Journal of Drug Delivery Science and Technology最新文献

{"title":"Brucine-Loaded Nickel oxide/Sodium alginate/Polyethylene glycol Nanocomposites Mitigates Inflammatory Responses and Oxidative stress in imiquimod-induced Psoriasis-Like Skin Inflammation in Mice","authors":"Shuang Wang ,&nbsp;Abdurahman Hajinur Hirad ,&nbsp;Abdullah A. Alarfaj ,&nbsp;Quan Shi","doi":"10.1016/j.jddst.2024.106521","DOIUrl":"10.1016/j.jddst.2024.106521","url":null,"abstract":"<div><h3>Background</h3><div>Psoriasis is a chronic inflammatory disease with an unpredictable pathophysiology and no proper cure. Nanomedicine is the use of nanotechnology in the medical field to diagnose, treat, and prevent diseases.</div></div><div><h3>Objective</h3><div>The objective of this work is to prepare and characterize the NiO/PEG/SA-Brucine NCs and evaluate their therapeutic effects against (imiquimod) IMQ-induced psoriasis in mice.</div></div><div><h3>Methodology</h3><div>The synthesized NiO/PEG/SA-Brucine NCs were characterized using several methods. The effect of NiO/PEG/SA-Brucine NCs on the viability and inflammatory cytokines of LPS-induced RAW 264.7 cells was assessed. The psoriasis was induced in the experimental mice using IMQ and topically treated with 10 and 20 mg/kg of NiO/PEG/SA-Brucine NCs. The levels of inflammatory markers, pro-inflammatory cytokines, and oxidative stress markers in the experimental mice were assessed using the kits. The histomorphometrical analysis was conducted on the ear and skin tissue samples of the experimental mice.</div></div><div><h3>Results</h3><div>The treatment with the synthesized NiO/PEG/SA-Brucine NCs effectively increased cell viability and reduced inflammatory markers in the LPS-induced RAW 264.7 cells. In the psoriasis-induced mice, the NiO/PEG/SA-Brucine NCs treatment successfully reduced inflammatory cell counts and improved histomorphometrical changes. The NiO/PEG/SA-Brucine NCs effectively decreased the inflammatory markers in the psoriasis mice. The NCs treatment also increased the antioxidant levels and mitigated the skin histological changes in the psoriasis mice.</div></div><div><h3>Conclusion</h3><div>The findings of this study revealed that NiO/PEG/SA-Brucine NCs successfully mitigated the IMQ-induced psoriatic condition in mice. Consequently, it was evident that NiO/PEG/SA-Brucine NCs may be a beneficial option for treating psoriasis.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106521"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A human GSDMD protein-derived cell-penetrating peptide enhances the antitumor effects of the proapoptotic peptide KLA","authors":"Xia Kong ,&nbsp;Na Li ,&nbsp;Rong-Xuan Ning ,&nbsp;Yu-Ke Liu ,&nbsp;Jing-Heng Wu ,&nbsp;Cun-Yu Liu ,&nbsp;Guo-Liang Huang ,&nbsp;Jie Ding ,&nbsp;Zhi-Wei He","doi":"10.1016/j.jddst.2024.106131","DOIUrl":"10.1016/j.jddst.2024.106131","url":null,"abstract":"<div><div>Cell-penetrating peptides (CPPs) possess significant potential for the transportation of cell-impermeable biological molecules into tumor cells. However, the nonhuman origins of CPPs can cause cytotoxicity and immunogenicity, limiting their clinical applicability. In this study, using <em>in silico</em> approaches combined with <em>in vitro</em> experiments, we identified and characterized a novel CPP named RYK derived from the human gasdermin D (GSDMD) protein. Compared with the R8 peptide, which served as a positive control, RYK exhibited superior penetration efficiency into A549 and HepG2 cells without inducing cytotoxic effects. Confocal laser scanning microscopy further demonstrated that RYK penetrated the nuclei of tumor cells more rapidly than did the R8 peptide. The subsequent experimental results demonstrated that RYK facilitates the cellular internalization of KLA without modifying its cytotoxic mechanism. To summarize, RYK has emerged as a promising CPP for the efficient delivery of exogenous biological agents into tumor cells.