Journal of diabetes and its complications最新文献

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(24)00185-5","DOIUrl":"10.1016/S1056-8727(24)00185-5","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108859"},"PeriodicalIF":2.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001855/pdfft?md5=d067c4de3b819fb03a4ed850e9729b85&pid=1-s2.0-S1056872724001855-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inter-relationship between Helicobacter pylori infection, dementia and mortality in type 2 diabetes: The Fremantle Diabetes Study Phase I","authors":"Timothy M.E. Davis ,&nbsp;David G. Bruce ,&nbsp;Katrin Schimke ,&nbsp;S.A. Paul Chubb ,&nbsp;Wendy A. Davis","doi":"10.1016/j.jdiacomp.2024.108854","DOIUrl":"10.1016/j.jdiacomp.2024.108854","url":null,"abstract":"<div><h3>Background</h3><p>Given sparse relevant data, the aim of this study was to determine whether <em>Helicobacter pylori</em> infection, including cytotoxin-associated gene-A (CagA) producing strains, is associated with dementia in type 2 diabetes (T2DM).</p></div><div><h3>Methods</h3><p>Longitudinal data from 1115 participants in the community-based Fremantle Diabetes Study Phase I (mean age 64.0 years, 48.0 % males; 38.0 % <em>H. pylori</em> seronegative, 24.3 % <em>H. pylori</em> seropositive/CagA seronegative, and 37.7 % <em>H. pylori</em>/CagA seropositive at baseline) were analyzed.</p></div><div><h3>Results</h3><p>During up to 19 years of follow-up, 50.3 % and 83.5 % of participants without and with incident dementia, respectively, died. In Cox proportional hazards models, <em>H. pylori</em>/CagA seropositivity (hazard ratio (95 % CI) 1.68 (1.15, 2.46), <em>P</em> = 0.008), but not <em>H. pylori</em> seropositivity/CagA seronegativity (<em>P</em> = 0.541) was an independent predictor of incident dementia, but neither <em>H. pylori</em> seropositivity/CagA seronegativity nor <em>H. pylori</em>/CagA seropositivity were significant predictors in competing risks models (<em>P</em> ≥ 0.280).</p></div><div><h3>Conclusions</h3><p>Although CagA seropositivity in T2DM may have a contributory etiologic role in the risk of dementia, this may be through its association with reduced cardiovascular/all-cause mortality.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108854"},"PeriodicalIF":2.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001806/pdfft?md5=fbebd4a96986440b0e993c6aff90ce7f&pid=1-s2.0-S1056872724001806-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary counseling, meal patterns, and diet quality in patients with type 2 diabetes mellitus with/without chronic kidney disease","authors":"Erika F. Gómez-García ,&nbsp;Alfonso M. Cueto-Manzano ,&nbsp;Héctor R. Martínez-Ramírez ,&nbsp;Laura Cortés-Sanabria ,&nbsp;Carla M. Avesani ,&nbsp;Claudia N. Orozco-González ,&nbsp;Enrique Rojas-Campos","doi":"10.1016/j.jdiacomp.2024.108853","DOIUrl":"10.1016/j.jdiacomp.2024.108853","url":null,"abstract":"<div><h3>Background</h3><p>Aim to this study is to investigate the association of Dietary Counseling, Meal Patterns, and Diet Quality (DietQ) in Patients with Type 2 Diabetes Mellitus (T2DM) with/without chronic kidney disease (CKD) in primary healthcare.</p></div><div><h3>Methods</h3><p>Cross-sectional study acquired data on dietary counseling and meal patterns by direct interview with a food-frequency questionnaire and one 24-h food-recall. The Healthy Eating Index (HEI) was used to classify DietQ [“good” DietQ (GDietQ, score ≥ 80) and “poor” DietQ (PDietQ, score &lt; 80)].</p></div><div><h3>Participants/setting</h3><p>This study included 705 patients with T2DM: 306 with normal kidney function; 236 with early nephropathy, and 163 with overt nephropathy (ON).</p></div><div><h3>Statistical analyses performed</h3><p>Multivariate linear-regression models for predicting HEI and χ² tests for qualitative variables and one-way ANOVA for quantitative variables were employed. Mann-Whitney U and independent Student t were performed for comparisons between GDietQ and PDietQ.