as well as more frequent PDietQ. Our findings reinforce the need for dietitians and nutritionists in primary healthcare to provide timely nutritional counseling.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108853"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Too good to be true: Are GLP-1 receptor agonists the new metformin?","authors":"Bernd Kowall ,&nbsp;Gregor Maier ,&nbsp;Wolfgang Rathmann","doi":"10.1016/j.jdiacomp.2024.108851","DOIUrl":"10.1016/j.jdiacomp.2024.108851","url":null,"abstract":"<div><p>Recently, a health-care database study showed that persons with type 2 diabetes taking GLP-1 receptor agonists (GLP-1 RA) had a significantly lower risk of 10 out of 13 obesity-related cancers than patients taking insulin (Wang L, et al. JAMA Netw Open. 2024 7: e2421305). For some cancers, hazard ratios &lt;0.5 were reported. This is reminiscent of studies published &gt;10 years ago showing that people with type 2 diabetes taking metformin had a lower risk of many types of cancer than those not taking metformin. In some studies, also risk reductions of &gt;50 % were reported.</p><p>The strong effects observed in the metformin studies were explained by time-related biases, in particular, immortal time bias. In the current GLP-1 RA study, it was striking that the curves for the cumulative incidence of several cancers in GLP-1 RA and insulin users diverged immediately after therapy onset. This indicates that there is most likely a time-related bias: insulin is given at much later stages of type 2 diabetes than GLP-1 RA.</p><p>The current study suggests that one should be sceptical about database results when spectacular risk reductions are reported. Time-related bias should always be considered as an alternative explanation.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108851"},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A gender-based analysis of retinal microvascular alterations in patients with diabetes mellitus using OCT angiography","authors":"Stela Vujosevic ,&nbsp;Celeste Limoli ,&nbsp;Gabriele Piccoli ,&nbsp;Eliana Costanzo ,&nbsp;Elisa Marenzi ,&nbsp;Emanuele Torti ,&nbsp;Daniela Giannini ,&nbsp;Maria Sole Polito ,&nbsp;Livio Luzi ,&nbsp;Paolo Nucci ,&nbsp;Mariacristina Parravano","doi":"10.1016/j.jdiacomp.2024.108852","DOIUrl":"10.1016/j.jdiacomp.2024.108852","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess the difference in microvascular changes between males and females with diabetes mellitus (DM) without diabetic retinopathy (NoDR) and with mild-to-moderate non-proliferative diabetic retinopathy (NPDR) using Optical Coherence Tomography Angiography (OCT-A).</p></div><div><h3>Design</h3><p>Retrospective cross-sectional study.</p></div><div><h3>Methods</h3><p>267 DM patients, 133 females (49.81 %), 111 with NoDR (41.57 %) and 156 NPDR (58.43 %) were included. Foveal-centered 3 × 3 mm OCT-A images corresponding to the superficial (SCP), intermediate (ICP) and deep capillary plexus (DCP), and full retinal (RET) slab were used for analysis. For each slab, FAZ area, perimeter, and circularity index (CI) were determined, following manual delineation of the FAZ; perfusion (PD) and vessel density (VD), fractal dimension (FD), vessel length density (VLD), geometric perfusion deficits (GPD) were also computed. Flow voids (FV) were determined in the choriocapillaris plexus; and perfused capillary density (PCD) in the RET slab.</p></div><div><h3>Results</h3><p>Females showed larger FAZ CI in SCP and greater FAZ area and perimeter than males in NPDR group. Males had higher central macular thickness than females in NPDR group. All density metrics at the level of ICP and DCP were affected in the NPDR group with no gender differences. Of note, the same significant findings were found in type 1 DM patients, and not in type 2 DM patients.</p></div><div><h3>Conclusions</h3><p>Our OCT-A findings suggest significant microvascular changes in females with NPDR compared to males, but no such differences in patients without DR. Therefore, gender-related vascular alterations might be present in early stages of DR with potential role.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108852"},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of novel atherogenic indices in patients with acute myocardial infarction with and without type 2 diabetes","authors":"Dominika Rokicka ,&nbsp;Bartosz Hudzik ,&nbsp;Marta Wróbel ,&nbsp;Tomasz Stołtny ,&nbsp;Dorota Stołtny ,&nbsp;Alicja Nowowiejska-Wiewióra ,&nbsp;Sonia Rokicka ,&nbsp;Mariusz Gąsior ,&nbsp;Krzysztof Strojek","doi":"10.1016/j.jdiacomp.2024.108850","DOIUrl":"10.1016/j.jdiacomp.2024.108850","url":null,"abstract":"<div><h3>Aims</h3><p>Atherogenic indices: Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli's Risk Index I and II (CRI-I, CRI-II) are used in clinical studies as surrogates of major adverse cardiac and cerebrovascular events (MACCE). Risk prediction of MACCE in patients with acute myocardial infarction (AMI) has vital role in clinical practice. We aimed to assess prognostic value of these indices following AMI.