A mediation analysis assessing if interleukin-6 mediates the association between obesity and new-onset type-2-diabetes

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2025-06-23 DOI:10.1016/j.jdiacomp.2025.109110

Nicholas W. Carris , Rahul Mhaskar , Emily Coughlin , Easton Bracey , Hariom Yadav , Ganesh V. Halade , Matthew J. Valente

引用次数: 0

Abstract

Obesity and chronic low-level inflammation increase chronic disease development. The study objective was to better understand how obesity is linked to inflammation and inflammation to new-onset type-2-diabetes. This observational mediation analysis found that 8.1 % of the total effect of increasing BMI on new-onset type-2-diabetes risk was mediated by interleukin-6.

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一项评估白细胞介素-6是否介导肥胖与新发2型糖尿病之间关联的中介分析

肥胖和慢性低水平炎症会增加慢性疾病的发展。这项研究的目的是为了更好地了解肥胖与炎症以及炎症与新发2型糖尿病之间的关系。这项观察性中介分析发现，BMI增加对新发2型糖尿病风险的总影响中有8.1%是由白细胞介素-6介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.