Journal of diabetes and its complications最新文献

{"title":"Vitamin A influences the incretin hormone profiles by activating the retinoic acid receptor β","authors":"Baowen Yu ,&nbsp;Jie Chen ,&nbsp;Yuming Wang ,&nbsp;Junming Zhou ,&nbsp;Huiying Wang ,&nbsp;Huiqin Li ,&nbsp;Tingting Cai ,&nbsp;Rong Huang ,&nbsp;Yunting Zhou ,&nbsp;Jianhua Ma","doi":"10.1016/j.jdiacomp.2024.108806","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108806","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to investigate the impact of Vitamin A (VA) on intestinal glucose metabolic phenotypes.</p></div><div><h3>Methods</h3><p>Male C57BL/6 mice were randomized assigned to a VA-normal diet (VAN) or a VA-deficient diet (VAD) for 12 weeks. After12 weeks, the VAD mice were given 30 IU/g/d retinol for 10 days and VAN diet (VADN) for 10 weeks. By using glucose tolerance tests, immunofluorescence staining, quantitative polymerase chain reaction, siRNA transduction, and enzyme-linked immunosorbent assay, the glucose metabolic phenotypes as well as secretory function and intracellular hormone changes of STC-1 were assessed.</p></div><div><h3>Results</h3><p>VAD mice showed a decrease of glucose-stimulated insulin secretion and a loss of intestinal glucagon-like peptide-1 (GLP-1) expression. Through reintroducing dietary VA to VAD mice, the intestinal VA levels, GLP-1 expression and normal glucose can be restored. The incubation with retinol increased VA signaling factors expression within STC-1 cells, especially retinoic acid receptor β (RARβ). The activation of RARβ restored intracellular incretin hormone synthesis and secretory function.</p></div><div><h3>Conclusions</h3><p>VA deficiency leads to an imbalance of intestinal glucose metabolic phenotypes through a mechanism involving RARβ signaling pathway, suggesting a new method to achieve the treatment for VAD induced glucose metabolism impairment.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108806"},"PeriodicalIF":2.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141592992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin combined with N-acetylcysteine attenuates type 1 diabetes-induced splenic inflammatory injury in canines by inhibiting the MAPKs-NF-κB signaling pathway and pyroptosis","authors":"Xinting Zhang ,&nbsp;Wenyue Qiu ,&nbsp;Jianjia Huang ,&nbsp;Xiaoyue Pang ,&nbsp;Yiman Su ,&nbsp;Jiali Ye ,&nbsp;Shuilian Zhou ,&nbsp;Zhaoxin Tang ,&nbsp;Rongmei Wang ,&nbsp;Rongsheng Su","doi":"10.1016/j.jdiacomp.2024.108805","DOIUrl":"10.1016/j.jdiacomp.2024.108805","url":null,"abstract":"<div><h3>Purpose</h3><p>Type 1 diabetes (T1DM) is a chronic metabolic disorder that can cause damage to multiple organs including the spleen. Sole insulin therapy is not satisfactory. This study aims to investigate the effects and mechanisms of combined treatment with insulin and <em>N</em>-acetylcysteine (NAC) on spleen damage in T1DM canines, in order to identify drugs that may better assist patients in the management of diabetes and its complications.</p></div><div><h3>Methods</h3><p>The canine model of T1DM was established by intravenous injection of alloxan (ALX) and streptozotocin (STZ). The therapeutic effects of insulin and NAC were evaluated by clinical manifestations, spleen protein and mRNA expression.</p></div><div><h3>Results</h3><p>The results indicate that the combined treatment of insulin and NAC can alleviate hyperglycemia and hematologic abnormalities, improve splenic histopathological changes, prevent fibrous tissue proliferation, and glycogen deposition. In addition, we observed that this combination treatment significantly suppressed the protein expression of p-P65/P65 (17.6 %, <em>P</em> &lt; 0.05), NLRP3 (46.8 %, <em>P</em> &lt; 0.05), and p-P38/P38 (37.1 %, <em>P</em> &lt; 0.05) induced by T1DM when compared to insulin treatment alone. Moreover, it also significantly decreased the mRNA expression of TLR4 (45.0 %, <em>P</em> &lt; 0.01), TNF-α (30.3 %, <em>P</em> &lt; 0.05), and NLRP3 (43.3 %, <em>P</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>This combination has the potential to mitigate splenic inflammatory injury in T1DM canines by suppressing the activation of MAPKs-NF-κB pathway and pyroptosis. These findings provide a reference for the treatment strategies of diabetes and its complications.