Journal of diabetes and its complications最新文献_第9页

Muscle mitochondrial function is impaired in adults with type 1 diabetes 1 型糖尿病成人患者的肌肉线粒体功能受损

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-13 DOI: 10.1016/j.jdiacomp.2024.108798

Daniel Gottlieb , Layla A. Abushamat , Kristen J. Nadeau , Judith G. Regensteiner , Jane E.B. Reusch , Kalie L. Tommerdahl , John Rice , Leslie A. Knaub , Cynthia M.F. Monaco , Thomas J. Hawke , Christopher G.R. Perry , Melanie G. Cree , Irene E. Schauer

{"title":"Muscle mitochondrial function is impaired in adults with type 1 diabetes","authors":"Daniel Gottlieb , Layla A. Abushamat , Kristen J. Nadeau , Judith G. Regensteiner , Jane E.B. Reusch , Kalie L. Tommerdahl , John Rice , Leslie A. Knaub , Cynthia M.F. Monaco , Thomas J. Hawke , Christopher G.R. Perry , Melanie G. Cree , Irene E. Schauer","doi":"10.1016/j.jdiacomp.2024.108798","DOIUrl":"10.1016/j.jdiacomp.2024.108798","url":null,"abstract":"<div><h3>Aims</h3><p>Type 1 diabetes has been associated with mitochondrial dysfunction. However, the mechanism of this dysfunction in adults remains unclear.</p></div><div><h3>Methods</h3><p>A secondary analysis was conducted using data from several clinical trials measuring <em>in-vivo</em> and <em>ex-vivo</em> mitochondrial function in adults with type 1 diabetes (<em>n</em> = 34, age 38.8 ± 14.6 years) and similarly aged controls (<em>n</em> = 59, age 44.6 ± 13.9 years). <em>In-vivo</em> mitochondrial function was assessed before, during, and after isometric exercise with <sup>31</sup>phosphorous magnetic resonance spectroscopy. High resolution respirometry of vastus lateralis muscle tissue was used to assess <em>ex-vivo</em> measures.</p></div><div><h3>Results</h3><p><em>In-vivo</em> data showed higher rates of anaerobic glycolysis (<em>p</em> = 0.013), and a lower maximal mitochondrial oxidative capacity (<em>p</em> = 0.012) and mitochondrial efficiency (<em>p</em> = 0.024) in adults with type 1 diabetes. After adjustment for age and percent body fat maximal mitochondrial capacity (<em>p</em> = 0.014) continued to be lower and anaerobic glycolysis higher (<em>p</em> = 0.040) in adults with type 1 diabetes. <em>Ex-vivo</em> data did not demonstrate significant differences between the two groups.</p></div><div><h3>Conclusions</h3><p>The <em>in-vivo</em> analysis demonstrates that adults with type 1 diabetes have mitochondrial dysfunction. This builds on previous research showing <em>in-vivo</em> mitochondrial dysfunction in youths with type 1 diabetes and suggests that defects in substrate or oxygen delivery may play a role in <em>in-vivo</em> dysfunction.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108798"},"PeriodicalIF":2.9,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141389839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contents/Barcode 内容/条形码

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-12 DOI: 10.1016/S1056-8727(24)00114-4

引用次数: 0

Real-world data on the Minimed 780G advanced hybrid closed-loop system use during type 1 diabetes pregnancy: One centre observational study 1 型糖尿病患者妊娠期间使用 Minimed 780G 高级混合闭环系统的实际数据：一个中心的观察研究

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-11 DOI: 10.1016/j.jdiacomp.2024.108795