</p></div><div><h3>Methods</h3><p>We analyzed patients with AMI with and without T2DM and the prognostic values of atherogenic indices for in-hospital death and MACCE within 12 months after AMI.</p></div><div><h3>Results</h3><p>Of 2461 patients, 152 in-hospital deaths (6.2 %) were reported (74 patients [7.4 %] with T2DM and 78 [5.3 %] without T2DM; <em>p</em> = 0.042). MACCE occurred in 22.7 % of patients (29.7 % with T2DM and 17.9 % without T2DM; <em>p</em> &lt; 0.001). TG/HDL-C and AIP were higher in T2DM patients compared to those without T2DM (<em>p</em> &lt; 0.001). Long-term MACCE was more prevalent in patients with T2DM (p &lt; 0.001). The AUC-ROC for predicting in-hospital death based on TG/HDL-C and AIP was 0.57 (<em>p</em> = 0.002).</p></div><div><h3>Conclusions</h3><p>None of the atherogenic indices was an independent risk factor for in-hospital death or MACCE at 12-month follow-up in patients with AMI. AIP was an independent risk factor for death at 12-month follow-up.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108850"},"PeriodicalIF":2.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001764/pdfft?md5=6bda50d070c82f5ff190d5866b000151&pid=1-s2.0-S1056872724001764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age at onset of type 2 diabetes and prevalence of vascular disease and heart failure: Systematic review and dose-response meta-analysis","authors":"Jonathan Goldney ,&nbsp;Mary M. Barker ,&nbsp;Martha Thomas ,&nbsp;Tommy Slater ,&nbsp;Monika Mickute ,&nbsp;Jack A. Sargeant ,&nbsp;Kamlesh Khunti ,&nbsp;Melanie J. Davies ,&nbsp;Francesco Zaccardi","doi":"10.1016/j.jdiacomp.2024.108849","DOIUrl":"10.1016/j.jdiacomp.2024.108849","url":null,"abstract":"<div><h3>Aim</h3><p>To investigate the relationship between age at diagnosis of type 2 diabetes and the risk of macrovascular disease, heart failure, and microvascular disease.</p></div><div><h3>Methods</h3><p>In August 2022, PubMed/EMBASE were searched for articles reporting (i) coronary artery disease, cerebrovascular disease, peripheral vascular disease, amputation; (ii) heart failure; and (iii) retinopathy, neuropathy, nephropathy (albuminuria, chronic kidney disease [CKD], end-stage renal disease) by age at diagnosis of type 2 diabetes. Random effects, non-linear dose-response meta-analysis was undertaken for each outcome to assess the association with age at diagnosis (40 years = reference), using both crude and maximally adjusted odds ratios separately, with and without adjustment for current age (age at sampling).</p></div><div><h3>Results</h3><p>We identified 42 articles (230,003 to 3,465,590 participants; 1035 to 391,140 events). Age at diagnosis was positively associated with the risk of macrovascular diseases, heart failure, and CKD, independent of current age, and negatively associated with retinopathy. For other microvascular outcomes, when adjusting for current age, a “reverse U\" relationship was observed (peak risk = 55–60 years).</p></div><div><h3>Discussion</h3><p>Retinopathy was negatively associated with age at diagnosis, highlighting the importance of retinopathy screening in early-onset type 2 diabetes. The implications of other associations were unclear due to the heterogeneity in methodologies and findings.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108849"},"PeriodicalIF":2.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001752/pdfft?md5=d1352b60b8393b7b5102b3a8eaa9149b&pid=1-s2.0-S1056872724001752-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism and promising therapeutic strategy of diabetic cardiomyopathy dysfunctions: Focus on pyroptosis","authors":"Xiao-fei Geng ,&nbsp;Wen-yu Shang ,&nbsp;Zhong-wen Qi ,&nbsp;Chi Zhang ,&nbsp;Wen-xiu Li ,&nbsp;Zhi-peng Yan ,&nbsp;Xin-biao Fan ,&nbsp;Jun-ping Zhang","doi":"10.1016/j.jdiacomp.2024.108848","DOIUrl":"10.1016/j.jdiacomp.2024.108848","url":null,"abstract":"<div><p>Diabetes is a major risk factor for cardiovascular diseases, and myocardial damage caused by hyperglycemia is the main cause of heart failure. However, there is still a lack of systematic understanding of myocardial damage caused by diabetes. At present, we believe that the cellular inflammatory damage caused by hyperglycemia is one of the causes of diabetic cardiomyopathy. Pyroptosis, as a proinflammatory form of cell death, is closely related to the occurrence and development of diabetic cardiomyopathy. Therefore, this paper focuses on the important role of inflammation in the occurrence and development of diabetic cardiomyopathy. From the perspective of pyroptosis, we summarize the pyroptosis of different types of cells in diabetic cardiomyopathy and its related signaling pathways. It also summarizes the treatment of diabetic cardiomyopathy, hoping to provide methods for the prevention and treatment of diabetic cardiomyopathy by inhibiting pyroptosis.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108848"},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}