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 9","pages":"Article 108805"},"PeriodicalIF":2.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can immature granulocytes and neutrophil-lymphocyte ratio be biomarkers to evaluate diabetic nephropathy?: A cross-sectional study","authors":"Fatih Yay ,&nbsp;Ergül Bayram ,&nbsp;Hunkar Aggul ,&nbsp;Ceren Önal Güçlü ,&nbsp;Durmus Ayan","doi":"10.1016/j.jdiacomp.2024.108807","DOIUrl":"10.1016/j.jdiacomp.2024.108807","url":null,"abstract":"<div><h3>Aims</h3><p>We aimed to examine the role of circulating immature granulocytes (IGs) in assessing Diabetic Nephropathy (DN) mainly and also associations of other leukocyte parameters with DN.</p></div><div><h3>Methods</h3><p>In this retrospective cross-sectional study, a total of 164 Diabetes Mellitus patients were grouped as normoalbuminuric and microalbuminuric according to urinary albumin excretion in the course of admission. Neutrophil-lymphocyte ratio (NLR), IG count (IG#) and IG percentage (IG%) levels were compared between the groups. The value of IG# and IG% levels in detecting microalbuminuria was analyzed with the Receiver operating characteristic (ROC) curve.</p></div><div><h3>Results</h3><p>NLR was remarkably higher in the microalbuminuric group (<em>p</em> = 0.036). Correlation results in the microalbuminuric group were as follows: A feeble positive correlation between neutrophil count (NEU#) and serum creatinine and albumin-to- creatinine ratio (ACR) (p = 0.036, <em>r</em> = 0.261; <em>p</em> = 0.005, <em>r</em> = 0.347, respectively), a feeble positive correlation between lymphocyte count (LYM#) and estimated glomerular filtration rate (<em>p</em> = 0.021, <em>r</em> = 0.285). Correlation results in the normooalbuminuric group were as follows: A feeble positive correlation between NEU# and ACR (<em>p</em> = 0.043, <em>r</em> = 0.204), a feeble negative correlation between LYM# and serum creatinine (<em>p</em> = 0.042, <em>r</em> = −0.205), a poor positive correlation between IG# and ACR and HBA1C% (<em>p</em> = 0.048, <em>r</em> = 0.199; <em>p</em> = 0.004, <em>r</em> = 0.290, respectively), a positive poor correlation between IG% and HBA1C% (<em>p</em> = 0.019, <em>r</em> = 0.235). Area under the ROC curve values for IG# and IG% were not statistically noteworthy in detecting microalbuminuria (<em>p</em> = 0.430; <em>p</em> = 0.510, respectively).</p></div><div><h3>Conclusions</h3><p>IG# and IG% values are insufficient to predict immediate microalbuminuria, but could be considered a weak biomarker for renal damage in normoalbuminuric (&lt;30 mg/g) diabetic patients. Further researches are needed for the use of leukocyte parameters in evaluating DN.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 9","pages":"Article 108807"},"PeriodicalIF":2.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors at admission of in-hospital dysglycemia, mortality, and readmissions in patients with type 2 diabetes and pneumonia","authors":"Mikkel Thor Olsen ,&nbsp;Carina Kirstine Klarskov ,&nbsp;Katrine Bagge Hansen ,&nbsp;Ulrik Pedersen-Bjergaard ,&nbsp;Peter Lommer Kristensen","doi":"10.1016/j.jdiacomp.2024.108803","DOIUrl":"10.1016/j.jdiacomp.2024.108803","url":null,"abstract":"<div><h3>Aims</h3><p>In-hospital dysglycemia is associated with adverse outcomes. Identifying patients at risk of in-hospital dysglycemia early on admission may improve patient outcomes.</p></div><div><h3>Methods</h3><p>We analysed 117 inpatients admitted with pneumonia and type 2 diabetes monitored by continuous glucose monitoring. We assessed potential risk factors for in-hospital dysglycemia and adverse clinical outcomes.