</p></div><div><h3>Results</h3><p>Only 18 % of the population was classified as GDietQ. Patients with ON and PDietQ <em>vs.</em> with GDietQ received significantly less dietary counseling from any health professional in general (45 % <em>vs</em> 72 %, respectively), or from any nutrition professional (36 % <em>vs.</em> 61 %, respectively). A better HEI was significantly predicted (F = 42.01; <em>p</em> = 0.0001) by lower HbA_1C (β −0.53, <em>p</em> = 0.0007) and better diet diversity (β 8.09, <em>p</em> = 0.0001).</p></div><div><h3>Conclusions</h3><p>Patients with more advanced stages of CKD had less nutritional counseling and worse dietary patterns, as well as more frequent PDietQ. Our findings reinforce the need for dietitians and nutritionists in primary healthcare to provide timely nutritional counseling.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108853"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Too good to be true: Are GLP-1 receptor agonists the new metformin?","authors":"Bernd Kowall ,&nbsp;Gregor Maier ,&nbsp;Wolfgang Rathmann","doi":"10.1016/j.jdiacomp.2024.108851","DOIUrl":"10.1016/j.jdiacomp.2024.108851","url":null,"abstract":"<div><p>Recently, a health-care database study showed that persons with type 2 diabetes taking GLP-1 receptor agonists (GLP-1 RA) had a significantly lower risk of 10 out of 13 obesity-related cancers than patients taking insulin (Wang L, et al. JAMA Netw Open. 2024 7: e2421305). For some cancers, hazard ratios &lt;0.5 were reported. This is reminiscent of studies published &gt;10 years ago showing that people with type 2 diabetes taking metformin had a lower risk of many types of cancer than those not taking metformin. In some studies, also risk reductions of &gt;50 % were reported.</p><p>The strong effects observed in the metformin studies were explained by time-related biases, in particular, immortal time bias. In the current GLP-1 RA study, it was striking that the curves for the cumulative incidence of several cancers in GLP-1 RA and insulin users diverged immediately after therapy onset. This indicates that there is most likely a time-related bias: insulin is given at much later stages of type 2 diabetes than GLP-1 RA.</p><p>The current study suggests that one should be sceptical about database results when spectacular risk reductions are reported. Time-related bias should always be considered as an alternative explanation.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108851"},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A gender-based analysis of retinal microvascular alterations in patients with diabetes mellitus using OCT angiography","authors":"Stela Vujosevic ,&nbsp;Celeste Limoli ,&nbsp;Gabriele Piccoli ,&nbsp;Eliana Costanzo ,&nbsp;Elisa Marenzi ,&nbsp;Emanuele Torti ,&nbsp;Daniela Giannini ,&nbsp;Maria Sole Polito ,&nbsp;Livio Luzi ,&nbsp;Paolo Nucci ,&nbsp;Mariacristina Parravano","doi":"10.1016/j.jdiacomp.2024.108852","DOIUrl":"10.1016/j.jdiacomp.2024.108852","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess the difference in microvascular changes between males and females with diabetes mellitus (DM) without diabetic retinopathy (NoDR) and with mild-to-moderate non-proliferative diabetic retinopathy (NPDR) using Optical Coherence Tomography Angiography (OCT-A).</p></div><div><h3>Design</h3><p>Retrospective cross-sectional study.</p></div><div><h3>Methods</h3><p>267 DM patients, 133 females (49.81 %), 111 with NoDR (41.57 %) and 156 NPDR (58.43 %) were included. Foveal-centered 3 × 3 mm OCT-A images corresponding to the superficial (SCP), intermediate (ICP) and deep capillary plexus (DCP), and full retinal (RET) slab were used for analysis. For each slab, FAZ area, perimeter, and circularity index (CI) were determined, following manual delineation of the FAZ; perfusion (PD) and vessel density (VD), fractal dimension (FD), vessel length density (VLD), geometric perfusion deficits (GPD) were also computed. Flow voids (FV) were determined in the choriocapillaris plexus; and perfused capillary density (PCD) in the RET slab.