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106131"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of inhaled corticosteroid deposition in pediatric mouth-throat airway with tonsil hypertrophy","authors":"Feilun Yang ,&nbsp;Ruiping Ma ,&nbsp;Yusheng Wang ,&nbsp;Siping Sun ,&nbsp;Lu Dang ,&nbsp;Jingbin Zhang ,&nbsp;Hongxian Ren ,&nbsp;Zehui Li ,&nbsp;Yewen Shi ,&nbsp;Guoxi Zheng ,&nbsp;Shaokoon Cheng ,&nbsp;Xiaoyong Ren ,&nbsp;Jingliang Dong ,&nbsp;Ya Zhang","doi":"10.1016/j.jddst.2024.106581","DOIUrl":"10.1016/j.jddst.2024.106581","url":null,"abstract":"<div><div>Pediatric tonsillar hypertrophy (TH) represents one of the most prevalent and frequently diagnosed respiratory conditions in children, in severe cases, it can precipitate obstructive sleep apnea (OSA), thereby increasing the potential risk of neurocognitive impairment and severely affecting the patient's psychological well-being and quality of life. Tonsillectomy is currently the primary therapeutic intervention. However, the formulation of treatment strategies largely depends on the clinician's experience. In this study, we developed a computational fluid-particle dynamics (CFPD) approach and conducted an investigation involving three cases (4, 5, and 7 years old respectively) of severe oropharyngeal obstruction caused by pediatric tonsillar hypertrophy (TH). This study examines the impact of oropharyngeal obstruction on airflow dynamics and the transport of medicinal aerosols within the MT airway. Utilizing models of MT obstruction exceeding 75 %, we created post-operative models after virtual tonsillectomy and meticulously compared the airflow dynamics and ICS particle deposition characteristics in the original pathological (pre-operative model) and post-operative healthy (post-operative model) MT airway models. Quantitative data supporting our findings demonstrate significant improvements: a 42.65 % reduction in pressure drop across the obstructed airway segments, a 92.94 % reduction in wall shear stress (WSS), and a 18.09 % reduction of Maximum DE in aerosol deposition efficiency following the intervention. These results underscore the profound influence of anatomical variations on treatment efficacy and highlight the significant impact of oropharyngeal obstruction on airflow dynamics and the transport of medicinal aerosols in the MT airway. Furthermore, the analysis of regional particle deposition reveals that post-surgical intervention (tonsillectomy) enhances the delivery efficiency of nebulized ICS particles in the oropharynx by restoring a normal flow field. Most significantly, the post-operative MT model demonstrates enhanced airflow and particle deposition in distal tracheal airway region, suggesting a broader applicability of nebulized ICS therapy for pulmonary diseases. These research findings establish a scientific foundation for developing tonsillectomy plans and nebulized inhalation treatments via the MT airway for intrathoracic respiratory tract conditions, including pediatric asthma, with the potential to significantly enhance current clinical treatment outcomes.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106581"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4D printing of shape-memory polymer-based floating tablets via fused deposition modelling: Transformable helical structure to tablet-like form","authors":"Pattaraporn Panraksa ,&nbsp;Sherif I. Hamdallah ,&nbsp;Ozkan Yilmaz ,&nbsp;Phennapha Saokham ,&nbsp;Pornchai Rachtanapun ,&nbsp;Sheng Qi ,&nbsp;Pensak Jantrawut","doi":"10.1016/j.jddst.2024.106534","DOIUrl":"10.1016/j.jddst.2024.106534","url":null,"abstract":"<div><div>The integration of four-dimensional (4D) printing technology into pharmaceutical manufacturing has introduced a transformative approach to drug delivery systems, offering flexible alternatives to improve drug bioavailability. This study advanced the field by developing an innovative 4D-printed floating drug delivery system using Fused Deposition Modelling (FDM) and a temperature-responsive polymer, polylactic acid (PLA). Unlike traditional methods and previous literature that relied on external devices or encapsulation, our approach utilised the shape-memory properties of PLA to create helical structures that transform into tablet-like forms when heated and subjected to an external force. Under gastric conditions, these structures reverted to their original shape, allowing them to float and release drugs over an extended period. In this work, eight helical models (M1 to M8), were designed and fabricated with varying geometric parameters, including helix diameter, number of helical turns, and top/base height, to assess their geometric accuracy, shape-memory performance, drug-loading efficiency, floatability, and release behaviour. Results showed that models with smaller