Journal of diabetes and its complications最新文献

{"title":"Health status in stage B heart failure from diabetic cardiomyopathy baseline results from ARISE-HF","authors":"Tariq Jamal Siddiqi ,&nbsp;Yuxi Liu ,&nbsp;Faiez Zannad ,&nbsp;W.H. Wilson Tang ,&nbsp;Scott Solomon ,&nbsp;Julio Rosenstock ,&nbsp;Riccardo Perfetti ,&nbsp;Thomas H. Marwick ,&nbsp;Gregory D. Lewis ,&nbsp;Carolyn S.P. Lam ,&nbsp;Nasrien E. Ibrahim ,&nbsp;Justin Ezekowitz ,&nbsp;Stefano Del Prato ,&nbsp;Javed Butler ,&nbsp;James L. Januzzi","doi":"10.1016/j.jdiacomp.2025.109059","DOIUrl":"10.1016/j.jdiacomp.2025.109059","url":null,"abstract":"<div><h3>Aims</h3><div>Assess the determinants of health status and its correlation with key parameters in individuals with diabetic cardiomyopathy (DbCM).</div></div><div><h3>Methods</h3><div>In the ARISE-HF trial, the Kansas City Cardiomyopathy Questionnaire (KCCQ), cardiopulmonary exercise testing (CPET), Physical Activity Scale for the Elderly (PASE) score, echocardiographic, and laboratory assessments were performed at baseline in 691 persons with DbCM.</div></div><div><h3>Results</h3><div>Study participants with lower KCCQ-Clinical Summary Score (CSS) were predominantly women, had poorer kidney function, higher body-mass index and natriuretic peptides, and lower hemoglobin levels. Lower KCCQ-CSS scores were associated with shorter CPET duration, lower peak exercise oxygen consumption (VO₂) and lower PASE scores, but the correlations were weak (CPET duration: <em>r</em> = 0.14, 95 % CI: 0.07–0.22; peak VO₂: <em>r</em> = 0.21, 95 % CI: 0.14–0.28; PASE score: <em>r</em> = 0.19, 95 % CI: 0.11–0.26), indicating that although worse health status was linked to poorer function and activity, the strength of these relationships was limited. No meaningful associations were observed between KCCQ-CSS and echocardiographic measurements, cardiac biomarkers, or kidney function.</div></div><div><h3>Conclusion</h3><div>Health status in Stage B heart failure due to DbCM is frequently impaired. Among those with DbCM the KCCQ is only weakly correlated with the CPET parameters and PASE score implying these assessments provide unique information.</div></div><div><h3>Trial registration</h3><div>ARISE-HF, <span><span>NCT04083339</span><svg><path></path></svg></span></div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109059"},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor by Lai-Ming Kathleen Pak et al on: Identifying predictors of SGLT2 inhibitor and GLP1R agonist use in hospital among adults with diabetes","authors":"Michael Colacci ,&nbsp;Ashley Raudanskis ,&nbsp;Michael Fralick","doi":"10.1016/j.jdiacomp.2025.109046","DOIUrl":"10.1016/j.jdiacomp.2025.109046","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 10","pages":"Article 109046"},"PeriodicalIF":3.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of circRNA in insulin resistance and its progression induced by adipose inflammation","authors":"Yifei Liu ,&nbsp;Jie Yue ,&nbsp;Yuxia Jiang ,&nbsp;Xu Tian ,&nbsp;Aihua Shu","doi":"10.1016/j.jdiacomp.2025.109042","DOIUrl":"10.1016/j.jdiacomp.2025.109042","url":null,"abstract":"<div><div>CircRNAs refer to a type of closed circular non-coding RNA without a 5′ cap or a 3′ poly (A) structure. They are largely distributed in the cytoplasm or localized in exosomes and cannot be easily degraded by RNA exonuclease activity. Their stable expression is broadly observed across eukaryotic species. Insulin resistance (IR) refers to the inability of insulin to exert its normal biological function, as manifested by the impairment of glucose utilization in peripheral tissues (e.g., muscle and fat tissues). IR is a key factor in the pathogenesis of Type 2 diabetes (T2D) and is closely associated with obesity. Recent studies have shown that certain circRNAs play critical roles in obesity-induced diabetes by regulating