Journal of diabetes and its complications最新文献

{"title":"Association of detectable C-peptide levels with glycemic control and chronic complications in individuals with type 1 diabetes mellitus: A systematic review and meta-analysis","authors":"Mahin Seifi Alan ,&nbsp;Amirhossein Tayebi ,&nbsp;Elmira Jafari Afshar ,&nbsp;Sanaz Seifi Alan ,&nbsp;Mahnaz Seifi Alan ,&nbsp;Ramina Fazeli ,&nbsp;Tooba Sohbatzade ,&nbsp;Parham Samimisedeh ,&nbsp;Hadith Rastad","doi":"10.1016/j.jdiacomp.2024.108867","DOIUrl":"10.1016/j.jdiacomp.2024.108867","url":null,"abstract":"<div><h3>Aims</h3><div>Multiple studies have addressed the association between detectable levels of C-peptide and glycemic control, as well as the development of chronic complications of type 1 diabetes mellitus (T1DM), including both macrovascular and microvascular diseases. We aimed to summarize the available evidence on the clinical significance of detectable levels of C-peptide in T1DM.</div></div><div><h3>Method</h3><div>A systematic search was performed on online databases using the following key terms: T1DM, C-peptide, diabetes mellitus complications, and glycemic parameters. We pooled standardized mean difference (SMD) and odds ratios (OR).</div></div><div><h3>Results</h3><div>Of the 1519 articles retrieved from the initial search, 38 (12 cohort and 26 cross-sectional studies) met our eligibility criteria. Individuals with T1DM in the detectable C-peptide group, compared with the undetectable C-peptide group, had lower mean HbA1c [pooled SMD (95 % confidence interval (95 % CI)): −0.08 (−0.13 to −0.02), I² = 0 %, p.value: 0.005] and daily insulin dose [−0.41 (−0.65 to −0.18), I² = 83 %, p.value &lt; 0.001]. They also showed lower odds for retinopathy [pooled crude OR (95 % CI): 0.53 (0.41 to 0.69), I² = 65 %, p.value &lt; 0.001] and nephropathy complications [0.62 (0.55 to 0.70), I² = 19 %, p.value &lt; 0.001]; however, the two groups were similar regarding neuropathy [0.92 (0.65 to 1.31), I² = 0 %, p.value: 0.31].</div></div><div><h3>Conclusions</h3><div>The available evidence suggests that individuals with T1DM in the detectable C-peptide group may experience better clinical outcomes.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 3","pages":"Article 108867"},"PeriodicalIF":2.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the liver as a part of the cardio-renal-metabolic continuum – What is cooking and burning with non-invasive tests and treatment options?","authors":"Špela Volčanšek ,&nbsp;Andrej Janež ,&nbsp;Manfredi Rizzo ,&nbsp;Emir Muzurović","doi":"10.1016/j.jdiacomp.2024.108875","DOIUrl":"10.1016/j.jdiacomp.2024.108875","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108875"},"PeriodicalIF":2.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Mediterranean diet adherence and peripheral artery disease in type 2 diabetes mellitus: An observational study","authors":"Sara Zúnica-García ,&nbsp;José F. Javier Blanquer-Gregori ,&nbsp;Ruth Sánchez-Ortiga ,&nbsp;Esther Chicharro-Luna ,&nbsp;María Isabel Jiménez-Trujillo","doi":"10.1016/j.jdiacomp.2024.108871","DOIUrl":"10.1016/j.jdiacomp.2024.108871","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate the relationship between adherence to the Mediterranean diet (MD) and periphereal artery disease (PAD) in patients with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>An observational sectional study was conducted with 174 patients diagnosed with T2DM, of which 78 patients had PAD. A patient was considered to have PAD if they obtained an ankle-brachial index (ABI) &lt; 0.9 and/or absence of both distal pulses in one of the two feet. Data on sociodemographic and anthropometric variables, physical activity, smoking habits, biochemical blood parameters, and comorbidities were recorded. Good adherence to the MD was considered with a score ≥ 9 in MEDAS-14. Vascular factors independently associated with adherence to the MD in patients with T2DM were identified through multivariate logistic regression analysis.