Ana Munda , Chiara Kovacic , Drazenka Pongrac Barlovic

{"title":"Real-world data on the Minimed 780G advanced hybrid closed-loop system use during type 1 diabetes pregnancy: One centre observational study","authors":"Ana Munda , Chiara Kovacic , Drazenka Pongrac Barlovic","doi":"10.1016/j.jdiacomp.2024.108795","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108795","url":null,"abstract":"<div><p>Aim</p><p>The efficacy of hybrid closed-loop systems (HCLs) in managing glycemic control in pregnant women with type 1 diabetes remains inadequately characterized. We evaluated the use of the Medtronic Minimed 780G HCLs.</p></div><div><h3>Methods</h3><p>The retrospective observational study analyzed the glycemic and perinatal outcomes of pregnant women using the HCLs, followed at our tertiary centre. Independent <em>t</em>-tests were employed to compare data among trimesters based on pre-pregnancy HbA<sub>1c</sub>. The associations between glycemic parameters and perinatal outcomes were explored using Spearman rho.</p></div><div><h3>Results</h3><p>Among the 21 women (age: 33.5 ± 4.2 years, diabetes duration: 21.2 ± 7.6 years, pre-pregnancy HbA<sub>1c</sub> 7.0 ± 1.1 % (52.9 ± 11.9 mmol/mol)) time in range (pTIR, 63–140 mg/dl; 3.5–7.8 mmol/l) increased progressively throughout pregnancy (trimesters: first: 64.0 ± 9.0 %; second:71.3 ± 11.8 %; third: 75.7 ± 8.1 %). Simultaneously, mean sensor glucose decreased (trimesters: first: 130 ± 10.4 mg/dl (7.2 ± 0.6 mmol/l); second: 120.9 ± 13.4 mg/dl (6.7 ± 0.7 mmol/l); third: 117.3 ± 9.1 mg/dl (6.5 ± 0.5 mmol/l)). Although a majority of women achieved the target pTIR until the third trimester, this did not consistently prevent the delivery of a large-for-gestational-age baby. Notably, one ketoacidosis event occurred, and there were no reported instances of severe hypoglycemia.</p></div><div><h3>Conclusion</h3><p>Use of the Minimed 780G HCLs enabled the attainment of recommended pregnancy glycemic targets for most women with type 1 diabetes in a real-world setting.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108795"},"PeriodicalIF":3.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A community health worker led diabetes self-management education program: Reducing patient and system burden 社区医疗工作者领导的糖尿病自我管理教育计划：减轻患者和系统负担

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-10 DOI: 10.1016/j.jdiacomp.2024.108794

Laura Porterfield , Xiaoying Yu , Victoria Warren , Michael E. Bowen , Carolyn Smith-Morris , Elizabeth M. Vaughan

{"title":"A community health worker led diabetes self-management education program: Reducing patient and system burden","authors":"Laura Porterfield , Xiaoying Yu , Victoria Warren , Michael E. Bowen , Carolyn Smith-Morris , Elizabeth M. Vaughan","doi":"10.1016/j.jdiacomp.2024.108794","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108794","url":null,"abstract":"<div><h3>Aims</h3><p>Conduct a secondary analysis of the <em>TIME</em> (Telehealth-supported, Integrated Community Health Workers (CHWs), Medication access, diabetes Education) <em>made simple</em> trial (SIMPLE) to evaluate healthcare utilization and explore variables that may have influenced HbA1c.</p></div><div><h3>Methods</h3><p>Participants (<em>N</em> = 134 [67/group]) were low-income, uninsured Hispanics with or at risk for type 2 diabetes mellitus. We included in-person and telehealth clinician visits, other visits, missed visits, orders placed, and guideline-adherence (e.g., vaccinations, quarterly HbA1c for uncontrolled diabetes). Using multivariable models, we explored for associations between HbA1c changes and these measures.</p></div><div><h3>Results</h3><p>The control arm had higher missed visits rates (intervention: 45 %; control: 56 %; <em>p</em> = 0.007) and missed telehealth appointments (intervention: 10 %; control: 27.4 %; <em>p</em> = 0.04). The intervention group received more COVID vaccinations than the control (<em>p</em> = 0.005). Other health measures were non-significant between groups. Intervention individuals' HbA1c improved with more missed visits (−0.60 %; <em>p</em> < 0.01) and worsened with improved guideline-adherent HbA1c measurements (HbA1c: 1.2 %; <em>p</em> = 0.057). The control group had non-significant HbA1c associations.</p></div><div><h3>Conclusions</h3><p>Findings suggest that the SIMPLE trial's improved HbA1c levels stemmed from a CHW-driven intervention and not additional healthcare contact. Exploratory outcomes resulted in seemingly counterintuitive HbA1c associations with missed visits and guideline-adherent measurements; these may suggest that an intervention that enhances communication provides support to reduce the amount of follow-up needed by participants without sacrificing clinical improvements.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108794"},"PeriodicalIF":3.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of lixisenatide on liquid gastric emptying in type 2 diabetes – Implications for the use of GLP-1 receptor agonists before procedures 利昔那肽对2型糖尿病患者液态胃排空的影响--对手术前使用GLP-1受体激动剂的启示

