Journal of diabetes and its complications最新文献

{"title":"All-cause mortality and factors associated with it in Finnish patients with type 1 diabetes","authors":"Elena Putula ,&nbsp;Tuuli Kauppala ,&nbsp;Sini Vanhamäki ,&nbsp;Jaason Haapakoski ,&nbsp;Tiina Laatikainen ,&nbsp;Saara Metso","doi":"10.1016/j.jdiacomp.2024.108881","DOIUrl":"10.1016/j.jdiacomp.2024.108881","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the effect of comorbidities, risk classification for chronic kidney disease (CKD) according to albuminuria and eGFR, HbA1c and LDL-cholesterol levels on all-cause mortality in patients with type 1 diabetes (DM1).</div></div><div><h3>Methods</h3><div>The study included all 45,801 DM1 patients from the Finnish Diabetes Registry during 2018–2022. Mortality of patients with DM1 was compared with mortality in non-diabetic population in Finland by estimating standardized mortality rates (SMRs). Poisson regression model was used to estimate the effect of risk factors on the SMR.</div></div><div><h3>Results</h3><div>A total of 2469 patients died during follow-up. SMR for the total cohort was 1.84 (95 % CI 1.77–1.92) peaking at the age of 30–49 years. The coverage of HbA1c values was 98 %, that of LDL-cholesterol 94 %, and U-ACR and eGFR 80 %. In a multivariate analysis, assessing the effect on mortality, the rate ratio for end-stage renal disease was 2.66, cardiovascular diseases 1.92, mental and behavioural disorders 1.64, foot complications 1.51, high or very high risk for CKD 3.64, LDL-cholesterol ≥2.6 mmol/l 1.33, and HbA1c ≥8 % (64 mmol/mol) 1.27.</div></div><div><h3>Conclusions</h3><div>There's substantial excess mortality due to DM1 in Finland. Interventions should focus on addressing both renal and cardiovascular risk factors but also pay more attention to mental health.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108881"},"PeriodicalIF":2.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes","authors":"Jia Xin Huang ,&nbsp;T. Charles Casper ,&nbsp;Casey Pitts ,&nbsp;Sage R. Myers ,&nbsp;Rebecca Lynch ,&nbsp;Lindsey Loomba ,&nbsp;Janani Ramesh ,&nbsp;Nathan Kuppermann ,&nbsp;Elaine Ku ,&nbsp;Nicole Glaser","doi":"10.1016/j.jdiacomp.2024.108880","DOIUrl":"10.1016/j.jdiacomp.2024.108880","url":null,"abstract":"<div><div>In a cohort of 2303 children with type 1 diabetes (T1D), we found that non-English speaking status (HR 2.82, 95% CI 1.54–5.18) and public insurance (HR 1.48, 95% CI 1.07–2.05) were associated with an increased risk of incident albuminuria, after adjusting for T1D-related variables (age, hemoglobin A1c, diabetic ketoacidosis episodes with acute kidney injury).</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108880"},"PeriodicalIF":2.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease","authors":"Luis F. Ferreira-Divino ,&nbsp;Christina G. Poulsen ,&nbsp;Viktor Rotbain Curovic ,&nbsp;Oliver B. Pedersen ,&nbsp;Nete Tofte ,&nbsp;Marie Frimodt-Møller ,&nbsp;Tine W. Hansen ,&nbsp;Anne-Mette Hvas ,&nbsp;Peter Rossing","doi":"10.1016/j.jdiacomp.2024.108879","DOIUrl":"10.1016/j.jdiacomp.2024.108879","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with type 2 diabetes and increased albuminuria, a well-established marker of microvascular complications, are at a higher risk for cardiovascular disease (CVD) and premature mortality. Therefore, a better understanding of the underlying pathophysiology is needed to improve risk stratification and tailor prevention and intervention.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study including 463 individuals with type 2 diabetes, various degrees of albuminuria and without CVD. We analysed the association between albuminuria and markers of endothelial function (thrombomodulin and syndecan-1), thrombin generation (thrombin-antithrombin complex, prothrombin fragment 1 + 2), fibrinogen, platelet function (activation using soluble plasma selectin and aggregation using Multiplate® Analyzer) using regression models.</div></div><div><h3>Results</h3><div>In the study cohort 33 % were women, the mean ± SD age was 65 ± 9 years, and median [IQR] diabetes duration was 15 [9–20] years. In total, 344 (74 %) individuals had normal albuminuria, 87 (19 %) moderately- and 32 (7 %) severely increased albuminuria levels. Higher markers of endothelial function and fibrinogen were independently associated with higher albuminuria levels (<em>p</em> &lt; 0.01). No association between albuminuria and markers of thrombin generation and platelet was demonstrated.</div></div><div><h3>Conclusion</h3><div>We demonstrated an independent association between albuminuria and markers of endothelial function and fibrinogen in individuals with type 2 diabetes and no history of CVD.