IR and participating in inflammatory processes. CircRNAs, with their multiple microRNA (miRNA) binding sites, act as miRNA sponges to eliminate the inhibitory actions of miRNAs and up-regulate the expression of target genes. CircRNAs play a significant role in regulating obesity-induced diabetes through their interactions with disease-related miRNAs. In the present study, we explored the biological characteristics of circRNAs and extensively discussed the role of circRNAs in the development of inflammation and IR in adipocytes, highlighting their potential as therapeutic targets for obesity-induced diabetes. Specific circRNAs (e.g., circARF3 and circ-ZNF609) have been identified as key players in modulating IR and inflammatory responses in adipose tissue. CircRNAs are emerging as important regulators of IR and inflammation in adipocytes, with significant potential for therapeutic intervention in obesity-induced diabetes. Further research is needed to elucidate the mechanisms underlying their actions and to explore strategies for targeting circRNAs in clinical applications.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 7","pages":"Article 109042"},"PeriodicalIF":2.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of SGLT2 inhibitors and GLP-1 receptor agonists on the triglyceride to HDL cholesterol ratio and the triglyceride-glucose index in patients with type 2 diabetes","authors":"Dimitra Voziki ,&nbsp;Georgios Dimakopoulos ,&nbsp;Ioannis Stergiou ,&nbsp;Ioanna Zografou ,&nbsp;Manfredi Rizzo ,&nbsp;Evangelos N. Liberopoulos ,&nbsp;Kalliopi Kotsa ,&nbsp;Theocharis Koufakis","doi":"10.1016/j.jdiacomp.2025.109044","DOIUrl":"10.1016/j.jdiacomp.2025.109044","url":null,"abstract":"<div><div>We analyzed the medical records of 100 patients with type 2 diabetes to evaluate the effects of new antidiabetic drugs on the TG/HDL-C ratio and the TG-glucose index. We found that GLP-1 RA treatment significantly improved both markers, while SGLT2 inhibitors led to significant reductions only in the latter.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 6","pages":"Article 109044"},"PeriodicalIF":2.9,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to statins and development of atherosclerosis-related events. A systematic review and meta-analysis","authors":"Athanasios Basios ,&nbsp;Christina A. Chatzi ,&nbsp;Georgios Markozannes ,&nbsp;Evangelia E. Ntzani ,&nbsp;Fotios Barkas ,&nbsp;Konstantinos K. Tsilidis ,&nbsp;Manfredi Rizzo ,&nbsp;Aikaterini Kalampoki ,&nbsp;Evangelos C. Rizos","doi":"10.1016/j.jdiacomp.2025.109040","DOIUrl":"10.1016/j.jdiacomp.2025.109040","url":null,"abstract":"<div><h3>Background</h3><div>Adherence to lipid-lowering treatment (LLT) is of paramount importance for the prevention of atherosclerosis-related events (ASCVD). The threshold for someone to be adherent is ≥80 % of the total prescribed medication. We conducted a meta-analysis to assess how adherence to LLT affects the development of ASCVD.</div></div><div><h3>Methods</h3><div>We searched PubMed (up to February 2025) for randomized controlled trials, cohorts and nested case control studies that assessed adherence to LLT. We performed random effects meta-analysis with primary outcome the development of ASCVD based on the level of adherence to LLT.</div></div><div><h3>Results</h3><div>We included 66 articles corresponding to 3,345,718 individuals. All studies evaluated statins as LLT. Good vs. poor statin adherence reduced by 35 % the risk for all-cause mortality (RR:0.65; 95%CI: 0.56–0.76; I² = 98 %), 24 % for any cardiovascular (CV) event (RR:0.76; 95%CI: 0.72–0.80; I² = 90 %), 30 % for myocardial infarction (MI) (RR:0.70; 95%CI: 0.62–0.80; I² = 90 %) and 32 % for stroke (RR:0.68; 95%CI: 0.58–0.79; I² = 81 %). For participants without established ASCVD, statin adherence reduced by 32 % the risk for any CV event (RR:0.68; 95%CI: 