</div></div><div><h3>Results</h3><div>ABI, DFU, intermittent claudication and pedal pulse absence correlated with MD adherence. DFU, intermittent claudication and posterior tibial pulse absence were associated with the final score obtained in the MEDAS-14. Nut consumption, white meat preference and sautéed dish intake were associated with PAD presence. Multivariate analysis linked MD adherence to sex (OR = 0.044, 95 % CI 0.003–0619), age (OR = 0.139, 95 % CI 0.029–0.666), duration of T2DM (OR = 7.383, 95 % CI 1.523–35.779) and age at diagnosis of T2DM (OR = 6082, 95 % IC 1.415–26.136), as well as the presence of DFU (OR = 0.000, 95 % IC 0.000–0.370) and intermittent claudication (OR = 0.004, 95 % IC 0.000–0.534).</div></div><div><h3>Conclusions</h3><div>Adherence to the MD is associated with a reduction in vascular complications in T2DM, highlighting its potential as a dietary intervention strategy.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108871"},"PeriodicalIF":2.9,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid profile is similar in both subjects with high 1-hour postload glucose and 2-hour postload glucose and is related to cardio-metabolic profile in prediabetes","authors":"Rumyana Dimova,&nbsp;Nevena Chakarova,&nbsp;Mina Serdarova,&nbsp;Tsvetalina Tankova","doi":"10.1016/j.jdiacomp.2024.108869","DOIUrl":"10.1016/j.jdiacomp.2024.108869","url":null,"abstract":"<div><h3>Aim</h3><div>The study aimed to investigate a lipid profile in people with normal glucose tolerance (NGT), NGT and 1hrOGTT &gt; 8.6 mmol/l, and impaired glucose tolerance (IGT); and to assess its association with some cardio-metabolic parameters.</div></div><div><h3>Material and methods</h3><div>A total of 90 subjects, of mean age 46.7 ± 10.5 years and mean BMI of 32.0 ± 6.3 kg/m² were enrolled. They were divided into 3 groups: 19 with NGT, 22 with NGT and 1hrOGTT &gt; 8.6 mmol/l, and 49 with IGT; and subdivided into 2 subgroups according to HOMA-IR: 40 with HOMA-IR &lt; 2.5 and 50 with HOMA-IR ≥ 2.5. Body composition (Inbody 720) and advanced glycation end products (AGE Reader) were assessed. Two functional tests (OGTT; MMTT) were performed and AUC for glucose, insulin and triglycerides were calculated.</div></div><div><h3>Results</h3><div>There was no difference across the glucose tolerance groups for all evaluated lipids. The results showed higher AUC_insulin during OGTT (<em>p</em> = 0.037 and 0.020), AUC_{triglycerides} during MMTT (<em>p</em> = 0.048) and triglycerides/HDL ratio (<em>p</em> = 0.064 and 0.016) in the 1hrOGTT and IGT subgroups with HOMA-IR ≥ 2.5 in comparison to those with HOMA-IR &lt; 2.5. AUC_{triglycerides} during OGTT is independently related to body composition, b-cell function and insulin sensitivity; and AUC_{triglycerides} during MMTT is independently related to blood pressure and hsCRP in prediabetes. Triglycerides/HDL-C ratio emerged as an independent contributor to glycaemia and insulinemia.</div></div><div><h3>Conclusion</h3><div>Our results demonstrate a similar lipid profile in subjects with 1hrOGTT &gt; 8.6 mmol/l and IGT, whereas increased AUC_{triglycerides} during OGTT, AUC_{triglycerides} during MMTT and triglycerides/HDL-C ratio have been found in the subgroups with insulin resistance. The triglycerides/HDL-C ratio outlined as an independent predictor of insulin secretion and action, and postload triglycerides appear to be independently related to most of the metabolic parameters.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108869"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001958/pdfft?md5=ea5ab3c3aff11eaa8f9916b47a5ef7fb&pid=1-s2.0-S1056872724001958-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of screening for foot complications in people with diabetes – A systematic review","authors":"Aleksandra Staniszewska ,&nbsp;Amy Jones ,&nbsp;Sarah Rudd ,&nbsp;Frank de Vocht ,&nbsp;Robert Hinchliffe","doi":"10.1016/j.jdiacomp.2024.108865","DOIUrl":"10.1016/j.jdiacomp.2024.108865","url":null,"abstract":"<div><h3>Background</h3><p>A quarter of people with diabetes develop foot ulcer in their lifetime and are six times more likely to require a major lower limb amputation compared to the general population. Risk stratification tools can reliably identify those at the highest risk of ulceration, but it remains unclear if screening for foot complications can prevent limb loss in people with diabetes.