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-08 DOI: 10.1016/j.jdiacomp.2024.108793

Joshua G. Kovoor , Christopher K. Rayner , Tongzhi Wu , Ryan J. Jalleh , Guy J. Maddern , Michael Horowitz , Karen L. Jones

引用次数: 0

Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: Systematic review and meta-analysis 新型降糖药对老年人心血管疾病的影响：系统回顾和荟萃分析

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-08 DOI: 10.1016/j.jdiacomp.2024.108783

Anika Bilal , Fanchao Yi , Gonzalo Romero Gonzalez , Mehreen Ali , KyungAh Im , Christian T. Ruff , Tina K. Thethi , Richard E. Pratley

{"title":"Effects of newer anti-hyperglycemic agents on cardiovascular outcomes in older adults: Systematic review and meta-analysis","authors":"Anika Bilal , Fanchao Yi , Gonzalo Romero Gonzalez , Mehreen Ali , KyungAh Im , Christian T. Ruff , Tina K. Thethi , Richard E. Pratley","doi":"10.1016/j.jdiacomp.2024.108783","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108783","url":null,"abstract":"<div><h3>Aim</h3><p>To demonstrate cardiovascular safety of dipeptidyl peptidase-4 inhibitors (DPP-4i), glucagon-like peptide-1 receptor agonists (GLP-1RA), and sodium/glucose cotransporter 2 inhibitors (SGLT-2i) across age-groups.</p></div><div><h3>Methods</h3><p>PubMed, Embase and Cochrane were searched for cardiovascular outcome trials (CVOTs) testing newer agents until August 31, 2022 (PROSPERO ID CRD42021260167). Studies with ≥1000 T2D participants enrolled for ≥12 months were included. Random effect models were used to report relative-risk (RR) for three-point major adverse cardiovascular events (3P-MACE) and its components by age subgroups (65 years; 75 years).</p></div><div><h3>Results</h3><p>For SGLT-2is, five CVOTs (46,969 patients, 45–50 % ≥65 years) were included. SGLT-2is reduced risk of MACE (RR; 0.91 [CI, 0.85–0.98]); cardiovascular death (CV-death) (RR; 0.84 [CI, 0.73–0.96]); and all-cause mortality (ACM) (RR; 0.86 [CI, 0.79–0.93]) with no difference in subgroups <65 or ≥65 years.</p><p>For GLP-1RAs, nine CVOTs (n = 64,236, 34–75 % ≥65 years) were included. GLP-1RAs reduced risk of MACE (RR; 0.89 [CI, 0.83–0.95]), stroke (RR; 0.86 [CI, 0.76–0.97]) and ACM (RR; 0.90 [CI, 0.83–0.97]) with no significant difference in subgroups <65 or ≥65 years. Additionally, GLP-1RAs reduced risk of MACE (10 %), ACM (12 %) and CV-death (12 %) with no significant difference in subgroups <75 or ≥75 years.</p><p>Four CVOTs (n = 33,063; 35–58 % ≥65 years) with DPP-4is were included. There were no significant differences in risk for CV outcomes with DPP-4is compared to placebo in any of the age subgroups.</p></div><div><h3>Conclusion</h3><p>The overall cardiovascular safety profile of newer anti-hyperglycemic agents is consistent in older and younger individuals.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108783"},"PeriodicalIF":3.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141314510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials 食用益生菌对非酒精性脂肪肝患者血脂状况、血糖指数、炎症指标和肝功能的影响：随机对照试验的系统回顾和荟萃分析

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2024-06-06 DOI: 10.1016/j.jdiacomp.2024.108780

