Journal of Drug Delivery Science and Technology最新文献

{"title":"Modulating drug delivery with nano-selenium capped chitosan reverse micelles for anticancer potential","authors":"Radha Gosala ,&nbsp;Raghunandhakumar Subramanian ,&nbsp;Balakumar Subramanian","doi":"10.1016/j.jddst.2025.106860","DOIUrl":"10.1016/j.jddst.2025.106860","url":null,"abstract":"<div><div>Combining nanoparticles with biopolymer protective coatings offer an appealing cancer treatment strategy. This study develops chitosan (CS) coated selenium (Se) nanocarriers <em>via</em> reverse micellar method using surfactants such as sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and N-cetyl-N,N,N-trimethylammonium bromide (CTAB) to enhance the sustained release of daunorubicin (DNR) and to improve the stability of drug carriers. The chemically reduced Se nanoparticles aggregated into elongated rod shapes, approximately 60 nm in diameter, and were coated with CS to form a protective layer that sustained the drug release. Zeta potential measurements revealed that CS coating increased the surface charge of Se nanoparticles, with values of 33 ± 6.1 mV for CTAB system and 30 ± 5.7 mV for AOT systems. Additionally, AOT resulted in higher encapsulation efficiency (70 %) compared to CTAB (62 %). DNR drug release at pH 5.4 showed a significantly higher cumulative release (88 %) compared to pH 7.4 (75 %), demonstrating pH-dependent release behavior. The CS coating acts as a gatekeeper, regulating the release of DNR from Se nanoparticles. <em>In vitro</em> studies showed that both CS-CTAB-Se@DNR and CS-AOT-Se@DNR carriers exhibited higher cytotoxicity and increased ROS generation compared to bare Se nanoparticles. These findings highlight the potential of CS-Se@DNR nanocarriers as an effective strategy for cancer treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"108 ","pages":"Article 106860"},"PeriodicalIF":4.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly synthesis and multifunctional evaluation of silver nanoparticles using Boleophthalmus dussumieri mucus: Antibacterial, anticancer, and predictive modeling applications","authors":"Fahimeh Saberi ,&nbsp;Ahmad Gharzi ,&nbsp;Ashraf Jazayeri ,&nbsp;Vahid Akmali ,&nbsp;Khosrow Chehri ,&nbsp;Naser Karimi ,&nbsp;Nasrin Babajani ,&nbsp;Muhammad Rizwan ,&nbsp;Elahe Baratalipour","doi":"10.1016/j.jddst.2025.106843","DOIUrl":"10.1016/j.jddst.2025.106843","url":null,"abstract":"<div><div>The synthesis of eco-friendly silver nanoparticles has attracted significant attention from researchers, primarily due to their wide-ranging applications in contemporary medicine, having antioxidant, antimicrobial, and anticancer properties. In this study, green-synthesized AgNPs (MM-Ag NPs) using <em>Boleophthalmus dussumieri</em> mucus were prepared and characterized for their antibacterial, antibiofilm, antihemolytic, and anticancer properties. Characterization techniques UV–vis, SEM, TEM, and AFM confirmed that the nanoparticles were uniformly spherical, ranging from 10 to 30 nm. The nanoparticles showed a UV–visible absorption peak at 428 nm, indicating a successful reduction of AgNO₃. FTIR analysis revealed bioactive molecules on their surfaces, while X-ray diffraction indicated a face-centered cubic structure, with a zeta potential of −16 ± 0.65 mV. MM-Ag NPs exhibited strong antibacterial activity against the confirmed bacterial strains, including <em>Escherichia coli</em>, <em>Pseudomonas aeruginosa</em>, and <em>Staphylococcus aureus</em>, with a notable 22 mm inhibition zone against <em>E. coli</em>. In cytotoxicity assays on MCF-7 cancer cells, an IC50 value of 48.73 % was recorded at 256 ppm, highlighting their anticancer potential. Biocompatibility tests demonstrated safety through membrane stabilization assays using red blood cells. Machine learning techniques were also applied to predict values related to <em>Citrobacter freundii</em> and <em>Morganella morganii</em> for MM-Ag NPs. The best model for predicting their concentrations was identified, showcasing the effectiveness of ML in enhancing research efficiency and reducing trial-and-error approaches. In conclusion, this study underscores the significant biological potential of AgNPs derived from <em>B. dussumieri</em> mucus as promising antimicrobial agents against bacterial infections; potential anticancer agents in cancer therapy, and eco-friendly candidates for drug delivery systems.