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108879"},"PeriodicalIF":2.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of arterial stiffness in pediatric patients with type 1 diabetes mellitus: What's new?","authors":"Evangelos C. Rizos ,&nbsp;Evangelia E. Ntzani ,&nbsp;Imran Rashid Rangraze ,&nbsp;Mohamed El-Tanani ,&nbsp;Manfredi Rizzo","doi":"10.1016/j.jdiacomp.2024.108877","DOIUrl":"10.1016/j.jdiacomp.2024.108877","url":null,"abstract":"<div><div>Youths with type 1 diabetes (T1D) exhibits higher levels of pulse wave velocity (PWV) compared to healthy controls. Higher PWV in T1D subjects is associated with increased hazard of progression in albuminuria, decline in eGFR, cardiovascular (CV) events and mortality. In the recently published work by Georeli et al., increased PWV was associated with poor glycemic control as expressed by time-in-range (TIR) &lt; 50 % in T1D children, adolescents and young adults. This finding is of great interest, since it is well known that glycemic control, as measured by TIR, is an important contributor of CV risk. The duration of TIR &lt; 50 % is not reported by the authors, but is of importance, knowing that CGM provide data for the last 3–6 months, depending on the CGM model. In conclusion, PWV looks promising for risk stratification in T1D, but its exact role in T1D still remains to be fully explored.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108877"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower extremity amputation rates in patients with chronic kidney disease: A database study comparing patients with and without diabetes mellitus","authors":"Dhruv Nandakumar ,&nbsp;Matthew J. Johnson ,&nbsp;Lawrence A. Lavery ,&nbsp;Benjamin M. Conover ,&nbsp;Katherine M. Raspovic ,&nbsp;David H. Truong ,&nbsp;Dane K. Wukich","doi":"10.1016/j.jdiacomp.2024.108876","DOIUrl":"10.1016/j.jdiacomp.2024.108876","url":null,"abstract":"<div><div>Lower extremity amputation (LEA) is one of the most feared consequences of diabetes mellitus (DM). The purpose of this study was to evaluate the impact of DM on LEA rates in patients at various stages of chronic kidney disease (CKD).</div><div>A commercially available de-identified database was searched for patients undergoing LEA and for CKD patients, from 2010 to 2023. Patients with DM and patients without DM who were followed for at least 5 years were included. LEA rates were then compared for patients at all 5 CKD stages in patients with and without diabetes.</div><div>Rates of all LEA were found to be significantly higher at all CKD stages for patients with diabetes (overall, minor and major LEA). Compared to patients without DM who have CKD stage 5 (end stage renal disease), patients with DM and CKD stage 5 have a 30 fold increased likelihood of undergoing overall LEA [OR 30.2 (24.48–37.19), <em>p</em> &lt; 0.001], 29 fold increased likelihood of undergoing minor LEA [28.9i (22.91–36.35), <em>p</em> &lt; 0.001] and 40 times fold increased likelihood of undergoing major LEA [40.1 (26.59–60.42), p &lt; 0.001]. For all stages of CKD, independent of diabetes status, minor LEA were performed with greater frequency than major LEA. In patients with DM, LEA rates significantly increased with CKD progression between stages 2–5 with a substantial jump between stages 4 and 5 [OR 2.6 (CI 2.49–2.74), <em>p</em> &lt; 0.001]. However, CKD progression between stages 1 and 2 was not significantly associated with increased LEA rates (OR 1.1 (CI 0.92–1.21), <em>p</em> = 0.24) in patients with diabetes.</div><div>Patients with comorbid diabetes have elevated risk for LEA at all stages of CKD compared to those without diabetes.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108876"},"PeriodicalIF":2.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of detectable C-peptide levels with glycemic control and chronic complications in individuals with type 1 diabetes mellitus: A systematic review and meta-analysis","authors":"Mahin Seifi Alan ,&nbsp;Amirhossein Tayebi ,&nbsp;Elmira Jafari Afshar ,&nbsp;Sanaz Seifi Alan ,&nbsp;Mahnaz Seifi Alan ,&nbsp;Ramina Fazeli ,&nbsp;Tooba Sohbatzade ,&nbsp;Parham Samimisedeh ,&nbsp;Hadith Rastad","doi":"10.1016/j.jdiacomp.2024.108867","DOIUrl":"10.1016/j.jdiacomp.2024.108867","url":null,"abstract":"<div><h3>Aims</h3><div>Multiple studies have addressed the association between detectable levels of C-peptide and glycemic control, as well as the development of chronic complications of type 1 diabetes mellitus (T1DM), including both macrovascular and microvascular diseases. We aimed to summarize the available evidence on the clinical significance of detectable levels of C-peptide in T1DM.