Sadegh Mozaffari , Mahdeyeh Aliari , Solaleh Emamgholipour , Hossein Hosseini , Pedram Rezaei Amirkiasar , Mina Zare , Niki Katsiki , Ghodratollah Panahi , Amirhossein Sahebkar

{"title":"The effect of probiotic consumption on lipid profile, glycemic index, inflammatory markers, and liver function in NAFLD patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Sadegh Mozaffari , Mahdeyeh Aliari , Solaleh Emamgholipour , Hossein Hosseini , Pedram Rezaei Amirkiasar , Mina Zare , Niki Katsiki , Ghodratollah Panahi , Amirhossein Sahebkar","doi":"10.1016/j.jdiacomp.2024.108780","DOIUrl":"10.1016/j.jdiacomp.2024.108780","url":null,"abstract":"<div><h3>Background-aim</h3><p>Non-alcoholic fatty liver disease (NAFLD<span><sup>1</sup></span>) is the most frequent chronic liver disorder worldwide. Currently, no pharmacological treatment has been approved for NAFLD. Probiotics have been suggested as a potential therapy for NAFLD. The aim of this systematic review and meta-analysis was to assess the impact of probiotic intake on liver tests, lipids, glycemic parameters and inflammatory markers in NAFLD patients.</p></div><div><h3>Methods</h3><p>We searched electronic databases using related terms. Meta-analysis was performed using random-effects models. Clinical outcomes were presented as standard mean difference (SMD<span><sup>2</sup></span>) with a 95 % confidence interval (CI<span><sup>3</sup></span>). Publication bias and heterogeneity were evaluated in eligible studies.</p></div><div><h3>Results</h3><p>Fifteen randomized clinical trials comprising 899 participants were included in our meta-analysis. Probiotic supplementation improved alanine transaminase [SMD -0.796; 95 % CI (−1.419, −0.172); <em>p</em> = 0.012], Homeostatic Model Assessment for Insulin Resistance (HOMA-IR<span><sup>4</sup></span>) [SMD -0.596; 95 % CI (−1.071, −0.121); p = 0.01] and insulin levels [SMD -1.10; 95 % CI (−2.121, −0.087); <em>p</em> = 0.03]. No significant effects were observed on fasting glucose, hemoglobin A1c, aspartate transaminase, lipid profile, interleukin-6 and tumor necrosis factor-α.</p></div><div><h3>Conclusions</h3><p>Probiotic intake may improve insulin sensitivity and alanine transaminase in NAFLD patients.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108780"},"PeriodicalIF":2.9,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of arterial stiffness in paediatric patients with type 1 diabetes mellitus 评估 1 型糖尿病儿科患者的动脉僵化。

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2024-05-31 DOI: 10.1016/j.jdiacomp.2024.108782

Eirini Georeli , Athina Stamati , Meropi Dimitriadou , Athanasia Chainoglou , Assimina Galli Tsinopoulou , Stella Stabouli , Athanasios Christoforidis