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"108 ","pages":"Article 106843"},"PeriodicalIF":4.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal Apocynin-loaded nanostructured lipid carriers (NLCs) for Alzheimer's disease therapy: Formulation, optimization, and pharmacokinetic evaluations","authors":"Supriya Samala,&nbsp;Akshada Mhaske,&nbsp;Rahul Shukla","doi":"10.1016/j.jddst.2025.106862","DOIUrl":"10.1016/j.jddst.2025.106862","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by cognitive impairment and neuronal degeneration. Delivering drugs to the brain remains a challenge due to the restrictive nature of the blood-brain barrier (BBB). Intranasal (IN) administration offers a promising alternative by utilizing the olfactory and trigeminal pathways to bypass the BBB. Apocynin (APO), a natural antioxidant, has been explored for its potential in reducing oxidative stress linked to AD. This study aimed to develop APO-loaded nanostructured lipid carriers (APO-NLCs) and evaluate their physicochemical properties, drug release profile, cellular uptake, and brain distribution following intranasal and oral administration.</div></div><div><h3>Methods</h3><div>APO-NLCs were formulated using a melt emulsification method and optimized via a Box-Behnken design. The nanoparticles were characterized for size, surface charge, entrapment efficiency, and drug loading. Morphological analysis, <em>in vitro</em> drug release, <em>ex vivo</em> nasal permeation using goat nasal mucosa, and cellular uptake studies in SH-SY5Y cells were conducted. Pharmacokinetic and biodistribution studies compared drug accumulation in the brain following intranasal and oral administration.</div></div><div><h3>Results</h3><div>The optimized APO-NLCs had a particle size of 138.8 nm, a zeta potential of −8.65 mV, an entrapment efficiency of 60.21 %, and a drug loading of 7.58 %. The formulation showed a biphasic release pattern, with 45.80 % of the drug released over 24 h, following Higuchi kinetics. Intranasal administration led to significantly higher brain drug accumulation compared to oral delivery, indicating improved bioavailability and CNS targeting.</div></div><div><h3>Conclusion</h3><div>APO-NLCs demonstrated effective drug delivery to the brain, with intranasal administration offering superior bioavailability over oral administration. These findings highlight their potential for treating AD and warrant further investigation.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"108 ","pages":"Article 106862"},"PeriodicalIF":4.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible zein-gum Arabic nanoparticles for astaxanthin encapsulation and topical delivery: Preparation and characterization","authors":"Wenpeng Song ,&nbsp;Wei Wei ,&nbsp;Biao Zhou ,&nbsp;Ning Lv ,&nbsp;Heng Qin ,&nbsp;Fei Huan ,&nbsp;Xiaoling Zhang","doi":"10.1016/j.jddst.2025.106858","DOIUrl":"10.1016/j.jddst.2025.106858","url":null,"abstract":"<div><div>Astaxanthin (AST), a potent antioxidant, holds great promise for skin health and cosmetic applications but is limited by poor water solubility and stability. This study presents the development of zein nanoparticles modified with gum arabic (GA) for the encapsulation of AST, serving as a topical nanocarrier for AST to enhance its dermal bioavailability and topical delivery. The optimized zein-GA-AST nanoparticles (Z-GA-AST) exhibited a spherical nanostructure with a mean particle size of 199.03 ± 4.63 nm (PDI &lt;0.2) and achieved a high encapsulation efficiency of 90.34 ± 1.74 %. FT-IR spectroscopy analysis confirmed the successful encapsulation of AST within the nanoparticles. The AST-loaded nanoparticles exhibited significantly superior antioxidant activity compared to free AST. At an equivalent astaxanthin concentration of 10 μg/mL, the ABTS and DPPH radical scavenging efficiencies of the nanoparticles were at least 153 % and 128 % higher than those of free AST, respectively. The incorporation of GA enhanced the