</div></div><div><h3>Method</h3><div>A systematic search was performed on online databases using the following key terms: T1DM, C-peptide, diabetes mellitus complications, and glycemic parameters. We pooled standardized mean difference (SMD) and odds ratios (OR).</div></div><div><h3>Results</h3><div>Of the 1519 articles retrieved from the initial search, 38 (12 cohort and 26 cross-sectional studies) met our eligibility criteria. Individuals with T1DM in the detectable C-peptide group, compared with the undetectable C-peptide group, had lower mean HbA1c [pooled SMD (95 % confidence interval (95 % CI)): −0.08 (−0.13 to −0.02), I² = 0 %, p.value: 0.005] and daily insulin dose [−0.41 (−0.65 to −0.18), I² = 83 %, p.value &lt; 0.001]. They also showed lower odds for retinopathy [pooled crude OR (95 % CI): 0.53 (0.41 to 0.69), I² = 65 %, p.value &lt; 0.001] and nephropathy complications [0.62 (0.55 to 0.70), I² = 19 %, p.value &lt; 0.001]; however, the two groups were similar regarding neuropathy [0.92 (0.65 to 1.31), I² = 0 %, p.value: 0.31].</div></div><div><h3>Conclusions</h3><div>The available evidence suggests that individuals with T1DM in the detectable C-peptide group may experience better clinical outcomes.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108867"},"PeriodicalIF":2.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the liver as a part of the cardio-renal-metabolic continuum – What is cooking and burning with non-invasive tests and treatment options?","authors":"Špela Volčanšek ,&nbsp;Andrej Janež ,&nbsp;Manfredi Rizzo ,&nbsp;Emir Muzurović","doi":"10.1016/j.jdiacomp.2024.108875","DOIUrl":"10.1016/j.jdiacomp.2024.108875","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108875"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Mediterranean diet adherence and peripheral artery disease in type 2 diabetes mellitus: An observational study","authors":"Sara Zúnica-García ,&nbsp;José F. Javier Blanquer-Gregori ,&nbsp;Ruth Sánchez-Ortiga ,&nbsp;Esther Chicharro-Luna ,&nbsp;María Isabel Jiménez-Trujillo","doi":"10.1016/j.jdiacomp.2024.108871","DOIUrl":"10.1016/j.jdiacomp.2024.108871","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate the relationship between adherence to the Mediterranean diet (MD) and periphereal artery disease (PAD) in patients with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>An observational sectional study was conducted with 174 patients diagnosed with T2DM, of which 78 patients had PAD. A patient was considered to have PAD if they obtained an ankle-brachial index (ABI) &lt; 0.9 and/or absence of both distal pulses in one of the two feet. Data on sociodemographic and anthropometric variables, physical activity, smoking habits, biochemical blood parameters, and comorbidities were recorded. Good adherence to the MD was considered with a score ≥ 9 in MEDAS-14. Vascular factors independently associated with adherence to the MD in patients with T2DM were identified through multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>ABI, DFU, intermittent claudication and pedal pulse absence correlated with MD adherence. DFU, intermittent claudication and posterior tibial pulse absence were associated with the final score obtained in the MEDAS-14. Nut consumption, white meat preference and sautéed dish intake were associated with PAD presence. Multivariate analysis linked MD adherence to sex (OR = 0.044, 95 % CI 0.003–0619), age (OR = 0.139, 95 % CI 0.029–0.666), duration of T2DM (OR = 7.383, 95 % CI 1.523–35.779) and age at diagnosis of T2DM (OR = 6082, 95 % IC 1.415–26.136), as well as the presence of DFU (OR = 0.000, 95 % IC 0.000–0.370) and intermittent claudication (OR = 0.004, 95 % IC 0.000–0.534).</div></div><div><h3>Conclusions</h3><div>Adherence to the MD is associated with a reduction in vascular complications in T2DM, highlighting its potential as a dietary intervention strategy.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108871"},"PeriodicalIF":2.9,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid profile is similar in both subjects with high 1-hour postload glucose and 2-hour postload glucose and is related to cardio-metabolic profile in prediabetes","authors":"Rumyana Dimova,&nbsp;Nevena Chakarova,&nbsp;Mina Serdarova,&nbsp;Tsvetalina Tankova","doi":"10.1016/j.jdiacomp.2024.108869","DOIUrl":"10.1016/j.jdiacomp.2024.108869","url":null,"abstract":"<div><h3>Aim</h3><div>The study aimed to investigate a lipid profile in people with normal glucose tolerance (NGT), NGT and 1hrOGTT &gt; 8.6 mmol/l, and impaired glucose tolerance (IGT); and to assess its association with some cardio-metabolic parameters.