</p></div><div><h3>Results</h3><p>Females showed larger FAZ CI in SCP and greater FAZ area and perimeter than males in NPDR group. Males had higher central macular thickness than females in NPDR group. All density metrics at the level of ICP and DCP were affected in the NPDR group with no gender differences. Of note, the same significant findings were found in type 1 DM patients, and not in type 2 DM patients.</p></div><div><h3>Conclusions</h3><p>Our OCT-A findings suggest significant microvascular changes in females with NPDR compared to males, but no such differences in patients without DR. Therefore, gender-related vascular alterations might be present in early stages of DR with potential role.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108852"},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of novel atherogenic indices in patients with acute myocardial infarction with and without type 2 diabetes","authors":"Dominika Rokicka ,&nbsp;Bartosz Hudzik ,&nbsp;Marta Wróbel ,&nbsp;Tomasz Stołtny ,&nbsp;Dorota Stołtny ,&nbsp;Alicja Nowowiejska-Wiewióra ,&nbsp;Sonia Rokicka ,&nbsp;Mariusz Gąsior ,&nbsp;Krzysztof Strojek","doi":"10.1016/j.jdiacomp.2024.108850","DOIUrl":"10.1016/j.jdiacomp.2024.108850","url":null,"abstract":"<div><h3>Aims</h3><p>Atherogenic indices: Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli's Risk Index I and II (CRI-I, CRI-II) are used in clinical studies as surrogates of major adverse cardiac and cerebrovascular events (MACCE). Risk prediction of MACCE in patients with acute myocardial infarction (AMI) has vital role in clinical practice. We aimed to assess prognostic value of these indices following AMI.</p></div><div><h3>Methods</h3><p>We analyzed patients with AMI with and without T2DM and the prognostic values of atherogenic indices for in-hospital death and MACCE within 12 months after AMI.</p></div><div><h3>Results</h3><p>Of 2461 patients, 152 in-hospital deaths (6.2 %) were reported (74 patients [7.4 %] with T2DM and 78 [5.3 %] without T2DM; <em>p</em> = 0.042). MACCE occurred in 22.7 % of patients (29.7 % with T2DM and 17.9 % without T2DM; <em>p</em> &lt; 0.001). TG/HDL-C and AIP were higher in T2DM patients compared to those without T2DM (<em>p</em> &lt; 0.001). Long-term MACCE was more prevalent in patients with T2DM (p &lt; 0.001). The AUC-ROC for predicting in-hospital death based on TG/HDL-C and AIP was 0.57 (<em>p</em> = 0.002).</p></div><div><h3>Conclusions</h3><p>None of the atherogenic indices was an independent risk factor for in-hospital death or MACCE at 12-month follow-up in patients with AMI. AIP was an independent risk factor for death at 12-month follow-up.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108850"},"PeriodicalIF":2.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001764/pdfft?md5=6bda50d070c82f5ff190d5866b000151&pid=1-s2.0-S1056872724001764-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age at onset of type 2 diabetes and prevalence of vascular disease and heart failure: Systematic review and dose-response meta-analysis","authors":"Jonathan Goldney ,&nbsp;Mary M. Barker ,&nbsp;Martha Thomas ,&nbsp;Tommy Slater ,&nbsp;Monika Mickute ,&nbsp;Jack A. Sargeant ,&nbsp;Kamlesh Khunti ,&nbsp;Melanie J. Davies ,&nbsp;Francesco Zaccardi","doi":"10.1016/j.jdiacomp.2024.108849","DOIUrl":"10.1016/j.jdiacomp.2024.108849","url":null,"abstract":"<div><h3>Aim</h3><p>To investigate the relationship between age at diagnosis of type 2 diabetes and the risk of macrovascular disease, heart failure, and microvascular disease.</p></div><div><h3>Methods</h3><p>In August 2022, PubMed/EMBASE were searched for articles reporting (i) coronary artery disease, cerebrovascular disease, peripheral vascular disease, amputation; (ii) heart failure; and (iii) retinopathy, neuropathy, nephropathy (albuminuria, chronic kidney disease [CKD], end-stage renal disease) by age at diagnosis of type 2 diabetes. Random effects, non-linear dose-response meta-analysis was undertaken for each outcome to assess the association with age at diagnosis (40 years = reference), using both crude and maximally adjusted odds ratios separately, with and without adjustment for current age (age at sampling).