helix diameters and fewer turns exhibited superior shape recovery, with the highest observed at 79.5 % for Model M1 (1.0 mm helix diameter, two helical turns, and 0.5 mm top/base height). Meanwhile, models with larger diameters showed higher drug-loading capacities. Additionally, the drug-loaded models demonstrated significant shape-recovery and floating performances, suggesting the potential for prolonging drug release for up to 12 h. These findings highlight the potential of 4D printing in developing advanced drug delivery systems, providing new insights into how this technology can improve drug administration and drug delivery through shape-changing tailored systems.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106534"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of drug-loaded coaxial electrospun nanofibers membranes with pH-responsive and antibacterial properties","authors":"Qingxi Hu ,&nbsp;Wenxiang Tang ,&nbsp;Yongteng Song ,&nbsp;Haiguang Zhang","doi":"10.1016/j.jddst.2024.106533","DOIUrl":"10.1016/j.jddst.2024.106533","url":null,"abstract":"<div><div>Cardiovascular diseases pose a serious threat to human life and health. Vascular stent intervention surgery is currently the main method for treating cardiovascular diseases in the clinic, but the implantation of bare mental vascular stents can easily cause surgical infection. Fortunately, covering the surface of vascular stents with antibacterial membranes can effectively solve this problem. Therefore, in this work, an electrospun nanofibers membrane loaded with amoxicillin (AMX) was developed via coaxial electrospinning, and the release of AMX can be controlled by a pH-responsive process. The nanofibers (PEO-AMX/PCL-SF) had core-shell structures, with polyethylene oxide (PEO) containing AMX as the core layer and silk fibroin (SF) and polycaprolactone (PCL) as the shell layer. The weakly acidic environment caused by bacterial metabolism could cause the pH-responsive of SF in the nanofiber shell layer, resulting in the release of AMX in the core layer for antibacterial purposes. The PEO-AMX/PCL-SF nanofibers membrane exhibited excellent physicochemical properties, with a tensile strength of 3.25 ± 0.04 MPa and a water contact angle of 41.99 ± 1.43°. Furthermore, the membrane showed excellent pH-responsive drug release characteristics and antibacterial properties. <em>In vivo</em> and <em>in vitro</em> experiments suggested that the prepared nanofibers membrane has great biocompatibility and antibacterial properties, which has the potential to prevent and treat surgical infection after vascular stent implantation.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106533"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into new emerging materials as antifungal agents and delivery systems: A scoping review","authors":"Hadeer M. Bedair ,&nbsp;Mahmoud Hamed ,&nbsp;Fotouh R. Mansour","doi":"10.1016/j.jddst.2024.106499","DOIUrl":"10.1016/j.jddst.2024.106499","url":null,"abstract":"<div><div>Fungal infections are among the leading causes of morbidity and mortality in individuals with compromised immune systems. Despite advances in knowledge and treatment techniques, mycoses are becoming increasingly prevalent due to the growing resistance to antifungal medications, frequently observed in clinical settings. Additionally, the emergence of antifungal drug resistance has rendered many accessible drug classes ineffective, significantly complicating the clinical management of fungal diseases. The primary mechanisms of fungal resistance include drug target modification or overexpression, increased efflux pump activity, and activation of cellular stress response pathways. The most concerning resistant fungi are <em>Candida auris</em> (C. auris), <em>Aspergillus fumigatus</em> (A. fumigatus), and <em>Trichophyton indotineae</em>. Furthermore, traditional antifungal drugs are limited by their narrow activity spectrum and lack of suitable targets. To address these limitations, new alternatives have been developed, including materials with antifungal properties, such as metal-organic frameworks (MOFs), quantum dots (QDs), carbon quantum dots (CQDs), deep eutectic solvents (DESs), layered double hydroxides (LDHs), and ionic liquids (ILs). These materials not only possess antifungal activity but can also enhance drug targeting. This review explores the nature of these emerging materials, their advantages, and the challenges associated with their application as antifungal agents.