0.46–1.00; I² = 97 %). For those with established ASCVD, statin adherence reduced by 25 % the risk for any CV event (RR:0.75; 95%CI: 0.64–0.88; I² = 64 %), 51 % for MI (RR:0.49; 95%CI: 0.32–0.73; I² = 80 %) and 50 % for stroke (RR:0.50; 95%CI: 0.26–0.97; I² = 87 %). Statin discontinuation increased by 90 % the mortality risk (RR:1.90; 95%CI: 1.33–2.71; I² = 87 %). Even good vs. intermediate adherence (40 %–79 %) decreased by 32 % the risk for any CV event (RR:0.68; 95%CI: 0.60–0.76; I² = 94 %). Sensitivity analyses including studies with different than the standard (≥80 %) threshold did not differ from the main results.</div></div><div><h3>Conclusion</h3><div>Statin adherence is of paramount importance to reduce ASCVD risk and mortality. Understanding adherence patterns or barriers and ensuring consistent adherence to LLT by tailored interventions should be a key priority in clinical practice and healthcare policies.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 8","pages":"Article 109040"},"PeriodicalIF":2.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144099307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to rebuttal","authors":"Bria George","doi":"10.1016/j.jdiacomp.2025.109036","DOIUrl":"10.1016/j.jdiacomp.2025.109036","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 6","pages":"Article 109036"},"PeriodicalIF":2.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143879098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(25)00080-7","DOIUrl":"10.1016/S1056-8727(25)00080-7","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 5","pages":"Article 109027"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study to investigate the risk factors for gestational diabetes mellitus and its impact on maternal and neonatal outcomes","authors":"Xiujuan Zhang ,&nbsp;Yonghui Wang ,&nbsp;Huirong Zhao ,&nbsp;Shenglin Chen ,&nbsp;Xia Gao","doi":"10.1016/j.jdiacomp.2025.109035","DOIUrl":"10.1016/j.jdiacomp.2025.109035","url":null,"abstract":"<div><h3>Background</h3><div>Currently, risk factors for gestational diabetes mellitus (GDM) and its impact on maternal and neonatal outcomes have not been fully elucidated. Therefore, we performed a retrospective epidemiologic study to explore the above research objectives.</div></div><div><h3>Methods</h3><div>We collected extensive clinical data from January 2020 to June 2023 for 855 maternity cases at the Department of Obstetrics and Gynecology, Chaoyang Hospital, Capital Medical University. Vitamin D deficiency, undergoing assisted reproductive techniques, advanced maternal age (≥35), multiparas, abortion history, pre-pregnancy body mass index (≥25.0), twin pregnancy, polycystic ovary syndrome (PCOS), family history of diabetes, history of delivering a low-birth-weight infant, and weight gain during gestation of &gt;2 kg per month (mean) as variables that may affect GDM to investigate the risk factors for GDM. In addition, a total of 15 adverse postpartum outcomes (including maternal complications and neonatal complications) were used to explore the adverse effects of maternal comorbidity with GDM. Variables that were significant in the univariate logistic regression model were included in the multivariate logistic regression model. Receiver operating characteristic (ROC) curves were conducted for the ability to predict the risk of the GDM and its impact on maternal and neonatal outcomes, using variables derived from the multivariate logistic regression models.