</div></div><div><h3>Material and methods</h3><div>A total of 90 subjects, of mean age 46.7 ± 10.5 years and mean BMI of 32.0 ± 6.3 kg/m² were enrolled. They were divided into 3 groups: 19 with NGT, 22 with NGT and 1hrOGTT &gt; 8.6 mmol/l, and 49 with IGT; and subdivided into 2 subgroups according to HOMA-IR: 40 with HOMA-IR &lt; 2.5 and 50 with HOMA-IR ≥ 2.5. Body composition (Inbody 720) and advanced glycation end products (AGE Reader) were assessed. Two functional tests (OGTT; MMTT) were performed and AUC for glucose, insulin and triglycerides were calculated.</div></div><div><h3>Results</h3><div>There was no difference across the glucose tolerance groups for all evaluated lipids. The results showed higher AUC_insulin during OGTT (<em>p</em> = 0.037 and 0.020), AUC_{triglycerides} during MMTT (<em>p</em> = 0.048) and triglycerides/HDL ratio (<em>p</em> = 0.064 and 0.016) in the 1hrOGTT and IGT subgroups with HOMA-IR ≥ 2.5 in comparison to those with HOMA-IR &lt; 2.5. AUC_{triglycerides} during OGTT is independently related to body composition, b-cell function and insulin sensitivity; and AUC_{triglycerides} during MMTT is independently related to blood pressure and hsCRP in prediabetes. Triglycerides/HDL-C ratio emerged as an independent contributor to glycaemia and insulinemia.</div></div><div><h3>Conclusion</h3><div>Our results demonstrate a similar lipid profile in subjects with 1hrOGTT &gt; 8.6 mmol/l and IGT, whereas increased AUC_{triglycerides} during OGTT, AUC_{triglycerides} during MMTT and triglycerides/HDL-C ratio have been found in the subgroups with insulin resistance. The triglycerides/HDL-C ratio outlined as an independent predictor of insulin secretion and action, and postload triglycerides appear to be independently related to most of the metabolic parameters.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108869"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001958/pdfft?md5=ea5ab3c3aff11eaa8f9916b47a5ef7fb&pid=1-s2.0-S1056872724001958-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of screening for foot complications in people with diabetes – A systematic review","authors":"Aleksandra Staniszewska ,&nbsp;Amy Jones ,&nbsp;Sarah Rudd ,&nbsp;Frank de Vocht ,&nbsp;Robert Hinchliffe","doi":"10.1016/j.jdiacomp.2024.108865","DOIUrl":"10.1016/j.jdiacomp.2024.108865","url":null,"abstract":"<div><h3>Background</h3><p>A quarter of people with diabetes develop foot ulcer in their lifetime and are six times more likely to require a major lower limb amputation compared to the general population. Risk stratification tools can reliably identify those at the highest risk of ulceration, but it remains unclear if screening for foot complications can prevent limb loss in people with diabetes.</p></div><div><h3>Aims</h3><p>The aim of this systematic review was to determine whether population-based foot screening in people with diabetes reduces lower limb complications as assessed by development of foot ulceration, minor and major lower limb amputations, hospitalisation, or death.</p></div><div><h3>Methods</h3><p>MEDLINE, Embase, Emcare and CINAHL databases were searched to identify randomised and non-randomised controlled trials and observational studies (cohort, case-control and cross-sectional surveys). The screening process, study quality assessment and data extraction were performed by two independent reviewers.</p></div><div><h3>Results</h3><p>Following abstract screening and assessment for eligibility, five out of 10,771 identified studies were included in the analysis. Of these studies, one demonstrated 24 % reduction in development of new ulceration following introduction of screening. Major amputations decreased by between 17 and 96 % in three studies. Hospitalisation rates were contradictory, with one study showing doubling in hospital admissions and another one reduction by 33 %. One study demonstrated no impact of screening on minor or major amputation rates. None of the studies addressed the effect of foot screening on all-cause mortality.</p></div><div><h3>Conclusions</h3><p>The number and quality of studies to support population-based foot screening to prevent lower limb complications in people with diabetes is low. Current evidence suggests variable impact of screening on important clinical outcomes.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108865"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001910/pdfft?md5=6eaa8aa54e8c4b048cdfb2ed1eb34f3e&pid=1-s2.0-S1056872724001910-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}