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106499"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Nature's microscopic messengers: Cutting-Edge viral and bacterial vectors revolutionize targeted therapies","authors":"AbdelRahman H. Shaban ,&nbsp;Ahmed M. Elgebaly ,&nbsp;Ahmed O. Sayed ,&nbsp;Amr M. Abdullatef ,&nbsp;Anas M. Ahmed ,&nbsp;Areej El-Beheady ,&nbsp;Doaa M. Mostafa ,&nbsp;Eman M.A. Eid ,&nbsp;Hazem A. El-Kady ,&nbsp;Heba H. Masoud ,&nbsp;Ibrahim M. Fangary ,&nbsp;Lougi Kh Bondok ,&nbsp;Mahmoud Gamaleldin ,&nbsp;Majdeldin E. Abdelgilil ,&nbsp;Omar H. Mohamed ,&nbsp;Omar Kh Elghamry ,&nbsp;Omar M. Mohamed ,&nbsp;Omar O. Ibrahim ,&nbsp;Rana T. El-Tantawi ,&nbsp;Youssef A. Ebrahim ,&nbsp;Amira A. Boseila","doi":"10.1016/j.jddst.2025.106660","DOIUrl":"10.1016/j.jddst.2025.106660","url":null,"abstract":"<div><div>Viral and bacterial vectors have significantly advanced targeted therapies over recent decades, particularly in drug delivery and cancer treatment. Retroviral vectors, especially those that are replication-competent, have improved the integration of therapeutic genes into host genomes, showing promise in treating gliomas and lung cancer. Lentiviral vectors, particularly HIV-1 derivatives, excel in gene therapy for genetic disorders like Wiskott-Aldrich syndrome due to their ability to transduce non-dividing cells with low genotoxicity. Clinical trials indicate their effectiveness in enhancing patient outcomes without major side effects. Bacterial vectors, such as \"bacteriabots,\" which combine bacterial cells with nanoparticles, improve targeting in chemotherapy. Various bacterial strains have been effective in activating T-cells and enhancing macrophage responses. Bacterial outer membrane vesicles (OMVs) also contribute to drug delivery and immune activation. In tumor phototherapy, bacterial biohybrids utilize photodynamic agents to enhance treatment efficacy while reducing side effects. Techniques like covalent conjugation and electrostatic interactions aid in developing these biohybrids. Overall, this review emphasizes the effectiveness of viral and bacterial vectors in targeting cancer cells and stimulating immune responses, while highlighting the need for continued research to overcome limitations and optimize their clinical applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106660"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of quercetin-loaded liposomal nanocarriers for alleviation of gemcitabine-induced hepatotoxicity: Optimization, in-vitro, and in-vivo evaluation","authors":"Mahran Mohamed Abd El-Emam ,&nbsp;Ahmed Alobaida ,&nbsp;Marwa Mohamed El Sayed ,&nbsp;Milad Reda Qelliny ,&nbsp;Mohamed Ibrahim ,&nbsp;Tarek Khamis ,&nbsp;Mahmoud Mostafa ,&nbsp;Ahmed A. Katamesh ,&nbsp;Gehad Mohammed Subaiea","doi":"10.1016/j.jddst.2025.106659","DOIUrl":"10.1016/j.jddst.2025.106659","url":null,"abstract":"<div><div>Gemcitabine (GEM) is an extensively utilized antineoplastic drug for treating many malignancies, including ovarian, bladder, and pancreatic cancers. Nevertheless, utilization of GEM has been linked to hepatotoxicity, which may limit its use in clinical applications. Quercetin (QUR) is a naturally occurring flavonoid with versatile biological activities, but its therapeutic utility is hindered by poor water solubility and low bioavailability. This study aimed to enhance QUR bioavailability by developing and evaluating different formulations of QUR liposomes (QUR-L). The optimal QUR-L formulation was determined based on various variables including particle size distribution, polydispersity index, zeta potential, entrapment efficiency, and <em>in vitro</em> release. Subsequently, the optimal formulation has been used to treat rats with induced hepatotoxicity upon gemcitabine administration via oral route. Rats were divided into control, QUR-L, GEM, and GEM + QUR-L groups. The rat's liver impairment severity was determined by measuring liver function tests, antioxidant capacity, anti-inflammatory markers, and nuclear factor erythroid–2–related factor–2 (Nrf2)-related gene expression across all groups. According to the findings, QUR-L reduced the severity of GEM-induced hepatotoxicity in rats, as evidenced by enhanced liver function tests and total hepatic antioxidant capacity. Furthermore, QUR-L upregulated mRNA expression of Nrf2 and downregulated expression of hepatic pro-inflammatory mediators such as nuclear factor kappa-light-chain-enhancer of activated β-cells (NF-κB) and tumor necrosis factor-α (TNF-α). Furthermore, QUR-L treatment enhanced the histological status of the hepatic tissue in GEM-treated rats. These findings suggest that QUR-L could serve as a safe and effective substitute for traditional hepatoprotectives in mitigating GEM-induced hepatic injury.