</div></div><div><h3>Results</h3><div>The results of multivariate logistic regression analyses shown that only multipara was not a risk factor for the development of GDM. Postpartum hemorrhage (blood loss ≥500 ml) and the neonatal Apgar score (≤9) (all <em>P</em> &gt; 0.05) was excluded in the multivariate logistic regression model. According to the results of multivariate logistic regression analyses, the incidence of hypothyroid complications, hyperlipidemic complications, postpartum anemia, gestational hypertension, racket placenta, premature rupture of membranes, fetal malposition, macrosomia (≥4000 g), low-birth-weight infants (&lt;2500 g), prematurity, neonatal infections, neonatal jaundice, and fetal distress was higher in pregnancies with combined GDM (all <em>P</em> &lt; 0.05). The model demonstrated excellent diagnostic performance, with an area under the ROC curve of 0.91, indicating its efficacy in predicting adverse prognostic outcomes associated with maternal GDM.</div></div><div><h3>Conclusions</h3><div>It is essential for women of childbearing age to correct vitamin D deficiency as well as to maintain their body mass index within the normal range before preparing for pregnancy. Maternal weight gain needs to be managed appropriately throughout pregnancy, which may reduce the risk of GDM to some extent. Therefore, our results suggest that effective measures to reduce the risk of GDM are essential for both the mother and the newborn.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 6","pages":"Article 109035"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum diabetes mellitus among patients with early gestational diabetes: A systematic review and meta-analysis","authors":"Sarah J. Weingarten ,&nbsp;Ariel T. Levy ,&nbsp;Huda B. Al-Kouatly ,&nbsp;Rodney A. McLaren Jr.","doi":"10.1016/j.jdiacomp.2025.109038","DOIUrl":"10.1016/j.jdiacomp.2025.109038","url":null,"abstract":"<div><h3>Aims</h3><div>It is unclear whether patients diagnosed with early gestational diabetes mellitus (GDM) (&lt;24 weeks) are at higher risk of diabetes mellitus (DM) in the postpartum period compared to those with standard GDM (diagnosed ≥24 weeks). This study assessed if rate of DM diagnosed postpartum differs among patients with early versus standard GDM.</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, WHO ICTRP, Clinicaltrials.gov and Cochrane Central Register of Controlled Trials were searched from inception to March 2023. Randomized controlled trials or observational studies that assessed rate of postpartum DM among patients with early GDM were included. Primary outcome was rate of DM diagnosed postpartum. Secondary outcomes were postpartum visit attendance, completion and results of postpartum oral glucose tolerance testing, and glycated hemoglobin (HbA1c) levels.</div></div><div><h3>Results</h3><div>Of 5682 studies screened, 11 met inclusion criteria (N = 1573 early GDM vs. N = 3340 standard GDM). Patients with early GDM had mean age of 30.2–37.0 years and mean body mass index (BMI) of 24.4–35.6 kg/m², while the standard group had a mean age of 28.9–32.8 years and mean BMI of 23.6–36.0 kg/m². Most studies evaluated postpartum glucose tolerance at 5–12 weeks, though one followed patients up to six years postpartum. Overall, patients with early GDM were more likely to be diagnosed with DM postpartum than those with standard GDM (12.8 % vs. 6.1 %, RR 1.89, 95 % CI 1.10–3.24). Impaired glucose tolerance was also higher in patients with early GDM (24.7 % vs. 13.0 %, RR 1.84, 95 % CI 1.32–2.57).</div></div><div><h3>Conclusions</h3><div>Rate of DM diagnosed postpartum was higher in patients with early GDM compared to standard GDM.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 6","pages":"Article 109038"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying predictors of sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide 1 agonist use in hospital among adults with diabetes","authors":"Lai-Ming Kathleen Pak ,&nbsp;Minh V. Le ,&nbsp;Dev Kevat ,&nbsp;Rahul Barmanray","doi":"10.1016/j.jdiacomp.2025.109022","DOIUrl":"10.1016/j.jdiacomp.2025.109022","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"39 10","pages":"Article 109022"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}