</p></div><div><h3>Results</h3><p>Time in range (3.9–10.0 mmol/l) decreased by 2.9 %-points [95 % CI 0.7–5.0] per 5 mmol/mol [2.6 %] increase in admission haemoglobin A1c, 16.2 %-points if admission diabetes therapy included insulin therapy [95 % CI 2.9–29.5], and 2.4 %-points [95 % CI 0.3–4.6] per increase in the Charlson Comorbidity Index (CCI) (integer, as a measure of severity and amount of comorbidities). Thirty-day readmission rate increased with an IRR of 1.24 [95 % CI 1.06–1.45] per increase in CCI. In-hospital mortality risk increased with an OR of 1.41 [95 % CI 1.07–1.87] per increase in Early Warning Score (EWS) (integer, as a measure of acute illness) at admission.</p></div><div><h3>Conclusions</h3><p>Dysglycemia among hospitalised patients with pneumonia and type 2 diabetes was associated with high haemoglobin A1c, insulin treatment before admission, and the amount and severity of comorbidities (i.e., CCI). Thirty-day readmission rate increased with high CCI. The risk of in-hospital mortality increased with the degree of acute illness (i.e., high EWS) at admission. Clinical outcomes were independent of chronic glycemic status, i.e. HbA1c, and in-hospital glycemic status.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108803"},"PeriodicalIF":2.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001296/pdfft?md5=117485bdd8f076b81ddb3b0a452d3c5e&pid=1-s2.0-S1056872724001296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of diabetic peripheral neuropathy with cardiac autonomic neuropathy in individuals with diabetes mellitus: A systematic review","authors":"Ana Vitoria Lima de Paula ,&nbsp;Gabrielly Menin Dykstra ,&nbsp;Rebeca Barbosa da Rocha ,&nbsp;Alessandra Tanuri Magalhães ,&nbsp;Baldomero Antônio Kato da Silva ,&nbsp;Vinicius Saura Cardoso","doi":"10.1016/j.jdiacomp.2024.108802","DOIUrl":"10.1016/j.jdiacomp.2024.108802","url":null,"abstract":"<div><p>This systematic review aimed to explore the relationship between diabetic peripheral neuropathy (DPN) and cardiac autonomic neuropathy (CAN) in individuals with type 1 and 2 diabetes mellitus (DM). Methods: The systematic review follow the protocol registered in Prospero (CRD42020182899). Two authors independently searched the PubMed, Scopus, Embase, Cochrane, and Web of Science databases. Discrepancies were resolved by a third author. The review included observational studies investigating the relationship between CAN and DPN in individuals with DM. Results: Initially, out of 1165 studies, only 16 were selected, with 42.8 % involving volunteers with one type of diabetes, 14.3 % with both types of diabetes and 14.3 % not specify the type. The total number of volunteers was 2582, mostly with type 2 DM. It was analyzed that there is a relationship between CAN and DPN. It was observed that more severe levels of DPN are associated with worse outcomes in autonomic tests. Some studies suggested that the techniques for evaluating DPN might serve as risk factors for CAN. Conclusion: The review presents a possible relationship between DPN and CAN, such as in their severity.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108802"},"PeriodicalIF":2.9,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N6-methyladenosine demethylase fat mass and obesity-associated protein suppresses hyperglycemia-induced endothelial cell injury by inhibiting reactive oxygen species formation via autophagy promotion","authors":"Di Xie ,&nbsp;Kelaier Yang ,&nbsp;Yang Xu ,&nbsp;Yang Li ,&nbsp;Chunnan Liu ,&nbsp;Yanghong Dong ,&nbsp;Jinyu Chi ,&nbsp;Xinhua Yin","doi":"10.1016/j.jdiacomp.2024.108801","DOIUrl":"10.1016/j.jdiacomp.2024.108801","url":null,"abstract":"<div><h3>Introduction</h3><p>Hyperglycemia-induced endothelial cell injury is one of the main causes of diabetic vasculopathy. Fat mass and obesity-associated protein (FTO) was the first RNA N6-methyladenosine (m6A) demethylase identified; it participates in the pathogenesis of diabetes. However, the role of FTO in hyperglycemia-induced vascular endothelial cell injury remains unclear.