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"105 ","pages":"Article 106659"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteric coating of halloysite nanotube/ o-butyrylated chitosan microspheres for the co-delivery of paeoniflorin and butyric acid to colon","authors":"Haigang Li ,&nbsp;Jiaxuan Liu ,&nbsp;Lei Zhang ,&nbsp;Xinru Zhu ,&nbsp;Jing Jiang ,&nbsp;Zhaohui Ge ,&nbsp;Yifei Zuo ,&nbsp;Xiangzhu Chen ,&nbsp;Chun Zhang","doi":"10.1016/j.jddst.2024.106508","DOIUrl":"10.1016/j.jddst.2024.106508","url":null,"abstract":"<div><div>This study aims to achieve co-delivery of paeoniflorin (PF) and butyric acid (BA) to the colon through Eudragit S100 (EUS100)-coated halloysite nanotube/o-butyryl chitosan microspheres (EUS100-HNT-BUCHNPs). O-butyrylated chitosan (BUCH) was prepared by the acylation reaction of chitosan (CH) and butyric anhydride with methane sulfonic acid as a catalyst. PF-loaded halloysite nanotube/o-butyrylated chitosan microspheres (HNT-BUCHNPs) were prepared by emulsion crosslinking with glutaraldehyde as the crosslinking agent and then coated with EUS100 using the emulsion solvent evaporation method. X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy results indicated the presence of EUS100 coating on the surface of HNT-BUCHNPs. In vitro release studies demonstrated that the EUS100 coating effectively prevented the release of PF and BA at pH 1.2, while the halloysite nanotube slowed down PF release at pH 6.8. Sequential release experiments in different pH media showed lower release of PF and BA at pH 1.2 and pH 6.8, and higher release at pH 7.4, reaching approximately 80 % and 85 %, respectively. Gastrointestinal tract retention studies in mice confirmed that EUS100-HNT-BUCHNPs reduced the release of PF and BA in the upper digestive tract, facilitating delivery to the colon. In vivo and in vitro results indicated efficient transport of PF and BA to the colon, suggesting the potential of EUS100-HNT-BUCHNPs as colon-targeted carriers for PF and BA.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106508"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attapulgite microspheres coated with poly(lactic acid-glycolic acid) nanoparticles form satellite structure to enhance doxorubicin delivery in bone cancer therapy","authors":"Yu Wang ,&nbsp;Lisi Yan ,&nbsp;Xu Yan ,&nbsp;Jianqiang Ding ,&nbsp;Bo Cheng ,&nbsp;Jing Yang ,&nbsp;Binbin Li ,&nbsp;Xinyu Wang","doi":"10.1016/j.jddst.2024.106509","DOIUrl":"10.1016/j.jddst.2024.106509","url":null,"abstract":"<div><div>The micro-nano structure of drug delivery systems, which realize the release of the drug in stages, represent a promising therapeutic approach for tumor chemotherapy. In this study, we developed a drug delivery system in which nano-PLGA was coated on the surface of attapulgite microspheres (ATT-MS) loaded with doxorubicin hydrochloride (DOX). Nano-PLGA surrounding ATT-MS formed a satellite structure, which improved the drug release rate by blocking the drug release channels with the nano-PLGA. The drug delivery system achieves a high DOX encapsulation efficiency (98 %) and enables passive, tumor-selective drug release. The zeta potential and drug release curve showed that DOX in this drug delivery system is more readily released in the tumor microenvironment. The fluorescence imaging and Western blot analysis showed that the drug delivery system has the potential to improve tumor resistance. Moreover, the <em>in vivo</em> experiment showed that the system not only maintained the anticancer activity but also reduced the organ damage. In conclusion, this micro-nano structure of the drug delivery system may provide a novel approach to effectively deliver DOX to the tumor and reduce systemic toxicity.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106509"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}