</p></div><div><h3>Aims</h3><p>The aim of this systematic review was to determine whether population-based foot screening in people with diabetes reduces lower limb complications as assessed by development of foot ulceration, minor and major lower limb amputations, hospitalisation, or death.</p></div><div><h3>Methods</h3><p>MEDLINE, Embase, Emcare and CINAHL databases were searched to identify randomised and non-randomised controlled trials and observational studies (cohort, case-control and cross-sectional surveys). The screening process, study quality assessment and data extraction were performed by two independent reviewers.</p></div><div><h3>Results</h3><p>Following abstract screening and assessment for eligibility, five out of 10,771 identified studies were included in the analysis. Of these studies, one demonstrated 24 % reduction in development of new ulceration following introduction of screening. Major amputations decreased by between 17 and 96 % in three studies. Hospitalisation rates were contradictory, with one study showing doubling in hospital admissions and another one reduction by 33 %. One study demonstrated no impact of screening on minor or major amputation rates. None of the studies addressed the effect of foot screening on all-cause mortality.</p></div><div><h3>Conclusions</h3><p>The number and quality of studies to support population-based foot screening to prevent lower limb complications in people with diabetes is low. Current evidence suggests variable impact of screening on important clinical outcomes.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108865"},"PeriodicalIF":2.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001910/pdfft?md5=6eaa8aa54e8c4b048cdfb2ed1eb34f3e&pid=1-s2.0-S1056872724001910-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating CD31+ Angiogenic T cells are reduced in prediabetes and increase with exercise training","authors":"Callum J. Baker ,&nbsp;Danqing Min ,&nbsp;Felix Marsh-Wakefield ,&nbsp;Elisha Siwan ,&nbsp;James Gerofi ,&nbsp;Xiaoyu Wang ,&nbsp;Samantha L. Hocking ,&nbsp;Stephen Colagiuri ,&nbsp;Nathan A. Johnson ,&nbsp;Stephen M. Twigg","doi":"10.1016/j.jdiacomp.2024.108868","DOIUrl":"10.1016/j.jdiacomp.2024.108868","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate circulating angiogenic cells in adults with prediabetes and the effect of a structured exercise program.</p></div><div><h3>Methods</h3><p>A cohort of adults with overweight/obesity and either normal glucose (NG) or prediabetes were randomised to receive exercise (Exercise) (as twice weekly supervised combined high intensity aerobic exercise and progressive resistance training, and once weekly home-based aerobic exercise) or an unsupervised stretching intervention (Control) for 12 weeks. Circulating angiogenic T cells, muscle strength, and cardiovascular disease risk factors, including blood lipids, arterial stiffness, central haemodynamic responses, and cardiorespiratory fitness (VO₂peak) in those with prediabetes (<em>n</em> = 35, 16 Control, 19 Exercise) and NG (<em>n</em> = 37, 17 Control, 20 Exercise) were analysed at baseline and after the 12-week intervention.</p></div><div><h3>Results</h3><p>At baseline, compared with NG those with prediabetes demonstrated reduced VO₂peak, angiogenic CD31⁺CD8⁺ T cells and VEGFR2⁺CD4⁺ T cells, and increased systolic blood pressure. CD31⁺ T cells were negatively correlated with cardiovascular disease (CVD) risk. Compared with Control, exercise training increased muscle strength, VO₂peak, and CD31⁺CD4⁺ and CD31⁺CD8⁺ T cells in NG and prediabetes.