physicochemical stability and astaxanthin retention of the nanoparticles under various conditions, including different salt ion concentrations, temperatures, and storage durations, by facilitating the formation of a more compact nanostructure. The skin permeation behavior of the nanoparticles was evaluated using Franz diffusion cells and porcine skin. The results demonstrated that Z-GA2-AST1 exhibited significantly higher skin retention (48.37 %) and lower astaxanthin permeation (10.20 %) compared to free astaxanthin. This study provides valuable insights into the preparation and characterization of biocompatible nanoparticles for AST encapsulation, could become a potential formulation for topical delivery applications in cosmetics and topical drug delivery systems.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"107 ","pages":"Article 106858"},"PeriodicalIF":4.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine phospholipid nanoliposomes mediate oral colonic delivery of 5-aminosalicylic acid and mitigate the severity of DSS-induced colitis in mouse models","authors":"Samah Shabana ,&nbsp;Hamed I. Hamouda ,&nbsp;Suzan Noureldin ,&nbsp;Zhe Chi ,&nbsp;Chenguang Liu","doi":"10.1016/j.jddst.2025.106821","DOIUrl":"10.1016/j.jddst.2025.106821","url":null,"abstract":"<div><div>5-Aminosalicylic acid (5-ASA) is the preferred medication for treating mild to moderate inflammatory bowel disease (IBD). However, side effects and sometimes insufficient efficacy pose challenges. This study introduces chitosan-coated orally targeted marine phospholipid nanoliposomes grafted with Vit. E. TPGS for delivering 5-aminosalicylic acid to the inflamed mucosa in IBD treatment. MTL nanoliposomes were prepared by the thin film hydration method, exhibiting sizes of 165.8 ± 2.19 nm pre-coating and 259.5 ± 1.77 nm size post-coating. The nanoliposomes showed controlled drug release at intestinal pH, with minimal release in the simulated gastric medium. They demonstrated excellent stability over a 45-day storage period. <em>In vitro</em>, cytocompatibility studies with L929 cells and <em>ex vivo</em> studies with RBCs showed excellent biocompatibility. MTL nanoliposomes showed selective deposition in inflamed RAW 264.7 macrophages and time-dependent uptake in Caco2 intestinal cells. <em>In vitro,</em> anti-inflammatory experiments significantly reduced inflammatory biomarkers like TNF-α, IL1-β, IL-6, and ROS. <em>In vivo,</em> DSS-induced colitis studies demonstrated improved colitis indices, colonic tissue change restoration, and myeloperoxidase activity inhibition. These findings underscore the potential of MTL nanoliposomes as a promising targeted delivery system for 5-aminosalicylic acid in treating IBD.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"108 ","pages":"Article 106821"},"PeriodicalIF":4.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-drug solid dispersions of two hydrophobic antipsychotics and DP-VPA-C18 with improved pharmacodynamic and pharmacokinetic profiles","authors":"Chao Hao ,&nbsp;Wenwen Liu ,&nbsp;Chenxin Duan ,&nbsp;Zhiling Chen ,&nbsp;Jinmeng Han ,&nbsp;Jie Song ,&nbsp;Tao Zhuang ,&nbsp;Xiaohua Zhang","doi":"10.1016/j.jddst.2025.106859","DOIUrl":"10.1016/j.jddst.2025.106859","url":null,"abstract":"<div><div>DP-VPA is a phospholipid prodrug of valproic acid which has been highly recommended as an adjunct to antipsychotics for the treatment of schizophrenia, and phospholipids are considered as promising excipients in solid dispersions (SDs). This study aimed to explore the effect of SDs of two poorly water-soluble antipsychotics (Aripiprazole, ARI; ziprasidone hydrochloride, ZIP·HCl) with DP-VPA on their pharmacodynamic and pharmacokinetic profiles. The SDs of ARI or ZIP·HCl containing DP-VPA-C₁₈ (DV₁₈) were prepared by the solvent evaporation methods and characterized by powder X-ray diffraction, differential scanning calorimetry and infrared spectroscopy. The apparent solubility of ARI or ZIP·HCl in the prepared SDs was improved at least 2-fold than pure drugs in four different media. Those SDs also exhibited synergistic antipsychotic effects in reversing apomorphine-induced climbing behavior in mice. Furthermore, the optimal drug ratios between ARI or ZIP·HCl and DV₁₈ were determined as 1:10 (SD-ARI 10) and 1:8 (SD-ZIP 8) respectively, and SD-ARI 10 and SD-ZIP 8 showed good physical stability under long-term storage conditions. The oral bioavailability of SD-ZIP 8 was improved 1.67 times in rats when compared to the pure drug. This study highlighted the potential of DP-VPA as a promising carrier drug for antipsychotics in SDs to improve their pharmacokinetic and pharmacodynamic profiles.