</p></div><div><h3>Materials and methods</h3><p>The effects of FTO on cellular m6A, autophagy, oxidative stress, proliferation, and cytotoxicity were explored in human umbilical vein endothelial cells (HUVECs) treated with high glucose (33.3 mmol/mL) after overexpression or pharmacological inhibition of FTO. MeRIP-qPCR and RNA stability assays were used to explore the molecular mechanisms by which FTO regulates autophagy.</p></div><div><h3>Results</h3><p>High glucose treatment increased m6A levels and reduced FTO protein expression in HUVECs. Wild-type overexpression of FTO markedly inhibited reactive oxygen species generation by promoting autophagy, increasing endothelial cell proliferation, and decreasing the cytotoxicity of high glucose concentrations. The pharmacological inhibition of FTO showed the opposite results. Mechanistically, we identified Unc-51-like kinase 1 (ULK1), a gene responsible for autophagosome formation, as a downstream target of FTO-mediated m6A modification. FTO overexpression demethylated ULK1 mRNA and inhibited its degradation in an m6A-YTHDF2-dependent manner, leading to autophagy activation.</p></div><div><h3>Conclusions</h3><p>Our study demonstrates the functional importance of FTO-mediated m6A modification in alleviating endothelial cell injury under high glucose conditions and indicates that FTO may be a novel therapeutic target for diabetic vascular complications.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108801"},"PeriodicalIF":2.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The glucosylamine oxidation pathway of vitamin C recycling","authors":"James M. Hempe ,&nbsp;Daniel S. Hsia ,&nbsp;Arthur Hagar ,&nbsp;Larry Byers","doi":"10.1016/j.jdiacomp.2024.108797","DOIUrl":"https://doi.org/10.1016/j.jdiacomp.2024.108797","url":null,"abstract":"<div><p>The proposed glucosylamine oxidation pathway (GOP) is a two-step, intraerythrocyte, thermodynamically favorable nonenzymatic reaction that first binds glucose to the N-terminal valine of beta globin (βVal1) to form a closed-chain glucosylamine that can spontaneously reduce oxidized vitamin C to its antioxidant form. This review summarizes analytical, biochemical and clinical research supporting the existence of the GOP and the surprising hypothesis that βVal1 glucosylamine is a reducing agent that works cooperatively with reduced glutathione to dynamically regulate vitamin C recycling during naturally occurring periods of transiently or chronically elevated blood glucose and oxidant production. Rationale for the existence of the GOP is presented from the perspective of the hemoglobin glycation index, a clinically practical biomarker of risk for chronic vascular disease that we propose is mechanistically explained by person-to-person variation in GOP activity.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108797"},"PeriodicalIF":2.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and pathological characteristics of gestational diabetes mellitus with different insulin resistance","authors":"Yidan Luo ,&nbsp;Yuqin Qin ,&nbsp;Lin Kong ,&nbsp;Junqing Long ,&nbsp;Veronika Lukacs-Kornek ,&nbsp;Jian Li ,&nbsp;Hongwei Wei ,&nbsp;Jie Qin","doi":"10.1016/j.jdiacomp.2024.108796","DOIUrl":"10.1016/j.jdiacomp.2024.108796","url":null,"abstract":"<div><h3>Aims</h3><p>To elucidate the clinical and pathological characteristics of gestational diabetes mellitus (GDM) with high and low insulin resistance.</p></div><div><h3>Methods</h3><p>In total, 1393 GDM and 1001 non-GDM singleton deliveries were included in this study. Insulin resistance subtypes were classified according to the HOMA2-IR value. Clinical data were analyzed using SPSS 26.0. Placenta samples were collected for pathological analysis.