</p></div><div><h3>Conclusions</h3><p>Circulating angiogenic CD31⁺ T cells are decreased in people with prediabetes and are enhanced with exercise training. Exercise increases CD31⁺ T cells, and through this mechanism it is proposed that it may reduce CVD risk.</p></div><div><h3>Trial registration</h3><p>Australian New Zealand Clinical Trials Registry number: ACTRN12617000552381.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108868"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycogenic hepatopathy associated with hepatic steatosis in type 1 diabetes","authors":"Stephanie Teasdale ,&nbsp;Xin Dong ,&nbsp;Alison Griffin ,&nbsp;Paul James Clark ,&nbsp;Janelle Nisbet ,&nbsp;Adam Morton ,&nbsp;Liza Phillips ,&nbsp;Mitchell Anthony Sullivan ,&nbsp;Graham Galloway","doi":"10.1016/j.jdiacomp.2024.108870","DOIUrl":"10.1016/j.jdiacomp.2024.108870","url":null,"abstract":"<div><h3>Aims</h3><p>Glycogenic hepatopathy is associated with significant psychosocial consequences and health costs. Metabolic Dysfunction-Associated Steatotic Liver Disease and glycogenic hepatopathy are frequently confused as “fatty liver” when seen on ultrasonography. We wished to examine liver fat and glycogen content in groups defined based on metabolic and liver disease phenotypes.</p></div><div><h3>Methods</h3><p>This case-control study undertaken in a tertiary hospital used nuclear proton magnetic resonance spectroscopy (¹H-MRS) to examine liver fat and glycogen content in five clinical groups, each containing five participants: 1. type 1 diabetes with glycogenic hepatopathy, 2. satisfactorily controlled type 1 diabetes with no liver disease, 3. poorly controlled type 1 diabetes without liver disease, 4. a control group of body mass index- and age-matched individuals without diabetes or liver disease, and 5. hepatic steatosis.</p></div><div><h3>Results</h3><p>Fat content was highest in the hepatic steatosis (median 15.4 %, IQR 10.0–19.3) and glycogenic hepatopathy (median 6.5 %, IQR 4.5–9.1) groups and compared to both of these groups was lower in the control group (median 1.0 %, IQR 0.7–1.1, p 0.002 and 0.022), the T1DM group with satisfactory control (median 0.3 %, IQR 0.2–0.6, <em>p</em> &lt; 0.001 and &lt;0.001), and the T1DM group with poor control without liver disease (median 1.1 %, IQR 0.9–1.1, p 0.001 and 0.012).</p><p>No participants from the type 1 diabetes poor control, type 1 diabetes satisfactory control or the no diabetes groups had ¹H-MRS-diagnosed hepatic steatosis.</p><p>¹H-MRS glycogen content could not be interpreted in the majority of those with glycogenic hepatopathy because of interference from the fat signal.</p></div><div><h3>Conclusions</h3><p>In cases diagnosed with glycogenic hepatopathy there may be significant concomitant fat accumulation, compounding the already elevated cardiovascular risk in this cohort.</p><p>The technique of ¹H-MRS has not been demonstrated to be useful for diagnosing glycogenic hepatopathy.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108870"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging treatment strategies for polycystic ovary syndrome women with obesity: Focus on glucagon-like peptide-1 receptor agonists","authors":"Mojca Jensterle ,&nbsp;Manfredi Rizzo ,&nbsp;Andrej Janez","doi":"10.1016/j.jdiacomp.2024.108872","DOIUrl":"10.1016/j.jdiacomp.2024.108872","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108872"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001983/pdfft?md5=bf59c2d5346189bde536705d66936189&pid=1-s2.0-S1056872724001983-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of neuropathy in children and adolescents with type 1 diabetes evaluated with bedside modalities","authors":"Julie A. Damm ,&nbsp;Amalie Dalgas-Madsen ,&nbsp;Christian Stevns Hansen ,&nbsp;Kasper A. Pilgaard ,&nbsp;Flemming Pociot ,&nbsp;Tine W. Hansen ,&nbsp;Jesper Johannesen","doi":"10.1016/j.jdiacomp.2024.108873","DOIUrl":"10.1016/j.jdiacomp.2024.108873","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the prevalence of diabetic polyneuropathy (DPN), cardiac autonomic neuropathy (CAN) and sudomotor dysfunction in children and adolescents with type 1 diabetes using bedside modalities. Secondly, to evaluate the co-existence of these types of diabetes neuropathies.