Journal of diabetes and its complications最新文献_第9页

Effects of empagliflozin and dapagliflozin, SGLT2 inhibitors, on miRNA expressions in diabetes-related cardiovascular damage in rats SGLT2抑制剂恩格列净和达格列净对糖尿病相关心血管损伤大鼠miRNA表达的影响

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-29 DOI: 10.1016/j.jdiacomp.2025.109063

Humeysa Kiyak-Kirmaci , Ayse Nur Hazar-Yavuz , Elif Beyzanur Polat , Hani Alsaadoni , Ozlem Tugce Cilingir-Kaya , Hanife Serife Aktas , Hatice Kubra Elcioglu

{"title":"Effects of empagliflozin and dapagliflozin, SGLT2 inhibitors, on miRNA expressions in diabetes-related cardiovascular damage in rats","authors":"Humeysa Kiyak-Kirmaci , Ayse Nur Hazar-Yavuz , Elif Beyzanur Polat , Hani Alsaadoni , Ozlem Tugce Cilingir-Kaya , Hanife Serife Aktas , Hatice Kubra Elcioglu","doi":"10.1016/j.jdiacomp.2025.109063","DOIUrl":"10.1016/j.jdiacomp.2025.109063","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) has become a global health concern due to its rapidly increasing prevalence and associated complications. Empagliflozin and dapagliflozin, sodium-glucose co-transporter 2 (SGLT2) inhibitors, have widely used in the management of T2DM. Moreover, empagliflozin and dapagliflozin reduce the risk of cardiovascular events and associated mortality both with and also without diabetes. In the present study, it was investigated empagliflozin and dapagliflozin effects on miRNA expression in nicotinamide/streptozotocin-induced T2DM rats. The male/female rats were divided into four groups: Control, T2DM, T2DM + Empagliflozin, and T2DM + Dapagliflozin. The body weights were monitored weekly and blood pressure measurement were evaluated first and last week. IL-1β, SOD, RAGE, and cTnI levels in serum and heart tissue were detected by ELISA. The RT-PCR was used to analyze the expression levels of miRNAs in the heart tissue of diabetic rats. As a result, the most remarkable findings miR-223, miR-373, miR-22, miR-9, miR-146a, miR-21, miR-144, miR-221, and miR-34a had significantly higher expressions in the control group. Moreover, miR-146a and miR-34a levels are remarkably increased empagliflozin group comparison to the T2DM group. The miR-146a expression was increased dapagliflozin group comparison to the T2DM group. Additionally, treatments with empagliflozin and dapagliflozin showed improvements in histopathological and biochemical examinations.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109063"},"PeriodicalIF":2.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Contents/Barcode 内容/条形码

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-28 DOI: 10.1016/S1056-8727(25)00104-7

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Dietary factors and cancer outcomes in individuals with type 2 diabetes: A systematic review and meta-analysis of prospective observational studies 2型糖尿病患者的饮食因素和癌症结局：前瞻性观察性研究的系统回顾和荟萃分析

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-28 DOI: 10.1016/j.jdiacomp.2025.109060

Janett Barbaresko , Alexander Lang , Tim Benedict Schiemann , Edyta Schaefer , Christina Baechle , Lukas Schwingshackl , Manuela Neuenschwander , Sabrina Schlesinger

{"title":"Dietary factors and cancer outcomes in individuals with type 2 diabetes: A systematic review and meta-analysis of prospective observational studies","authors":"Janett Barbaresko , Alexander Lang , Tim Benedict Schiemann , Edyta Schaefer , Christina Baechle , Lukas Schwingshackl , Manuela Neuenschwander , Sabrina Schlesinger","doi":"10.1016/j.jdiacomp.2025.109060","DOIUrl":"10.1016/j.jdiacomp.2025.109060","url":null,"abstract":"<div><h3>Introduction</h3><div>Cancer is a major health concern in persons with type 2 diabetes (T2D). Diet plays an important role in progression of diabetes and cancer. We aimed to systematically summarize the evidence on diet and cancer in individuals with T2D.</div></div><div><h3>Methods</h3><div>PubMed and Web of Science were searched until August 2023 and followed up via PubMed alert until December 2024. Prospective studies investigating any dietary factor in association with cancer in individuals with T2D were eligible.</div></div><div><h3>Results</h3><div>We identified 68 studies and conducted 20 meta-analyses. A general low-carbohydrate diet was not associated with cancer outcomes, whereas an inverse association was found for vegetable-based low-carbohydrate diet (HR per 5 points [95 % CI]: 0.90 [0.84, 0.97]; <em>n</em> = 2). We found indications of lower cancer incidence for higher adherence to Dietary Approaches to Stop Hypertension diet, (Alternate) Healthy Eating Index, higher intakes of n-3 fatty acids (0.73 [0.55, 0.98]; <em>n</em> = 2) and higher serum vitamin D (0.95 [0.93, 0.97]; <em>n</em> = 2), as well as a positive association for serum manganese concentrations (1.44 [1.11, 1.87]; n = 2), rated with low to very low certainty of evidence.</div></div><div><h3>Conclusion</h3><div>So far, the certainty of evidence is very limited due to the small numbers of primary studies. There is an indication of a possible association between diet and cancer risk among persons with T2D, but further well-designed prospective cohort studies are warranted.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109060"},"PeriodicalIF":2.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Health status in stage B heart failure from diabetic cardiomyopathy baseline results from ARISE-HF 糖尿病性心肌病B期心力衰竭患者的健康状况