</p></div><div><h3>Results</h3><p>We identified 42 articles (230,003 to 3,465,590 participants; 1035 to 391,140 events). Age at diagnosis was positively associated with the risk of macrovascular diseases, heart failure, and CKD, independent of current age, and negatively associated with retinopathy. For other microvascular outcomes, when adjusting for current age, a “reverse U\" relationship was observed (peak risk = 55–60 years).</p></div><div><h3>Discussion</h3><p>Retinopathy was negatively associated with age at diagnosis, highlighting the importance of retinopathy screening in early-onset type 2 diabetes. The implications of other associations were unclear due to the heterogeneity in methodologies and findings.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108849"},"PeriodicalIF":2.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1056872724001752/pdfft?md5=d1352b60b8393b7b5102b3a8eaa9149b&pid=1-s2.0-S1056872724001752-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism and promising therapeutic strategy of diabetic cardiomyopathy dysfunctions: Focus on pyroptosis","authors":"Xiao-fei Geng ,&nbsp;Wen-yu Shang ,&nbsp;Zhong-wen Qi ,&nbsp;Chi Zhang ,&nbsp;Wen-xiu Li ,&nbsp;Zhi-peng Yan ,&nbsp;Xin-biao Fan ,&nbsp;Jun-ping Zhang","doi":"10.1016/j.jdiacomp.2024.108848","DOIUrl":"10.1016/j.jdiacomp.2024.108848","url":null,"abstract":"<div><p>Diabetes is a major risk factor for cardiovascular diseases, and myocardial damage caused by hyperglycemia is the main cause of heart failure. However, there is still a lack of systematic understanding of myocardial damage caused by diabetes. At present, we believe that the cellular inflammatory damage caused by hyperglycemia is one of the causes of diabetic cardiomyopathy. Pyroptosis, as a proinflammatory form of cell death, is closely related to the occurrence and development of diabetic cardiomyopathy. Therefore, this paper focuses on the important role of inflammation in the occurrence and development of diabetic cardiomyopathy. From the perspective of pyroptosis, we summarize the pyroptosis of different types of cells in diabetic cardiomyopathy and its related signaling pathways. It also summarizes the treatment of diabetic cardiomyopathy, hoping to provide methods for the prevention and treatment of diabetic cardiomyopathy by inhibiting pyroptosis.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108848"},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of GLP-1 agonists in PCOS women living with obesity in promoting weight loss and hormonal regulation: A meta-analysis of randomized controlled trials","authors":"Beatriz Austregésilo de Athayde De Hollanda Morais ,&nbsp;Vitória Martins Prizão ,&nbsp;Mariana de Moura de Souza ,&nbsp;Beatriz Ximenes Mendes ,&nbsp;Maria Luiza Rodrigues Defante ,&nbsp;Otavio Cosendey Martins ,&nbsp;Adriane Maria Rodrigues","doi":"10.1016/j.jdiacomp.2024.108834","DOIUrl":"10.1016/j.jdiacomp.2024.108834","url":null,"abstract":"<div><h3>Background</h3><p>The efficacy of GLP1 receptor agonists (GLP1-RAs) in treating polycystic ovarian syndrome (PCOS) remains unclear. While GLP1-RAs are known to promote weight loss in patients with diabetes and living with obesity, their impact on weight reduction and hormonal regulation in women with PCOS is understudied. Therefore, we aimed to assess the efficacy of GLP1-RAs in PCOS women living with obesity through a meta-analysis, comparing their effects to placebo.</p></div><div><h3>Hypothesis</h3><p>The use of GLP1-RAs in PCOS women living with obesity can reduce body mass index and waist circumference as well as improve hyperinsulinism, and hyperandrogenism as well as normalize total testosterone, total cholesterol and HOMA-IR markers in PCOS women living with obesity.