</p></div><div><h3>Results</h3><p>Maternal age and fasting glucose were identified as independent risk factors for GDM with high insulin resistance (<em>p</em> &lt; 0.01), while fasting glucose was the sole risk factor for GDM with low insulin resistance (<em>p</em> &lt; 0.001). Fetal distress was associated with both of GDM subtypes (both <em>p</em> &lt; 0.01), while anemia, fetal growth restriction, large for gestational age and intrahepatic cholestasis in pregnancy were related to specific GDM insulin resistance subtype. In addition, GDM with high insulin resistance showed an increase of syncytial knots with down-regulation of PI3K/AKT signaling, while GDM with low insulin resistance showed normal syncytial knot counts and up-regulation of PI3K/AKT signaling.</p></div><div><h3>Conclusions</h3><p>Our findings provide novel perspectives to the clinical and pathological comprehensions of GDM with high and low insulin resistance, which might facilitate the mechanism study of GDM and its precision pregnancy management.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108796"},"PeriodicalIF":2.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analysis of diabetic patient data before and during the COVID-19 pandemic – Lessons from the MÉRY diabetes database (MDD)","authors":"Zsolt Hermányi ,&nbsp;Adrienn Menyhárt ,&nbsp;Anna Erzsébet Körei ,&nbsp;Ildikó Istenes ,&nbsp;Genevieve Arany Lao-kan ,&nbsp;Vanda Csiki ,&nbsp;Abdallah Benhamida ,&nbsp;Miklos Kozlovszky ,&nbsp;Attila Berey ,&nbsp;Peter Markovich ,&nbsp;Péter Kempler","doi":"10.1016/j.jdiacomp.2024.108799","DOIUrl":"10.1016/j.jdiacomp.2024.108799","url":null,"abstract":"<div><h3>Aims</h3><p>Our study examined changes in average blood glucose levels (ABG), measurement frequency (MF), and data uploading (DU) before and during the COVID-19 pandemic in 882-day spans, which were divided into further 20-week intervals to highlight the pandemic's impact.</p></div><div><h3>Methods</h3><p><em>T</em>-Tests assessed the statistical significance of blood glucose data from 26,655/20,936 patients and 19.5/16.6 million records during pre-COVID/COVID.</p></div><div><h3>Results</h3><p>During COVID, patients had significantly lower ABG levels (9.1/8.9 mmol/L, <em>p</em> &lt; 0.001). Weekly DU decreased (155,945/128,445, <em>p</em> &lt; 0.05), while daily MF increased (0.83/0.87, p &lt; 0.001). Comparing the last 20 weeks pre-COVID to the first 20 weeks during COVID, ABG levels were lower (9.0 /8.9, <em>p</em> &lt; 0.01), MF increased (0.83 /0.99, p &lt; 0.001), and DU decreased (153,133/145,381, p &lt; 0.05). In the initial 20 weeks of COVID compared to the second 20 weeks of COVID, ABG increased (8.9/9.1, p &lt; 0.01), MF decreased (0.99/0.95, p &lt; 0.001), and DU decreased (145,381/140,166, p &lt; 0.05). Our most striking observation was the temporary dramatic fall in glucose uploads during the first few weeks of COVID. The changes of ABG and MF values were statistically significant, but were not deemed clinically relevant.</p></div><div><h3>Conclusions</h3><p>Despite COVID's prolonged impact, diabetic patients showed improved attitudes. A significant drop in data uploads occurred during the first 20 weeks of COVID; home office and lockdowns apparently disrupted patient routines.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108799"},"PeriodicalIF":3.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achievement of normoglycemia with tirzepatide in type 2 diabetes mellitus: A step closer to drug-induced diabetes remission?","authors":"Djordje S. Popovic ,&nbsp;Dimitrios Patoulias ,&nbsp;Theocharis Koufakis ,&nbsp;Konstantinos Stavropoulos ,&nbsp;Paschalis Karakasis ,&nbsp;Ieva Ruža ,&nbsp;Nikolaos Papanas ,&nbsp;Manfredi Rizzo ,&nbsp;Michael Doumas","doi":"10.1016/j.jdiacomp.2024.108800","DOIUrl":"10.1016/j.jdiacomp.2024.108800","url":null,"abstract":"<div><p>We sought to determine whether treatment with tirzepatide in type 2 diabetes mellitus (T2DM) patients can increase the odds for achieving normoglycemia, compatible with glycated hemoglobin levels lower than 5.7 %. We demonstrated that treatment with tirzepatide versus control increased the odds for achievement of normoglycemia by &gt;16 times.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 8","pages":"Article 108800"},"PeriodicalIF":3.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}