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-25 DOI: 10.1016/j.jdiacomp.2025.109059

Tariq Jamal Siddiqi , Yuxi Liu , Faiez Zannad , W.H. Wilson Tang , Scott Solomon , Julio Rosenstock , Riccardo Perfetti , Thomas H. Marwick , Gregory D. Lewis , Carolyn S.P. Lam , Nasrien E. Ibrahim , Justin Ezekowitz , Stefano Del Prato , Javed Butler , James L. Januzzi

{"title":"Health status in stage B heart failure from diabetic cardiomyopathy baseline results from ARISE-HF","authors":"Tariq Jamal Siddiqi , Yuxi Liu , Faiez Zannad , W.H. Wilson Tang , Scott Solomon , Julio Rosenstock , Riccardo Perfetti , Thomas H. Marwick , Gregory D. Lewis , Carolyn S.P. Lam , Nasrien E. Ibrahim , Justin Ezekowitz , Stefano Del Prato , Javed Butler , James L. Januzzi","doi":"10.1016/j.jdiacomp.2025.109059","DOIUrl":"10.1016/j.jdiacomp.2025.109059","url":null,"abstract":"<div><h3>Aims</h3><div>Assess the determinants of health status and its correlation with key parameters in individuals with diabetic cardiomyopathy (DbCM).</div></div><div><h3>Methods</h3><div>In the ARISE-HF trial, the Kansas City Cardiomyopathy Questionnaire (KCCQ), cardiopulmonary exercise testing (CPET), Physical Activity Scale for the Elderly (PASE) score, echocardiographic, and laboratory assessments were performed at baseline in 691 persons with DbCM.</div></div><div><h3>Results</h3><div>Study participants with lower KCCQ-Clinical Summary Score (CSS) were predominantly women, had poorer kidney function, higher body-mass index and natriuretic peptides, and lower hemoglobin levels. Lower KCCQ-CSS scores were associated with shorter CPET duration, lower peak exercise oxygen consumption (VO₂) and lower PASE scores, but the correlations were weak (CPET duration: <em>r</em> = 0.14, 95 % CI: 0.07–0.22; peak VO₂: <em>r</em> = 0.21, 95 % CI: 0.14–0.28; PASE score: <em>r</em> = 0.19, 95 % CI: 0.11–0.26), indicating that although worse health status was linked to poorer function and activity, the strength of these relationships was limited. No meaningful associations were observed between KCCQ-CSS and echocardiographic measurements, cardiac biomarkers, or kidney function.</div></div><div><h3>Conclusion</h3><div>Health status in Stage B heart failure due to DbCM is frequently impaired. Among those with DbCM the KCCQ is only weakly correlated with the CPET parameters and PASE score implying these assessments provide unique information.</div></div><div><h3>Trial registration</h3><div>ARISE-HF, <span><span>NCT04083339</span><svg><path></path></svg></span></div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109059"},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Response to letter to the editor by Lai-Ming Kathleen Pak et al on: Identifying predictors of SGLT2 inhibitor and GLP1R agonist use in hospital among adults with diabetes 对Lai-Ming Kathleen Pak等人致编辑的信的回复：确定医院中成人糖尿病患者使用SGLT2抑制剂和GLP1R激动剂的预测因素。

IF 3.1 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-23 DOI: 10.1016/j.jdiacomp.2025.109046