{"title":"Assessment of arterial stiffness in paediatric patients with type 1 diabetes mellitus","authors":"Eirini Georeli , Athina Stamati , Meropi Dimitriadou , Athanasia Chainoglou , Assimina Galli Tsinopoulou , Stella Stabouli , Athanasios Christoforidis","doi":"10.1016/j.jdiacomp.2024.108782","DOIUrl":"10.1016/j.jdiacomp.2024.108782","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate early indicators of cardiovascular disease (CVD) in children and adolescents with type 1 diabetes mellitus (T1DM), focusing on pulse wave velocity (PWV) and its associations with various anthropometric and glycemic parameters.</p></div><div><h3>Patients and methods</h3><p>A total of 124 children and adolescents with T1D (mean age 10.75 ± 3.57 years) were included in this cross-sectional study. Anthropometric data, including height, weight, body mass index (BMI), glycemic parameters, such as HbA1c and time in range (TIR) were assessed. PWV was assessed by oscillometric method using the Mobil-O-Graph PWA device. Univariate and multivariate linear regression were used to explore the association of PWV z-score with anthropometric, demographic, and glycaemic variables.</p></div><div><h3>Results</h3><p>Significant negative association between PWV and age and height (β = −0.336, 95 % CI -0.44 to −0.25, <em>p</em> < 0.001 and β = −0.491, 95 % CI -0.62 to −0.36, p < 0.001, respectively), while gender showed a significant positive association with PWV, with females displaying higher PWV values compared to males (β = 0.366, 95 % CI 0.17 to 0.56, <em>p</em> < 0.001). TIR was positively associated with PWV (β = 0.092, 95 % CI 0.01 to 0.16, <em>p</em> = 0.017 only for patients having TIR ≤ 50 %. Finally, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were positively associated with PWV (β = 0.086, 95 % CI 0.02 to 0.14, <em>p</em> = 0.007 and β = 0.152, 95 % CI 0.07 to 0.23, <em>p</em> < 0.001, respectively).</p></div><div><h3>Conclusion</h3><p>Youth with T1DM who spend <50 % of time in range exhibit uniquely increased signs of arterial stiffness, indicating that poor glycemic control may contribute to early vascular damage. Differences related to age, gender and height should be considered.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108782"},"PeriodicalIF":2.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of SGLT2 inhibitors and GLP1 receptor agonists on arterial stiffness: A meta-analysis of randomized controlled trials SGLT2 抑制剂和 GLP1 受体激动剂对动脉僵化的影响：随机对照试验荟萃分析

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-05-31 DOI: 10.1016/j.jdiacomp.2024.108781

Evangelos C. Rizos , Christos F. Tagkas , Alexandros-Georgios I. Asimakopoulos , Vasileios Tsimihodimos , Georgia Anastasiou , Manfredi Rizzo , Aris P. Agouridis , Evangelia E. Ntzani

{"title":"The effect of SGLT2 inhibitors and GLP1 receptor agonists on arterial stiffness: A meta-analysis of randomized controlled trials","authors":"Evangelos C. Rizos , Christos F. Tagkas , Alexandros-Georgios I. Asimakopoulos , Vasileios Tsimihodimos , Georgia Anastasiou , Manfredi Rizzo , Aris P. Agouridis , Evangelia E. Ntzani","doi":"10.1016/j.jdiacomp.2024.108781","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108781","url":null,"abstract":"<div><h3>Background</h3><p>Pulse wave velocity (PWV) and augmentation index (AIx) are indices used to assess arterial stiffness. We evaluated the effect of sodium glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1-RA) on arterial stiffness indices.</p></div><div><h3>Methods</h3><p>We searched PubMed (up to January 2024) for RCTs assessing the effect of SGLT2i or GLP1-RA on arterial stiffness with reporting outcomes PWV and AIx. Effect sizes of the included studies were expressed as weighted mean difference (WMD) and 95 % confidence interval. Subgroup analyses were performed based on comparator (placebo vs. active comparator), design (RCT vs. crossover), population (diabetic vs. all) and blindness (yes vs. no).</p></div><div><h3>Results</h3><p>A total of 19 studies (SGLT2i, 12 studies; GLP1-RA, 5 studies; SGLT2i/GLP1-RA combination, 2 studies) assessing 1212 participants were included. We did not find any statistically significant association between GLP1-RA or SGLT2i and PWV or AIx. None of the subgroup analyses showed any statistically significant result.</p></div><div><h3>Conclusion</h3><p>No evidence of a favorable change in arterial stiffness indices (PWV, AIx) was found following the administration of SGLT2i or GLP1-RA.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 7","pages":"Article 108781"},"PeriodicalIF":3.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141242330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tirzepatide ameliorates eating behaviors regardless of prior exposure to glucagon-like peptide receptor agonists in Japanese patients with type 2 diabetes mellitus 无论日本 2 型糖尿病患者之前是否接触过胰高血糖素样肽受体激动剂，替扎帕肽都能改善其进食行为

IF 3 3区医学

Journal of diabetes and its complications Pub Date : 2024-05-29 DOI: 10.1016/j.jdiacomp.2024.108779

Toru Suzuki , Tatsuya Sato , Marenao Tanaka , Keisuke Endo , Kei Nakata , Toshifumi Ogawa , Itaru Hosaka , Yukinori Akiyama , Araya Umetsu , Masato Furuhashi

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