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"108 ","pages":"Article 106859"},"PeriodicalIF":4.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclodextrin-based chemically modified pH-Responsive new kind of aldehyde-functionalized nanosponge nanoparticles for doxorubicin hydrochloride delivery","authors":"Ayhan Bergal ,&nbsp;Muberra Andac ,&nbsp;Francesco Trotta","doi":"10.1016/j.jddst.2025.106853","DOIUrl":"10.1016/j.jddst.2025.106853","url":null,"abstract":"<div><div>This study aimed to develop and assess ALD-NS nanoparticles (NPs) as pH-responsive drug delivery systems. Functionalized β-cyclodextrin derivatives (OX-β-CDs) containing aldehyde (CHO) groups were synthesized and crosslinked with pyromellitic dianhydride (PMDA) to form water-soluble ALD-NS-NPs. Doxorubicin hydrochloride (DOX·HCl), containing an NH₂ side group, was incorporated bidirectionally into ALD-NS through the reflux method, forming pH-sensitive Schiff base (C=N) bonds and integrating into the hydrophilic portion of ALD-NS. Characterization of the ALD-NS + DOX complex confirmed successful drug loading, with a particle size of 372.7 ± 8.21 nm, a negative zeta potential of −12.8 ± 1.54 mV, and a high encapsulation efficiency of 85.5 %. In vitro drug release studies conducted under three distinct buffer conditions revealed a higher release rate at pH 5.2 compared to pH 7.4, which was attributed to the hydrolysis of Schiff base bonds and crosslinker in the acidic environment. Cytotoxicity and cellular uptake assays performed on A549 cancer cells demonstrated dose- and time-dependent responses. ALD-NS + DOX displaying higher cell viability and increased drug accumulation within cells when compared to free DOX at equivalent concentrations. Drug release kinetics, assessed using the Korsmeyer-Peppas model (R² = 0.97), revealed a release mechanism that involves both dissolution (hydrolysis) and non-Fickian diffusion, with diffusion coefficients of 0.622 in PBS and 0.71 in NaOAc at pH 5.2. These findings suggest that the ALD-NS-NP system is a promising candidate for targeted drug delivery, particularly for drugs with NH₂ functional groups in acidic environments.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"107 ","pages":"Article 106853"},"PeriodicalIF":4.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the complexities of diabetic foot ulcers: From pathophysiology to advanced treatment strategies","authors":"Giriraj Pandey ,&nbsp;Tejaswini Kolipaka ,&nbsp;Dadi A. Srinivasarao,&nbsp;Noella Abraham,&nbsp;Akshita Jain,&nbsp;Saurabh Srivastava","doi":"10.1016/j.jddst.2025.106852","DOIUrl":"10.1016/j.jddst.2025.106852","url":null,"abstract":"<div><div>Diabetic foot ulcers (DFUs) are the most prevalent and serious complication among diabetic patients, causing substantial health and economic burden due to low rate of healing and high recurrence. Current therapies for DFUs include surgical debridement, wound dressings, pressure offloading, revascularization, hyperbaric oxygen therapy, low-level laser therapy, and negative pressure wound therapy. In this review, we discussed conventional and emerging therapies using hydrogel and nanofiber-based treatments, stem cell approaches, 3D bioprinting, growth factors, matrix metalloproteinase (MMP) modulators, and bioengineered skin substitutes, which showed improved healing and reduced the risk of amputation. The current article attempts to give an in-depth overview of DFU management by examining established and innovative techniques. Further, this review emphasizes the necessity of multidisciplinary approaches to enhance patient compliance and lessen the burden of devastating pathological conditions.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"107 ","pages":"Article 106852"},"PeriodicalIF":4.