</p></div><div><h3>Methods</h3><p>Cross-sectional study including 221 children and adolescents with type 1 diabetes. DPN was assessed by vibration sensation threshold and sural nerve conductance, CAN by cardiac reflex tests and sudomotor function by electrochemical skin conductance.</p></div><div><h3>Results</h3><p>Median (interquartile range) age was 14.2 (11.9, 16.5) years, diabetes duration 4.8 (2.7, 7.7) years and Hba1c 7.1 (6.6, 7.9) %, (54: 49, 63 mmol/mol). Three had retinopathy; all had normal albuminuria. DPN was present in 40 %, early CAN in 17 %, established CAN in 3 % and sudomotor dysfunction in the feet in 5 %. Of these, 60 % had one type of neuropathy, while 35 % had two types. Only 1 participant manifested all three types of neuropathies.</p></div><div><h3>Conclusions</h3><p>Bedside modalities demonstrated a high prevalence of neuropathy in children and adolescents with type 1 diabetes, despite good glycemic outcome, short diabetes duration and absence of complications. A lack of co-existing neuropathies was shown, underscoring the need for multiple screening modalities.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108873"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between patients with type 2 diabetes mellitus and chronic microvascular complications during the glucose peak time","authors":"Yanqiu Jiang ,&nbsp;Xinlei Wang ,&nbsp;Xiaoqin Zhao ,&nbsp;Yi Sun ,&nbsp;Ping Huang ,&nbsp;Qianfeng Que ,&nbsp;Rongfeng Shi ,&nbsp;Xuying Zhao ,&nbsp;Honghong Lu ,&nbsp;Yunjuan Gu","doi":"10.1016/j.jdiacomp.2024.108866","DOIUrl":"10.1016/j.jdiacomp.2024.108866","url":null,"abstract":"<div><h3>Introduction</h3><div>To assess the Type 2 Diabetes Mellitus (T2DM) patients in association with Chronic Microvascular Complications at Glucose Peak Time and the association among chronic microvascular complications in T2DM patients and the glucose peak period in the typical steamed bread meal test.</div></div><div><h3>Methods</h3><div>Overall 1095 T2DM patients were classified as three groups: (1) Group G1: glucose peak time ≤ 1 h (<em>n</em> = 84), Group G2: 1 h &lt; glucose peak time ≤ 2 h (<em>n</em> = 648) and Group G3: glucose peak time &gt; 2 h (<em>n</em> = 363). The clinical characteristics, insulin characteristics and glucose peak time and chronic microvascular complications markers of patients in each group was analyzed and compared. Statistical analyses were performed using SPSS 23.0, employing chi-square tests, Kruskal-Wallis tests, one-way ANOVA, and binary logistic regression analysis, with significance set at <em>P</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Age, length of disease, glycated hemoglobin (HbA1c), urine albumin-creatinine ratio (UACR), and the number of patients with diabetic retinopathy (DR) increased (all <em>P</em> &lt; 0.05) in those with postponed glucose peak time, while insulinogenic indexes, the AUC for C-p (AUCC-p), fasting, and 120-min C-peptide (C-p) decreased (all <em>P</em> &lt; 0.05). Only age was connected to patients with diabetic kidney disease (DKD) independently in binary logistic regression analysis, although delayed glucose peak time was related to the presence of patients with DR. (all <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Delayed glucose peak time contributed to DR. Attention should be paid to condition of chronic microvascular complications in T2DM patients with a postponed peak glucose timing.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108866"},"PeriodicalIF":2.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001922/pdfft?md5=3cecf78c66379e34d13552b9178491be&pid=1-s2.0-S1056872724001922-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}