Michael Colacci , Ashley Raudanskis , Michael Fralick

引用次数: 0

GLP-1 receptor agonists and MASLD in diabetes: A promising path? GLP-1受体激动剂和MASLD治疗糖尿病：一条有希望的途径？

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-22 DOI: 10.1016/j.jdiacomp.2025.109041

Grazia Pennisi , Salvatore Petta , Viviana Maggio , Manfredi Rizzo

引用次数: 0

Obesity and its management in primary care setting 初级保健机构的肥胖及其管理

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-19 DOI: 10.1016/j.jdiacomp.2025.109045

Mahmoud Ibrahim , Ebtesam M. Ba-Essa , Jessica A. Alvarez , Jason Baker , Vincenzo Bruni , Avivit Cahn , Antonio Ceriello , Francesco Cosentino , Melanie J. Davies , Francesco De Domenico , Robert H. Eckel , Allon N. Friedman , Jonathan Goldney , Omer Hamtzany , Scott Isaacs , Sehnaz Karadeniz , Richard David Leslie , Ildiko Lingvay , Sue McLaughlin , Omar Mobarak , Guillermo E. Umpierrez

{"title":"Obesity and its management in primary care setting","authors":"Mahmoud Ibrahim , Ebtesam M. Ba-Essa , Jessica A. Alvarez , Jason Baker , Vincenzo Bruni , Avivit Cahn , Antonio Ceriello , Francesco Cosentino , Melanie J. Davies , Francesco De Domenico , Robert H. Eckel , Allon N. Friedman , Jonathan Goldney , Omer Hamtzany , Scott Isaacs , Sehnaz Karadeniz , Richard David Leslie , Ildiko Lingvay , Sue McLaughlin , Omar Mobarak , Guillermo E. Umpierrez","doi":"10.1016/j.jdiacomp.2025.109045","DOIUrl":"10.1016/j.jdiacomp.2025.109045","url":null,"abstract":"<div><div>Obesity is a worldwide epidemic affecting adults and children, regardless of their socioeconomic status. Significant progress has been made in understanding the genetic causes contributing to obesity, shedding light on a portion of cases worldwide. In young children with severe obesity however, recessive mutations, i.e., leptin or leptin receptor deficiency should be sought. Much more has been learned about the far-reaching impact of obesity on complications, including cardiovascular disease, liver and kidney dysfunction, diabetes, inflammation, hypertension, sleep, cancer, and the eye. Preventive strategies, particularly in children, are crucial for reducing obesity rates and mitigating its long-term complications. While dietary modifications and lifestyle changes remain the cornerstone of obesity prevention or treatment, recent advancements have introduced highly effective pharmacological options complementing weight-reduction surgery.</div><div>Newer medications, like incretin-based therapies including glucagon-like peptide-1 agonists (GLP-1RA), have demonstrated remarkable efficacy in promoting weight loss, offering new insights into margining obesity-related conditions. Primary care providers, whether treating adults or children, play a pivotal role in preventing obesity, initiating treatment, and making onward referrals to specialists to assist in managing obesity and obesity-related complications.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109045"},"PeriodicalIF":2.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of circRNA in insulin resistance and its progression induced by adipose inflammation circRNA在脂肪炎症诱导的胰岛素抵抗及其进展中的作用

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-19 DOI: 10.1016/j.jdiacomp.2025.109042

