Uric acid in diabetic microvascular complications: Mechanisms and therapy.

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-12-05 DOI:10.1016/j.jdiacomp.2024.108929

Xin Li, Bo Huang, Yue Liu, Meng Wang, Jing-Qiu Cui

引用次数: 0

Abstract

Uric acid (UA) is mainly synthesized in the liver, intestine, and vascular endothelium and excreted by the kidney (70 %) and intestine (30 %). Hyperuricemia (HUA) occurs when UA production exceeds excretion. Many studies have found that elevated UA is associated with diabetic microvascular complications (DMC), including diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic peripheral neuropathy (DPN). In addition, too high or too low UA levels will promote the occurrence and development of chronic diseases, but the relationship between UA and diabetic microvascular complications (DMC) is not clear. Therefore, the rational treatment of UA in patients with diabetes is essential. In this review, we summarize and discuss the mechanism and treatment of UA and DMC and may provide potential advice for rational drug selection.

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尿酸在糖尿病微血管并发症中的作用：机制和治疗。

尿酸（UA）主要由肝脏、肠道和血管内皮合成，由肾脏（70%）和肠道（30%）排出体外。当尿酸生成量超过排泄量时，就会出现高尿酸血症（HUA）。许多研究发现，尿酸升高与糖尿病微血管并发症（DMC）有关，包括糖尿病视网膜病变（DR）、糖尿病肾病（DN）和糖尿病周围神经病变（DPN）。此外，UA 水平过高或过低都会促进慢性疾病的发生和发展，但 UA 与糖尿病微血管并发症（DMC）之间的关系尚不明确。因此，合理治疗糖尿病患者的尿酸至关重要。在这篇综述中，我们总结并讨论了 UA 与 DMC 的机制和治疗方法，为合理选药提供了可能的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.