</p></div><div><h3>Methods</h3><p>We systematically searched the PubMed, Cochrane Central, Scopus and Embase databases to identify randomized controlled trials (RCT) comparing GLP1-RAs versus placebo among women diagnosed with PCOS based on the Rotterdam Criteria. Our primary outcomes of interest included body mass index (BMI), triglycerides, waist circumference, total testosterone, total cholesterol, and HOMA-IR. We performed data extraction and quality assessment for studies that met the inclusion criteria. We pooled mean difference (MD) and 95 % confidence intervals (CI) with a random-effect model for continuous endpoints.</p></div><div><h3>Results</h3><p>We included 176 participants from four RCTs. Semaglutide and Liraglutide were used in 23 (13 %) and 103 (58 %) participants, respectively. GLP1-RAs use was associated with a significant reduction in waist circumference (MD: −5.16 cm; 95 % CI: −6.11 to −4.21; p ˂ 0.00001), body mass index (BMI) (MD: −2.42; 95 % CI: −3.10 to −1.74; p ˂ 0.00001), serum triglycerides (MD: −0.20; 95 % CI: −0.30 to −0.11; p ˂ 0.00001) and total testosterone levels (MD: −1.33; 95 % CI: −2.55 to −0.12; <em>p</em> = 0.03) when compared to placebo. There was no significant difference in total cholesterol (MD: −0.04; 95 % CI: −0.10 to 0.01; <em>p</em> = 0.15) and HOMA-IR (MD: −0.30; 95 % CI: −0.92 to 0.32; <em>p</em> = 0.35) levels. Adverse events information was available for 112 patients, where 49 had light side effects such as nausea and abdominal pain.</p></div><div><h3>Conclusion</h3><p>The use of GLP1-RAs demonstrates efficacy in reducing BMI, triglycerides, waist circumference and total testosterone. There was no significant difference in total cholesterol and HOMA-IR levels. These results signify its viability as a favourable treatment option for managing PCOS symptoms in women living with obesity.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 10","pages":"Article 108834"},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Predicting diabetic kidney disease in youth with type 1 diabetes: Insights from genetic risk assessment”","authors":"Ferda Evin ,&nbsp;Tarık Kırkgöz ,&nbsp;Tahir Atik ,&nbsp;Güneş Ak ,&nbsp;Timur Köse ,&nbsp;Caner Kabasakal ,&nbsp;Behzat Özkan ,&nbsp;Samim Özen ,&nbsp;Şükran Darcan ,&nbsp;Damla Gökşen","doi":"10.1016/j.jdiacomp.2024.108833","DOIUrl":"10.1016/j.jdiacomp.2024.108833","url":null,"abstract":"<div><h3>Objective</h3><p>Diabetic kidney disease (DKD) is influenced by multiple factors, yet its precise progression mechanisms remain largely unclear. This study aimed to create a clinical risk-scoring system based on genetic polymorphisms in the AFF3, CARS, CERS2, ERBB4, GLRA3, RAET1L, TMPO, and ZMIZ1 genes.</p></div><div><h3>Methods</h3><p>The study included a DKD group diagnosed with diabetic kidney disease before age 18 and a WDC group matched by age, gender, and age at diabetes diagnosis. Genetic data and clinical data from diabetes diagnosis to moderately increased albuminuria (MIA) detection were compared between the groups.</p></div><div><h3>Results</h3><p>Among 43 DKD cases, 22 were girls and 21 were boys. At MIA diagnosis, mean body weight SDS was −0.24 ± 0.94, height SDS was 0.34 ± 1.15, and BMI SDS was −0.26 ± 0.94. Systolic blood pressure was at the 72nd percentile (2–99), and diastolic blood pressure was at the 74th percentile (33–99). Significant differences in rs267734, rs267738, and rs942263 polymorphisms were found between DKD and non-complication diabetic groups (13[30.2 %] vs 5[11.6 %], <em>p</em> = 0.034; 14[32.6 %] vs 5[11.6 %], <em>p</em> = 0.019; 26[60.5 %] vs 40[93 %], <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Several factors were identified as significant in DKD onset, including low follow-up weight SDS, elevated diastolic blood pressure, presence of rs267734, and absence of rs942263 polymorphisms. The model demonstrated a specificity of 81.4 % and a sensitivity of 74.4 %.</p></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108833"},"PeriodicalIF":2.9,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}