Association between muscle fatigability and diabetic kidney disease complications in patients with type 2 diabetes

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2025-02-01 DOI:10.1016/j.jdiacomp.2025.108955

Yuma Hirano , Daisuke Tsuriya , Kenichi Kono , Tomoyuki Fujikura , Tomoya Yamaguchi , Kento Matsushita , Yurina Yokoyama , Katsuya Yamauchi , Yusuke Nishida

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引用次数: 0

Abstract

Aims

Type 2 diabetes mellitus (T2DM) requires the maintenance of high physical activity levels and specific interventions tailored to the characteristics of each patient. We hypothesized that T2DM combined with diabetic kidney disease (DKD) could increase muscle fatigability, becoming a specific contributor to physical inactivity. This study aimed to determine the association between muscle fatigability and DKD complications and investigate the relationship between muscle fatigability and physical activity in patients with T2DM.

Methods

Overall, 50 patients with T2DM aged 40–65 years and with an estimated glomerular filtration rate of 30 mL/min/1.73 m² or higher were included. Muscle function was assessed using an isokinetic dynamometer. Muscle fatigability (maximal voluntary concentric contraction [ΔMVCC] velocity, maximal voluntary isometric contraction [ΔMVIC] torque), which indicated the decrease in angular velocity and muscle strength associated with the exercise task, was calculated. The patient characteristics, physical activity (IPAQ-SV), knee extensor strength, and skeletal muscle index were evaluated. Participants were divided into two groups (DKD and non-DKD) according to the presence of DKD, and ΔMVCC velocity and ΔMVIC torque were compared.

Results

ΔMVCC velocity was significantly higher in the DKD group than in the non-DKD group (p < 0.05). Similarly, ΔMVIC torque was significantly higher in the DKD group than in the non-DKD group (p < 0.05). Subgroup analyses showed that ΔMVCC velocity was independently associated with physical activity in the DKD group (odds ratio: 0.93, 95 % confidence interval: 0.88–0.99).

Conclusions

Muscle fatigability increased with DKD in patients with T2DM and might be related to physical activity.

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.