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Cu- and Fe-based metal-organic frameworks as innovative nanocarriers for enhanced fluconazole delivery in topical management of Candida albicans","authors":"Mrunali Patel ,&nbsp;Jigisha Panchal ,&nbsp;Richa Dave ,&nbsp;Jigar Nandha ,&nbsp;Mitesh Patel ,&nbsp;Bhavtosh Kikani ,&nbsp;Alkesh Patel ,&nbsp;Vanarajsinh Solanki ,&nbsp;Mahendra Rai ,&nbsp;Rashmin Patel","doi":"10.1016/j.jddst.2025.106854","DOIUrl":"10.1016/j.jddst.2025.106854","url":null,"abstract":"<div><div>Fungal infections pose significant challenges in healthcare, with current treatments often limited by low efficacy and side effects. This study explores fluconazole (FLCZ) loaded metal-organic frameworks (MOF) as innovative nanocarriers to enhance antifungal therapy through synergistic action and controlled drug release. MOF synthesized using copper (Cu) and iron (Fe) metals with suitable linker via the room temperature conversion method were converted into topical gels using Carbopol® 971 NP. Comprehensive evaluations revealed that the Cu- and Fe-based MOF gels were clear and translucent, with skin-compatible pH (5.96 ± 0.07 and 5.02 ± 0.04, respectively), high drug content (&gt;98 %w/w), and favorable application properties, including pseudoplastic flow, good spreadability (35 ± 2 mm and 23 ± 3 mm), and high viscosity (6489.33 ± 7.15 cps and 6247.41 ± 5.69 cps, respectively). Drug release studies showed sustained profiles with Cu- and Fe-MOF gels following a Higuchi matrix diffusion-controlled mechanism. <em>In-vitro</em> antifungal studies demonstrated enhanced efficacy, with larger zones of inhibition against <em>Candida albicans</em> compared to marketed formulation, indicating a synergistic mechanism of action. Acute dermal toxicity assessment confirmed the safety of MOF gels, with minimal skin irritation and improved histological outcomes. This investigation highlights the potential of MOF-based gels as advanced nanocarrier systems for fungal infections, offering controlled release, enhanced antifungal activity, and reduced skin toxicity, paving the way for effective, targeted antifungal therapies.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"107 ","pages":"Article 106854"},"PeriodicalIF":4.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of adipose, bone marrow, and tendon stem cell-derived exosomes on tendon healing","authors":"Ahmad Oryan ,&nbsp;Mohammad Kalhorniagolkar ,&nbsp;Nicola Maffulli","doi":"10.1016/j.jddst.2025.106844","DOIUrl":"10.1016/j.jddst.2025.106844","url":null,"abstract":"<div><div>One of the most common musculoskeletal conditions in orthopedic clinical practice is tendon injury, often leading to severe pain and significant disability. Traditional methods such as physical therapy, rest, and non-steroidal anti-inflammatory drugs (NSAIDs) are often unsuccessful, leading to a prolonged or incomplete recovery. Therefore, identifying novel treatment approaches to accelerate tendon healing is crucial. Recent research has increasingly demonstrated the advantageous outcomes of stem cell therapy facilitated by exosomes. Exosomes are nanoscale cellular vesicles associated with various physiological and pathological states. By transporting bioactive materials including proteins, lipids, and nucleic acids like mRNAs and miRNAs, they promote intercellular communication. Exosomes are beneficial for tissue healing and regeneration. Furthermore, exosomes from different origins (adipose stem cells, bone marrow stem cells, and tendon stem cells) differentially affect tendon healing. Each type of exosome affects the healing process through specific biological pathways, contributing positively to tendon repair. In this review, we explored the process of exosome biogenesis and we compared its isolation methods and also considered the pathways and mechanisms influenced by these three types of exosomes in tendon healing. Finally, we addressed the current challenges and proposed future research directions.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"107 ","pages":"Article 106844"},"PeriodicalIF":4.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}