Yifei Liu , Jie Yue , Yuxia Jiang , Xu Tian , Aihua Shu

{"title":"The role of circRNA in insulin resistance and its progression induced by adipose inflammation","authors":"Yifei Liu , Jie Yue , Yuxia Jiang , Xu Tian , Aihua Shu","doi":"10.1016/j.jdiacomp.2025.109042","DOIUrl":"10.1016/j.jdiacomp.2025.109042","url":null,"abstract":"<div><div>CircRNAs refer to a type of closed circular non-coding RNA without a 5′ cap or a 3′ poly (A) structure. They are largely distributed in the cytoplasm or localized in exosomes and cannot be easily degraded by RNA exonuclease activity. Their stable expression is broadly observed across eukaryotic species. Insulin resistance (IR) refers to the inability of insulin to exert its normal biological function, as manifested by the impairment of glucose utilization in peripheral tissues (e.g., muscle and fat tissues). IR is a key factor in the pathogenesis of Type 2 diabetes (T2D) and is closely associated with obesity. Recent studies have shown that certain circRNAs play critical roles in obesity-induced diabetes by regulating IR and participating in inflammatory processes. CircRNAs, with their multiple microRNA (miRNA) binding sites, act as miRNA sponges to eliminate the inhibitory actions of miRNAs and up-regulate the expression of target genes. CircRNAs play a significant role in regulating obesity-induced diabetes through their interactions with disease-related miRNAs. In the present study, we explored the biological characteristics of circRNAs and extensively discussed the role of circRNAs in the development of inflammation and IR in adipocytes, highlighting their potential as therapeutic targets for obesity-induced diabetes. Specific circRNAs (e.g., circARF3 and circ-ZNF609) have been identified as key players in modulating IR and inflammatory responses in adipose tissue. CircRNAs are emerging as important regulators of IR and inflammation in adipocytes, with significant potential for therapeutic intervention in obesity-induced diabetes. Further research is needed to elucidate the mechanisms underlying their actions and to explore strategies for targeting circRNAs in clinical applications.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109042"},"PeriodicalIF":2.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body-weight functional exercise promotes greater and safer blood glucose reduction compared to aerobic and strength exercises in type 1 diabetics: a randomised crossover study 与有氧运动和力量运动相比，体重功能运动在1型糖尿病患者中促进更大、更安全的血糖降低：一项随机交叉研究

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-19 DOI: 10.1016/j.jdiacomp.2025.109043

Pooya Soltani , Fernanda Mendes Almeida , Hildene Carneiro de Castro Melo , Guilherme Bruno Santiago Ferreira , Leiticiany Melo dos Santos , Jorge Luiz de Brito Gomes

{"title":"Body-weight functional exercise promotes greater and safer blood glucose reduction compared to aerobic and strength exercises in type 1 diabetics: a randomised crossover study","authors":"Pooya Soltani , Fernanda Mendes Almeida , Hildene Carneiro de Castro Melo , Guilherme Bruno Santiago Ferreira , Leiticiany Melo dos Santos , Jorge Luiz de Brito Gomes","doi":"10.1016/j.jdiacomp.2025.109043","DOIUrl":"10.1016/j.jdiacomp.2025.109043","url":null,"abstract":"<div><h3>Aims</h3><div>Aerobic and strength exercises are commonly recommended for patients with type-1 diabetes (T1DM) but may not suit everyone. Body-weight functional exercise (BWFE) could offer an alternative for diabetes management. We aimed to compare blood glucose (BG), cardiovascular responses and enjoyment levels following a 30-min session of BWFE versus interval aerobic exercise (IAE) and strength exercise (STE) in patients with T1DM.</div></div><div><h3>Methods</h3><div>Ten T1DM participants (seven female) completed three randomised exercise sessions. BG, heart rate (HR), blood pressure (BP) and double product (DP) were measured before (PRE), immediately after (POST-0) and 20 min post-exercise (POST-20). Maximum and average HR were recorded, and enjoyment levels (EL) were assessed post-exercise. Statistical analysis used generalised estimated equations, with minimal detectable difference for assessing clinical significance.</div></div><div><h3>Results</h3><div>We observed clinically meaningful reductions in BG after all sessions, but only BWFE showed a statistically significant drop at POST-0 (−2.2 mmol/L) without hypoglycaemia. HR, BP and DP responses were similar across sessions. BWFE showed the highest EL and maximal HR.</div></div><div><h3>Conclusions</h3><div>BWFE effectively lowered BG safely and provided comparable cardiovascular effects to IAE and STE while being more enjoyable. These findings support incorporating functional exercises into T1DM management to encourage sustained physical activity.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109043"},"PeriodicalIF":2.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of SGLT2 inhibitors and GLP-1 receptor agonists on the triglyceride to HDL cholesterol ratio and the triglyceride-glucose index in patients with type 2 diabetes SGLT2抑制剂和GLP-1受体激动剂对2型糖尿病患者甘油三酯/高密度脂蛋白胆固醇比值及甘油三酯-葡萄糖指数的影响

IF 2.9 3区医学

Journal of diabetes and its complications Pub Date : 2025-04-18 DOI: 10.1016/j.jdiacomp.2025.109044

Dimitra Voziki , Georgios Dimakopoulos , Ioannis Stergiou , Ioanna Zografou , Manfredi Rizzo , Evangelos N. Liberopoulos , Kalliopi Kotsa , Theocharis Koufakis

引用次数: 0